Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sammy's Science House 泡泡蟲的實驗室 | PC | 1.0.0.0 | Original | | | |
| Sammy 3D Jump 'n' Fun: Gold Edition | PC | 1.02 | Original | | 11022 | |
| Samantha Swift and the Roses of Athena | PC | | Play + Smile | | | |
| Samanta Svift. Tajna Zolotogo Prikosnoveniya Саманта Свифт. Тайна Золотого Прикосновения | PC | 1.2 | Original | | | |
| Samanta Svift. Tajna Atlantidy' Саманта Свифт. Тайна Атлантиды | PC | 1.3 | Original | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | 1.0 | LucasArts Classic | | 41117.101.GM | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.AU | |
| Salt Lake 2002 | PC | | Original | | MSALTPGE81 | |
| Sali Mali 123 | PC | 2.0 Build 216 | Original | | TPPC27 | |
| Salaryman Kintarou: Dai-2-kan Netsuai Roman-hen サラリーマン金太郎 第2巻 熱愛浪漫篇 | PC | | Original | | SCR90403 | |
| Salammbo (Disc 2) Саламмбо | PC | | 1C: Kollekciya igrushek | | | |
| Salammbo (Disc 1) Саламмбо | PC | | 1C: Kollekciya igrushek | | | |
| Salammbô (Disc 2) | PC | | Original | | SLBOCD2 | |
| Salammbô (Disc 1) | PC | | Original | | SLBOCD1 | |
| Salad Days: Shin Seitouha Ren'ai Typing サラダデイズ 新・正統派恋愛タイピング | PC | | Original | | | |
| Sakura Taisen: Denmaku Club 2 サクラ大戦 電幕倶楽部2 | PC | | Gouka Genteiban | | 673-01444 | |
| Sakura Taisen Monogatari: Mysterious Paris: Special Disc サクラ大戦物語 ~ミステリアス巴里~ Special Disc | PC | | Promo | | | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Desktop Accessories サクラ大戦3 ~巴里は燃えているか~ デスクトップアクセサリーズ | PC | | Tokubetsu Genteiban B | | DWWWC-50121~50123 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 6) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03916 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 5) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03915 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 4) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03914 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 3) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03913 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 2) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03912 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 1) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03911 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02557 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02558 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02559 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02554 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02555 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02556 | |
| Saint Eyes セイントアイズ | PC | | Shokai Genteiban | | | |
| Sailing: Baltic Sea Под Парусом: Балтика и Северное море | PC | | Original | | | |
| Saikyou Densetsu: Mahjong Haou 2: Kanzenban 最強伝説 麻雀覇王2 完全版 | PC | 1.04 | Best Selections | | | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| The Saga of Ryzom (Disc 2) | PC | | Original | | 75402104/2 | |
| The Saga of Ryzom (Disc 1) | PC | | Original | | 75402104/1 | |
| Saga Heroes of Might and Magic I-III (Disc 2) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Disc 1) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Safecracker | PC | | Rerelease | | | |
| Sado Gurumi no Machi: Tada de JK ni Nama Hame Dekiru to Omottara Shasei Shisugite Konsui Joutai ni Natta サドぐるみの町 ~タダでJKに生ハメ出来ると思ったら射精しすぎて昏睡状態になった~ | PC | 1.0.0.0 | Original | | SEA-097 | |
| Sacrifice: Uzuki no Kubiwa サクリファイス ~疼きの首輪~ | PC | | Original | | CNDL-0001 | |
| Sacrifice: Kamigami no Houkou サクリファイス ~神々の咆哮~ | PC | 0533.01.12 | Original | | | |
| Sacrifice (Scapex Tutorial Video) | PC | | Preproduction | | | |
| Sacrifice (Editors Press Kit) | PC | | Press Kit | | | |
| Sacrifice (Disc 3) (Poradnik do Edytora Scapex) | PC | | Original | | | |
| Sacrifice (Disc 2) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Disc 1) | PC | 0521.12.14 | Original | | | |
| Sacrifice (Bonus CD 1) | PC | | Blood Pack | | CD-C95-1041-SC1 | |
| Sacrifice (Bonus CD 2) | PC | | Blood Pack | | CD-C95-1041-SC2 | |
| The Sacred Rings (Disc 4) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 3) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 2) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Rings (Disc 1) | PC | 1.0 | Original | | PCO466CD | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Amulet | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 4) | PC | | Beta | | | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | | | | | |
| Sacred (Disc 1) | PC | | | | | |
| Sabrina the Teenage Witch: Brat Attack | PC | | Original | | S02560 | |
| Sabre Ace | PC | 1.0 | Covermount | | | |
| Sabotain: Break the Rules (Disc 2) Sabotain: Rúgd Fel a Szabályokat | PC | | Original | | SBT0000S60098075 | |
| Sabotain: Break the Rules (Disc 1) Sabotain: Rúgd Fel a Szabályokat | PC | | Original | | SBT0000S60098074 | |
| S3d Game Pak | PC | | Bundle Version S3 OEM | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| S²: Silent Storm (Disc 2) | PC | 1.0 | Original | | 28015-CD2 | |
| S²: Silent Storm (Disc 1) | PC | 1.0 | Original | | 28015-CD1 | |
| S²: Silent Storm (Disc 2) | PC | 1.2 | Original | | ROSILENTST0011lab2 | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | ROSILENTST0011lab1 | |
| S²: Silent Storm (Disc 2) | PC | | Gold Edition | | ROSILENTST0006lab2 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0006lab1 | |
| S.W.I.N.E. (Disc 2) (Play CD) | PC | 1.3 | Original | | AUT 180-2 | |
| S.W.I.N.E. (Disc 1) (Install CD) | PC | 1.3 | Original | | AUT 180-1 | |
| S.W.I.N.E. (Install Disk) | PC | | LTAS! Rerelease | | ROSWINE0000005LAB1 | |
| S.W.I.N.E. (Play Disk) | PC | | LTAS! Rerelease | | ROSWINE0000005LAB2 | |
| S.T.A.L.K.E.R.: Clear Sky (Płyta Dodatkowa) S.T.A.L.K.E.R.: Czyste Niebo | PC | | Original | | P_33142_02A_PL | |
| S.T.A.L.K.E.R.: Clear Sky (Assets) | PC | | Press Kit | | | |
| S.T.A.L.K.E.R.: Call of Pripyat (Soundtrack CD) | PC | | Special Edition | | | |
| S.S.D.S.: Setsuna no Akogare S.S.D.S. ー刹那の英雄- | PC | | Original | | | |
| S.C.A.R.S. | PC | 1.0 | | | | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8V-EUR-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8V-SCN-E0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8X-LTN-E0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXY-SCN-E0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXX-LTN-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59P-EUR-E0 | |
| Suzumiya Haruhi no Gekidou 涼宮ハルヒの激動 | WII | | Chou DX Pack | | RVL-RHHJ-JPN | |
| Survivor | WII | | Original | | RVL-RLNP-UKV-B0 | |
| Supersonic Racer | WII | | Original | | RVL-SRSP-EUR-B0 | |
| Super Truck Racer | WII | | Original | | RVL-SN7P-EUR-B0 | |
| Super Sentai Battle: Ranger Cross スーパー戦隊バトル レンジャークロス | WII | | Original | | RVL-SRJJ-JPN-B0 | |
| Super Robot Taisen Neo スーパーロボット大戦ネオ | WII | | Original | | RVL-RRWJ-JPN-B0 | |
| Super Karts | WII | | Original | | RVL-SN6P-EUR-B0 | |
| Super Fruit Fall | WII | | Original | | RVL-RF4E-USA | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJP-EUR-B0 | |
| Summer Challenge: Athletics Tournament | WII | | Original | | RVL-RE6P-EUR-B0 | |
| Summer Athletics 2009 | WII | | Original | | RVL-R9MP-EUR-B0 | |
| Sudoku Ball: Detective | WII | | Original | | RVL-R9SP-EUR | |
| Stunt Flyer: Hero of the Skies | WII | | Original | | RVL-SSTP-EUR-B0 | |
| Het Studio 100 Speeleiland | WII | | Original | | RVL-SPWH-HOL-B0 | |
| Street Football | WII | | Original | | RVL-R8KP-EUR-B0 | |
| Story Hour: Fairy Tales | WII | | Original | | RVL-R4FP-EUR | |
| Step to the Beat | WII | | Original | | RVL-RY6P-EUR-B0 | |
| Star Wars: The Force Unleashed II | WII | | Beta | | | |
| SSX Blur | WII | | Beta | | | |
| SSX Blur SSXブラー | WII | | Original | | RVL-RSXJ-JPN | |
| Squeeballs Party | WII | | Original | | RVL-R6YE-USA-B0 | |
| Squeeballs Party | WII | | Original | | RVL-R6YP-EUR-B0 | |
| Spyborgs | WII | | Original | | RVL-RSWE-USA-B0 | |
| Spyborgs | WII | | Beta | | | |
| Spy Fox in "Dry Cereal" Spy Fox: Dry Cereal | WII | | Original | | RVL-RDLP-EUR | |
| Sprint Cars | WII | | Original | | RVL-SN8P-EUR-B0 | |
| SPRay | WII | | Beta | | | |
| SPRay | WII | | Original | | RVL-RYIP-EUR-B0 | |
| The Spirit of the Wolf | WII | | Original | | RVL-SLPP-EUR-B0 | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48E-USA | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48P-EUR | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOX-EUR | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOP-UKV | |
| Spider-Man 3 | WII | Rev 1 | Original | | RVL-RS3P-UKV | |
| Spider-Man 3 | WII | | Original | | RVL-RS3X-EUR | |
| Spellbound Party | WII | | Original | | RVL-SPBP-EUR-B0 | |
| Speed 2 | WII | | Bundled with Wii Wheel | | RVL-SQPP-EUR-B0 | |
| Speed | WII | | Original | | RVL-SPEP-EUR-B0 | |
| Space Station Tycoon | WII | | Prototype | | | |
| Space Camp | WII | | Original | | RVL-RIYP-EUR | |
| Sonic World Adventure ソニック ワールドアドベンチャー | WII | | Original | | RVL-RSVJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Taikenban | | RVL-DSRJ-JPN | |
| Sonic to Ankoku no Kishi ソニックと暗黒の騎士 | WII | | Original | | RVL-RENJ-JPN | |
| Sonic Colors ソニック カラーズ | WII | | Original | | RVL-SNCJ-JPN-B0 | |
| Sonic and the Black Knight | WII | | Original | | RVL-RENP-EUR | |
| Sniper Elite | WII | | Original | | RVL-SSNP-EUR-B0 | |
| The Smurfs Party Pack | WII | | Original | | RVL-S7SP-EUR-B0 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDP-EUR | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXI-EUZ-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: SuperChargers Racing | WII | | Starter Pack | | RVL-SKNE-USA-B0 | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPX-SCN-B2 | |
| Skylanders: Spyro's Adventure | WII | Rev 2 | Starter Pack | | RVL-SSPX-SCN-B1 | |
| Skylanders: Spyro's Adventure | WII | Rev 1 | Starter Pack | | RVL-SSPX-SCN-B0 | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPP-EUR-B2 | |
| Skylanders: Spyro no Daibouken スカイランダーズ スパイロの大冒険 | WII | | Starter Pack | | RVL-SSPJ-JPN-B0 | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYY-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Skate It | WII | | Beta | | | |
| Skate City Heroes | WII | | Original | | RVL-RHUP-EUR-B0 | |
| Six Flags Fun Park | WII | | Original | | RVL-R6FE-USA | |
| The Sims 3 | WII | | Beta | | | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PP-EUR | |
| The Sims 2: Castaway | WII | Rev 1 | Original | | RVL-R42P-EUR | |
| The Sims 2: Castaway | WII | | Beta | | | |
| SimCity Creator | WII | | Original | | RVL-R4CP-EUR | |
| SimCity Creator | WII | | Beta | | | |
| SimCity Creator | WII | Rev 1 | Original | | RVL-R4CP-AUS | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDP-EUR-B0 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Shikakui Atama o Maruku Suru. Wii シカクいアタマをマルくする。 Wii | WII | | Original | | RVL-R4MJ-JPN | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-REKJ-JPN-1 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | | Original | | RVL-REKJ-JPN-1 | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-SHIJ-JPN-B0 | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | | Original | | RVL-SHIJ-JPN-B0 | |
| Shakedown: Hawaii | WII | | Original | | RVL-SEVP-EUR-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Original | | RVL-SS3U-AUS-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Original | | RVL-SS4U-AUS-B0 | |
| Sengoku Basara 3: Utage 戦国BASARA3 宴 | WII | | Original | | RVL-S3HJ-JPN-B0 | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2) 戦国BASARA2 | WII | | Original | | RVL-RBSJ-1-JPN | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2: Heroes) 戦国BASARA2 英雄外伝 | WII | | Original | | RVL-RBSJ-0-JPN | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85P-EUR-B0 | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUP-EUR | |
| Secret Files 2: Puritas Cordis | WII | | | | RVL-RZFP-EUR | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ | WII | | Original | | RVL-SD9J-JPN-B0 | |
| Scrabble Interactive | WII | | Original | | RVL-RVHP-EUR-B0 | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Scene It? Ganz großes Kino! | WII | | Original | | RVL-SSCD-NOE-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCP-EUR | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCU-AUS-B0 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | WII | Rev 1 | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XP-EUR | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWP-EUR | |
| The Saddle Club | WII | | Original | | RVL-SSLP-EUR-B0 | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Taikenban | | DL-DOL-DM2J-DIS | |
| Super Mario Sunshine 슈퍼 마리오 선샤인 | GC | | Original | | DL-DOL-GMSE-KOR | |
| Summoner: La Déesse Réincarnée | GC | | Original | | DL-DOL-GS2F-FRA | |
| Star Wars: The Clone Wars | GC | | Original | | DL-DOL-GSXF-FRA | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRD-NOE | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRF-FRA | |
| Star Wars: La Guerra dei Cloni | GC | | Original | | DL-DOL-GSXI-ITA | |
| Star Wars: Jedi Knight II: Jedi Outcast | GC | | Original | | DL-DOL-GJKF-FRA | |
| Star Wars: Bounty Hunter | GC | | Original | | DL-DOL-GBWF-FRA | |
| Star Fox Adventures スターフォックスアドベンチャー | GC | Rev 1 | Original | | DL-DOL-GSAJ-JPN | |
| SRS: Street Racing Syndicate | GC | | Original | | DL-DOL-GCSP-EUR | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Space Raiders 스페이스 레이더스 | GC | | Original | | DL-DOL-GIJK-KOR | |
| Sonic Riders ソニックライダーズ | GC | | Original | | DL-DOL-GXEJ-JPN | |
| Sonic Adventure DX ソニック アドベンチャー DX デラックス | GC | | Original | | DL-DOL-GASJ-JPN | |
| Sonic Adventure 2: Battle ソニックアドベンチャー2 バトル | GC | | Original | | DL-DOL-GSBJ-JPN | |
| SmaBro DX Event-you Disc スマブラDX イベント用ディスク | GC | | Promo | | DL-DOL-D24J-DIS | |
| The Sims ザ・シムズ | GC | | Original | | DL-DOL-G4PJ-JPN | |
| Shadow the Hedgehog シャドウ・ザ・ヘッジホッグ | GC | | Original | | DL-DOL-GUPJ-JPN | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ 体験版 | GC | | Taikenban | | DL-DOL-PGPJ-JPN | |
| Scooby-Doo! Le Livre des Ténèbres | GC | | Original | | DL-DOL-GC3F-FRA | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Super Prologue 21 Games Vol. 1 スーパー・プロローグ21 ゲームス Vol.1 | SP21 | 1.002 | Original | | SKT-3500 | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Sturmwind | DC | 1.0 | Unlicensed (Rerelease) | | | |
| Space Channel 5 Theme Music: Mexican Flyer スペース・チャンネル5 | DC | 1.080 | Not for Sale | | | |
| Sydney 2000 | DC | 1.000 | Original | | T-36808D-09 | |
| Super Street Fighter II X for Matching Service スーパーストリートファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1236M | |
| Super Speed Racing スーパースピードレーシング | DC | 1.004 | Original | | HDR-0013 | |
| Super Runabout: San Francisco Edition | DC | 1.005 | Original | | T-12511N | |
| Super Runabout: San Francisco Edition スーパーランナバウト サンフランシスコエディション | DC | 1.000 | Original | | T-22102M | |
| Super Runabout スーパーランナバウト | DC | 1.003 | Original | | T-22101M | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206D-50 | |
| Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N | |
| Stupid Invaders (Disc 2) | DC | 1.000 | Original | | T-17711D-09 | |
| Stupid Invaders (Disc 1) | DC | 1.000 | Original | | T-17711D-09 | |
| Stupid Invaders (Disc 2) | DC | 1.000 | Original | | T-17711D-71 | |
| Stupid Invaders (Disc 1) | DC | 1.000 | Original | | T-17711D-71 | |
| Stunt GP | DC | 1.001 | Original | | T-22904D-50 | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-7006D-50 | |
| Street Fighter III: 3rd Strike: Fight for the Future ストリート・ファイターⅢ サードストライク ~ファイト・フォー・ザ・フューチャー~ | DC | 1.003 | Original | | T-1209M | |
| Street Fighter III: 3rd Strike | DC | 1.000 | Original | | T-7013D-50 | |
| StarLancer | DC | 1.003 | Original | | T-17723D-05 | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.004 | Original | | T-23002N | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.003 | Original | | T-23002D-50 | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Star Gladiator 2: Nightmare of Bilstein スターグラディエイター2 ~ナイトメアオブビルシュタイン~ | DC | 1.000 | Tentou Taikenban | | 610-7181 | |
| Spirit of Speed 1937 | DC | 1.001 | Original | | T-8118N | |
| Spirit of Speed 1937 スピリット オブ スピード 1937 | DC | 1.000 | Original | | T-8102M | |
| Spirit of Speed 1937 | DC | 1.002 | Original | | T-8117D-50 | |
| Spider-Man | DC | 1.000 | Original | | T-13011D-50 | |
| Speed Devils: Online Racing | DC | 1.003 | Original | | T-17713D-50 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
| Space Channel 5 スペース・チャンネル5 | DC | 0.203 | Taikenban | | 610-7368 | |
| South Park: Chef's Luv Shack | DC | 1.000 | Original | | T-8105D-50 | |
| Soulcalibur ソウルキャリバー | DC | 0.600 | Book Bundle | | 610-7175 | |
| Sonic Shuffle ソニックシャッフル | DC | 1.001 | Original | | HDR-0125 | |
| Sonic Shuffle | DC | 1.000 | Original | | MK-51060-50 | |
| Sonic Adventure International ソニックアドベンチャー・インターナショナル | DC | 1.003 | Original | | HDR-0043 | |
| Sonic Adventure 2: The Trial | DC | 1.001 | Demo | | 610-7994-50 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Sonic Adventure 2 ソニックアドベンチャー2 | DC | 1.002 | Taikenban | | 610-8057 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | MK-51117-50 | |
