Region | Title | System | Version | Edition | Languages | Serial | Status |
| Samurai Dou 2 Portable 侍道2ポータブル | PSP | 1.03 | Original | | UCAS-40277 | |
| Samurai Dou Portable 侍道ポータブル | PSP | 1.02 | Original | | ULJS-00155 | |
| Samurai Warriors: State of War | PSP | 1.00 | Original | | ULES-00297 | |
| Samurai Warriors: State of War | PSP | 1.00 | Original | | ULES-00298 | |
| Samurai Warriors: State of War | PSP | 1.00 | Original | | ULES-00299 | |
| Samurai Warriors: State of War | PSP | 1.01 | Original | | ULUS-10089 | |
| Sangokushi V 三國志Ⅴ | PSP | 1.03 | Koei Teiban Series | | ULJM 05200 | |
| Sangokushi VI 三國志Ⅵ | PSP | 1.02 | Original | | ULJM 05038 | |
| Sangokushi VII 三國志Ⅶ | PSP | 1.03 | Original | | ULJM 05083 | |
| SBK 08: Superbike World Championship | PSP | 1.02 | Original | | ULES-01063 | |
| SBK 09: Superbike World Championship | PSP | 1.02 | Original | | ULES-01247 | |
| SBK: Superbike World Championship | PSP | 1.01 | Original | | ULUS-10395 | |
| Scooby-Doo! Who's Watching Who? Scooby-Doo! Chi sta guardando chi? / Scooby-Doo! ¿Quién está mirando a quién? | PSP | 1.00 | Original | | ULES-00573 | |
| Scudetto 2006: Championship Manager | PSP | 1.00 | Original | | ULES-00332 | |
| Shin Master of Monsters Final EX: Mukunaru Nageki, Tenmei no Saika 真・マスターオブモンスターズ Final EX ~無垢なる嘆き、天冥の災禍~ | PSP | 1.01 | Original | | ULJS 00282 | |
| Shin Megami Tensei: Persona | PSP | 1.00 | Original | | ULUS-10432 | |
| Shin Sangoku Musou 2nd Evolution 真・三國無双 2nd Evolution | PSP | 1.00 | PSP the Best | | ULJM 08020 | |
| Shin Seiki Evangelion: Koutetsu no Girlfriend 2nd Portable 新世紀エヴァンゲリオン 鋼鉄のガールフレンド2nd ポータブル | PSP | 1.01 | Original | | ULJM 05477 | |
| Shinkyoku Soukai Polyphonica: 0~4 wa Full Pack 神曲奏界ポリフォニカ 0~4話フルパック | PSP | 1.02 | Original | | ULJM-05347 | |
| Shirokishi Monogatari Episode Portable: Dogma Wars 白騎士物語 -episode.portable- ドグマ・ウォーズ | PSP | 1.00 | Original | | UCJS 10115 | |
| Shougi ga Tsuyokunaru: Gekisashi: Jouseki Doujou 将棋が強くなる 激指 定跡道場 | PSP | 1.02 | Original | | ULJM 05263 | |
| Sid Meier's Pirates! | PSP | 0.01 | Pre-Production | | ULET-00696 | |
| Sid Meier's Pirates! | PSP | 1.01 | Original | | ULES-00688 | |
| Sid Meier's Pirates! | PSP | 1.02 | Original | | ULUS-10224 | |
| Simple 2000 Series Portable!! Vol. 1: The Mahjong SIMPLE2000シリーズシリーズポータブル!! Vol.1 THE 麻雀 | PSP | 1.04 | Original | | ULJS 00301 | |
| Simple 2500 Series Portable!! Vol. 10: The IQ Cube: Moyatto Atama o Puzzle de Sukkiri! SIMPLE2500シリーズポータブル!! Vol.10 THE IQ CUBE ~モヤっと頭をパズルでスッキリ!~ | PSP | 1.03 | Original | | ULJS 00108 | |
| Simple 2500 Series Portable!! Vol. 11: The Puzzle Quest: Agaria no Kishi SIMPLE2500シリーズポータブル!! Vol.11 THE パズルクエスト ~アガリアの騎士~ | PSP | 1.01 | Original | | ULJS-00114 | |
| Simple 2500 Series Portable!! Vol. 3: The Dokodemo Suiri: IT Tantei Zen 68 no Jikenbo SIMPLE2500シリーズポータブル!! Vol.3 THEどこでも推理 -IT探偵:全68の事件簿ー | PSP | 1.07 | Original | | ULJS 00053 | |
| Simple 2500 Series Portable!! Vol. 4: The Unou Drill SIMPLE2500シリーズポータブル!! Vol.4 THE 右脳ドリル | PSP | 1.01 | Original | | ULJS 00039 | |
| I Simpson: Il Videogioco | PSP | 1.00 | Original | | ULES-00977 | |
| Les Simpson: Le Jeu | PSP | 1.00 | Platinum: The Best of PSP | | ULES-00976 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULAS 42115 | |
| The Simpsons Game | PSP | 1.00 | Original | | ULUS-10295 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 0.01 | Pre-Production | | UCET-00222 … | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Public Beta v1.0 | | UCUS 98637 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 1.00 | Best Buy Demo | | UCUS 98692 | |
| Solomon's Ring: Chi no Shou Solomon's Ring ~地の章~ | PSP | 1.01 | Genteiban | | PP-0004, U … | |
| Sony Computer Science Kenkyuusho Mogi Kenichirou Hakushi Kanshuu: Nou ni Kaikan Aha Taiken ソニーコンピュータサイエンス研究所 茂木健一郎博士監修 脳に快感 アハ体験! | PSP | 1.00 | Original | | ULJM-05135 | |
| Sony Computer Science Kenkyuusho Mogi Kenichirou Hakushi Kanshuu: Nou ni Kaikan Minna de Aha Taiken ソニーコンピュータサイエンス研究所 茂木健一郎博士監修 脳に快感 みんなでアハ体験! | PSP | 1.01 | Original | | ULJM-05189 | |
| Space Invaders Extreme | PSP | 0.01 | Pre-Production | | ULET-01077 | |
| Space Invaders Extreme | PSP | 1.00 | Original | | ULES-01078 | |
| Space Invaders Extreme | PSP | 1.00 | Original | | ULUS-10346 | |
| Space Invaders Pocket スペースインベーダー ポケット | PSP | 1.04 | Original | | ULJM 05015 | |
