Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.C.A.R.S. | PC | 1.0 | | | | |
| S.C.A.R.S. | PC | | Original | | | |
| S.O.E.: Operation Avalanche | PC | | EMCx: Gli Imperdibili | | | |
| S.S.D.S.: Setsuna no Akogare S.S.D.S. ー刹那の英雄- | PC | | Original | | | |
| S.T.A.L.K.E.R.: Call of Pripyat (Soundtrack CD) | PC | | Special Edition | | | |
| S.T.A.L.K.E.R.: Clear Sky (Assets) | PC | | Press Kit | | | |
| S.T.A.L.K.E.R.: Shadow of Chernobyl (Electronic Press Kit) | PC | | Press Kit | | | |
| S.V.I.N. (Disc 1) С.В.И.Н. | PC | 1.4 | | | | |
| S.V.I.N. (Disc 2) С.В.И.Н. | PC | 1.4 | | | | |
| S.W.I.N.E. (Play Disk) | PC | 1.2 | Original | | | |
| S.W.I.N.E. (Install Disk) | PC | 1.2 | Original | | | |
| S.W.I.N.E. (Install-CD) | PC | 1.0 | Original | | | |
| S.W.I.N.E. (Play-CD) | PC | 1.0 | Original | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| SAAR + AMOK PD CD-ROM Überarbeitete Version 12/93 | ACD | | Original | | | |
| SAAR AMOK II Oktober 1994 | ACD | | Original | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| Sabre Ace: Conflict over Korea | PC | | Original | | | |
| Sacred (Disc 1) | PC | | | | | |
| Sacred (Disc 1) | PC | 1.2.0.20 | Original | | | |
| Sacred (Disc 2) | PC | | | | | |
| Sacred (Disc 2) | PC | 1.2.0.20 | Original | | | |
| Sacred (Disc 1) | PC | | Original | | | |
| Sacred (Disc 1) | PC | 1.2.0.0 | Original | | | |
| Sacred (Disc 2) | PC | | Original | | | |
| Sacred (Disc 2) | PC | 1.2.0.0 | Original | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| The Sacred Amulet | PC | | Original | | | |
| Sacred Plus (Disc 1) | PC | | Big Bytes | | | |
| Sacred Plus (Disc 1) | PC | | GSP White Label: Reload | | | |
| Sacred: Underworld (Disc 1) | PC | 2.0.1.1 | Original | | | |
| Sacred: Underworld (Disc 2) | PC | 2.0.1.1 | Original | | | |
| Sacrifice | PC | | Sold Out Software | | | |
| Sacrifice (Disc 1) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Disc 2) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Disc 3) (Poradnik do Edytora Scapex) | PC | | Original | | | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice: Blood Pack (Bonus CD) | PC | | Blood Pack | | | |
| Sacrifice: Kamigami no Houkou サクリファイス ~神々の咆哮~ | PC | 0533.01.12 | Original | | | |
| Safari Hunter: Safari Hunt Challenge | PC | 1.00 | Microforum | | | |
| Safari Kongo | PC | 1.2 | Original | | | |
| Safecracker | PC | | Original | | | |
| Safecracker | MAC | | Original | | | |
| Safecracker | PC | | Rerelease | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Disc 1) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Disc 2) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| Saga: Gniew Wikingów | PC | 1.0.0.1 | eXtra Klasyka | | | |
| Saga: Rage of the Vikings | PC | | Covermount | | | |
| Die Sage von Nietoom | PC | | Original | | | |
| Saikyou Kareshi: Dynamic Darling 最強彼氏 | MAC | | Original | | | |
| Sail 2000 | PC | 1.04 | Original | | | |
| Sailing: Baltic Sea Под Парусом: Балтика и Северное море | PC | | Original | | | |
| Saint Eyes セイントアイズ | PC | | Shokai Genteiban | | | |
| Saint Eyes セイントアイズ | PC | | TGL-2000 Series | | | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| The Saint: Abgrund der Verzweiflung | PC | | Original | | | |
| Saints of Virtue | PC | 1.1 | Original | | | |
| Sakura no Mori 櫻の杜 | FMT | | PC-9821 Release | | | |
| Sakura Taisen Monogatari: Mysterious Paris: Special Disc サクラ大戦物語 ~ミステリアス巴里~ Special Disc | PC | | Promo | | | |
