Region | Title | System | Version | Edition | Languages | Serial | Status |
| Shutter Island Shutter Island: The Adventure Game | PC | | Original | | | |
| Sheep, Dog 'n' Wolf | PC | | Original | | SHEDOPCD | |
| S.C.A.R.S. | PC | 1.0 | | | | |
| S.O.E.: Operation Avalanche | PC | | EMCx: Gli Imperdibili | | | |
| S.T.A.L.K.E.R.: Clear Sky (Assets) | PC | | Press Kit | | | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S.W.I.N.E. (Play Disk) | PC | 1.2 | Original | | | |
| S.W.I.N.E. (Install Disk) | PC | 1.2 | Original | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | 28015-CD2 | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| Saban's Power Rangers Zeo: Full Tilt Battle Pinball | PSX | | Original | | SLES-00597 | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| Sabre Ace: Conflict over Korea | PC | | Original | | | |
| Sabre Ace: Conflict over Korea | PC | 1.0 | Original | | D83115 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLES-03561 | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabrina the Teenage Witch: Spellbound | PC | 1.0c | Original | | S03836 | |
| Sacred (Disc 1) | PC | | | | | |
| Sacred (Disc 1) | PC | 1.2.0.20 | Original | | | |
| Sacred (Disc 2) | PC | | | | | |
| Sacred (Disc 2) | PC | 1.2.0.20 | Original | | | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| Sacred Gold (Disc 1) | PC | 2.24 | Original | | 10130-CD1 | |
| Sacred Gold (Disc 2) | PC | 1.0 | Original | | 10130-CD2 | |
| Sacred Gold (Disc 3) | PC | 1.0 | Original | | 10130-CD3 | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacred Plus (Disc 1) | PC | | GSP White Label: Reload | | | |
| The Sacred Rings (Disc 1) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 2) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 3) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 4) | PC | 1.0 | Original | | PCO466CD | |
| Sacrifice (Bonus CD 1) | PC | | Blood Pack | | CD-C95-1041-SC1 | |
| Sacrifice (Bonus CD 2) | PC | | Blood Pack | | CD-C95-1041-SC2 | |
| Sacrifice | PC | | Sold Out Software | | | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice | PC | | Bundle Version Hewlett Packard OEM | | CD-C951041-PC2E | |
| The Saddle Club: Willowbrook Stables (Disc 1) (Install) | PC | | Original | | IRG-SCWB | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Safari Kongo | PC | 1.2 | Original | | | |
| Safecracker | PC | | Rerelease | | | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.0 | Original | | PCO519CD | |
| Safecracker: The Ultimate Puzzle Adventure | PC | 1.01 | Original | | PCO519CD | |
| Saga: Rage of the Vikings | PC | | Covermount | | | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Saint & Sinner | PS2 | 1.01 | Original | | SLES-55076 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Sali Mali 123 | PC | 2.0 Build 216 | Original | | TPPC27 | |
| Salt Lake 2002 | PS2 | 1.01 | Original | | SLUS-20378 | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.AU | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | | Kixx XL | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Same or Different | PC | | Book Bundle | | 08028 | |
| Samidare 五月雨 | PC | 1.051 | Original | | PNB-001 | |
| Sammy Soza Softball Slam | PC | | Original | | PCD-5048-001 | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Samorost 2 | PC | | Machinarium + Samorost 2 | | | |
| Samurai Aces | PS2 | 1.00 | Original | | SLES-53872 | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Shodown II Samurai Spirits | PC | | All You Can Play: 10 Action-Games | | | |
| Samurai Shodown II Samurai Spirits | PC | | Original | | | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown III | PSX | | Original | | SCES-00563 | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 011143 | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| SATS Test & Learn English Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn English Key Stage 2 (Disc 2) | PC | | Original | | | |
| SATS Test & Learn Maths Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn Maths Key Stage 2 (Disc 2) | PC | | Original | | | |
| SATS Test & Learn Science Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn Science Key Stage 2 (Disc 2) | PC | | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage 2: A Tortured Soul | PC | 01.00.00 | Original | | | |
| Savage Arena | PC | | Dixons | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| Scarab S.C.A.R.A.B. | PC | | Original | | EAE08801181D | |
| Scarface: The World Is Yours (Scarface EPK) | PC | | Press Kit | | | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Press Event: Tokyo Game Show 2005: September 2005 | PC | | Press Kit | | | |
| SCEE Press Information: Corporate & Hardware: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 1: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 2: Autumn 2002 | PC | | Press Kit | | | |
| Schizm: Mysterious Journey | PC | 0.99 | Playable Demo | | | |
| Scholastic's The Magic School Bus Discovers Flight: Activity Center | PC | 1.0.0.2 | Original | | 0201 Part No. X06-16068 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | 1.0.0.1528 | Handi-Snacks Promotional | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.0 | Original | | 0894 Part No. 59104, Disc Assy 299-052-002 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.0 | Original | | 0396 Part No. 90618, Disc Assy. 296-052-002 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0010 | Bundle Version OEM | | 0296 Disc Assy. 000-30505 | |
| Scholastic's The Magic School Bus in Concert: Activity Center | PC | 1.0.0.2 | Original | | 0400 Part No. X05-64231 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| School Tycoon | PC | | Scholastic | | P/N: CDR 21661-1R | |
| School Tycoon | PC | | Original | | | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| School Zone Math: Grade 2 | PC | v.5 | Original | | 08032 | |
| School Zone Phonics: Grades 2-3 | PC | v.5 | Original | | 08064 | |
| School Zone Transition Math: Grades K-1 | PC | .5 | Original | | 08034 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 1) (3rd Grade) | PC | | Original | | SGD744AE-CD1 | |
| Schoolhouse Rock! 3rd & 4th Grade Essentials (Disc 2) (4th Grade) | PC | | Original | | SGD744AE-CD2 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Grammar Rock | PC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Schoolhouse Rock! Grammar Rock | PC | 1.0 | Scholastic | | P/N CDR9835984 | |
| Schoolhouse Rock! Math Rock | PC | | Smart Saver | | SHR744AE-CD | |
| Schoolhouse Rock! Math Rock | PC | 1.0 | Scholastic | | P/N CDR9835976 | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744BE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| The Sci-Fi Collection | PC | | Original | | | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| Science Blaster Jr. | PC | | Rerelease | | | |
| Science Blaster Jr. | PC | | Original | | | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | | Original | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | | PC Fun Club | | PFC028/D | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | | GSP | | 1063A | |
| Scooby-Doo! First Frights + Scooby-Doo! The Mystery Begins (Asset Disc) | PC | | Press Kit | | | |
| Scooby-Doo! Jinx at the Sphinx | PC | | GSP | | 1065A | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.0 | | | SCA844AB | |
| Scooby-Doo! Jinx at the Sphinx | PC | | Scholastic | | 380849-CD | |
| Scooby-Doo! Jinx at the Sphinx | PC | 1.02 | | | 380849B-CD | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Phantom of the Knight | PC | | SoftKey | | SPK854BB-CD | |
| Scooby-Doo! Phantom of the Knight | PC | 1.0 | Original | | 380325-CD | |
| Scooby-Doo! Phantom of the Knight | PC | | GSP | | 1064A | |
| Scooby-Doo! Showdown in Ghost Town | PC | 1.0 | Original | | SGW844AB-CD | |
| Scooby-Doo! Showdown in Ghost Town | PC | | GSP | | 1066A | |
| Scooter Pro | PC | | Original | | APWCDR1001 | |
| Scooter Pro | PC | | Original | | APWCDR1001 | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scorched Planet | PC | | Original | | | |
| Score 4 | PC | | Original | | | |
| The Scorpion King: Rise of the Akkadian | PS2 | 1.00 | Demo | | SLUS 29036 | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| The Scottish Open: Virtual Golf | PC | | Euro Power Pack | | | |
| Scrabble | PC | | General Mills | | | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble CD-ROM | PC | | Original | | 23713-0726 Rev a | |
| Scrabble Complete | PC | | Cosmi | | CDRZ652D1, SJ122005 | |
| Scrabble Interactive: 2007 Edition | PC | 1.1.0 | Ubisoft eXclusive / Focus Essential | | ESS760 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Scramble Cobra | 3DO | | Original | | FZ-SE0404 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut (Disc 1) | PC | | Original | | | |
| Scratches: Director's Cut (Disc 2) | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Screamball: The Ultimate Pinball Experience | PC | | Original | | | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Sold Out Software | | | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer | PC | | White Label | | | |