| Space Invaders: Galaxy Beat スペースインベーダー ギャラクシービート | PSP | 1.02 | Original | | ULJM 05045 | |
| Spelling Challenges and More! | PSP | 1.00 | Original | | ULUS 10255 | |
| Spider-Man: Freund oder Feind | PSP | 1.01 | Original | | ULES-00901 | |
| Spider-Man: Friend or Foe Spider-Man: Allié Ou Ennemi / Spider-Man: Amigo o Enemigo | PSP | 1.01 | Original | | ULES-00900 | |
| Spider-Man: Friend or Foe | PSP | 1.00 | Original | | ULUS-10318 | |
| Starry Sky: After Autumn Portable: Etsuran Shite Please: Etsu Plea 2 Starry☆Sky ~After Autumn~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.00 | Shokai Genteiban | | HONEY-007, … | |
| Starry Sky: After Spring Portable: Etsuran Shite Please: Etsu Plea 2 Starry☆Sky ~After Spring~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.03 | Shokai Genteiban | | ULJM 06227 | |
| Starry Sky: After Summer Portable: Etsuran Shite Please: Etsu Plea 2 Starry☆Sky ~After Summer~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.01 | Shokai Genteiban | | HONEY-006, … | |
| Starry Sky: After Winter Portable: Etsuran Shite Please: Etsu Plea 2 Starry★Sky ~スタ・スカ~ ~After Winter~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.00 | Shokai Genteiban | | HONEY-008, … | |
| Street Cricket Champions | PSP | 1.00 | Original | | UCES-01320 | |
| Street Cricket Champions 2 | PSP | 1.03 | Original | | UCES 01579 | |
| Street Fighter Zero 3 Double Upper ストリートファイターZERO3 ダブルアッパー | PSP | 1.01 | CapKore | | ULJM 05225 | |
| Street Supremacy | PSP | 1.02 | Original | | ULES-00239 | |
| Street Supremacy | PSP | 1.00 | Original | | ULUS-10069 | |
| Strike Witches: Hakugin no Tsubasa ストライクウィッチーズ -白銀の翼- | PSP | 1.00 | Original | | ULJM 06086 | |
| Sudoku SUDOKU 数独 | PSP | 1.00 | Original | | ULJM 05146 | |
| Sudoku Coach Carol Vorderman's Sudoku | PSP | 1.03 | Original | | ULES-00387 | |
| Summon Night 5 | PSP | 1.01 | Original | | ULUS-10656 | |
| Sunday vs. Magazine Shuuketsu! Choujou Daikessen サンデーVSマガジン 集結!頂上大決戦 | PSP | 1.05 | Original | | ULJM-05450 | |
| Super Monkey Ball Adventure | PSP | 1.02 | Original | | ULUS-10132 | |
| Suzumiya Haruhi-chan no Mahjong 涼宮ハルヒちゃんの麻雀 | PSP | 1.02 | Original | | ULJM 05751 | |
| Syphon Filter: Dark Mirror | PSP | 1.01 | Demo | | UCED-00413 … | |
| System Software Update Ver. 3.73 システムソフトウェアアップデート Ver. 3.73 | PSP | 1.00 | Original | | UCJX 90027 … | |
| S.Y.K Renshouden Portable S.Y.K ~蓮咲伝~ Portable | PSP | 1.01 | Shokai Genteiban | | ULJM 05866 | |
| Sakura Sakura: Haru Urara さくらさくら -HARU URARA- | PSP | 1.02 | Original | | ULJM 05758 | |
| Samurai Shodown Anthology | PSP | 1.01 | Original | | ULES-01211 | |
| Sangoku-hime: Sangoku Ransei: Haten no Saihai 三極姫~三国乱世・覇天の采配~ | PSP | 1.00 | Limited Edition | | ULJS 00434 | |
| Satomi Hakkenden: Hamaji Hime no Ki 里見八犬伝~浜路姫之記~ | PSP | 1.03 | Original | | ULJM 06379 | |
| School Rumble: Anesan Jiken desu! スクールランブル ~姉さん事件です!~ | PSP | 1.00 | Original | | ULJS 00019 | |
| School Wars: Sotsugyou Sensen スクール・ウォーズ~卒業戦線~ | PSP | 1.02 | Goukaban | | ROSE 00027 … | |
| SD Gundam GGeneration Overworld SDガンダム ジージェネレーション オーバーワールド | PSP | 1.01 | Original | | ULJS 00536 | |
| Secret Game: Killer Queen: Portable シークレットゲーム -KILLER QUEEN- PORTABLE | PSP | 1.01 | Yeti Best | | ULJM 05953 | |
| Sekai de Ichiban NG na Koi: Full House 世界でいちばんNGな恋 ふるはうす | PSP | 01.00 | Shokai Genteiban | | ULJM 05878 | |
| Sengoku Musou 3 Z Special 戦国無双3 Z Special | PSP | 1.01 | Original | | ULJM 06024 | |
| Sengoku-hime: Senran ni Mau Otome-tachi 戦極姫 ~戦乱に舞う乙女達~ | PSP | 1.02 | Original | | ULJM 05540 | |
| Senjou no Valkyria 3 E2: Extra Edition 戦場のヴァルキュリア3 E2: Extra Edition | PSP | 1.00 | Original | | ULJM 05957 | |
| Senritsu no Stratus 戦律のストラタス | PSP | 1.01 | Original | | ULJM 05934 | |
| Shadow of Memories | PSP | 1.02 | Original | | ULJM-05512 | |
| Shin Megami Tensei: Persona 2: Innocent Sin | PSP | 1.00 | Collector's Edition | | ULES-01557 | |
| Shin Megami Tensei: Persona 3 Portable | PSP | 1.00 | Pre-Production | | ULES-01523 … | |
| Shin Megami Tensei: Persona 3 Portable | PSP | 1.00 | Trade Demo | | ULUS-80022 | |
| Shin Sangoku Musou 5 Empires 真・三國無双5 Empires | PSP | 1.02 | Original | | ULJM 05584 | |
| Shinigami to Shoujo 死神と少女 | PSP | 1.01 | Original | | ULJS 00403 | |
| Shinki Gensou: SSII Unlimited Side 新紀 幻想 SSII Unlimited Side | PSP | 1.04 | Original | | UCAS 40027 | |
