| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Earthworm Jim: Special Edition | PC | | SoftKey |  | JIM844AE-CD |  |
 | Eclipse: Story of Summer Menace | PC | | Original |  | | |
| Ečstatica | PC | | Bundle Version OEM | | 7509, CDRS1241800 | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Einsatz!
あいんざっつ！ ーＥｉｎｓａｔｚー | PC | | Original | | ZN-001 | |
| The Embodiment of Scarlet Devil for Busy Person.
忙しい人のための紅魔郷 | PC | | Original | | KSG-0001 | |
| eXceed 2nd: Vampire | PC | 0.01 | Original | | | |
| eXceed: Gun Bullet Children.
イクシード | PC | 0.01 | Original | | | |
| El Shaddai: Ascension of the Metatron | PS3 | 01.01 | Original |     | BLUS-30466 | |
| Earth Treks | PC | 1.0 | Original | | SOFTEAR020795 | |
| eGames Collector's Edition 251 | PC | 1.0 | Original | | 02-7500-10 | |
| Escape from Monkey Island (Disc 2) | PC | 1.0 | Original | | 1101831, 1101831R1 | |
 | Escape from Monkey Island (Disc 1) | PC | 1.0 | Original | | 1101830, 41022.101.UK | |
| The Elder Scrolls IV: Oblivion | PC | 1.0.228 | Collector's Edition | | | |
| eXceed 2nd: Vampire REX
イクシードセカンド・ヴァンパイア／レックス | PC | 1.00 | Original | | | |
| eXceed 3rd: Jade Penetrate
イクシードサード・ジェイドペネトレータ | PC | 1.00 | Original | | | |
 | EZF Advance | PC | 1.00 beta 4 | | | | |
| Engage to Jabberwock
ジャッバウォックの花嫁 | PC | 1.01 | Original | | MSCD-0017 | |
| The Even More! Incredible Machine | PC | 1.01c | SierraOriginals | | | |
| eXceed 3rd: Jade Penetrate: Black Package
イクシードサードージェイド／ペネトレーターブラックパッケージ | PC | 1003 | Original | | | |
