Region | Title | System | Version | Edition | Languages | Serial | Status |
| SaGa Frontier | PSX | | Original | | SCUS-94230 | |
| SaGa Frontier 2 | PSX | | Original | | SLUS-00933 | |
| The Secret of Googol 1b: Reshaping Googol: The Tower | PSX | | Original | | LSP-020150 … | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PSX | | Original | | LSP-020650 … | |
| Shadow Man | PSX | | Original | | SLUS-00895 | |
| Shadow Tower | PSX | | Original | | SLUS-00863 | |
| Skydiving Extreme | PSX | | Original | | SLUS-01392 | |
| Space Jam | PSX | | Original | | SLUS-00243 | |
| Suikoden | PSX | | Original | | SLUS-00292 | |
| Suikoden II | PSX | | Original | | SLUS-00958 | |
| Syphon Filter 2 (Disc 1) | PSX | | Original, Greatest Hits | | SCUS-94451 | |
| Syphon Filter 2 (Disc 2) | PSX | | Original, Greatest Hits | | SCUS-94451 … | |
| Strawberry Shortcake: The Sweet Dreams Game | PS2 | 1.02 | Original | | SLUS 21497 | |
| Second Sight | PS2 | 1.00 | Original | | SLUS-21033 | |
| Sega Genesis Collection | PS2 | 1.01 | Original | | SLUS 21542 | |
| Silent Hill Origins | PS2 | 1.00 | Original | | SLUS-21731 | |
| Spyro: Enter the Dragonfly | PS2 | 3.00 | Original, Greatest Hits | | SLUS 20315 … | |
| Star Ocean: Till the End of Time (Disc 1) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20488 … | |
| Star Ocean: Till the End of Time (Disc 2) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20891 … | |
| Suikoden III | PS2 | 1.00 | Original | | SLUS-20387 | |
| Suikoden IV | PS2 | 1.00 | Original | | SLUS-20979 | |
| Suikoden Tactics | PS2 | 1.00 | Original | | SLUS-21245 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Sewer Shark | MCD | Rev 1 | Original | | T-6201 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| Shining Force CD | MCD | | Original | | 4656 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| Stellar-Fire | MCD | | Original | | T-110025 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Sorry! | PC | 1.3 | Original | | 99040 | |
| Star Wars: Jar Jar's Journey Adventure Book | PC | 1.0 | Original | | #3520530 | |
| Star Wars: Jedi Knight II: Jedi Outcast | PC | 1.02a | Original | | 9541830 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: Knights of the Old Republic (Disc 2) | PC | 1.0.0.0 | Original | | 3191831 | |
| Star Wars: Knights of the Old Republic (Disc 3) | PC | 1.0.0.0 | Original | | 3191832 | |
| Star Wars: Knights of the Old Republic (Disc 4) | PC | 1.0.0.0 | Original | | 3191833 | |
| StarCraft | PC | 1.0 | Original | | 630235 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |