| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Etoiles et Galaxies: Astronomie Flammarion | CDI | 2.01 | Original |  | 812 0091 | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
 | E-Z Play Today Keyboard | CDI | 1.05 | Original | | 810 0137 |  |
| Evil Twin: Cyprien's Chronicles | DC | 1.001 | Original |     | T-46605D-80 | |
| Evil Twin: Cyprien's Chronicles | DC | 1.001 | Original | | T-46605D-71 | |
| Enemy Engaged: RAH-66 Comanche Versus KA-52 Hokum | PC | 1.0.1C | AOL Promotional Disc | | | |
| Earthworm Jim: Special Edition | PC | 1.0 | Original, The Essential Collection | | 1000142.101.UK, CDD-3114-101-3L | |
| EarthSiege 2
EarthSiege II | PC | 1.0 | Original | | S4510210Z12ZZ | |
| EyeToy: Kinetic (Press Disc) | PC | | Press Kit | | | |
 | Eye of the Beholder II: The Legend of Darkmoon
アイ・オブ・ザ・ビホルダーⅡ | FMT | | Original |  | HME-201 | |
 | Exit 7: The Harley-Davidson Experience on CD-i | CDI | | | | | |
 | Evoluon: Philips Competence Centre: An Interactive Journey Through the Evoluon
Philips Competence Centre: The Evoluon | CDI | | | | 8180069 | |
| The European School | CDI | | Original | | 819 0041 | |
| The European CD-i Association: CD-i Presentation | CDI | | Original | | 2020.009 | |
| Eureka: Gutenberg: L'Imprimerie et Ses Précurseurs | CDI | | Beta | | | |
 | Essentials: The New Shape of Home Shopping | CDI | | Original | | | |
 | Escape from CyberCity | CDI | | Original, Demonstration Disc, Nur für Demonstrationszwecke | | 310-690-071-2, 310690071-2, 690 071-2, 690 0712, 810 0005, 812 0043, 813 0041, 815 0029 | |
| Les Encastrables
De Dietrich: Les Encastrables | PHOTO-CD | | Original | | | |
| L'Empereur
ランペルール | FMT | | with Soundware | | HMB-223 | |
| Elsevier's Interactive Anatomy: Volume 1-I (Paranasal Sinuses & Anterior Skull Base) | CDI | | Original | | | |
 | Electronic Art Gallery: Funkausstellung Berlin 1991 | CDI | | Original | | | |
| The Elder Scrolls V: Skyrim | PC | | Original | | DIS-43531-FRA | |
 | Egypt Kids | PC | | Original | | VG:1034 | |
| Effectief Communiceren I: School Version | CDI | | Beta | | | |
| Ecstatica II | PC | | Original | | | |
| Ečstatica | PC | | Original | | ECST PCCD | |
| Ecolauto: No 5: Tests Codoroute
Ecolauto: N°5: Tests Codoroute | CDI | | Original | | T5-01 | |
| Ecolauto: No 4: Tests Codoroute
Ecolauto: N°4: Tests Codoroute | CDI | | Original | | 4-1-12-96 | |
| Ecolauto: No 3: Cours de Formation B
Ecolauto: N° 3: Cours de Formation B | CDI | | Original | | 3-2-6-94 | |
| Ecolauto: Moto 1 DV: Maniabilité
CD-i Moto I DV: Maniabilité Sécurité: Digital Vidéo | CDI | | Original | | 1-1-01-96 | |
| Ecolauto: Groupe Lourd No 2: Question Écrites
Ecolauto: Groupe Lourd N° 2: Question Écrites | CDI | | Original | | GL-2-1-01-95 | |
| Ecolauto: Groupe Lourd No 1: Épreuve Orale
Ecolauto: Groupe Lourd N° 1: Épreuve Orale | CDI | | Original | | GL-1-1-12-94 | |
| Ecolauto: DV No 4: Cours de Formation B
Ecolauto: DV N° 4: Cours de Formation B | CDI | | Original | | 4-2-7-94 | |
| Ecolauto: DV No 4: Cours de Formation B
Ecolauto: DV N° 4: Cours de Formation B | CDI | | Original | | 4-1-5-94 | |
| ECCO Electronic Coaching: Messegespräche | CDI | | Original | | | |
| ECCO Electronic Coaching: Erst Stirbt das Image... | CDI | | Original | | | |
| ECCO Electronic Coaching: Ein Meeting Jagt das Andere | CDI | | Original | | | |
| Earth 2140 | PC | | Les Grands Jeux: Collection PointSoft Nº3 | | CD1037 | |
| E-Cat No 3
E-Cat N° 3 | CDI | | Original | | | |
| E-Cat No 2
E-Cat N° 2 | CDI | | Original | | | |
| E-Cat No 1
E-Cat N° 1 | CDI | | Original | | 818 0061 | |