| Shinobi, Koiutsutsu 忍び、恋うつつ | PSP | 1.01 | Genteiban | | ULJM 06352 | |
| Shinten Makai: GOC IV Another Side 新天魔界 ~GOCⅣ アナザサイド~ | PSP | 1.06 | Original | | ULJM 05013 | |
| Shirahana no Ori: Hiiro no Kakera 4 白華の檻 ~緋色の欠片4~ | PSP | 1.01 | Genteiban | | ULJM 06166 | |
| Shirahana no Ori: Hiiro no Kakera 4: Shiki no Uta 白華の檻 ~緋色の欠片4~ 四季の詩 | PSP | 1.01 | Genteiban | | ULJM 06313 | |
| Shiratsuyu no Kai しらつゆの怪 | PSP | 1.01 | Original | | ULJM-06289 | |
| Shirogane no Cal to Aoi no Joou 白銀のカルと蒼空の女王 | PSP | 1.00 | Original | | ULJM 05954 | |
| Shirokuma Bell Stars: Happy Holidays! しろくまベルスターズ♪ ハッピーホリデーズ! | PSP | 1.01 | Shokai Genteiban | | ULJM 06111 | |
| Silent Hill: Shattered Memories | PSP | 1.00 | Original | | ULUS-10450 | |
| The Sims 2 | PSP | 1.00 | Original | | ULUS-10031 | |
| The Sims 2: Castaway | PSP | 1.00 | Original | | ULUS 10296 | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULES-00596 | |
| The Sims 2: Pets 심즈 2: 펫츠 | PSP | 1.00 | Original | | ULKS 46117 | |
| The Sims 2: Pets | PSP | 1.00 | Original | | ULUS 10130 | |
| Singi Hwansang: SSII Unlimited Side 신기환상 ~SS II 언리미티드 사이드~ | PSP | 1.00 | Original | | ULKS-46094 | |
| Smash Court Tennis 3 | PSP | 1.00 | Original | | UCES-00758 | |
| Smash Court Tennis 3 | PSP | 1.00 | Original | | ULUS-10269 | |
| Snow Bound Land スノウ バウンド ランド | PSP | 1.02 | Genteiban | | ULJM 06327 | |
| SOCOM: U.S. Navy SEALs Portable ソーコム:U.S. ネイビーシールズ ポータブル | PSP | 1.01 | Original | | UCJS 10102 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo | PSP | 1.00 | Original | | UCES-00038 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 | PSP | 0.02 | Press Disc | | UCET-00794 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 2 소콤 U.S.네이비 씰 파이어팀 브라보 2 | PSP | 1.00 | Original | | UCKS 45043 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 3 소콤 U.S.네이비 씰 파이어팀 브라보 3 | PSP | 1.01 | Original | | UCKS 45128 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 3 | PSP | 1.01 | Original | | UCUS-98716 | |
| Sol Trigger ソールトリガー | PSP | 1.01 | Original | | ULJM 06093 | |
| Sorayume Portable ソラユメ portable | PSP | 1.02 | Original | | ULJS 00203 | |
| Soukoku no Kusabi: Hiiro no Kakera 3: Ashita e no Tobira 蒼黒の楔 緋色の欠片3 明日への扉 | PSP | 1.04 | Shokai Genteiban | | ULJM 06071 | |
| Spectral Souls: Resurrection of the Ethereal Empires | PSP | 1.00 | Original | | ULUS-10076 | |
| Split/Second スプリットセカンド | PSP | 1.04 | Original | | ULJM 05812 | |
| Starry Sky: After Spring Portable Starry☆Sky~After Spring~Portable | PSP | 1.03 | Shokai Genteiban | | ULJM 06207 | |
| Starry Sky: After Winter Portable Starry★Sky ~スタ・スカ~ ~After Winter~ Portable | PSP | 1.01 | Shokai Genteiban | | HONEY-008, … | |
| Starry Sky: In Winter Portable Starry☆Sky~In Winter~Portable | PSP | 1.01 | Shokai Genteiban | | HONEY-004, … | |
| Stealth feat. WipEout Pure Stealth Edition ステルス feat.「ワイプアウト ピュア STEALTH edition」 | PSP | 1.00 | Original | | ULJM 05105 | |
| Storm Lover | PSP | 1.02 | Shokai Seisan-ban | | ULJS 00299 | |
| Storm Lover | PSP | 1.02 | Original | | ULJS 00300 | |
| Storm Lover Kai!! ストーム ラバー 快!! | PSP | 1.03 | Mune-Kyun Otome Collection Vol. 10 | | ULJS 00609 | |
| Storm Lover Natsukoi!! ストーム ラバー 夏恋!! | PSP | 1.02 | Original | | ULJS 00396 | |
| SuGirly Wish Limited シュガーリィ ウィッシュ リミテッド | PSP | 1.02 | Original | | ULJM 06205 | |
| Summon Night 3 サモンナイト3 | PSP | 2.00 | Original | | ULJS 00303 | |
| Summon Night 3 サモンナイト3 | PSP | 3.00 | PSP the Best | | ULJS 19094 | |
| Summon Night 4 サモンナイト4 | PSP | 2.00 | Original | | ULJS 00375 | |
| Super Robot Taisen MX Portable スーパーロボット大戦 MX ポータブル | PSP | 1.04 | Original | | ULJS-00041 | |
| Super Robot Taisen OG Saga: Masoukishin: The Lord of Elemental スーパーロボット大戦OGサーガ 魔装機神 THE LORD OF ELEMENTAL | PSP | 1.01 | Shokai Gentei Seisan | | ULJS 00445 | |
| Suzumiya Haruhi no Tsuisou 涼宮ハルヒの追想 | PSP | 1.02 | Original | | ULJS 00371 | |
| Suzumiya Haruhi no Yakusoku 涼宮ハルヒの約束 | PSP | 1.06 | Super Premium Box | | ULJS 00123 | |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The Secret of Monkey Island モンキー・アイランド ~ユーレイ海賊大騒動!~ | MCD | | Original | | T-60044 | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| Sega CD Demo | MCD | | Prototype | | | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sherlock Holmes: Consulting Detective | MCD | | Original | | 4650 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