| Screamer 2 | PC | | Sold Out Software | | | |
| Screamer Rally | PC | | Sold Out Software | | | |
| Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited (Asset Disc) | PC | | Press Kit | | | |
| The Scroll | PC | | | | | |
| The Scroll Daughter of Serpents | PC | | Original | | | |
| SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 | |
| SDevTC: Version 2 | PC | 2 | Original | | | |
| SDevTC: Version 2.4 | PC | 2.4 | Original | | DTL-S2200 | |
| Sea Dogs | PC | 1.06 | Green Pepper | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Sold Out Software | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Sea Monsters: A Prehistoric Adventure | PS2 | 1.01 | Original | | SLUS-21741 | |
| Sea Plane Adventures Sea Plane Adventures for FS2002/2004 | PC | | Original | | | |
| Sea-Doo Hydro Cross | PSX | | Original | | SLUS-01149 | |
| Search & Destroy | PS2 | 1.01 | Original | | SLES-54033 | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Search and Rescue Air Rescue | PC | | Grabit | | GDL024 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Season Ticket Baseball 2003 | PC | 1.0 | Original | | 04-23416CDSL | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| Secret Agent Barbie | PC | 1.0c | Original | | S7127810 | |
| The Secret Island of Dr. Quandary | PC | | Softkey | | PDQ944AB-CD | |
| The Secret Island of Dr. Quandary | PC | 1.0 | SoftKey | | PDQ944AE-CD | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| Secret Service: Security Breach | PC | 1.1 | Original | | 31035.101.US | |
| Secret Weapons of the Luftwaffe | PC | | Collezione CD-Rom by C.T.O. | | | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 32609.101.UK | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 32609.102.UK | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 32609.103.UK | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 32609.104.UK | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 2101830 | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 2101831 | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 2101832 | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 2101833 | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Secrets of the Ark: A Broken Sword Game (Disc 1) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 2) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 3) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek and Destroy Seek & Destroy | CD32 | | Original | | | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Bass Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1607 | |
| Sega Bass Fishing | DC | 1.020 | Original | | MK-51006-50 | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| Sega CD Demo | MCD | | Prototype | | | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Extreme Sports セガ エクストリーム スポーツ | DC | 1.003 | Original | | HDR-0146 | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega GT (Disc 2) (Play Disc) | PC | | Original | | EI-1266-2 | |
| Sega GT (Disc 1) (Installation Disc) | PC | | Original | | EI-1266-1 | |
| Sega GT (Disc 2) (Play Disc) | PC | | Original | | EI-1266-2 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Marine Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1606 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Mega Drive Classic Collection: Złota Edycja | PC | 1.0.019 | Platynowa Kolekcja | | P_37010_04A_PL | |
| Sega Press Materials | PC | | Press Kit | | | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Puzzle Pack | PC | | Rerelease | | 85091 / FS22923 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship PC | PC | 1.0 | Expert Software | | XP 202022 01 | |
| Sega Rally Championship PC | PC | 2.11 | Original | | MK 85048MX-50 | |
| Sega Rally Championship PC | PC | | Green Pepper | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Original | | 670-9827 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | MKW-031 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Mihon-hin | | 670-10314 | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Screams Volume 2 | SS | 2.000 | Not for Resale | | 81077 | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Smash Pack | PC | | Original | | 673-01668 | |
| Sega Smash Pack | PC | | Original | | 85087 | |
| Sega Smash Pack | PC | 1.0 | Expert Software | | 682601.101.US | |
| Sega Smash Pack II | PC | | Bundle Version Tiny OEM | | KDGT44 | |
| Sega Touring Car Championship | PC | | Fair Game: Quality Value | | FG-1306 EUROPEAN | |
| Sega Touring Car Championship | PC | 1.0 | Expert Software | | 681301.201.UK 01 | |
