Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sanrio Puroland Carnival サンリオピューロランド カーニバル | PC | | | | RS-13 | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| The Serpent of Isis: The First 2 Chapters The Serpent of Isis / The Serpent of Isis: Your Journey Continues | PC | | Original | | 33393010US | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Shadow Wolf Mysteries: Curse of the Full Moon / Bane of the Family | PC | | | | 33425010US | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Shinjuwan Kougeki Taiheiyou Sensen 3: For Combat Flight Simulator 真珠湾攻撃 太平洋戦線3 For Combat Flight Simulator | PC | | Original | | | |
| Shobi University: Geijutsu Jouhou Gakubu Jouhou Hyougen Gakka: Gakusei Game & CG Eizou Sakuhinshuu 尚美学園大学 芸術情報学部情報表現学科 学生ゲーム&CG映像作品集 | PC | | Original | | | |
| Shock Price 500 Game Series: Volleyball SHOCK PRICE 500 GAME SERIES バレーボール | PC | | Original | | SSRW 30032 | |
| SimPeople: Magical Dream! (Data Set) (Disc 1) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Magical Dream! (Data Set) (Disc 2) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 1) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 2) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 1) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 2) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Vacation! (Data Set) シムピープル バケーション!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| The Sims 3: Fast Lane Stuff | PC | 5.0.44.008001 | Original | | 1950207 | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| The Sims 3: Outdoor Living Stuff | PC | 7.0.55.010001 | Original | | 1950307 | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | | Original | | 1640617 | |
| SimTunes | PC | | Original | | 0135-000-0601-A | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| Singles: Flirt Up Your Life! | PC | 1.2 | | | | |
| Ski Park Manager 2003: Gold Edition Val d'Isère Ski Park Manager 2003: Gold Edition | PC | | | | 71102221 | |
| Slingo Deluxe Slingo Deluxe Bundle | PC | | Original | | | |
| Slingo Mystery: Who's Gold | PC | | Big Fish Games Backup CD | | | |
| Smoking Guns Smoking Guns: Shooting Gallery! | PC | 1.0 | Cosmi | | 02-2503-10 | |
| Sniper: Path of Vengeance | PC | | Original | | | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | | Original | | | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| SSI Strategy Collection: Critic's Choice Ultimate Domain / Serf City / Archon Ultra / Dark Legions / Chessmaster 3000 | PC | 1.0 | Original | | | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Trek: Starship Creator Deluxe | PC | | Original | | 0-671-31776-8 | |
| Star Wars Galaxies: 10-Day Trial | PC | | Original | | 8330530 | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| Steven Spielberg's Director's Chair (Disc 1) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD100CD | |
| Steven Spielberg's Director's Chair (Disc 2) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD200CD | |
| Steven Spielberg's Director's Chair (Disc 3) Steven Spielberg's Director's Chair: Big Bucks. Big Stars. Big Problems. | PC | | | | ZZSDC10CD300CD | |
| Stowaway DK Multimedia: Stephen Biesty's Incredible Cross-Section: Stowaway | PC | | | | | |
| The Sudoku Challenge! Collection | PC | | Original | | | |
| Sudoku Crunch for Kids! | PC | | Original | | P/N 61081-CD | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Sugoi Dennou Club すごい電脳倶楽部 | X68K | | Original | | MKCD-0002 | |
| Super Collapse! 3 | PC | | Original | | | |