| The Smurfs | MCD | | Original | | T-151015-50 | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Sakamoto Ryouma: Ishin Kaikoku 坂本竜馬 ~維新開国~ | SS | 1.002 | Original | | T-19709G | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen Teikokukagekidan Taiin Meibo サクラ大戦 帝国華撃団隊員名簿 | SS | 1.000 | Hibaihin | | SKR-00468 | |
| Sakura Taisen: Hanagumi Taisen Columns サクラ大戦 ~花組対戦コラムス~ | SS | 1.000 | Original | | GS-9138 | |
| Samurai Spirits: Amakusa Kourin サムライ・スピリッツ ~天草降臨~ | SS | 1.001 | Hibaihin | | 610-6730 | |
| Sangokushi Koumeiden 三國志孔明伝 | SS | 1.000 | Original | | T-7629G | |
| SatMag Sono CD サタマガ・ソノCD | SS | 1.001 | Bundled with Magazine (SegaSaturn Taikenban CD-ROM) | | 610-6833 | |
| Saturn Bomberman サターン・ボンバーマン | SS | 1.000 | Sample Disc | | ST-14302G | |
| Saturn Super Vol. 11 Furoku CD-ROM サターン・スーパー Vol.11 付録CD‐ROM | SS | 1.000 | | | 610-6020-12 | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Ages: Memorial Selection Vol. 1 セガエイジス メモリアル・セレクションVOL.1 | SS | 1.002 | Original | | GS-9135 | |
| Sega Rally Championship セガラリー・チャンピオンシップ | SS | 1.000 | Mihonban | | SGS-9047 | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Screams Volume 2 | SS | 2.000 | Not for Resale | | 81077 | |
| Sega Touring Car Championship セガ・ツーリングカーチャンピオンシップ | SS | 1.002 | Taikenban (Bundled with Sega Touring Car Championship OST) | | 610-6747 | |
| Sega Worldwide Soccer '98: Club Edition | SS | 1.003 | Original | | MK81123-50 | |
| SegaColle Sega Bible Mogitate SegaSaturn Soukan-gou セガコレセガバイブルモギタテセガサターン。 創刊号 1997.11 | SS | 1.000 | Hibaihin | | 610-6805-01 | |
| SegaSaturn: Graphic & Sound Tools for Macintosh | SS | | Original | | N16-1000 | |
| SegaSaturn: Movie Tools: Cinepak for Sega Saturn | SS | | Hybrid Version | | L17-1000 | |
| SegaSaturn: SGL Tool Kit: Sega 3D Game Library | SS | 1.000 | Original | | L15-1000 | |
| Sentimental Graffiti (Disc 1) (Game Disc) センチメンタル・グラフィティ | SS | 1.003 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 2) (Second Window) センチメンタル・グラフティ | SS | 1.000 | Original | | T-20106G | |
| Sentimental Graffiti: First Window センチメンタル・グラフティ ~ファースト・ウィンドウ~ | SS | 1.002 | Original | | T-20111G | |
| Sento Monogatari Sono I 「占都物語」そのⅠ | SS | 1.000 | Original | | T-6801G | |
| Shanghai: Great Moments 上海 ~グレート・モーメンツ~ | SS | 1.200 | Original | | T-1512G | |
| Shanghai: Great Moments 上海 ~グレート・モーメンツ~ | SS | 1.200 | Original | | T-1512G | |
| Shichisei Toushin Guyferd: Crown Kaimetsu Sakusen 七星闘神ガイファード ~クラウン壊滅作戦~ | SS | 1.001 | Original | | T-1242G | |
| Shichuu Suimei Pitagraph 四柱推命ピタグラフ | SS | 1.060 | Original | | T-19501G | |
| Shin Seiki Evangelion: Eva to Yukaina Nakama-tachi 新世紀エヴァンゲリオン エヴァと愉快な仲間たち | SS | 1.001 | Original | | T-35103G | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 2.000 | Original | | GS-9188 | |
| Shining Wisdom シャイニング・ウィズダム | SS | 1.000 | Mihonban | | SGS-9057 | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shiroki Majo: Mou Hitotsu no Eiyuu Densetsu 白き魔女 ~もうひとつの英雄伝説~ | SS | 1.000 | Taikenban | | 610-6860 | |
| Shougi Matsuri 将棋まつり | SS | 1.002 | Original | | T-16502G | |
| Shutsudou! Miniskirt Police 出動!ミニスカ・ポリス | SS | 1.001 | Shokai Gentei Double Tokuten | | T-30812G | |
| Sid Meier's Civilization: Shin Sekai Shichidai Bunmei シヴィライゼーション ~新・世界七大文明~ | SS | 1.003 | Original | | T-2003G | |
| Silhouette Mirage シルエット・ミラージュ | SS | 1.100 | Satakore | | T-32903G | |
| Simulation RPG Tkool シミュレーションRPGツクール | SS | 1.003 | Original | | T-2106G | |
| Simulation Zoo シミュレーション・ズー | SS | 1.001 | Original | | T-18611G | |
| Slam 'n Jam '96 featuring Magic & Kareem マジック・ジョンソン・と・カリーム・アブドュール・ジャバーの スラム・ジャム’96 | SS | 1.000 | Original | | T-15905G | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Sotsugyou Album 卒業アルバム | SS | 1.002 | Original | | T-10504G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.) サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Space Jam スペース・ジャム | SS | 1.000 | Original | | T-8119G | |
| Steamgear Mash スチームギア・マッシュ | SS | 1.000 | Original | | T-10301G | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Suikoden: Tenmei no Chikai 水滸伝 ~天命の誓い~ | SS | 1.000 | Original | | T-7624G | |