| Salad Days: Shin Seitouha Ren'ai Typing サラダデイズ 新・正統派恋愛タイピング | PC | | Original | | | |
| Salammbo (Disc 1) Саламмбо | PC | | 1C: Kollekciya igrushek | | | |
| Salammbo (Disc 2) Саламмбо | PC | | 1C: Kollekciya igrushek | | | |
| Salvage Yard Simulator | PC | | Original | | | |
| Salvat Enciclopedia Interactiva: Nueva Versión '98 | CDI | L.01.01 | Original | | | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | | Kixx XL | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Samanta Svift. Tajna Atlantidy' Саманта Свифт. Тайна Атлантиды | PC | 1.3 | Original | | | |
| Samanta Svift. Tajna Zolotogo Prikosnoveniya Саманта Свифт. Тайна Золотого Прикосновения | PC | 1.2 | Original | | | |
| Samantha Swift and the Roses of Athena | PC | | Play + Smile | | | |
| Samba World Cup | ACD | | Original | | | |
| Same Game FX | PC-FX | | Bundled with PC-FXGA | | | |
| Samgukji II 2000 Plus 三國志Ⅱ 2000 PLUS | PC | | Original | | | |
| Sammy's Science House 泡泡蟲的實驗室 | PC | 1.0.0.0 | Original | | | |
| Sammy's Science House | PC | 1.0 | Original | | | |
| Sammy's Science House | PC | 1.1 | Original | | | |
| Samogonki Самогонки | PC | | Original | | | |
| Samorost 2 | PC | | Machinarium + Samorost 2 | | | |
| Samorost 2: Zvezdanutoe priklyuchenie (Igrovoj disk) Саморост 2. Звезданутое приключение | PC | | Podarochnoe izdanie | | | |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| Samurai Shodown II Samurai Spirits | PC | | All You Can Play: 10 Action-Games | | | |
| Samurai Shodown II Samurai Spirits | PC | | Original | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| Sanae-chan wa Torawarete Shimatta! (Disc 1) さなえチャンは囚われてしまった! | PC | | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Sangokushi Koumeiden 三國志孔明傳 | PC | | Original | | | |
| Sangokushi Tai Sen: Dairyuusei 三国志戴閃-大流星- | PC | 1.01 | Original | | | |
| Sangokushi X Power-Up Kit 三國志Ⅹ パワーアップキット | PC | 1.2.0.1 | Sourcenext Selection | | | |
| Sangokushi: Returns 三國志 リターンズ | PC | 1.0 | Kikan Gentei Hatsubai | | | |
| Sanguo Mahjong Fengyun 三國麻將風雲 | PC | | Original | | | |
| Sanguo Qunyingzhuan 三國群英傳 | PC | 1.00 | Original | | | |
| Sanguo Qunyingzhuan II (Disc 1) 三國群英傳Ⅱ | PC | 1.0 | Rerelease | | | |
| Sanguo Qunyingzhuan III (Disc 1) (Anzhuangpan) 三国群英传Ⅲ | PC | 1.06C | Original | | | |
| Sanguo Qunyingzhuan III (Disc 2) (Youxipan) 三国群英传Ⅲ | PC | 1.06C | Original | | | |
| Sanguo Qunyingzhuan IV (Disc 3) (Yinyuepan) 三国群英传Ⅳ | PC | | Luanshi-Yingxiongbao | | | |
| Sanguo Qunyingzhuan IV Ziliao Sheding 三国群英传Ⅳ 资料设定 | PC | | Bundled with Book | | | |
| Sanguo Yinghao 三國英豪 | PC | | Original | | | |
| Sanguo Yingxiongzhuan 三国英雄传 | PC | | Shiji Zhencangban | | | |
| Sanguo Zhi Xinghai Fengyun (Disc 1) 三國之星海風雲 | PC | | Original | | | |
| Sanguo Zhi Xinghai Fengyun (Disc 2) 三國之星海風雲 | PC | | Original | | | |
| Sanguozhi Fengyun Zaiqi 三國志·風雲再起 | PC | 1.2 | Original | | | |
| Sanguozhi IV 三國志Ⅳ | PC | | Original | | | |
| Sanguozhi Shu-Han Yingxiongzhuan 三國志 蜀漢英雄傳 | PC | 1.3 | Original | | | |
| Sanguozhi VII 三國志Ⅶ | PC | 1.0 | Original | | | |
| Sanguozhi X (Anzhuangpan) 三国志Ⅹ | PC | 1.0 | Original | | | |
| Sanguozhi X (Youxipan) 三国志Ⅹ | PC | 1.0 | Original | | | |
| Sanitarium (Disc 1) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 1) Шизариум | PC | 1.01 | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 1) | PC | 1.00 RC15 / Build 836 | Original | | | |
