Region | Title | System | Version | Edition | Languages | Serial | Status |
 | Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N |  |
 | A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 |  |
 | Super Runabout: San Francisco Edition | DC | 1.005 | Original | | T-12511N |  |
 | Super Magnetic Neo | DC | 1.001 | Original | | T-40206N |  |
 | Sturmwind | DC | 1.0 | Unlicensed (Rerelease) | | |  |
 | Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N |  |
 | Stupid Invaders (Disc 1) | DC | 1.001 | Original | | T-17708N |  |
 | Sports Jam | DC | 1.001 | Original | | T-44304N |  |
 | Spider-Man | DC | 1.000 | Original | | T-13008N |  |
 | Speed Devils: Online Racing | DC | 1.002 | Original | | T-17718N |  |
 | Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H |  |
 | The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 |  |
 | South Park Rally | DC | 1.001 | Original | | T-8116N |  |
 | Sonic Adventure | DC | 1.004 | Original | | 51000 |  |
 | Soldier of Fortune | DC | 1.001 | Original | | T-40212N |  |
 | SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N |  |
 | SmartKids Challenge One | VIS | | Original | | 25-6176 |  |
 | Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T162035 |  |
 | Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T162035 |  |
 | Silver | DC | 1.001 | Original | | T-15108N |  |
 | Shinobi Legions | SS | 1.000 | Original | | T-2301H |  |
 | Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 |  |
 | Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 |  |
 | Shadow Man | DC | 1.001 | Original | | T-8106N |  |
 | Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N |  |
 | Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 |  |
 | The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 |  |
 | Search for the Sea | VIS | | Original | | 25-6143 |  |
 | Samurai Shodown | MCD | | Original | | T-60175 |  |
 | Sail with Columbus | VIS | | Original | | 25-6181 |  |