| Super Adventure Rockman (Disc 1) (Episode 1: Tsuki no Shinden) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 2) (Episode 2: Shitou! Wily Numbers) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 3) (Episode 3: Saigo no Tatakai!!) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | P's Club Special Edition | | T-16506G | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | Original | | T-16504G | |
| Super Real Mahjong P7 スーパーリアル麻雀P7 | SS | 1.003 | P's Club Special Edition | | T-16510G | |
| Super Real Mahjong P7 スーパーリアル麻雀P7 | SS | 1.003 | Original | | T-16509G | |
| Super Real Mahjong PVI スーパーリアル麻雀PⅥ | SS | 1.000 | Original | | T-16507G | |
| Super Tempo スーパー・テンポ | SS | 1.103 | Original | | T-26413G | |
| System-Disc (KD02) Columbia | SS | 1.000 | Original | | 610-5732-06 | |
| System-Disc (KD02) JVC | SS | 1.000 | Original | | 610-5732-03 | |
| Sakura Taisen 3: Paris wa Moeteiru ka サクラ大戦3 ~巴里は燃えているか~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8022 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Sakura Taisen 3 Movie Disc サクラ大戦3 ~巴里は燃えているか~ サクラ大戦3 ムービーディスク | DC | 1.002 | Original | | HDR-0136 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8333 | |
| Sakura Taisen Dream Passport 3 サクラ大戦 ドリームパスポート 3 | DC | 1.007 | Original | | 610-7996 | |
| Sakura Taisen Kinematron Hanagumi Mail サクラ大戦 キネマトロン 花組メール | DC | 1.008 | Original | | HDR-0136 | |
| Sakura Taisen: Hanagumi Taisen Columns 2 サクラ大戦 ~花組対戦コラムス2~ | DC | 1.000 | Original | | HDR-0046 | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Samba de Amigo Ver. 2000 | DC | 1.001 | Original | | HDR-0131 | |
| Sangokushi VI 三國志Ⅵ | DC | 1.000 | Original | | T-7603M | |
| Sangokushi VI with Power-Up Kit 三國志Ⅵ with パワーアップキット | DC | 1.000 | Original | | T-7607M | |
| Seaman Esa Disc: Kimos Shu no Youchuu Hojuu Kit シーマン えさ ディスク <キモス種の幼虫補充キット> | DC | 1.001 | Bundled with Seaman Ikusei Shien Kit | | 610-7804 | |
| Sega Bass Fishing | DC | 1.020 | Original | | MK-51006-50 | |
| Sega Extreme Sports セガ エクストリーム スポーツ | DC | 1.003 | Original | | HDR-0146 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 0.800 | Taikenban | | 610-7727 | |
| Sega Marine Fishing セガマリンフィッシング | DC | 1.003 | Original | | HDR-0104 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Worldwide Soccer 2000 | DC | 1.300 | Original | | MK-51031-50 | |
| Sega Worldwide Soccer 2000: Euro Edition SWWS 2000: Euro Edition | DC | 1.030 | Original | | MK-51083-50 | |
| SegaKara for Dreamcast セガカラ for ドリームキャスト | DC | 1.002 | Bundled with Dreamcast Karaoke | | 610-7762 | |
| Seitai Heiki Expendable 生体兵器 エクスペンダブル | DC | 1.001 | Original | | T-15003M | |
| Sekai Fushigi Hakken! Troia 世界ふしぎ発見! トロイア | DC | 1.002 | Original | | T-39701M | |
| Sengoku Turb 戦国TURB | DC | 1.001 | Original | | T-38801M | |
| Sengoku Turb: Fanfan I Love Me Dunce-doublentendre 戦国TURB Fanfan I ♥ me Dunce-doublentendre | DC | 1.001 | Original | | T-38805M | |
| Sentimental Graffiti: Yakusoku センチメンタルグラフティ ~約束~ | DC | 1.003 | Original | | T-20128M | |
| Shadow Man | DC | 1.002 | Original | | T-8104D-50 | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Man | DC | 1.010 | Original | | T-8106N | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.010 | Genteiban | | HDR-0031 | |
| Shin Honkaku Hanafuda 真 本格花札 | DC | 1.005 | Original | | T-16601M | |
| Shin Nihon Pro Wrestling: Toukon Retsuden 4 新日本プロレスリング 闘魂烈伝4 | DC | 1.006 | Shokai Genteiban | | T-28202M | |
| Shin Seiki Evangelion: Ayanami Ikusei Keikaku 新世紀エヴァンゲリオン 綾波育成計画 | DC | 1.002 | Original | | T-46303M | |
| Shin Seiki Evangelion: Typing Hokan Keikaku 新世紀エヴァンゲリオン タイピング補完計画 | DC | 1.002 | Original | | T-35102M | |
| Shinki Sekai Evolution 2: Tooi Yakusoku 神機世界 エヴォリューション 2 遠い約束 | DC | 1.002 | Original | | T-38703M | |
| The Shinri Game ザ・心理ゲーム | DC | 1.004 | Original | | T-43403M | |
| Simple 2000 Series DC Vol. 01: Bittersweet Fools: The Ren'ai Adventure SIMPLE2000シリーズDC Vol.01 BITTERSWEET FOOLS THE 恋愛アドベンチャー | DC | 1.002 | Original | | T-47401M | |
| Simple 2000 Series DC Vol. 03: Fureai: The Ren'ai Simulation SIMPLE2000シリーズDC Vol.03 ふれあい THE恋愛シミュレーション | DC | 1.003 | Original | | T-47402M | |
| Skies of Arcadia (Disc 1) | DC | 1.000 | Original | | MK-51052-50 | |
| Skies of Arcadia (Disc 2) | DC | 1.000 | Original | | MK-51052-50 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | 830-0223-50, T-17722D-50 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| Snow Surfers | DC | 1.001 | Original | | MK-51010-50 | |