| Sanitarium (Disc 1) | PC | 1.01 | Original | | | |
| Sanitarium (Disc 2) | PC | 1.01 | Original | | | |
| Sanjieyu II: Zhenai Bu si (Disc 1) 三界諭II真愛不死 | PC | 2.0 | Original | | | |
| Sanjieyu II: Zhenai Bu si (Disc 2) 三界諭II真愛不死 | PC | 2.0 | Original | | | |
| Sansuu Senshi Blaster: Anzan Power de Spot-kun o Sukue! 算数戦士ブラスター 暗算パワーでスポット君を救え! | PC | | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 1) | PC | 1.0 | Original | | | |
| Santa Fe Mysteries: Sacred Ground (Disc 2) | PC | 1.0 | Original | | | |
| Saru Suberi サルすべり | PC | | Original | | | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | eXtra Klasyka XK HIT | | | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | Original | | | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | eXtra Klasyka Next | | | |
| SAT.1 Superball | PC | | Original | | | |
| SAT.1 Swing | PC | | Original | | | |
| Satomi: Yami no Kyouzou SATOMI 闇の鏡像 | PC | | Original | | | |
| SATS Test & Learn English Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn English Key Stage 2 (Disc 2) | PC | | Original | | | |
| SATS Test & Learn Maths Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn Maths Key Stage 2 (Disc 2) | PC | | Original | | | |
| SATS Test & Learn Science Key Stage 2 (Disc 1) | PC | | Original | | | |
| SATS Test & Learn Science Key Stage 2 (Disc 2) | PC | | Original | | | |
| Saturday Night Live Goes Political | PC | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Savage 2: A Tortured Soul | PC | 01.00.00 | Original | | | |
| Savage Arena | PC | | Dixons | | | |
| Savage Warriors | PC | 1.0 | Original | | | |
| Savage: The Battle for Newerth | PC | 1.0 | Original | | | |
| Savage: The Ultimate Quest for Survival | PC | 1.0 | | | | |
| Save Planet Polluto | PC | 1.0 | Original | | | |
| Say What You Want | CDI | | Original | | | |
| Sayma | PC | | Original | | | |
| Sayonara さよなら 体験版 | PC | | Taikenban | | | |
| Sbornik e'roticheskix igr: Special'naya redakciya (Disc 1) Сборник эротических игр: Специальная редакция | PSX | | Unlicensed | | | |
| Sbornik e'roticheskix igr: Special'naya redakciya (Disc 2) Сборник эротических игр: Специальная редакция | PSX | | Unlicensed | | | |
| Scacchi 3D | PC | | Microforum | | | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| SCAR: Squadra Corse Alfa Romeo | PC | | Original | | | |
| SCAR: Squadra Corse Alfa Romeo | PC | | Original | | | |
| Scarface: The World Is Yours (Scarface EPK) | PC | | Press Kit | | | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Press Event: Tokyo Game Show 2005: September 2005 | PC | | Press Kit | | | |
| SCEE Press Information: Corporate & Hardware: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 1: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 2: Autumn 2002 | PC | | Press Kit | | | |
| Scenariomania Scenariomania Vol. 1 | PC | | Original | | | |
| The Scene Archive: 1988-1998 | ACD | | Original | | | |
| Scene Storm | ACD | | | | | |
| Scene Xplorer '97 Scene Explorer: From the Beginning into the Future | ACD | | Original | | | |
| Schach & Matt | PC | | Original | | | |
| Schach & Matt 2 | PC | | Original | | | |
| Der Schatz der Versunkenen Brigantine | PC | | Original | | | |
| Der Schatz von El Dorado | PC | | Original | | | |
| Schiene & Strasse: Der 3D-Transport-Manager: 1820-2020 | PC | | Original | | | |
| Schiff-Simulator 2008 Ship Simulator 2008 | PC | | Original | | | |