| Suteki na Dennou Club すてきな電脳倶楽部 | X68K | | Original | | MKCD-0001 | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Systemax Ultimate Software Collection (Disc 01) (Daria's Inferno / Who Wants to Beat Up a Millionaire) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 02) (I See Sue... the T. Rex / Amazons & Aliens / Cheerios: Playtime) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 03) (How Many Bugs in a Box? / More Bugs in Boxes / Jim Henson's Muppet Babies: Toyland Train / Miss Spider's Tea Party) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 04) (Forbes: Corporate Warrior / Starwebs: Web Shop / Writing Tutor / Complete Idiots Guide: Marketing Materials Maker) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 05) (S&S Encyclopedia / Typing Tutor 12) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 06) (Women's Fitness / Christina Aguilera: Follow Your Dreams) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 08) (Garfield: Mad About Cats / Money Town) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 09) (Darkened Skye: Disc 1 / Zoboomafoo with the Kratt Brothers Animal Kids) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 10) (Deer Avenger / Ski-Doo X-Team Racing) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 11) (Pearl Harbor: Zero Hour / Real War) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 12) (S&S Encyclopedia of Science / Curious George: Reads, Writes and Spells) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 13) (Multimedia Billiards / Astrology Starscopes / Music Match Juke Box Deluxe 6.1 / Extreme Chess / Typing Tutor Jr. / Bumper Wars) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 14) (Darkened Skye: Disc 2) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 18) (M&M's: The Lost Formulas) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Systemax Ultimate Software Collection (Disc 26) (Sabrina, the Teenage Witch: Brat Attack) | PC | | Original | | | |
| Systemax Ultimate Software Collection (Disc 27) (Star Trek: Deep Space Nine - The Fallen) | PC | | Original | | | |
| Space Engineers | PC | | Limited Edition | | | |
| The Sims 2 (Disc 1) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 2) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 3) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 4) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| Spice and Wolf VR 狼と香辛料VR | PC | | Kickstarter (Deluxe Edition) | | | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | 28015-CD2 | |
| Sacra Terra: Angelic Night | PC | | Original | | | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Saddle Club: Willowbrook Stables (Disc 1) (Install) | PC | | Original | | IRG-SCWB | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Schizm: Mysterious Journey | PC | 0.99 | Playable Demo | | | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Scooby-Doo! Jinx at the Sphinx | PC | | Scholastic | | 380849-CD | |
| Score 4 | PC | | Original | | | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| The Scroll | PC | | | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| The Secret Island of Dr. Quandary | PC | 1.0 | SoftKey | | PDQ944AE-CD | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | PC | | Original | | | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| Shannara | PC | 1.0 | Rerelease | | 7-81055-33802-6 | |
| Shape Shifter | PC | | Original | | | |
| Shattered Steel | PC | 1.0 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| The Shield: The Game | PC | 1.0.0.0 | | | 11451-1DDA | |
| The Ship | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shock Price 500 Game Series: Smash Hockey SHOCK PRICE 500 GAME SERIES スマッシュホッケー | PC | | Original | | SSRX 3084 | |
| Shock Price 500 Game Series: The Room SHOCK PRICE 500 GAME SERIES ザ・ルーム | PC | | Original | | SSRX 3050 | |
| Shooting Gallery | PALM | | Original | | | |
| Shrek 2 | PC | | | | 32585.101.US | |
| Shutter Island: The Adventure Game | PC | 1.0.0 | Original | | | |
| Sid Meier's Civil War Collection | PC | 1.00f | | | 1225507 | |