| Sonic Adventure 2 | DC | 1.002 | Beta | | MK-5111750 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | MK-51117-50 | |
| Sonic Shuffle | DC | 1.000 | Original | | MK-51060-50 | |
| Soukou no Kihei: Space Griffon 蒼鋼の騎兵 -SPACE GRIFFON- | DC | 1.001 | Original | | T-39601M | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-1216N | |
| Spec Ops II: Omega Squad | DC | 1.002 | Original | | T-45004D-50 | |
| Spec Ops II: Omega Squad | DC | 1.008 | Original | | T-41704N | |
| Spider-Man | DC | 1.000 | Original | | T-13011D-50 | |
| Spider-Man | DC | 1.000 | Original | | T-13008N | |
| Spirit of Speed 1937 スピリット オブ スピード 1937 | DC | 1.000 | Original | | T-8102M | |
| Sports Jam スポーツ・ジャム | DC | 1.005 | Original | | HDR-0153 | |
| Sports Jam | DC | 1.001 | Original | | T-44304N | |
| Star Gladiator 2: Nightmare of Bilstein スターグラディエイター2 ~ナイトメアオブビルシュタイン~ | DC | 1.000 | Tentou Taikenban | | 610-7181 | |
| Star Wars: Demolition | DC | 1.000 | Original | | 830-0215-50, T-13010D-50 | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Street Fighter III: 3rd Strike: Fight for the Future ストリート・ファイターⅢ サードストライク ~ファイト・フォー・ザ・フューチャー~ | DC | 1.003 | Original | | T-1209M | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-7006D-50 | |
| Suigetsu: Mayoigokoro (Disc 1) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Suigetsu: Mayoigokoro (Disc 2) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Super Euro Soccer 2000 スーパーユーロサッカー2000 | DC | 1.002 | Original | | T-15006M | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206D-50 | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206N | |
| Super Magnetic Niuniu スーパーマグネチックニュウニュウ | DC | 1.002 | Original | | T-30802M | |
| Super Magnetic Niuniu: Promotion Disc スーパーマグネチック ニュウニュウ Promotion Disc | DC | 1.000 | Demo | | 610-7386 | |
| Super Producers: Mezase Show Biz Kai スーパープロデューサーズ 目指せショウビズ界 | DC | 1.001 | Original | | T-14303M | |
| Super Puzzle Fighter II X for Matching Service スーパーパズルファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1250M | |
| Super Runabout スーパーランナバウト | DC | 1.003 | Original | | T-22101M | |
| Super Runabout スーパーランナバウト | DC | 2.001 | Original | | T-22101M | |
| Super Runabout: San Francisco Edition スーパーランナバウト サンフランシスコエディション | DC | 1.000 | Original | | T-22102M | |
| Super Street Fighter II X for Matching Service スーパーストリートファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1236M | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703D-50, T-17703D-74 | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N | |
| Space Channel 5 Theme Music: Mexican Flyer スペース・チャンネル5 | DC | 1.080 | Not for Sale | | | |
| Sturmwind | DC | 1.0 | Unlicensed (Rerelease) | | | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Super Prologue 21 Games Vol. 1 スーパー・プロローグ21 ゲームス Vol.1 | SP21 | 1.002 | Original | | SKT-3500 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCP-EUR | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Scooby-Doo! Mystery Mayhem | GC | | Original | | DL-DOL-GC3P-UKV | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DP-EUR | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ 体験版 | GC | | Taikenban | | DL-DOL-PGPJ-JPN | |
| SD Media Launcher for GameCube / Wii SDメディアランチャー Wii用/GC用 | GC | | Unlicensed | | | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZP-EUR | |
| Sega Soccer Slam セガ サッカースラム | GC | | Original | | DL-DOL-GSSJ-JPN | |
| Serious Sam: Next Encounter | GC | | Original | | DL-DOL-G3BP-EUR | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Shaman King: Soul Fight シャーマンキング ソウルファイト | GC | Rev 1 | Original | | DL-DOL-GSEJ-JPN | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shrek 2 | GC | | Original | | DL-DOL-G3RM-SWE | |
| The Sims ザ・シムズ | GC | | Original | | DL-DOL-G4PJ-JPN | |
| SmaBro DX Event-you Disc スマブラDX イベント用ディスク | GC | | Promo | | DL-DOL-D24J-DIS | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWP-EUR | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWE-USA | |
| Special Jinsei Game Special 人生ゲーム | GC | | Original | | DL-DOL-GLIJ-JPN | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSMP-UKV | |
| Spider-Man | GC | | Original | | DL-DOL-GSMF-FRA | |
| Spider-Man | GC | | Original | | DL-DOL-GSMD-NOE | |
| Spider-Man スパイダーマン | GC | | Original | | DL-DOL-GSMJ-JPN | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2F-FRA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2D-NOE | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3MP-EUR | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3ME-USA | |