| Sonic Adventure 2 | DC | 1.002 | Beta | | MK-5111750 | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Soldier of Fortune | DC | 1.000 | Original | | T-17726D-50 | |
| Slave Zero | DC | 1.002 | Original | | T-15106N | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Slave Zero | DC | 1.000 | Original | | T-15104D-50 | |
| Silver | DC | 1.000 | Original | | T-15109D-92 | |
| Silver | DC | 1.001 | Original | | T-15109D-91 | |
| The Shinri Game ザ・心理ゲーム | DC | 1.004 | Original | | T-43403M | |
| Shin Seiki Evangelion: Typing Hokan Keikaku 新世紀エヴァンゲリオン タイピング補完計画 | DC | 1.002 | Original | | T-35102M | |
| Shin Seiki Evangelion: Ayanami Ikusei Keikaku 新世紀エヴァンゲリオン 綾波育成計画 | DC | 1.002 | Original | | T-46303M | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.010 | Genteiban | | HDR-0031 | |
| Shadow Man | DC | 1.002 | Original | | T-8104D-50 | |
| SGGG: Segagaga セガガガ | DC | 2.000 | Tentou-ban | | HDR-0171 | |
| Sekai Fushigi Hakken! Troia 世界ふしぎ発見! トロイア | DC | 1.002 | Original | | T-39701M | |
| Seireiki Rayblade 聖霊機ライブレード | DC | 1.002 | Demo | | 610-7747 | |
| Sega Worldwide Soccer 2000 | DC | 1.300 | Original | | MK-51031-50 | |
| Sega Worldwide Soccer 2000 | DC | 1.200 | Sample | | 952-0007-50 | |
| Sega Rally 2 セガ・ラリー2 | DC | 1.04 | Original | | HDR-0010 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 0.800 | Taikenban | | 610-7727 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega Extreme Sports セガ エクストリーム スポーツ | DC | 1.003 | Original | | HDR-0146 | |
| Sangokushi VI with Power-Up Kit 三國志Ⅵ with パワーアップキット | DC | 1.000 | Original | | T-7607M | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| San Francisco Rush 2049 | DC | 1.002 | Original | | T-9709D-50 | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Sakura Taisen Online: Teito no Nagai Hibi サクラ大戦オンライン ~帝都の長い日々~ | DC | 1.007 | Original | | HDR-0184 | |
| Sakura Taisen Online: Paris no Yuuga na Hibi サクラ大戦オンライン ~巴里の優雅な日々~ | DC | 1.007 | Original | | HDR-0185 | |
| Sakura Taisen Kinematron Hanagumi Mail サクラ大戦 キネマトロン 花組メール | DC | 1.008 | Original | | HDR-0136 | |
| Sakura Taisen Dream Passport 3 サクラ大戦 ドリームパスポート 3 | DC | 1.007 | Original | | 610-7996 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8333 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Sakura Taisen 3 Movie Disc サクラ大戦3 ~巴里は燃えているか~ サクラ大戦3 ムービーディスク | DC | 1.002 | Original | | HDR-0136 | |
| Sakura Taisen 3: Paris wa Moeteiru ka サクラ大戦3 ~巴里は燃えているか~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8022 | |
| Sakura Taisen (Disc 2) サクラ大戦 | DC | 1.010 | Sakura Wars Complete Box | | HDR-0201 | |
| Sakura Taisen (Omake Disc) サクラ大戦 | DC | 1.001 | Genteiban | | HDR-0089 | |
| Saka Tsuku Tokudai-gou: J.League Pro Soccer Club o Tsukurou! サカつく特大号 J.LEAGUE プロサッカークラブをつくろう! | DC | 1.003 | Original | | HDR-0126 | |
| System-Disc (KD02) Columbia | SS | 1.000 | Original | | 610-5732-06 | |
| Super Puzzle Fighter II Turbo | SS | 1.000 | Original | | T-7030H-50 | |
| Super Casino Special スーパー・カジノ・スペシャル | SS | 1.003 | Original | | T-7306G | |
| Super Adventure Rockman (Disc 3) (Episode 3: Saigo no Tatakai!!) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 2) (Episode 2: Shitou! Wily Numbers) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 1) (Episode 1: Tsuki no Shinden) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Suikoden: Tenmei no Chikai 水滸伝 ~天命の誓い~ | SS | 1.000 | Original | | T-7624G | |
| Striker 96 ストライカー’96 | SS | 1.002 | Original | | T-8114G | |
| Striker 96 | SS | 1.001 | Original | | T-8133H-50 | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Stellar Assault SS ステラ・アサルト・ダブル・エス | SS | 1.001 | Original | | T-4403G | |
| Steamgear Mash スチームギア・マッシュ | SS | 1.000 | Original | | T-10301G | |
| StarFighter 3000 | SS | 1.000 | Original | | T-29701H-50 | |
| Star Wars: Rebel Strike Spike | SS | 1.000 | Prototype | | | |
| Star Fighter | SS | 1.001 | Original | | T-8135H | |
| Spot Goes to Hollywood | SS | 1.400 | Original | | T-7001H-50 | |
| Special Disc with SegaSaturn Internet 2 SPECIAL DISC with SEGASATURN インターネット2 | SS | 1.020 | Hibaihin | | T-31303G | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H | |
| Soviet Strike | SS | 1.000 | Original | | T-5013H-18 | |
| Soviet Strike | SS | 1.000 | Original | | T-5013H-50 | |