| Sega Touring Car Championship | PC | 1.0 | Xplosiv | | EI-1306 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Worldwide Soccer '97 | SS | 1.001 | Original | | 81112 | |
| Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 | |
| Sega Worldwide Soccer PC | PC | | Fair Game | | FG-1281 | |
| Senha N. 1 | PC | | | | | |
| Sensei 2 | PC | | Original | | GC-007 | |
| Sentient | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Original | | | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Serious Sam: The First Encounter シリアス サム | PC | 1.00 | Original | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The Second Encounter 英雄萨姆2 | PC | 1.05 | Original | | | |
| Serious Sam: The Second Encounter シリアス サム:ザ セカンド エンカウンター | PC | 1.05 | Original | | | |
| Serve & Volley | PC | | Telstar Fun & Games | | TFGD 2178/4 | |
| Sesame Street Kazu Asobi: A Visit to Sesame Street: Numbers セサミストリート かずあそび | CDI | | Original | | PCIM-00013 | |
| Sesame Street Moji Asobi: A Visit to Sesame Street: Letters セサミストリート もじあそび | CDI | | Original | | PCIM-00012 | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street Sports | PSX | | Original | | SLES-03180 | |
| Sesame Street: Art Workshop | PC | | Original | | 9369 | |
| Sesame Street: Create & Draw in Elmo's World | PC | | Original | | 24139-0919 | |
| Sesame Street: Elmo's Art Workshop | PC | | Original | | EAW844AE-CD | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original | | SLES-02510 | |
| Sesame Street: Elmo's Preschool | PC | | | | 11040CD | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 1) (Elmo's Preschool) | PC | 2.0 | | | SPC844AE-CD-1 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 2) (Search & Learn Adventures) | PC | 2.0 | | | SPC844AE-CD-2 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Sesame Street: First Steps | PC | | Original | | 05SSRTLXT-01 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Sesame Street: Let's Make a Word! | PC | | Bundle Version Creative Labs OEM | | 1713310119-1 | |
| Sesame Street: Letters | PC | | | | 9367A | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: My Baby & Me (Disc 1) (Baby & Me) | PC | 1.0 | Original | | SSY744AE-CD1 | |
| Sesame Street: My Baby & Me (Disc 2) (Sesame Street Greatest Hits Sampler) | PC | 1.0 | Original | | SSY744AE-CD2 | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Reading Basics | PC | | Encore | | 10200 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| The Settlers II | PC | 1.02 | Dice | | DCG 901570 | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | | Budget | | MMICDR 5803 | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | PC Best Buy | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers III (Disc 1) 工人物語III | PC | 1.23 | Original | | | |
| The Settlers III (Disc 1) | PC | 0.0.0.91 | Original | | | |
| The Settlers III (Disc 1) | PC | 1.54 | PC Best Buy | | 900562a | |
| The Settlers III (Disc 2) | PC | 1.54 | PC Best Buy | | 900562b | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| The Settlers III: Gold Edition (Disc 1) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Gold Edition (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Nowe Misje (Disc 1) | PC | 1.25.0.125 | | | | |
| The Settlers IV | PC | 1.01.761 | Original | | | |
| The Settlers IV The Settlers: Fourth Edition | PC | | Original | | 610335-CD | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Focus Essential | | ESS565 | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Focus Essential | | ESS565 | |
| The Settlers IV: Mission CD | PC | 1.10.908 | Original | | | |
| The Settlers IV: The Trojans and the Elixir of Power | PC | 2.01.1056 | Original | | | |
| The Settlers | PC | | Rerelease | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Seven Kingdoms II: The Fryhtan Wars | PC | | Cool Games | | | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| Sewer Shark | MCD | | Original | | T-93015-50 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-UK1 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-UK2 | |
| Shadoan | PC | | Interactive Preview | | | |
| Shadow Company: Left for Dead (Digital Press Kit) | PC | | Press Kit | | 5051895 | |
| Shadow Company: Left for Dead | PC | 1.0 | Original | | 5051802 | |
| Shadow Force: Razor Unit | PC | | Special Forces Pack | | SFRU-0414 | |
| Shadow Man | PC | | Rerelease | | CD196141.01-ENG | |
| Shadow Man シャドウマン | PC | | Original | | ACLC-W1007E1 | |
| Shadow Man | PC | | Original | | | |
| Shadow Man | DC | 1.010 | Original | | T-8106N | |
