Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sniper: Ghost Warrior | XBOX360 | | Original | | CY-2001 | |
| De Snipers: Invisible, Silentadly | XBOX360 | | Original | | W6-2002 | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2072 | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Sonic & Sega All-Stars Racing with Banjo-Kazooie | XBOX360 | | Original | | SE-2069 | |
| Sonic the Hedgehog ソニック・ザ・ヘッジホッグ | XBOX360 | | Original | | SE-2006 | |
| Sonic Unleashed | XBOX360 | | Original, Platinum Hits | | SE-2066 | |
| Sonic World Adventure ソニック ワールドアドベンチャー | XBOX360 | | Original | | SE-2066 | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| South Park: Der Stab der Wahrheit | XBOX360 | | Original | | US-2245 | |
| South Park: The Stick of Truth | XBOX360 | | Original | | US-2245 | |
| South Park: The Stick of Truth South Park: Палка Истины | XBOX360 | | Classics | | US-2245 | |
| Space Chimps | XBOX360 | | Original | | BT-2004 | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| Spectral Force 3 | XBOX360 | | Original | | AT-2003 | |
| Spectral Force 3: Innocent Rage スペクトラルフォース3 ~イノセント レイジ~ | XBOX360 | | Original | | IF-2001 | |
| Spectral Force 3: Innocent Rage | XBOX360 | | Original | | IF-2001 | |
| Spider-Man 3 | XBOX360 | | Original | | AV-2018 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| Split/Second Split/Second: Velocity | XBOX360 | | Original | | BV-2023 | |
| Split/Second: Velocity | XBOX360 | | Original | | BV-2023 | |
| Sports Island Freedom | XBOX360 | | Original | | HU-2015 | |
| Star Ocean: The Last Hope (Disc 2) | XBOX360 | | Original | | SQ-2013 | |
| Star Ocean: The Last Hope (Disc 1) スターオーシャン4 -THE LAST HOPE- | XBOX360 | | Original | | SQ-2013 | |
| Star Ocean: The Last Hope (Disc 2) スターオーシャン4 -THE LAST HOPE- | XBOX360 | | Original | | SQ-2013 | |
| Star Ocean: The Last Hope (Disc 3) スターオーシャン4 -THE LAST HOPE- | XBOX360 | | Original | | SQ-2013 | |
| Star Trek | XBOX360 | | Original | | NM-2139 | |
| Steins;Gate 命運石之門 | XBOX360 | | Original | | FV-2008 | |
| Steins;Gate: Senkei Kousoku no Phenogram STEINS;GATE 線形拘束のフェノグラム | XBOX360 | | Limited Edition | | FV-2035 | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Stoked ストークト | XBOX360 | | Original | | DE-2003 | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Stormrise | XBOX360 | | Original | | SE-2054 | |
| Street Fighter IV: The Ties That Bind (Bonus Disc) | XBOX360 | | Xbox 360 Game Bundle | | CC-2033 | |
| Strike Witches: Hakugin no Tsubasa ストライクウィッチーズ -白銀の翼- | XBOX360 | | Original | | CF-2003 | |
| Stuntman: Ignition | XBOX360 | | Demo | | TQ-2069 | |
| Summer Athletics 2009 | XBOX360 | | Original | | DT-2006 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Summer Challenge: Athletics Tournament | XBOX360 | | Original | | RL-2014 | |
| Summer Stars 2012 | XBOX360 | | Original | | KM-2027 | |
| Super Robot Taisen XO スーパーロボット大戦XO | XBOX360 | | Original | | BP-2001 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Superstars V8 Racing | XBOX360 | | Original | | LS-2003 | |
| Superstars V8: Next Challenge | XBOX360 | | Original | | LS-2008 | |
| Supreme Commander | XBOX360 | | Original | | AY-2005 | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Supreme Commander 2 スプリームコマンダー2 | XBOX360 | | Original | | SQ-2019 | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Shodai Xbox Game Gokansei Update Disc: 2007-nen 7-gatsuban 初代 Xbox ゲーム互換性アップデート ディスク (2007 年 7 月版) | XBOX360 | | Bundled with Halo History Pack | | | |
| The Sims 3: Pets | XBOX360 | | Beta | | | |
| The Sims 3: Pets | XBOX360 | | Beta | | | |