| Schizm II: Kameleon (Disc 2) | PC | | Original | | | |
| Schizm II: Kameleon (Disc 3) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | Build: 744 | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | Build: 744 | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | Build: 744 | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | Build: 744 | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | Build: 744 | Original | | | |
| Schizm: Mysterious Journey | PC | 0.99 | Playable Demo | | | |
| Die Schlaue Bande: 5. Klasse Lernsystem | PC | | Original | | | |
| Die Schlaue Bande: 6. Klasse Lernsystem | PC | | Original | | | |
| Schleichfahrt | PC | | Hemming | | | |
| Schleichfahrt | PC | | Original | | | |
| Schleichfahrt | PC | | | | | |
| Die Schlümpfe: Farben und Formen | PC | | Original | | | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | Beta | | | | |
| School Tycoon | PC | | Original | | | |
| Schoolmates: The Mystery of the Magical Bracelet | PC | | Original | | | |
| Schrottplatz-Simulator 2011 | PC | | Original | | | |
| Der Schuh des Manitu Der Schuh des Manitu: Das Computerspiel zum Film | PC | | Original | | | |
| Das Schwarze Auge: Schatten über Riva | PC | | All You Can Play: Adventure & Fantasy | | | |
| Das Schwarze Auge: Sternenschweif (Disc 1) | PC | | Original | | | |
| Das Schwarze Auge: Sternenschweif (Disc 2) | PC | | Original | | | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| SCI Media Kit: Version: 2 | PC | | Press Kit | | | |
| SCI Media Kit: Version: 4 SCI Media Kit: Version: 4.0 | PC | | Press Kit | | | |
| The Sci-Fi Collection | PC | | Original | | | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science Blaster Jr. | PC | | Rerelease | | | |
| Science Blaster Jr. | PC | | Original | | | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby Doo: Strachy na Lachy | PC | | | | | |
| Scooby-Doo 2: Monsters Unleashed | PC | | Original | | | |
| Scooby-Doo! First Frights + Scooby-Doo! The Mystery Begins (Asset Disc) | PC | | Press Kit | | | |
| Scooby-Doo! Le Mystere du Parc Fantome | PC | | Original | | | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scooby-Doo! Night of 100 Frights | PSX | | Prototype | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Night of 100 Frights | PS2 | 0.00 | Beta | | | |
| Scooby-Doo! Pierwsze Strachy | PC | | Demo | | | |
| Scooter's Magic Castle & Kid Pix | PC | | Bundle Version Creative Labs OEM | | | |
| Scorched 3D | PC | | Original | | | |
| Scorched Planet | PC | | Original | | | |
| Scorched Planet | PC | | Original | | | |
| Score 4 | PC | | Original | | | |
| Scotland Yard | PC | | Original | | | |
| Scotland Yard | PC | | Original | | | |
| The Scottish Open: Virtual Golf | PC | | Euro Power Pack | | | |
| Scrabble | PC | | General Mills | | | |
| Scrabble Interactive: 2003 Edition | PC | | Original | | | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Scratches | PC | | Original | | | |
| Scratches: Director's Cut (Disc 1) | PC | | Original | | | |
| Scratches: Director's Cut (Disc 2) | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Graffi Mortali | PC | | Original | | | |
| Screamball: The Ultimate Pinball Experience | PC | | Original | | | |
| Screamer | PC | | Sold Out Software | | | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer | PC | | Original | | | |
| Screamer | PC | | White Label | | | |