| Shadow of Ganymede | PS2 | 1.03 | Original | | SLES-53345 … | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 | |
| Shadowbane: The Rise of Chaos | PC | | Original | | 651727-CD | |
| ShadowCaster | PC | | Top Ten Pak II | | 5454 | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| Shadowgrounds (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Shadowgrounds (Disc 2) | PC | 1.0.0.1 | Original | | | |
| Shadowgrounds (Disc 1) | PC | 1.01 | Original | | 000046-CD1 | |
| Shadowgrounds (Disc 2) | PC | 1.01 | Original | | 000046-CD2 | |
| Shadowlands | PC | | Megapak 2 | | | |
| Shadows of Cairn | PC | 1.0.022 | Softkey Platinum | | SHC444AB-CD | |
| Shadows of Cairn | PC | | Rerelease | | | |
| Shadows of Cairn | PC | 1.0.022 | Rerelease | | ROM-53337 | |
| Shakii il Lupo Shakii the Wolf | PC | | Microforum | | | |
| Shakii the Wolf | PC | | Original | | | |
| Shane Warne Cricket | PSX | | Original | | SLES-01576 | |
| Shanghai Double Pack | PC | | Original | | | |
| Shanghai Dragon | PC | | Covermount | | | |
| Shanghai II: Dragon's Eye | PC | 1.05 | 2 for 1 | | CDD-3044-101-U3 | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Shanghai: Second Dynasty | PC | 1.0 | Essential Collection | | 1000930.101.AU | |
| Shanghai: Second Dynasty | PC | | Xplosiv | | EI-1588 ENGLISH | |
| Shanghai: Second Dynasty | PC | 1.0 | Original | | 1000930.101.UK | |
| Shanghai: True Valor | PSX | | Original | | SLES-01618 | |
| Shannara | PC | 1.0.0 | Original | | | |
| Shannara | PC | 1.0 | Rerelease | | 7-81055-33802-6 | |
| Shaolin | PSX | | Preview | | | |
| Shape Shifter | PC | | Original | | | |
| SharkPort: Code and Save Transfer Kit | PS2 | 1.23 | Unlicensed | | | |
| Sharks! An Interactive Journey An Interactive Journey With... Sharks! | PC | | Original | | | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.0 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.00 | Original | | CD-ICD-201-0 | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-1 | |
| Shattered Steel | PC | 1.03 | Original | | CD-ICD-201-2 | |
| Shattered Steel | PC | 1.12 | Rerelease | | CD-ICD-732-0 | |
| Shaun Palmer's Pro Snowboarder | PS2 | 1.00 | Demo | | SLED-50626 | |
| Shellshock | PC | | Kixx | | | |
| Shellshock | PC | | Original | | | |
| Shellshock | SS | 1.000 | Original | | T-11502H-50 | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Original | | MTC000653-D | |
| Sherlock Holmes: Consulting Detective | MCD | | Original | | 4650 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 5.1 | 5 ft. 10 PAK Vol. 2 | | CD 7012 SPI | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| Sherlock Holmes: Nemesis (Disc 1) | PC | 1.00.0777 | Original | | PCO589CD1, SNY 1.0 | |
| Sherlock Holmes: Nemesis (Disc 2) | PC | 1.00.0777 | Original | | PCO589CD2, SNY 1.0 | |
| Sherlock Holmes: The Mystery of the Mummy Sherlock Holmes: Het Mysterie van de Mummie | PC | 1.000.0000 | Rerelease | | | |
| Sherman M4 | PC | | Action Sixteen | | | |
| Shin Contra 真魂斗羅 | PS2 | 1.01 | Original | | SLPM 62264 | |
| Shin Senki Van-Gale: The War of Neo-Century 新戦記ヴァンゲイル | PSX | | Original | | SLPS 00873 | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Shining Force III | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| Shinobi Legions | SS | 1.000 | Original | | T-2301H | |
| The Ship | PC | | Press Kit | | | |
| Shivers | PC | | Original | | S4430210Z12ZZ | |
| Shivers Two: Harvest of Souls | PC | 1.0 | Demo | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.00 | | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | 831744330/S174150 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shock Price 500 Game Series: Smash Hockey SHOCK PRICE 500 GAME SERIES スマッシュホッケー | PC | | Original | | SSRX 3084 | |
| Shock Price 500 Game Series: The Room SHOCK PRICE 500 GAME SERIES ザ・ルーム | PC | | Original | | SSRX 3050 | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave Assault | PC | | Original | | E354WCED | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H-50 | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H | |
| Shogo: Mobile Armor Division 机器人大战:升刚 | PC | 2.2.14 | Original | | | |
| Shogo: Mobile Armor Division | PC | 1.0 | Original | | CDR5051 | |
| Shogo: Mobile Armor Division 昇剛 | PC | 1.0 | Original | | | |
| Shogo: Mobile Armor Division | PC | 2.2 | Bundle Version Creative Labs OEM | | 1713310341 | |
| Shogun: Total War (Sneak Preview) | PC | | | | EAX08901965DD | |
| Shogun: Total War (Disc 1) | PC | | Rerelease | | EAE088019651D | |
| Shogun: Total War (Disc 2) | PC | | Rerelease | | EAE088019651D2 | |