| Street Fighter X Tekken | XBOX360 | | Beta | | | |
| Samba World Cup | ACD | | Original | | | |
| The Scene Archive: 1988-1998 | ACD | | Original | | | |
| Scene Storm | ACD | | | | | |
| The Second AMUC CD | ACD | | | | CDRM1251610 | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Sid Meier's Civilization | ACD | | | | | |
| Sixth Sense Investigations | ACD | | Original | | | |
| Software 2000: Volume 1 (Disc 1) | ACD | | Original | | | |
| Software 2000: Volume 1 (Disc 2) | ACD | | Original | | | |
| Software Explosion | ACD | | | | | |
| StormC 4 | ACD | 4 | Original | | | |
| Street Racer | ACD | | | | | |
| Sleepwalker | CD32 | | Original | | | |
| Soccer Kid | CD32 | | Original | | | |
| Sports: Football | CD32 | | | | | |
| Striker | CD32 | | Original | | | |
| Super Methane Bros. | CD32 | | Original | | | |
| Super Skidmarks | CD32 | 2.2 | Original | | | |
| Super Street Fighter II Turbo | CD32 | | Original | | | |
| Snoopy: The Case of the Missing Blanket | CDTV | | Original | | | |
| Sengoku Denshou 2 ~ Sengoku 2 戦国伝承2 | NGCD | | Original | | NGCD-040 | |
| Super Sidekicks: Tokuten-ou 得点王 | NGCD | | Original | | NGCD-052 | |
| Sangokushi IV 三國志Ⅳ | 3DO | | Original | | FZ-SJ2853 | |
| Scramble Cobra スクランブル・コブラ | 3DO | | Original | | FZ-SJ0404 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Shock Wave 지구공습 2019 | 3DO | | Original | | GDT-GA 101 | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Slam 'n Jam '95 | 3DO | | Beta (CD-R) | | | |
| Slayer | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| Space Ace | 3DO | | Bundled with Magazine (Demo) | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | Beta 8 | Beta (CD-R) | | | |
| The Super Model: Gail McKenna スーパー・モデル ゲイル・マッケンナ | 3DO | | Mihonban | | TPS-18012 | |
| Super Nova: Battery Navi バッテリー・ナビ | 3DO | | Hibaihin | | V1-9507 | |
| Super Street Fighter II Turbo | 3DO | | Bundled with Magazine (4 Character Demo Disc) | | | |
| Super Wing Commander | 3DO | | Original | | R988DCXD | |
| System Catalog: Kigyou-muke System no Goannai System Catalog 企業向けシステムのご案内 | 3DO | | Hibaihin | | HOU-013DO01 | |
| Shichi Sokusen 死地則戦 | PIPPIN | Rev A | Original | | BDS-20019 | |
| Sakura no Mori 櫻の杜 | FMT | | PC-9821 Release | | | |
| Samurai Spirits サムライ・スピリッツ | FMT | | Original | | JH-012 | |
| Sangokushi II 三國志Ⅱ | FMT | | with Soundware | | HMB-159 | |
| Sargon V: World Class Chess サルゴンⅤ | FMT | | Original | | HMD-191 | |
| Sayaka + Miho 沙也香/美穂 | FMT | | Original | | HMF-179 | |
| Sayonara no Mukougawa さよならの向こう側 | FMT | | Original | | CBF-0008 | |
| Scavenger 4 スカベンジャー4 | FMT | | Demo-ban | | HME-918 | |
| Scavenger 4 スカベンジャー4 | FMT | Rev A | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217A | |
| Scholar Movie Magazine Soukan-gou スコラ MOVIE MAGAZINE 創刊号 | FMT | | Original | | DWDC 4815 | |
| Schwarzschild シュヴァルツシルト | FMT | | Original | | HMC-171 | |
| Schwarzschild IV: The Cradle End シュヴァルツシルトⅣ -THE CRADLE END- | FMT | | Original | | HME-223 | |
| Secre Volume 3: Fumie Hosokawa SECRE VOLUME ③ 「細川 ふみえ」 | FMT | | Original | | HME-191 | |
| Secre Volume 4: Hitomi Fujisaki SECRE VOLUME ④ 「藤崎 仁美」 | FMT | | Original | | HME-196 | |
| Secre Volume 5: Tina Gushiken SECRE VOLUME ⑤ 「具志堅 ティナ」 | FMT | | Sample | | HME-204 | |
| Secre Volume 6: Reiko Kato SECRE VOLUME ⑥ 「かとう れいこ」 | FMT | | Original | | HME-205 | |
| Secre Volume 7: Reiko Chiba SECRE VOLUME ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 | |
| Secre Volume I: Naoko Iijima SECRE VOLUME ① 「飯島 直子」 | FMT | | Original | | HME-168 | |
| The Secret of Monkey Island モンキー・アイランド | FMT | | Original | | HMD-155 | |