| Screamer 2 | PC | | Sold Out Software | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer 2 | PC | | eXtra Klasyka | | | |
| Screamer 4x4 | PC | | Sold Out Software | | | |
| Screamer 4x4 | PC | | Covermount | | | |
| Screamer Rally | PC | | Sold Out Software | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited (Asset Disc) | PC | | Press Kit | | | |
| The Scroll | PC | | | | | |
| The Scroll Daughter of Serpents | PC | | Original | | | |
| Scubeginners: I Misteri di Dive Island | PC | 1.1 | Original | | | |
| Scudetto 2 | PC | 1.48 | CD-ROM Classic Collection 3 | | | |
| SD Gundam: GGeneration SD 건담: G-제네레이션 | PC | 1.0.0.1 | Original | | | |
| SDevTC: Version 2 | PC | 2 | Original | | | |
| Sea Adventures | PC | | Microforum | | | |
| Sea Battle | PC | | Original | | | |
| Sea Dogs | PC | 1.06 | Green Pepper | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Sold Out Software | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.0 | Original | | | |
| Sea Dogs: Piraci | PC | 1.06 | Nowa eXtra Klasyka | | | |
| Sea Dogs: Piraci | PC | 1.06 | Original | | | |
| Sea Plane Adventures Sea Plane Adventures for FS2002/2004 | PC | | Original | | | |
| Sea Rescue | PC | | Nestlé Corn Flakes | | | |
| Seafight II | PC | | Original | | | |
| Search & Rescue 3 | PC | 1.0.0.0 | Original | | | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Search for the Golden Dolphin Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| SEC: Southeastern Conference Educational Software | PC | | Original | | | |
| The Second Guest | PC | | Original | | | |
| Second Sight | PC | | Original | | | |
| Le Secret du Templier | MAC | 1.0 | Covermount | | | |
| Secret Game: Code:Revise: Trial Version シークレットゲーム CODE:Revise 体験版 | PC | | Demo | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| Secret Service CD 36 | PC | | | | | |
| Secret Service CD 37 | PC | | | | | |
| Secret Service CD 38 | PC | | | | | |
| Secret Service CD 39 | PC | | | | | |
| Secret Service CD 40 | PC | | | | | |
| Secret Service CD 43 | PC | | | | | |
| Secret Service CD 44 (Strona A) | PC | | | | | |
| Secret Service CD 44 (Strona B) | PC | | | | | |
| Secret Service CD 45 | PC | | | | | |
| Secret Service CD 47 (Strona A) | PC | | | | | |
| Secret Service CD 47 (Strona B) | PC | | | | | |
| Secret Service CD 48 (Strona B) | PC | | | | | |
| Secret Service CD 49 (Strona A) | PC | | | | | |
| Secret Service CD 49 (Strona B) | PC | | | | | |
| Secret Service CD 50 (Strona A) | PC | | | | | |
| Secret Service CD 50 (Strona B) | PC | | | | | |
| Secret Service CD 51 (Strona B) | PC | | | | | |
| Secret Service CD 52 (Strona A) | PC | | | | | |
| Secret Service CD 52 (Strona B) | PC | | | | | |
| Secret Service CD 53 (Strona A) | PC | | | | | |
| Secret Service CD 53 (Strona B) | PC | | | | | |
| Secret Service CD 60 | PC | | | | | |
| Secret Service CD 61 | PC | | | | | |
| Secret Service CD 64 | PC | | | | | |
| Secret Service CD 87 | PC | | | | | |
| Secret Service CD 88 | PC | | | | | |
| Secret Service CD 89 | PC | | | | | |
| Secret Service CD 90 | PC | | | | | |
| Secret Service CD 91 | PC | | | | | |
| Secret Weapons of the Luftwaffe | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secrets of Alamût (Disc 1) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2) The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Da Vinci: Il Manoscritto Proibito (Disc 1) | PC | 1.02 | Original | | | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 1) Sekrety Leonarda Da Vinci: Zakazany Manuskrypt | PC | | | | | |