| Soukuu no Tsubasa: Gotha World 蒼空の翼 -GO THAWORLD- | SS | 1.000 | Sample CD | | 610-6710 | |
| Sotsugyou: Graduation S 卒業S | SS | 1.001 | Original | | T-20103G | |
| Sonic R ソニックR | SS | 1.002 | Original | | GS-9170 | |
| Söldnerschild ゼルドナーシルト | SS | 1.001 | Original | | GS-9155 | |
| Slayers Royal 2 スレイヤーズろいやる2 | SS | 1.005 | Original | | T-27907G | |
| Slam 'n Jam '96 featuring Magic & Kareem マジック・ジョンソン・と・カリーム・アブドュール・ジャバーの スラム・ジャム’96 | SS | 1.000 | Original | | T-15905G | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Skeleton Warriors | SS | 1.000 | Original | | T-7018H-50 | |
| Simulation RPG Tkool シミュレーションRPGツクール | SS | 1.003 | Original | | T-2106G | |
| Side Pocket 3 サイド・ポケット3 | SS | 1.000 | Original | | T-1314G | |
| Shutsudou! Miniskirt Police 出動!ミニスカ・ポリス | SS | 1.001 | Shokai Gentei Double Tokuten | | T-30812G | |
| Shunsai 駿才 | SS | 1.003 | Original | | T-18703G | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H-50 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shinouken 神凰拳 | SS | 1.003 | Original | | T-3113G | |
| Shining Wisdom | SS | 1.000 | Beta | | | |
| Shining Wisdom | SS | 1.000 | Preview | | | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 2.000 | Original | | GS-9188 | |
| Shining Force III: Scenario 1: Outo no Kyoshin シャイニング・フォースⅢ シナリオ1 ~王都の巨神~ | SS | 2.005 | Original | | GS-9175 | |
| Shin Seiki Evangelion: Eva to Yukaina Nakama-tachi 新世紀エヴァンゲリオン エヴァと愉快な仲間たち | SS | 1.001 | Original | | T-35103G | |
| Shin Kaitei Gunkan: Koutetsu no Kodoku 新海底軍艦 ~鋼鉄の孤独~ | SS | 1.008 | Original | | T-2105G | |
| Shichisei Toushin Guyferd: Crown Kaimetsu Sakusen 七星闘神ガイファード ~クラウン壊滅作戦~ | SS | 1.001 | Original | | T-1242G | |
| Shellshock | SS | 1.000 | Original | | T-11502H-18 | |
| Shellshock | SS | 1.000 | Original | | T-11502H-09 | |
| Sentimental Graffiti: First Window センチメンタル・グラフティ ~ファースト・ウィンドウ~ | SS | 1.002 | Original | | T-20111G | |
| Sengoku Blade: Sengoku Ace Episode II 戦国ブレード | SS | 1.002 | Mihonhin | | ST-14410G | |
| Seifuku Densetsu: Pretty Fighter X 制服伝説 プリティ・ファイターX | SS | 1.002 | Original | | T-15001G | |
| SegaSaturn: SGL Tool Kit: Sega 3D Game Library | SS | 1.000 | Original | | L15-1000 | |
| SegaSaturn: Movie Tools: Cinepak for Sega Saturn | SS | | Hybrid Version | | L17-1000 | |
| SegaSaturn: Graphic & Sound Tools for Macintosh | SS | | Original | | N16-1000 | |
| SegaSaturn Photo CD Operator セガサターン フォトCDオペレーター | SS | 1.007 | Original | | HSS-0121 | |
| SegaSaturn Internet Vol. 1 SEGASATURN インターネット Vol.1 | SS | 1.000 | Bundled with SegaSaturn Modem | | T-31301G | |
| SegaSaturn Internet 2 SEGASATURN インターネット 2 | SS | 1.030 | Bundled with SegaSaturn Modem | | T-31302G | |
| SegaSaturn FDD Operator セガサターン FDDオペレーター | SS | 1.003 | Bundled with SegaSaturn FDD | | HSS-0128 | |
| SegaSaturn Electronic Book Operator セガサターン 電子ブック・オペレーター | SS | 1.00C | Original | | HSS-0120 | |
| SegaColle Sega Bible Mogitate SegaSaturn Soukan-gou セガコレセガバイブルモギタテセガサターン。 創刊号 1997.11 | SS | 1.000 | Hibaihin | | 610-6805-01 | |
| Sega Worldwide Soccer '98: Club Edition | SS | 1.004 | Original | | MK81123-50 | |
| Sega Worldwide Soccer '98: Club Edition | SS | 1.003 | Original | | MK81123-50 | |
| Sega Rally Championship セガラリー・チャンピオンシップ | SS | 1.000 | Mihonban | | SGS-9047 | |
| Sega Ages: Space Harrier セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 | |
| Sega Ages: Space Harrier セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 | |
| Sega Ages: Shukudai ga Tanto R セガエイジス 宿題がタントアール | SS | 1.06 | Original | | GS-9042 | |
| Sega Ages: Rouka ni Ichidanto R セガエイジス 廊下にイチダントアール | SS | 1.002 | Original | | GS-9043 | |
| Sega Ages: Memorial Selection Vol. 1 セガエイジス メモリアル・セレクションVOL.1 | SS | 1.002 | Original | | GS-9135 | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| SD Gundam: GCentury S SDガンダム・ジー・センチュリーS | SS | 1.001 | Original | | T-13324G | |
| Scorcher | SS | 2.000 | Original | | 81214 | |
| Saturn Super Vol. 8 サターン・スーパー Vol.8 | SS | 1.000 | Bundled with Magazine | | 610-6020-09 | |
| Saturn Super Vol. 7 サターン・スーパー Vol.7 | SS | 1.000 | Bundled with Magazine | | 610-6020-08 | |
| Saturn Super Vol. 6 サターン・スーパー Vol.6 | SS | 1.000 | Bundled with Magazine | | 610-6020-07 | |
| Saturn Super Vol. 6 サターン・スーパー Vol.6 | SS | 1.000 | Bundled with Magazine | | 610-6020-07 | |
| Saturn Super Vol. 4 サターン・スーパー Vol.4 | SS | 1.000 | Bundled with Magazine | | 610-6020-05 | |
| Saturn Super Vol. 3 サターン・スーパー Vol.3 | SS | 1.001 | Bundled with Magazine | | 610-6020-03 | |
| Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | Bundled with Magazine | | 610-6020-02 | |
| Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | Bundled with Magazine | | 610-6020-02 | |
| Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | Bundled with Magazine | | 610-6020-02 | |
| Saturn Super Vol. 11 Furoku CD-ROM サターン・スーパー Vol.11 付録CD‐ROM | SS | 1.000 | Bundled with Magazine | | 610-6020-12 | |
| Saturn Super Vol. 1 サターン・スーパー Vol.1 | SS | 1.000 | Bundled with Magazine | | 610-6020-01 | |
| Saturn Super Vol. 1 サターン・スーパー Vol.1 | SS | 1.000 | Bundled with Magazine | | 610-6020-01 | |
| Saturn Super Vol. 1 サターン・スーパー Vol.1 | SS | 1.000 | Bundled with Magazine | | 610-6020-01 | |
| Saturn Super Henshuubu Hen: Taikenban Saturn Soft Taizen サターン・スーパー 編集部 編 体験版サターンソフト大全 | SS | 1.000 | Bundled with Magazine | | 610-6020-04 | |
| SatMag Sono CD サタマガ・ソノCD | SS | 1.001 | Bundled with Magazine (SegaSaturn Taikenban CD-ROM) | | 610-6833 | |
| Sanguozhi Yingjiezhuan 三國志英傑伝 | SS | 1.000 | Zhongwenban | | T-7603H-11, T-7603H-16 | |
| Sanguozhi V 三國志Ⅴ | SS | 1.000 | Zhongwenban | | T-7606H-11, T-7606H-16 | |
| Sangokushi V 三國志Ⅴ | SS | 2.000 | Sangokushi Value Set | | T-7636G | |
| Sangokushi Koumeiden 三國志孔明伝 | SS | 1.000 | Original | | T-7629G | |
| Sangokushi IV with Power-Up Kit 三國志Ⅳ with パワーアップ・キット | SS | 1.000 | Original | | T-7644G | |
| Sakura Taisen: Hanagumi Taisen Columns サクラ大戦 ~花組対戦コラムス~ | SS | 1.000 | Original | | GS-9138 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Surgical Strike サージカル・ストライク | MCD | | Original | | G-6044 | |
| Surgical Strike | MCD | | Sega CD 32X (Disc 2) | | 4435, 157036 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Super Strike Trilogy | MCD | | Unlicensed | | | |
| Starblade | MCD | | Original | | 4284-50 | |
| Sonic the Hedgehog CD | MCD | 1.05 | Beta | | | |
| Sonic the Hedgehog CD | MCD | 0.70 | Beta | | | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
| Sonic CD | MCD | 1.15 | Beta | | | |
| Sonic CD | MCD | | Bundled with Sega CD | | 4407 | |
| Sonic CD | MCD | | Original | | 4407 | |
| Sonic CD | MCD | 1.11 | Beta | | | |
| Sonic CD | MCD | 1.09 | Beta | | | |
| Sol-Feace | MCD | RE | Bundled with Sega CD | | 4130 | |
| Sol-Feace | MCD | | Bundled with Mega-CD (Sol-Feace / Cobra Command Bundle) | | 4130 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-158025-50 | |
| Snatcher | MCD | | Beta | | | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Silpheed シルフィード | MCD | | Sample | | ST-45054 | |
| Silpheed シルフィード | MCD | | Sample (Fixed Dump) | | ST-45054 | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective | MCD | | Original | | 4650 | |
| Shadow of the Beast II | MCD | | Original | | T-113045 | |
| Sewer Shark | MCD | | Original | | T-6201 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega CD Demo | MCD | | Prototype | | | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island モンキー・アイランド ~ユーレイ海賊大騒動!~ | MCD | | Original | | T-60044 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| Syphon Filter: Logan's Shadow | PSP | 0.10 | Test Sample | | UCUS-98606 | |
| Suzumiya Haruhi no Yakusoku 涼宮ハルヒの約束 | PSP | 1.06 | Super Premium Box | | ULJS 00123 | |
| Suzumiya Haruhi no Tsuisou 涼宮ハルヒの追想 | PSP | 1.02 | Original | | ULJS 00371 | |
| Super Robot Taisen OG Saga: Masoukishin: The Lord of Elemental スーパーロボット大戦OGサーガ 魔装機神 THE LORD OF ELEMENTAL | PSP | 1.01 | Shokai Gentei Seisan | | ULJS 00445 | |
| Super Robot Taisen A Portable スーパーロボット大戦A ポータブル | PSP | 1.02 | Original | | ULJS 00143 | |
| Super Danganronpa 2: Sayonara Zetsubou Gakuen スーパーダンガンロンパ2 さよなら絶望学園 | PSP | 1.02 | Original | | ULJS 00522 | |
| Summon Night 4 サモンナイト4 | PSP | 2.00 | Original | | ULJS 00375 | |
| Summon Night 3 サモンナイト3 | PSP | 2.00 | Original | | ULJS 00303 | |
| SuGirly Wish Limited シュガーリィ ウィッシュ リミテッド | PSP | 1.02 | Original | | ULJM 06205 | |
| Storm Lover Natsukoi!! ストーム ラバー 夏恋!! | PSP | 1.02 | Original | | ULJS 00396 | |
| Storm Lover Kai!! ストーム ラバー 快!! | PSP | 1.03 | Mune-Kyun Otome Collection Vol. 10 | | ULJS 00609 | |
| Storm Lover | PSP | 1.02 | Shokai Seisan-ban | | ULJS 00299 | |
| Storm Lover | PSP | 1.02 | Original | | ULJS 00300 | |