| Sexy in the Hawaii: Nice Gal Hawaii-hen Sexy in The Hawaii ~ナイス・ギャル ハワイ編~ | FMT | | Original | | | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | Rev 1 | Original | | HMC-157 | |
| Shijou Saikyou no Video Bible: The Greatest Video Bible in the World 史上最強のビデオバイブル | FMT | | Original | | HMA-251 | |
| Shinc | FMT | | Original | | HME-131 | |
| Shinseiki Kouboushi: Dead Force 新世紀興亡史 デッド・フォース | FMT | | Original | | | |
| Shougaku Ongaku (5·6-nensei-you) 小学音楽(5·6年生用) | FMT | Rev A | Original | | HMB-512A | |
| Shuukan Shounen Magazine History 週刊少年マガジンヒストリー | FMT | 1.0 | Original | | HMD-151 | |
| Sid Meier's Railroad Tycoon レイルロード・タイクーン デラックス | FMT | | Original | | HME-245 | |
| Silent Möbius: Case: Titanic サイレント・メビウス | FMT | | Original | | HMC-143 | |
| Sim Sports Diving: Soreyuke! Diving それゆけ!ダイイビング | FMT | | Original | | HMB-161 | |
| SimCity シム・シティ | FMT | Rev A | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121A | |
| SimCity 2000 シム・シティ2000 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 52 | | HMF-191 | |
| SimFarm シムファーム | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 48 | | HMF-170 | |
| SimFarm: SimCity's Country Cousin シムファーム | FMT | | Demo | | HMF-920 | |
| Soft de Hard na Monogatari ソフトでハードな物語 | FMT | | Original | | | |
| Soft de Hard na Monogatari 2 ソフトでハードな物語2 | FMT | | Original | | HMA-214 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev A | Original | | HMC-139A | |
| Soreike! Anpanman: Tanoshii Eigo Asobi それいけ! アンパンマン ~たのしいえいごあそび~ | FMT | | Original | | FMB-3010 | |
| Sotsugyou: Graduation '93 卒業’93 | FMT | | Original | | JH-002 | |
| Space Museum スペース・ミュージアム | FMT | | Original | | | |
| Special & Delicious! Original CD-ROM | FMT | | Bundled with Book | | TAIYOU-001 | |
| Speech Trainer V1.0 L10 スピーチ・トレーナー | FMT | | Original | | HMD-224 | |
| Splatterhouse スプラッターハウス | FMT | | Ving Vol. 13 | | HMD-146 | |
| SSL Gallery Ver. 1 | FMT | | Original | | | |
| StarCruiser II for CD-ROM スタークルーザー Ⅱ for CD‐ROM | FMT | | Original | | JH-006 | |
| Steepia スティーピア | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 25 | | HMD-179 | |
| Steepia Lite スティーピア ライト | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 34 | | HME-118 | |
| Strike Commander ストライク・コマンダー | FMT | | Original | | HMDC-1915 | |
| Strike Commander Plus ストライク・コマンダーPLUS | FMT | | Original | | | |
| Suikoden: Tenmei no Chikai 水滸伝・天命の誓い | FMT | | with Soundware | | HMB-108 | |
| Super Collection 1: Game Technopolis (Himitsu no Hanazono & Kimi dake ni Ai o... +) スーパー・コレクション① (秘密の花園&キミだけに愛を…+) | FMT | | Original | | HMD-134 | |
| Super Collection 2: Game Technopolis (IV: Tesera & Hatsukoi Monogatari +) スーパー・コレクション② (Ⅳ~テセラ~&初恋物語+) | FMT | | Original | | HME-184 | |
| Super Shanghai: Dragon's Eye スーパー上海 ~ドラゴンズ・アイ ~ | FMT | | Original | | HMC-181 | |
| Suzaku | FMT | | Original | | HMD-178 | |
| Syndicate シンジケート | FMT | | Original | | HMF-163 | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Safecracker | MAC | | Original | | | |
| Saikyou Kareshi: Dynamic Darling 最強彼氏 | MAC | | Original | | | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sangokushi Eiketsuden 三國志英傑伝 | MAC | | Original | | KN10-82104 | |
| Sanzennen Shokudou: Shoku Culture Simulation Game 三千年食堂 食カルチャーシミュレーションゲーム | MAC | | Original | | G012JAP-M | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Le Secret du Templier | MAC | 1.0 | Covermount | | | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Sexy PK: World Cup-ban セクシー・ピーケー ワールドカップ版 | MAC | | Original | | MMC-4065 | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| SimCity 2000: CD Collection | MAC | 1.20 | Original | | 1074-029-0601-A | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims | MAC | | | | | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| SimTown: The Town You Build Yourself! シムタウン | MAC | | Original | | MMC-4093 | |