| Sid Meier's Civilization | PC | 474.03 | Rerelease | | MP 190128D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Colonization Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Sid Meier's Pirates! (Disc 1) | PC | | Rerelease | | | |
| Sid Meier's Pirates! (Disc 2) | PC | | Rerelease | | | |
| Silent Hunter | PC | 1.0 | Rerelease | | WWD144AE-CD | |
| Silent Steel (Disc 1) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 2) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 3) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| Silent Steel (Disc 4) Silent Steel: A Cinematic Strategy Adventure | PC | | Original | | | |
| SimCity (Preview Disc) | PC | | Target | | 7298103301 | |
| SimCity 2000: CD Collection | PC | 1.2cj | Windows | | 0026-000-0601-A | |
| SimCity 3000 | PC | | Domino's Pizza / Easter Seals | | | |
| SimCity 4 (Disc 1) | PC | 1.0 | Cosmi | | 1474007, CDR123D1 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Cosmi | | 1474017, CDR123D2 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | | Original | | 1474007 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.0 | Scholastic | | CDR5034957 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.0 | Scholastic | | CDR5034957 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimClassics: 3 in 1 Pack | PC | | Original | | 0543-000-0601-A | |
| SimClassics: Maxis Collections 2 | PC | | Original | | 0092-000-0601-A | |
| Simon the Sorcerer | ARCH | | Original | | | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | | | 1491707 | |
| The Sims 3: University Life (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 1980803301 | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.0 | Scholastic | | 1457627 | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.0 | Scholastic | | 1457637 | |
| SimTheme Park Sim Theme Park | PC | | Original | | 1403307 | |
| SimTower SimTower: The Vertical Empire | PC | 1.0 | Original | | 0051-040-0601-B | |
| SimTown | PC | | The Kids Collection | | 1258607 | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| SkyMaze X3D SkyMaze | PC | | X3D | | | |
| SkyTrip America SkyTrip America: An Incredible Ride Through U.S. History! | PC | 1.0 | | | | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | | Original | | WTY744AE-CD | |
| Slam Dunk Typing All-Star Typing: Ages 9-12: Slam Dunk Typing | PC | 1.01 | Rerelease | | TYN744BE-CD | |
| Slingo | PC | | Oregon Lottery | | | |
| Slingo 2-Pack | PC | | Original | | | |
| Slingo Quest | PC | 0.0.0.104 | Original | | | |
| Slingo: 15th Anniversary Edition | PC | | Original | | | |
| Slingo: Wild 7's | PC | | Oregon Lottery | | | |
| Slot City Jackpot Games (120 Slot Machines) | PC | | Jackpot Games | | CD-4700 | |
| Slots Dual Pack Best of Slots from Bally Gaming / Best of Slots II | PC | | Original | | | |
| Slots Featuring WMS Gaming | PC | 1.0.3 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.1 | Original | | | |
| Slots Featuring WMS Gaming II Masque Slots 8 | PC | 1.0.2 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Slots from Bally Gaming Masque Slots 3 | PC | 1.0.0 | Original | | | |
| Smart Games: Challenge 1 | PC | | Rerelease | | 99168 | |
| Snap! 400 Word Searches | PC | | Original | | CS-296 | |
| Snap! Subtraction: Ages 5-8 | PC | | Original | | | |
| Snowboard Park Tycoon | PC | | | | 30983.101.US | |
| The Software Toolworks CD Deluxe Pack: Version 2 | PC | | Bundle Version Packard Bell OEM | | 2192611-590001 170122 | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | PC | | Rerelease | | | |
| Solitaire Master 4 | PC | 1.0 | Original | | 02-8156-10 | |
| Sonic & Knuckles Collection | PC | | Expert Software | | 6820 01 | |
| Sophie's World | PC | UK Version 1.0 | Original | | | |
| Sorting Adventures: Interactive Activities | PC | | Original | | AAP899, PP463 | |
| The Space Bar (Disc 1) | PC | | Original | | 115-7A | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| The Space Bar (Disc 2) | PC | | Original | | 115-7B | |