| Secrets of the Dark: Der finstere Berg | PC | | Original | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures 2: 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Seek and Destroy Seek & Destroy | CD32 | | Original | | | |
| Sega Bass Fishing 钓鱼高手 | PC | 1.0 | Original | | | |
| Sega CD Demo | MCD | | Prototype | | | |
| Sega E3 Press Kit 2005 2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Game Honpo: Puyo Puyo セガゲーム本舗 ぷよぷよ | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega Press Materials | PC | | Press Kit | | | |
| Sega Rally Championship PC | PC | | Green Pepper | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Screenshots 2000 Sega E3 2000 | PC | | Press Kit | | | |
| Sega Touring Car Championship 世嘉巡回车大赛 | PC | | Original | | | |
| SegaKara for PC セガカラ for PC | PC | 4.0.100 | Original | | | |
| Sekai Saikyou Ginsei Igo 2 世界最強銀星囲碁2 | PC | 3.0 | Yuuyuu 1,980-yen | | | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Sem' Samuraev (Disc 1) Семь Самураев | PC | | Original | | | |
| Sem' Samuraev (Disc 2) Семь Самураев | PC | | Original | | | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! Harukaze no Shou 戦国美少女絵巻 空を斬る!! ~春風の章~ | PC | | Original | | | |
| Senha N. 1 | PC | | | | | |
| Senjou de Shoujo wa Karada o Kakeru: Briefing Disc 戦場デ少女ハ躰ヲカケル ブリーフィングDISC | PC | | Demo | | | |
| Senkaku Mondai o Yatchimasu 2 尖閣問題を殺っちます2 | PC | | Original | | | |
| Sensei 2 Запретное влечение | PC | | Original | | | |
| Sensible Soccer 2006 | PC | 0.0.0.1 | Original | | | |
| Sensible World of Soccer | PC | 1.0 | Original | | | |
| Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Replay | | | |
| Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | | |
| Sentient | PC | 1.4.0.124 | Original | | | |
| Sentient | PC | | Original | | | |
| Sentimental Graffiti 2 (Disc 1) 青澀寶貝2:青澀之戀 | PC | 1.00 | Original | | | |
| Sentimental Graffiti 2 (Disc 2) 青澀寶貝2:青澀之戀 | PC | 1.00 | Original | | | |
| Sentinel Returns | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Sentinel: Il Regno delle Illusioni (Disc 1) | PC | 1.0 | | | | |
| Sentinel: Il Regno delle Illusioni (Disc 2) | PC | 1.0 | | | | |
| Sentinel: Strazh vremeni (Disc 1) Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sentinel: Strazh vremeni (Disc 2) Sentinel: Страж времени | PC | 1.0 | Original | | | |
| Sento Monogatari: Sono I 「占都物語」 そのI | PC | | Original | | | |
| Septerra Core: Legacy of the Creator 赛普特拉战记 | PC | 1.02 | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Original | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00I | Covermount | | | |
| Septerra Core: Legacy of the Creator | PC | 1.02 | Original | | | |
| Serious Sam Gold (Disc 1) | PC | 1.05 | Original | | | |
| Serious Sam Gold (Disc 2) | PC | 1.05 | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam: Drugie Starcie Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Serious Sam: Pierwsze Starcie Serious Sam: The First Encounter | PC | 1.00b | Original | | | |
| Serious Sam: The First Encounter | PC | | | | | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.05 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The First Encounter | PC | 1.00a | Covermount | | | |
| Serious Sam: The First Encounter シリアス サム | PC | 1.00 | Original | | | |
| Serious Sam: The Second Encounter | PC | | | | | |