| Summoner: A Goddess Reborn | GC | | Original | | DL-DOL-GS2P-EUR | |
| Summoner: La Déesse Réincarnée | GC | | Original | | DL-DOL-GS2F-FRA | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | Rev 1 | Original | | DL-DOL-GMSJ-JPN | |
| Super Mario Sunshine 슈퍼 마리오 선샤인 | GC | | Original | | DL-DOL-GMSE-KOR | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Original | | DL-DOL-GM2J-JPN | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Taikenban | | DL-DOL-DM2J-DIS | |
| Super Smash Bros. Melee 대난투 스매쉬 브라더스 DX | GC | | Original | | DL-DOL-GALE-KOR | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUP-EUR | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | Rev 1 | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Samba de Amigo サンバDEアミーゴ | WII | | Original | | RVL-R3BJ-JPN | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSP-EUR | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Spirits: 6beonui Seungbu 사무라이 스피리츠 6번의 승부 | WII | | Original | | RVL-RSSK-KOR | |
| Samurai Spirits: Rokuban Shoubu サムライスピリッツ 六番勝負 | WII | | Original | | RVL-RSSJ-JPN | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ | WII | | Original | | RVL-SD9J-JPN-B0 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: Scad Hammers SDガンダム スカッドハンマーズ | WII | | Original | | RVL-RSDJ-JPN | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sengoku Musou: Katana 戦国無双 KATANA | WII | | Original | | RVL-RS5J-JPN | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Original | | RVL-SS4U-AUS-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Original | | RVL-SS3U-AUS-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shikakui Atama o Maruku Suru. Wii シカクいアタマをマルくする。 Wii | WII | | Original | | RVL-R4MJ-JPN | |
| Shikigami no Shiro III 式神の城Ⅲ | WII | | Original | | RVL-RS4J-JPN | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Chuuka Taisen: Michael to Meimei no Bouken 新・中華大仙 ~マイケルとメイメイの冒険~ | WII | | Original | | RVL-RTDJ-JPN | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDP-EUR-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| SimAnimals シムアニマル | WII | | Original | | RVL-R4AJ-JPN | |
| SimAnimals: Africa シムアニマル アフリカ | WII | | Original | | RVL-R7AJ-JPN-B0 | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimCity Creator | WII | Rev 1 | Original | | RVL-R4CP-AUS | |
| SimCity Creator | WII | | Beta | | | |
| SimCity Creator | WII | | Original | | RVL-R4CP-EUR | |
| SimCity Creator シムシティ クリエイター | WII | | Original | | RVL-R4CJ-JPN | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimCity Namanui Dosi 심시티 나만의 도시 | WII | | Original | | RVL-R4CK-KOR | |
| I Simple 2000 Series Wii Vol. 1: The Table Game: Mahjonggo, Shougi, Card, Hanafuda, Reversi, Gomoku Narabe SIMPLE2000シリーズWii Vol.1 THE テーブルゲーム ~麻雀・囲碁・将棋・カード・花札・リバーシ・五目ならべ~ | WII | | Original | | RVL-RZ8J-JPN | |
| Simple 2000 Series Wii Vol. 2: The Party Game SIMPLE2000シリーズWii Vol.2 THE パーティーゲーム | WII | | Original | | RVL-RZ9J-JPN | |
| Simple Wii Series Vol. 1: The Minna de Kart Race SIMPLE Wii シリーズ Vol.1 THE みんなでカート・レース | WII | | Original | | RVL-RZ2J-JPN | |
| Simple Wii Series Vol. 2: The Minna de Bass Tsuri Taikai SIMPLE Wii シリーズ Vol.2 THE みんなでバス釣り大会 | WII | | Original | | RVL-RZ3J-JPN | |
| Simple Wii Series Vol. 3: Asonde Oboeru: The Party Casino SIMPLE Wii シリーズ Vol.3 遊んで覚える THE パーティー・カジノ | WII | | Original | | RVL-RZ4J-JPN | |
| Simple Wii Series Vol. 4: The Shooting Action SIMPLE Wii シリーズ Vol.4 THE シューティング・アクション | WII | | Original | | RVL-RZ5J-JPN | |
| Simple Wii Series Vol. 5: The Block Kuzushi SIMPLE Wii シリーズ Vol.5 THE ブロックくずし | WII | | Original | | RVL-RZ6J-JPN | |
| Simple Wii Series Vol. 6: The Wai Wai Combat SIMPLE Wii シリーズ Vol.6 THE ワイワイ・コンバット | WII | | Original | | RVL-RZ7J-JPN | |
| Les Simpson: Le Jeu | WII | | Original | | RVL-RSNF-FRA | |
| The Simpsons Game Los Simpson: El Videojuego / I Simpson: Il Videogioco | WII | | Original | | RVL-RSNX-EUS | |
| Die Simpsons: Das Spiel | WII | | Original | | RVL-RSND-NOE | |
| The Sims 2: Castaway | WII | | Beta | | | |
| The Sims 2: Castaway | WII | Rev 1 | Original | | RVL-R42P-EUR | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PP-EUR | |
| The Sims 3 | WII | | Beta | | | |