| The Space Bar (Disc 2) | MAC | | Original | | 115-7E | |
| The Space Bar (Disc 3) | PC | | Original | | 115-7C | |
| The Space Bar (Disc 3) | MAC | | Original | | 115-7F | |
| Space Colony | PC | | Original | | | |
| Space Jam | PC | 1.00 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers Space Quest IV | PC | 1.0 | Original | | CDRM SQU344AE-CD | |
| Space Rangers / Space Rangers 2: Dominators | PC | | | | | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | PC | Rev A | Bundle Version OEM | | RVL 13-004-073 | |
| Speed Thief X3D Speed Thief | PC | | X3D | | | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| Sphera: The Inner Journey | PC | 1.0 | Original | | 27791-CD | |
| Star Miner: Battle for Supremacy Asteroid Miner | PC | 1.30 FULL | Pocketware | | #9 | |
| Star Trek: Deep Space Nine: The Fallen | PC | 11-2000-a | Demo | | | |
| Star Wars Trilogy CD-ROM: Limited Edition Entertainment Utility | PC | | Original | | | |
| Star Wars: Episode I: Racer | PC | 1.0 | Limited Run Games | | | |
| Star Wars: Galactic Battlegrounds (Disc 1) (Install) | PC | 1.0 | Original | | 8531830 | |
| Star Wars: Galactic Battlegrounds (Disc 2) (Play) | PC | 1.0 | Original | | 8531831 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Rerelease | | 9521830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Rerelease | | 9521831 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | | | 7101830 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.00 | Original | | 41118.101.UK | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wolves (Disc 1) (CD de Jogo) | PC | | Original | | 54804 | |
| Star Wolves (Disc 2) | PC | | Original | | 54804 | |
| Starship Tycoon | PC | Build 2.24 | Original | | | |
| Starsiege | PC | 1.02 | Original | | | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steel Panthers III: Campaign Disk | PC | | Original | | 2220210-590001 | |
| Steel Soldiers | PC | | Original | | | |
| StepMania | PC | 3.9 rc2a | Dance Pad Bundle | | | |
| Stonekeep | PC | 1.2 | Rerelease | | CD-ICD-045-1 | |
| Strategic Command: European Theater | PC | 1.0 | Original | | | |
| Stray Souls: Dollhouse Story | PC | | Original | | | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Street Sports: Jammit | PC | | Super 16 CD Pak Volume 2 | | MQ 13-004-166 | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Sub Culture | PC | | Original | | | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744CE-CD | |
| SuperPower | PC | 1.0 | | | PC35320JC | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Surface: Mystery of Another World | PC | | Collector's Edition | | 33418010US | |
| Survival: The Ultimate Challenge | PC | 1.0 | Original | | 31209.101.US | |
| SWAT: Career Pack (Disc 4) (Police Quest: SWAT) | PC | | Original | | | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| Syberia (Bonus CD) | PC | 1.0 | Game of the Year Edition | | PCO379CDB | |
| Sitting Ducks | PC | 1.0 | | | | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Risk: Gold Edition | | Product # 99227 | |
| The Sims Carnival: BumperBlast | PC | 1.0.10 | Original | | 1586907 | |
| Starball | PC | 1.20 | Original | | | |
| SpellForce: Universe (Disc 2) | PC | 2.00 | Original | | DVD563CD | |
| Sheep | PC | | | | EI-1246 | |
| Spelunky | PC | | Fangamer (Collector's Edition) | | | |
| Spider-Man: Shattered Dimensions Spider-Man: Dimensions | PC | | Original | | 33355101EU | |
| Systemax Ultimate Software Collection (Disc 21) (Mob Rule) | PC | | Original | | | |
| Super Breakout | PC | | Pocketware | | P/N: LTATPSUBRP | |
| Syndicate | MAC | | Original | | 7558 | |
| Stronghold 3 Gold Stronghold 3: Gold | PC | | Original | | 50080-LBL | |
| Syndicate Plus Syndicate+ | PC | | CD-ROM Classics: RComp | | E2825CCD | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original | | | |
| Silent Hunter 4: Wolves of the Pacific Silent Hunter 4: Wolves of the Pacific: U-Boat Missions | PC | 1.5 | Gold Edition | | 684589-DVD1 | |
| Siege of Avalon: Chapter 4 Siege of Avalon: 4. Kapitel | PC | Rev 1.4.1.0618 | Original | | | |
| Simsala Grimm: Das Tapfere Schneiderlein Simsala Grimm: Die Märchen der Brüder Grimm: Das Tapfere Schneiderlein | PC | | Original | | | |
| Shock Price 500 Game Series: Cankeri: Kick Kick Kick SHOCK PRICE 500 GAME SERIES 缶蹴り~KICKKICKKICK~ | PC | | Original | | SRRW 69 | |
| The Sims 3 ザ・シムズ3 | PC | 1.0.631.00005 | Original | | 15390EPWNJP | |
| The Sims 2 (Disc 3) | PC | 1.0.0.932 | Original | | 1472627 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original | | 1536717 | |
| The Sims 2: Celebration! Stuff | PC | 1.8.0.64 | Original | | 1564707 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | Original | | 1672907 | |
| The Sims 2: Double Deluxe The Sims 2: Store Edition | PC | 2.0 | Rerelease | | 1597037 | |
| The Sims 2: Holiday Edition (Disc 1) | PC | 1.0.0.1048 | Original | | 1518907 | |
| The Sims 2: Holiday Edition (Disc 2) | PC | 1.0.0.1048 | Original | | 1518917 | |
| The Sims 2: Holiday Edition (Disc 3) | PC | 1.0.0.1048 | Original | | 1518927 | |
| The Sims 2: Holiday Edition (Disc 4) | PC | 1.0.0.1048 | Original | | 1518937 | |
| The Sims 2: Kitchen & Bath Interior Design Stuff | PC | 1.14.0.72 | Original | | 1578007 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: University Life Collection | PC | 2.0 | Original | | 1685207 | |
| The Sims Castaway Stories | PC | 1.0 | Original | | 1575007 | |
| The Sims: Complete Collection (Disc 1) | PC | 1.0 | Original | | 1647407 | |
| The Sims: Complete Collection (Disc 2) | PC | 1.0 | Original | | 1647417 | |
| The Sims: Complete Collection (Disc 3) | PC | 1.0 | Original | | 1647427 | |
| The Sims: Complete Collection (Disc 4) | PC | 1.0 | Original | | 1647437 | |
| Scratches: Dans l'Antre de la Peur | PC | 0.92 Build 109 | Original | | 7816 | |
| SimCity StratéJ PC: Numéro 1: Septembre-Octobre 97 | PC | | Covermount | | SJ1 | |
| Die Schlaue Bande: 5. Klasse Lernsystem | PC | | Original | | | |
| Die Schlaue Bande: 6. Klasse Lernsystem | PC | | Original | | | |
| Spaß am Turnierreiten Equestriad 2001 | PC | | Original | | | |
| Supercow Super Cow | PC | | Original | | | |
| Sanrio Character Encyclopedia サンリオキャラクター大百科 | PC | | | | R-10 | |
| Sanrio Tiny Park Vol. 2 サンリオ タイニー・パーク Vol.2 | PC | | | | RS-9 | |
| SBFR the Best 2: Black | PC | | Original | | SSEB-0042 | |
| SBFR the Best 2: White | PC | | Original | | SSEB-0041 | |
| SBFR the Best 3: Kirby First History | PC | | Original | | SSEB-0054 | |
| SBFR the Best 4: PKMN First History | PC | | Original | | SSEB-0055 | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| SegaKara for PC セガカラ for PC | PC | 4.0.100 | Original | | | |
| Shissou, Yankee Tamashii. 疾走、ヤンキー魂。 | PC | | BB Games Online Game Fantasista | | disc_02 | |
| Shock Price 500 Game Series: Dasshutsu! SHOCK PRICE 500 GAME SERIES 脱出! | PC | | Rerelease | | SSRX 3029 | |
| Shock Price 500 Game Series: Doki-Doki Mouse SHOCK PRICE 500 GAME SERIES ドキドキマウス | PC | | Original | | SSRX 3011 | |
| Shock Price 500 Game Series: Shooting Machine SHOCK PRICE 500 GAME SERIES シューティングマシーン | PC | | Original | | SSRX 3010 | |
| Shock Price 500 Game Series: Space Hockey SHOCK PRICE 500 GAME SERIES スペースホッケー | PC | | Original | | SSRX 3019 | |
| Shuukan Pokémon Housoukyoku: Tokuhou "Pokémon Daisuki Club" Hajimaruyo! 週刊ポケモン放送局 特報「ポケモンだいすきクラブ」はじまるよ! | PC | | ANA Promo | | | |
| Spore スポア | PC | 1.0 | Original | | 15352EPWNJP | |
| Samanta Svift. Tajna Atlantidy' Саманта Свифт. Тайна Атлантиды | PC | 1.3 | Original | | | |
| Samanta Svift. Tajna Zolotogo Prikosnoveniya Саманта Свифт. Тайна Золотого Прикосновения | PC | 1.2 | Original | | | |