| Serious Sam: The Second Encounter 英雄萨姆2 | PC | 1.05 | Original | | | |
| Serious Sam: The Second Encounter | PC | 1.07 | Gold Edition (PC Gamer Presents) | | | |
| Serious Sam: The Second Encounter | PC | | Rerelease | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Software Pyramide | | | |
| Serious Sam: The Second Encounter シリアス サム:ザ セカンド エンカウンター | PC | 1.05 | Original | | | |
| Serp i Molot (Disc 1) Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 2) Серп и Молот | PC | | 1C: Igroteka | | | |
| Serp i Molot (Disc 3) Серп и Молот | PC | | 1C: Igroteka | | | |
| Serpent of Isis: Your Journey Continues | PC | | Big Fish Games Backup CD | | | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Sesame Street: Letters | PC | | Original | | | |
| Sesame Street: Numbers Улица Сезам: Учись считать | PC | | Original | | | |
| Sesame Street: Numbers | PC | | Original | | | |
| Sesame Street: Preschool Улица Сезам: Элмо готовит в школу | PC | | Original | | | |
| Sethi und das Geheimnis der Neandertaler | PC | | Rerelease | | | |
| Sethi: Abenteuer im Mittelalter National Geographic: Sethi: Abenteuer im Mittelalter | PC | | Original | | | |
| The Settlers II | PC | | Demo | | | |
| The Settlers II | PC | 1.51 | Strefa Niskich Cen | | | |
| The Settlers II: 10-lecie The Settlers II: 10th Anniversary | PC | | eXtra Klasyka Next | | | |
| The Settlers II: Nowe Misje | PC | 1.51 | Strefa Niskich Cen | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | PC Best Buy | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| The Settlers II: Złota Edycja | PC | 1.51 | eXtra Klasyka | | | |
| The Settlers III (Disc 1) 工人物語III | PC | 1.23 | Original | | | |
| The Settlers III (Disc 1) | PC | 0.0.0.91 | Original | | | |
| The Settlers III (Disc 1) | PC | 0.0.0.123 | | | | |
| The Settlers III (Disc 2) | PC | 0.0.0.123 | Original | | | |
| The Settlers III: Gold Edition (Disc 1) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Gold Edition (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Misja Amazonek | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Nowe Misje (Disc 1) | PC | 1.25.0.125 | | | | |
| The Settlers III: Nowe Misje (Disc 2) | PC | 1.25.0.125 | Original | | | |
| The Settlers III: Quest of the Amazons | PC | | Original | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | 1.25.0.125 | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | 1.25.0.125 | | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | 1.25.0.125 | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | 1.25.0.125 | | | | |
| The Settlers IV 工人物语IV | PC | 1.09.876 | Original | | | |
| The Settlers IV | PC | 1.01.761 | Original | | | |
| The Settlers IV | PC | | Original | | | |
| The Settlers IV | PC | 1.06.815 | Original | | | |
| The Settlers IV ザ・セトラーズ4 | PC | 2.04.1090 | | | | |
| The Settlers IV | PC | 1.06.811 | Original | | | |
| The Settlers IV: Gold Edition (Disc 1) | PC | | Original | | | |
| The Settlers IV: Gold Edition (Disc 2) | PC | | Gold Edition | | | |
| The Settlers IV: Mission CD | PC | 1.10.908 | Original | | | |
| The Settlers IV: The Trojans and the Elixir of Power | PC | 2.01.1056 | Original | | | |
| The Settlers IV: Złota Edycja | PC | | Nowa eXtra Klasyka | | | |
| The Settlers IV: The Trojans and the Elixir of Power The Settlers IV: A Trójaiak és a Hatalom Elixírje | PC | 2.50.1508 | Original | | | |
| The Settlers | PC | | Rerelease | | | |
| The Settlers | PC | | Strefa Niskich Cen | | | |
| The Settlers | PC | | Strefa Niskich Cen | | | |
| The Settlers: Dziedzictwo Królów (Disc 1) The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | | |
| The Settlers: Dziedzictwo Królów (Disc 2) The Settlers: Heritage of Kings | PC | 1.01.0163 | Original | | | |
| The Settlers: Heritage of Kings (Disc 1) The Settlers: Dědictví Králů | PC | 1.03.0190 | Original | | | |
| The Settlers: Heritage of Kings (Disc 2) The Settlers: Dědictví Králů | PC | 1.03.0190 | Original | | | |
| The Settlers: Nasledie korolej (Disc 1) The Settlers: Наследие королей | PC | 1.03.0190 | Original | | | |
| The Settlers: Nasledie korolej (Disc 2) The Settlers: Наследие королей | PC | 1.03.0190 | Original | | | |
| Seven Games of the Soul (Disc 1) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 2) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 3) Faust | PC | | Original | | | |
| Seven Games of the Soul (Disc 4) Faust | PC | | Original | | | |
| Seven Kingdoms | PC | 1.1 | Colección 'Juega y Aprende' | | | |
| Seven Kingdoms II: The Fryhtan Wars 七国演义II:群魔乱舞 | PC | 1.0 | Rerelease | | | |
| Seven Kingdoms II: The Fryhtan Wars | PC | | Original | | | |
| Seven Kingdoms II: The Fryhtan Wars | PC | | Cool Games | | | |
| Seven Kingdoms: Ancient Adversaries | PC | | | | | |
| Seven Years War 2 決戰王朝 | PC | 1.090ER | Original | | | |
| Seven Years War 2 + Joseonui Bangyeok 임진록 2 + 조선의 반격 | PC | | Hapbon | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 1) 第七封印:魔神甦醒 | PC | | Original | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 2) 第七封印:魔神甦醒 | PC | | Original | | | |
| The Seventh Seal: The Resurrection of the Dark Lord (Anzhuang Cidie 3) 第七封印:魔神甦醒 | PC | | Original | | | |
| Sex Sensou: Aiaru H wa Kinshi desu! H-na Hiyakeato Patch SEX戦争~愛あるHは禁止ですっ!~Hな日焼け跡パッチ | PC | | Original | | | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Outside Dreams | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Sexy in the Hawaii: Nice Gal Hawaii-hen Sexy in The Hawaii ~ナイス・ギャル ハワイ編~ | FMT | | Original | | | |
| Sfera Сфера | PC | | | | | |
| Sfera II: Arena Сфера II: Арена | PC | | Original | | | |
| Sfera: Materik Vlasti Сфера: Материк Власти | PC | | 1C: Kollekciya igrushek | | | |
| Sfera: Prokljatie Giperiona Сфера: Проклятие Гипериона | PC | | 1C: Kollekciya igrushek | | | |
| Sfida nella Piramide! | PC | | Evviva! Software | | | |
| Shade: Wrath of Angels Shade: Hněv Andělů | PC | 1.01 | Original | | | |
| Shade: Wrath of Angels (Press Disc) | PC | | Press Kit | | | |
| Shadoan | PC | | Interactive Preview | | | |
| Shadow Company: Left for Dead | PC | | Back to Games | | | |
| Shadow Company: Left for Dead | PC | 1.2 | Covermount | | | |
| Shadow Fight (Disc 1) Бой с тенью | PC | | Original | | | |
| Shadow Fight (Disc 2) Бой с тенью | PC | | Original | | | |
| Shadow Hearts: Special Disc SHADOW HEARTS スペシャルディスク | PC | | Hibaihin | | | |
| Shadow Man | PC | | Demo | | | |
| Shadow Man | PC | | Original | | | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Rerelease | | | |
| Shadow Vault Bonus CD Extra 1/2008 | PC | | | | | |
| Shadow Vault: Demos and Materials | PC | | Original | | | |
| Shadow Warrior: Digital Press Kit | PC | | Press Kit | | | |
| Shadow Watch | PC | | Original | | | |
| Shadowbane | PC | | Taikenban | | | |
| Shadowgrounds (Disc 1) | PC | 1.0.0.1 | Original | | | |