| Steins;Gate: Hiyoku Renri no Darling シュタインズ・ゲート 比翼愛理のだーりん | PSP | 1.02 | Original | | ULJM 06040 | |
| Steins;Gate シュタインズ・ゲート | PSP | 1.01 | Original | | ULJM 05887 | |
| Stealth feat. WipEout Pure Stealth Edition ステルス feat.「ワイプアウト ピュア STEALTH edition」 | PSP | 1.00 | Original | | ULJM 05105 | |
| Stealth + WipEout Pure | PSP | 2.00 | Original | | ULES-00230 | |
| Stealth + WipEout Pure | PSP | 2.00 | Original | | ULES-00232 | |
| Starry Sky: In Winter Portable Starry☆Sky~In Winter~Portable | PSP | 1.01 | Shokai Genteiban | | HONEY-004, … | |
| Starry Sky: After Winter Portable Starry★Sky ~スタ・スカ~ ~After Winter~ Portable | PSP | 1.01 | Shokai Genteiban | | ULJM 06210 | |
| Starry Sky: After Spring Portable Starry☆Sky~After Spring~Portable | PSP | 1.03 | Shokai Genteiban | | ULJM 06207 | |
| Star Wars: The Force Unleashed | PSP | 1.00 | Original | | ULES-00982 … | |
| Star Wars Battlefront: Renegade Squadron 스타워즈 배틀프론트 레니게이드 스쿼드런 | PSP | 1.01 | Original | | ULKS 46017 | |
| Split/Second スプリットセカンド | PSP | 1.04 | Original | | ULJM 05812 | |
| Soukoku no Kusabi: Hiiro no Kakera 3: Ashita e no Tobira 蒼黒の楔 緋色の欠片3 明日への扉 | PSP | 1.04 | Shokai Genteiban | | ULJM 06071 | |
| Sol Trigger ソールトリガー | PSP | 1.01 | Original | | ULJM 06093 | |
| SOCOM: U.S. Navy SEALs: Fireteam Bravo 3 소콤 U.S.네이비 씰 파이어팀 브라보 3 | PSP | 1.01 | Original | | UCKS 45128 | |
| SOCOM: U.S. Navy SEALs Portable ソーコム:U.S. ネイビーシールズ ポータブル | PSP | 1.01 | Original | | UCJS 10102 | |
| Snow Bound Land スノウ バウンド ランド | PSP | 1.02 | Genteiban | | ULJM 06327 | |
| SNK Arcade Classics Vol. 1 SNK 아케이드 클래식 Vol.1 | PSP | 1.02 | Original | | ULKS 46179 | |
| SNK Arcade Classics Vol. 1 | PSP | 1.00 | Original | | ULJS 00193 | |
| Smash Court Tennis 3 スマッシュコートテニス3, 스매시 코트 테니스3 | PSP | 1.00 | Original | | UCKS 45051 | |
| Singi Hwansang: SSII Unlimited Side 신기환상 ~SS II 언리미티드 사이드~ | PSP | 1.00 | Original | | ULKS-46094 | |
| The Sims 2: Pets 심즈 2: 펫츠 | PSP | 1.00 | Original | | ULKS 46117 | |
| The Sims 2: Castaway | PSP | 1.00 | Original | | ULUS 10296 | |
| Silhwang Powerful Pro Yagu 2011 실황 파워풀 프로야구 2011 | PSP | 1.01 | Original | | ULKS 46270 | |
| Silhwang Powerful Pro Yagu 2010 실황 파워풀 프로야구 2010 | PSP | 1.00 | Original | | ULKS 46255 | |
| Shirogane no Cal to Aoi no Joou 白銀のカルと蒼空の女王 | PSP | 1.00 | Original | | ULJM 05954 | |
| Shirahana no Ori: Hiiro no Kakera 4: Shiki no Uta 白華の檻 ~緋色の欠片4~ 四季の詩 | PSP | 1.01 | Genteiban | | ULJM 06313 | |
| Shirahana no Ori: Hiiro no Kakera 4 白華の檻 ~緋色の欠片4~ | PSP | 1.01 | Genteiban | | ULJM 06166 | |
| Shinten Makai: GOC IV Another Side 新天魔界 ~GOCⅣ アナザサイド~ | PSP | 1.06 | Original | | ULJM 05013 | |
| Shinobi, Koiutsutsu 忍び、恋うつつ | PSP | 1.01 | Genteiban | | ULJM 06352 | |
| Shinki Gensou: SSII Unlimited Side 新紀 幻想 SSII Unlimited Side | PSP | 1.04 | Original | | UCAS 40027 | |
| Shinigami to Shoujo 死神と少女 | PSP | 1.01 | Original | | ULJS 00403 | |
| Shin Sangoku Musou 5 Empires 真・三國無双5 Empires | PSP | 1.02 | Original | | ULJM 05584 | |
| Senritsu no Stratus 戦律のストラタス | PSP | 1.01 | Original | | ULJM 05934 | |
| Senjou no Valkyria 3 E2: Extra Edition 戦場のヴァルキュリア3 E2: Extra Edition | PSP | 1.00 | Original | | ULJM 05957 | |
| Sengoku-hime: Senran ni Mau Otome-tachi 戦極姫 ~戦乱に舞う乙女達~ | PSP | 1.02 | Original | | ULJM 05540 | |
| Sengoku Musou 3 Z Special 戦国無双3 Z Special | PSP | 1.01 | Original | | ULJM 06024 | |
| Secret Agent Clank | PSP | .01 | Beta | | UCUS-98697 | |
| Secret Agent Clank 시크릿 에이전트 클랭크 | PSP | 1.00 | Original | | UCKS 45096 | |
| Secret Agent Clank Clank: Agente-Secreto | PSP | 0.01 | Review | | UCET-01101 | |
| Secret Agent Clank | PSP | 1.01 | Original | | UCAS-40218 | |
| SD Gundam GGeneration Overworld SDガンダム ジージェネレーション オーバーワールド | PSP | 1.01 | Original | | ULJS 00536 | |
| School Wars: Sotsugyou Sensen スクール・ウォーズ~卒業戦線~ | PSP | 1.02 | Goukaban | | ROSE 00027 … | |
| School Rumble: Anesan Jiken desu! スクールランブル ~姉さん事件です!~ | PSP | 1.00 | Original | | ULJS 00019 | |
| Satomi Hakkenden: Hamaji Hime no Ki 里見八犬伝~浜路姫之記~ | PSP | 1.03 | Original | | ULJM 06379 | |
| Sangoku-hime: Sangoku Ransei: Haten no Saihai 三極姫~三国乱世・覇天の采配~ | PSP | 1.00 | Limited Edition | | ULJS 00434 | |
| Sakura Sakura: Haru Urara さくらさくら -HARU URARA- | PSP | 1.02 | Original | | ULJM 05758 | |
| S.Y.K Renshouden Portable S.Y.K ~蓮咲伝~ Portable | PSP | 1.01 | Shokai Genteiban | | ULJM 05866 | |