| Sin Junghwa-daeseon: Michaelgwa Meimeiui Moheom 신중화대선 ~마이클과 메이메이의 모험~ | WII | | Original | | RVL-RTDK-KOR | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8D-FAH-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDP-EUR | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| The Smurfs Party Pack | WII | | Original | | RVL-S7SP-EUR-B0 | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Original | | RVL-RSRJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Taikenban | | RVL-DSRJ-JPN | |
| Space Camp | WII | | Original | | RVL-RIYP-EUR | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |
| Spider-Man 3 | WII | | Original | | RVL-RS3X-EUR | |
| Spider-Man 3 | WII | Rev 1 | Original | | RVL-RS3P-UKV | |
| Spider-Man 3 スパイダーマン3 | WII | | Original | | RVL-RS3J-JPN | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOP-UKV | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOX-EUR | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| Spore: Kimi ga Tsukuru Hero スポア キミがつくるヒーロー | WII | | Original | | RVL-RQOJ-JPN-B0 | |
| Spy Games: Elevator Mission | WII | | Original | | RVL-RECE-USA-B0 | |
| Sugoro Chronicle: Migite ni Ken o Hidarite ni Saikoro o スゴロクロニクル ~右手に剣を左手にサイコロを~ | WII | | Original | | RVL-RDUJ-JPN | |
| Summer Athletics | WII | Rev 1 | Original | | RVL-RUMP-EUR | |
| Summer Athletics 2009 | WII | | Original | | RVL-R9MP-EUR-B0 | |
| Summer Challenge: Athletics Tournament | WII | | Original | | RVL-RE6P-EUR-B0 | |
| Summer Sports 2: Island Sports Party | WII | | Original | | RVL-RI6E-USA-B0 | |
| Summer Sports: Paradise Island | WII | | Original | | RVL-RSUE-USA | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJP-EUR-B0 | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJE-USA-B0 | |
| Super Mario Collection 슈퍼 마리오 컬렉션 | WII | | Super Mario Bros. 25th Anniversary | | RVL-SVMK-KOR-B0 | |
| Super Mario Galaxy 2 超級瑪利歐銀河2 | WII | | Original | | RVL-SB4W-CHT-B0 | |
| Super Mario Stadium: Family Baseball スーパーマリオスタジアム ファミリーベースボール | WII | | Original | | RVL-RMBJ-JPN | |
| Super Monkey Ball Athletic スーパーモンキーボール アスレチック | WII | | Original | | RVL-SMBJ-JPN-B0 | |
| Super Monkey Ball: Uki Uki Party Daishuugou スーパーモンキーボール ウキウキパーティー大集合 | WII | | Original | | RVL-RSMJ-JPN | |
| Super Paper Mario スーパーペーパーマリオ | WII | Rev 1 | Original | | RVL-R8PJ-JPN | |
| Super Paper Mario 슈퍼 페이퍼 마리오 | WII | | Original | | RVL-R8PK-KOR | |
| Suzumiya Haruhi no Gekidou 涼宮ハルヒの激動 | WII | | Chou DX Pack | | RVL-RHHJ-JPN | |
| Suzumiya Haruhi no Heiretsu 涼宮ハルヒの並列 | WII | | Original | | RVL-R44J-JPN | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKP-UKV-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59P-EUR-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Sengoku Musou 3: Moushouden 戦国無双3 猛将伝 | WII | | Original | | RVL-S5QJ-JPN-E0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8X-LTN-E0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8V-SCN-E0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8V-EUR-B0 | |
| S.T.O.R.M. (Disc 1) | PC | | Dice | | DMM 031730 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0007lab1 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0006lab1 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Original | | JW002243 | |
| S²: Silent Storm (Disc 2) | PC | | Gold Edition | | ROSILENTST0006lab2 | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | Original | | JW002243 | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | ROSILENTST0011lab1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | ROSILENTST0011lab2 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 1) | PC | 1.0 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 2) | PC | 1.0 | Original | | 28015-CD2 | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| The Sacred Amulet | PC | | Original | | | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice: Kamigami no Houkou サクリファイス ~神々の咆哮~ | PC | 0533.01.12 | Original | | | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Sado Gurumi no Machi: Tada de JK ni Nama Hame Dekiru to Omottara Shasei Shisugite Konsui Joutai ni Natta サドぐるみの町 ~タダでJKに生ハメ出来ると思ったら射精しすぎて昏睡状態になった~ | PC | 1.0.0.0 | Original | | SEA-097 | |
| Safecracker Safecracker: L'avventura definitiva per aspiranti scassinatori | PC | 1.01 | Original | | SAFEMULTICD1 | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |