Region | Title | System | Version | Edition | Languages | Serial | Status |
| Syyrah: The Warp Hunter | PC | | Original | | | |
| System Shock | PC | | Collezione CD-Rom by C.T.O. | | | |
| Syndicate Wars | PC | | Collezione CD-Rom by C.T.O. | | ECA545 | |
| Sydney 2000 | PSX | | Original | | SLES-02860 | |
| Syberia: Edizione Oro | PC | | FX Interactive | | | |
| SWAT 4: The Stetchkov Syndicate | PC | 1.0.0 | Original | | S1003598 | |
| SWAT 4 (Disc 2) | PC | 1.0.31763 | Original | | S1002655 | |
| SWAT 4 (Disc 1) | PC | 1.0.31763 | Original | | S1002641 | |
| SWAT 3: Close Quarters Battle | PC | 1.400 | Elite Edition: BestSeller Series | | S1001685 | |
| SWAT 3: Close Quarters Battle | PC | 1.400 | Elite Edition: Covermount | | | |
| SWAT 3: Close Quarters Battle | PC | 1.400 | Elite Edition: BestSeller Series | | S0024182 | |
| Suzuki Alstare: Extreme Racing | PC | | Covermount | | | |
| Surgery Simulator | PC | 1.0 | Original | | | |
| Surf's Up | WII | | Original | | RVL-RXUX-EUU | |
| Super Game: Visual CD Game | PC | | | | | |
| Super Collapse! 3 | PSP | 1.00 | Original | | ULES-01027 | |
| Super Botte & Bamba II Turbo | PC | | Original | | | |
| SunAge | PC | 1.02 | Original | | | |
| Suikoden II | PSX | | Original | | SLES-02446 | |
| Sudoku: Il Rompicapo Preferito dagli Italiani | PC | 1.0.0.1000 | Original | | | |
| Stronghold Deluxe FireFly Studios' Stronghold Deluxe | PC | 1.2 | BIS Collezione CD-ROM | | | |
| Stronghold Deluxe FireFly Studios' Stronghold Deluxe | PC | 1.2 | Rerelease | | | |
| Strip Poker Strip Poker: Il gioco si fa sexy! | PC | 1.0 | Original | | CD5206 | |
| Strike Fighters Flight Simulator | PC | 08.13.04 | FX Interactive | | S.L. IT v.08.30.06 b P - DVD | |
| Street Fighter II | PC | | Original | | 9108 | |
| Stone Quarry Simulator | PC | 1.2 | Original | | AST-STONE-CD | |
| Still Life | PC | 1.0 | Covermount | | | |
| Stellaris: Sfida a Starcity | PC | | Original | | | |
| Startopia | PC | 1.00 | Covermount | | | |
| Star Wars: Yoda Stories + Star Wars: Screen Entertainment | PC | 1.0 | | | FD005, LUC629 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Collezione CD-Rom by C.T.O. | | | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Disco 1) (Gioco) | PC | 1.10 | Collezione CD-Rom by C.T.O. | | LUC629 | |
| Star Wars: X-Wing vs. TIE Fighter (Disco 2) (Multiplayer) | PC | 1.10 | Collezione CD-Rom by C.T.O. | | LUC629 | |
| Star Wars: X-Wing vs. TIE Fighter (Disco 1) (Gioco) | PC | | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Disco 2) (Multiplayer) | PC | | Original | | | |
| Star Wars: X-Wing Alliance (Disco 2) | PC | 1.0 | Original | | | |
| Star Wars: X-Wing Alliance (Disco 1) | PC | 1.0 | Original | | | |
| Star Wars: Starfighter | PC | 1.0 | Original | | | |
| Star Wars: Rogue Squadron II: Rogue Leader | GC | | Original | | DL-DOL-GSWI-ITA | |
| Star Wars: Rogue Squadron 3D | PC | 1.0 | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | 1.08 | Collezione CD-Rom by C.T.O. | | 3091830 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | 1.08 | Collezione CD-Rom by C.T.O. | | 3091830 | |
| Star Wars: Rebel Assault | PC | 1.7 | Collezione CD-Rom by C.T.O. | | | |
| Star Wars: Prime Scoperte: Activity Center | PC | 1.0 | I CD-ROM di Donna Moderna | | | |
| Star Wars: La Guerra dei Cloni | PS2 | 1.01 | Original | | SLES-50829 | |
| Star Wars: La Guerra dei Cloni | GC | | Original | | DL-DOL-GSXI-ITA | |
| Star Wars: La Forza nella Matematica: La Galassia dei Giochi di Jabba | PC | 1.0 | I CD-ROM di Donna Moderna | | | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 4) | PC | | Original | | 41127.104.IT | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 3) | PC | | Original | | 41127.103.IT | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 2) | PC | | Original | | 41127.102.IT | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) | PC | | Original | | 41127.101.IT | |
| Star Wars: Knights of the Old Republic (Disc 4) | PC | 1.00 | Original | | 41118.104.IT | |
| Star Wars: Knights of the Old Republic (Disc 3) | PC | 1.00 | Original | | 41118.103.IT | |
| Star Wars: Knights of the Old Republic (Disc 2) | PC | 1.00 | Original | | 41118.102.IT | |
| Star Wars: Knights of the Old Republic (Disc 1) (Disco di Gioco) | PC | 1.00 | Original | | 41118.101.IT | |
| Star Wars: Galactic Battlegrounds (Disco 2) (Gioco) | PC | 1.0 | Original | | | |
| Star Wars: Galactic Battlegrounds (Disco 1) (Installazione) | PC | 1.0 | Original | | | |
| Star Wars: Force Commander (Disco 2) | PC | 1.0 | Original | | | |
| Star Wars: Force Commander (Disco 1) | PC | 1.0 | Original | | | |
| Star Wars: Episodio I: Racer | PC | 2.0 | LucasArts Classic | | 41171.101.IT | |
| Star Wars: Episodio I: Oltre la Terra dei Gungan | PC | 1.0 | Original | | | |
| Star Wars: Episodio I: Battle for Naboo Star Wars: Episodio 1: Battaglia per Naboo | PC | 1.0 | Original | | | |
| Star Wars: Episode III: Revenge of the Sith: Activity Centre | PC | | Ubisoft eXclusive | | 5004401 | |
| Star Wars: Battlefront (Disco 1) (Disco di gioco) | PC | 1.0 | Original | | 41121.101.IT | |
| Star Wars: Battlefront (Disco 3) | PC | 1.0 | Original | | 41121.103.IT | |
| Star Wars: Battlefront (Disco 2) | PC | 1.0 | Original | | 41121.102.IT | |
| Star Trek: Generazioni (Disc 2) | PC | 1.00 | CD-ROM Classic Collection | | MP591 261 DO2R | |
| Star Trek: Generazioni (Disc 1) | PC | 1.00 | CD-ROM Classic Collection | | MP591 261 DO1R | |
| SSN-21 Seawolf | PC | | Collezione CD-Rom by C.T.O. | | | |
| SRS: Street Racing Syndicate (Disc 2) | PC | | Serie Maxima | | | |
| SRS: Street Racing Syndicate (Disc 1) | PC | | Serie Maxima | | | |
| Sports Car GT (Manuale Elettronico) | PC | | Original | | ECA430 DK2 | |
| Spike: The Hedgehog | PC | | Covermount | | | |
| Spider-Man 2: The Game | PC | | Covermount | | 32581.101.IT | |
| Spider-Man 2 | XBOX | | Classics | | AV-043 | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| Spellcross: L'Ultima Battaglia | PC | | CD-ROM Classic Collection 7 | | | |
| Speedboat Attack | PC | 0.9.9.0 | Covermount | | | |
| Speed Demons | PC | | Covermount | | | |
| Speed Busters | PC | 1.01 | Covermount | | | |
| Speed Busters | PC | | Covermount | | | |
| Spec Ops: Ranger Assault | PC | | Original | | 76896 428512 | |
| Spartan | PC | 1.013 | Covermount | | | |
| SpaceHaste 2 SpaceHaste: The Next Levels | PC | 2.001 | Covermount | | | |
| Space Empires V | PC | 1.30 | Covermount | | | |
| Space Colony (Disc 2) (Jugar) | PC | | Original | | | |
| Space Colony (Disc 1) (Instalación) | PC | | Original | | | |
| Sonic 3D: Flickies' Island | PC | | Covermount | | | |
| Söldner: Secret Wars: Reloaded | PC | 30600 | Original | | ROSOELDNER0021LAB | |
| Soldier of Fortune II: Double Helix (Disc 1) | PC | 1.00 | Original | | 31147.101.IT | |
| Soldier of Fortune | PC | 1.07f | Platinum Edition (Xplosiv) (Covermount) | | | |
| Solaris 1.0.4. Solaris | PC | | Microforum | | | |
| SOFTline hiGames n. 26: Novembre 1997 | PC | | | | | |
| SOFTline hiGames n. 25: Settembre 1997 | PC | | | | | |
| SOFTline hiGames n. 24: Luglio/Agosto 1997 | PC | | | | | |
| SOFTline hiGames n. 23: Giugno 1997 | PC | | | | | |
| SOFTline hiGames n. 22: Maggio 1997 | PC | | | | | |
| SOFTline hiGames n. 21: Aprile 1997 | PC | | | | | |
| SOFTline hiGames n. 17: Novembre 1996 | PC | | | | | |
| SoccerChamp | PC | | Original | | | |
| Soccer Compilation | PC | | | | | |
| Sniper: L'Arte della vittoria | PC | 1.0.0.0 | Original | | | |
| Smash Up Derby | PC | | Covermount | | | |
| Small Soldiers: Squad Commander | PC | | Covermount | | | |
| Small Pak | PC | | | | | |
| Sleeping Dogs | PS3 | 01.01 | Original | | BLES-01662 … | |
| Sled Storm | PSX | | Original | | SLES-02194 | |
| Ski Region Simulator Ski Region Simulator 2012 | PC | 4.1.6.1 | Original | | | |
| Sins of a Solar Empire | PC | 1.05 | Covermount | | | |
| Sinkha 1: Hyleyn | PC | 8.5.0.321 | Original | | | |
| SingStar Queen | PS2 | 1.00 | Original | | SCES-55485 | |
| SingStar Motown | PS2 | 1.00 | Original | | SCES-55551 | |
| SingStar Cantautori Italiani | PS2 | 1.00 | Original | | SCES-55640 | |
| SingStar | PS2 | 1.00 | Original | | SCES-52566 | |
| Sin Episodes: Emergence SiN Episodes: Emergence | PC | 1.0.0.0 | Original | | VAI07705155D | |
| Simulmondo Interactive: Little Computer People n. 4 | PC | | | | | |
| Simulmondo Interactive: Little Computer People n. 1 | PC | | | | | |
| Simulmondo Compilation 3 PC CD-ROM: Dylan Dog + Tex | PC | | Original | | | |
| Il Simulatore di Sopralluogo | PC | | Covermount | | | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.6 | The Black Box PC Collection | | | |
| The Sims 2: World Adventure (Expansion Pack) The Sims 2: Bon Voyage (Expansion Pack) | PC | 1.10.0.111 | Original | | MXX07705691D | |
| The Sims 2 (Disc 1) | PC | 1.0.0.932 | Original | | MXX08004261D1 | |
| I Simpson: Il Videogioco | PSP | 1.00 | Original | | ULES-00977 | |
| SimCity Societies | PC | 1.0 | Original | | MXX07705800D | |
| SimCity 2000 Special Edition | PC | | SoftKey | | ESC744BB-CD | |
| Sim Train: Il treno dal 1830 ad oggi Bit A Train | PC | | Original | | 8032853240175 | |
| Silver (Disc 2) | PC | | Original | | SILVCDR2IT | |
| Silver (Disc 1) | PC | | Original | | SILVCDR1IT | |
| Silent Bomber | PSX | | Original | | SLES-02991 | |
| Il Signore di Atlantide: Poseidon | PC | 2.0 | Original | | S0027713 | |
| Il Signore degli Anelli: Tactics | PSP | 1.00 | Original | | ULES-00201 | |
| Il Signore degli Anelli: La Terza Era | XBOX | | Original | | EA-095 | |
| Il Signore degli Anelli: La Compagnia dell'Anello | PC | | BestSeller Series | | S1000034 | |
| Il Signore degli Anelli: La Compagnia dell'Anello | PC | | Original | | S1001534 | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 3) (Disco di Gioco) | PC | 1.0 | EA Classics | | EAI08004073BD3 | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 3) (Disco di Gioco) | PC | | Original | | EAI08004073D3 | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 2) (Disco d'Installazione) | PC | 1.0 | EA Classics | | EAI08004073BD2 | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 2) (Disco d'Installazione) | PC | | Original | | EAI08004073D2 | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 1) (Disco d'Installazione) | PC | 1.0 | EA Classics | | EAI08004073BD | |
| Il Signore degli Anelli: Il ritorno del Re (Disc 1) (Disco d'Installazione) | PC | | Original | | EAI08004073D | |
| Il Signore degli Anelli: Il ritorno del Re | XBOX | | Original | | EA-062 | |
| La Signora Calibro 32 (Disc 2) The Dame Was Loaded | PC | | Covermount | | | |
| La Signora Calibro 32 (Disc 1) The Dame Was Loaded | PC | | Covermount | | | |
| Sierra Sports Golf | PC | | Covermount | | SIAE 9826PA | |
| Sierra Pro Pilot (Disc 2) | PC | 1.0 | Original | | | |
| Sierra Pro Pilot (Disc 1) | PC | 1.0 | Original | | | |
| Sid Meier's Pirates! (Disc 2) | PC | 1.0.0.0 (16395) | Limited Edition | | 1016601 | |
| Sid Meier's Pirates! (Disc 1) | PC | 1.0.0.0 (16395) | Limited Edition | | 1016600 | |
| Shrek 2 | XBOX | | Original | | AV-055 | |
| Shellshock | PC | | Kixx | | | |
| Shanghai: True Valor | PSX | | Original | | SLES-01618 | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadow Warrior | PC | | Original | | MTC000875-D | |
| Shadow Man | PC | | Wanted Games | | CD194141.00-EUR | |
| Shadow Man | PC | | Original | | CD194141.05-ITA | |
| Shadow Madness (Disc 2) | PSX | | Original | | SCES-12102 | |
| Shadow Madness (Disc 1) | PSX | | Original | | SCES-02102 | |
| Shadow Company: Left for Dead | PC | 1.2 | Covermount | | | |
| Sfida nella Piramide! | PC | | Evviva! Software | | | |
| The Settlers: Heritage of Kings: Gold Edition | PC | | Covermount | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Covermount | | | |
| Serious Sam II | PC | 2.068.00 : 62787 | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| Secret Files: Il Mistero di Tunguska | PC | 1.00 | Covermount | | | |
| Sea Adventures | PC | | Microforum | | | |
| Scudetto 5 Scudetto Championship Manager 5 | XBOX | | Original | | ES-026 | |
| Scudetto 4: Championship Manager: Stagione 2002-2003 | PC | 4.0.4 | Original | | MCHM4PIT81 | |
| Scudetto 2006: Championship Manager | PSP | 1.00 | Original | | ULES-00332 | |
| Scubeginners: I Misteri di Dive Island | PC | 1.1 | Original | | | |
| Screamer Rally | PC | | Covermount | | G02 | |
| Screamer 2 | PC | | Original | | | |
| Screamer | PC | | Original | | | |
| Scooby-Doo! Who's Watching Who? Scooby-Doo! Chi sta guardando chi? / Scooby-Doo! ¿Quién está mirando a quién? | PSP | 1.00 | Original | | ULES-00573 | |
| Scene It? Ciak! Si Gira! Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCI-ITA-B0 | |
| SCAR: Squadra Corse Alfa Romeo | PC | | Original | | | |
| Scacchi 3D | PC | | Microforum | | | |
| SBK X: Superbike World Championship | PC | 1.0 | Original | | | |
| Samurai Shodown Anthology | PSP | 1.01 | Original | | ULES-01211 | |
| Salvage Yard Simulator | PC | | Original | | | |
| Salammbô (Disc 2) | PC | | Original | | SLBOCD2 | |
| Salammbô (Disc 1) | PC | | Original | | SLBOCD1 | |
| Saints Row: Double Pack | PS3 | 01.00 | Original | | BLES-02094 | |
| Saints Row 2 | PC | | Covermount | | | |
| Safecracker Safecracker: L'avventura definitiva per aspiranti scassinatori | PC | 1.01 | Original | | SAFEMULTICD1 | |
| Sacrifice | PC | 0506.11.09 | Original | | CD-C95-1041-IT | |
| Sacred 2: Fallen Angel (Disc 2) | PC | 2.0.2 Build 1371 | Original | | ECD008419D | |
| Sacred 2: Fallen Angel (Disc 1) | PC | 2.0.2 Build 1371 | Original | | ECD008419D | |
| Sacred | PC | 1.8.90 | FX Interactive | | IT v1.8 DVD | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | ROSILENTST0011lab2 | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | ROSILENTST0011lab1 | |