| SiN Gold | MAC | | MacPlay | | | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| The Space Bar (Disc 1) | MAC | 1.0 | Original | | 115-7H | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Spectre VR CD | MAC | | Original | | | |
| Spider-Man | MAC | | Original | | | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Star Trek: New Worlds: Ad | MAC | | Art Assets | | | |
| Star Trek: Starfleet Command II: Empires at War: Ad | MAC | | Art Assets | | | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Screen Entertainment | MAC | | Mac Game Bundle | | | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.0 | Original | | 2052130 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| Syndicate | MAC | | Original | | 7558 | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims: Complete Collection | MAC | 2.9.1 | Original | | 11370-1DDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| Salvat Enciclopedia Interactiva | CDI | | Original | | B-44677-96 | |
| Sandy's Circus Adventure | CDI | | Original | | 690 0222 | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Say What You Want | CDI | | Original | | | |
| Die Schöne und das Tier | CDI | | Original | | 813 0040 | |
| Les Schtroumpfs: Le Téléportaschtroumpf | CDI | | Original | | SCHTRFR4011 | |
| Secret Mission | CDI | 1.01 | Beta | | 810 0272 | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| Si Balla! | CDI | 1.01 | Beta | | 815 0066 | |
| Sieben Schritte zum Erfolg | CDI | | | | | |
| Sieben Schritte zum Erfolg II | CDI | | | | | |
| Simulation Eikaiwa: CD-I Taiken America Ryokou シュミレーション英会話 CD-I体験アメリカ旅行 | CDI | | Original | | | |
| Sliver (Disc 1) | CDI | | Original | | 310690309-2 | |
| Sliver (Disc 2) | CDI | | Original | | 310690309-2 | |
| Smilde | CDI | | Original | | | |
| Solitaire | CDI | | Prototype | | | |
| Somewhere: Une Envie de Naturel | CDI | | | | | |
| Somewhere: Une Envie de Naturel: Printemps 96 | CDI | | Original | | | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Star Trek VI: Das unentdeckte Land (Disc 1) | CDI | 1.04 | Original | | 813 1023 | |
| Star Trek VI: Das unentdeckte Land (Disc 2) | CDI | 1.01 | Original | | 813 1024 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Starring You: BZN Starring You: Zing Mee met Bekende Duetten van BZN | CDI | | Original | | 2700586 | |
| Stickybear Preschool | CDI | 1.03 | Beta | | 690 2572 | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Stomach in Motion | CDI | | Original | | WIM 060792 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Maschine: Galaxis | CDI | | Original | | 813 0032 | |
| Stretch-Top System: Wasserbett-Information Stretch-Top System: Waterbed-Information | CDI | | Original | | | |
| Strip Poker Live | CDI | 1.04 | Original | | 810 0257 | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Stories: My Favorite Things | CDI | | | | | |
| SuperTest | CDI | 1.01 | Beta | | 810 0168 | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Sangaku Shashin Photo CD Series Vol. 1: Shirouma Takeshi Ushiro Tateyama Renpou 山岳写真フォトCDシリーズVol.1 白馬岳・後立山連峰 | PHOTO-CD | | Original | | AS 0001 | |
| Sangaku Shashin Photo CD Series Vol. 2: Hotaka Kamikochi 山岳写真フォトCDシリーズVol.2 穂高・上高地 | PHOTO-CD | | Original | | AS 0004 | |
| Sangaku Shashin Photo CD Series Vol. 3: Yatsugatake 山岳写真フォトCDシリーズVol.3[八ケ岳] | PHOTO-CD | | Original | | AS 0005 | |
| Sangaku Shashin Photo CD Series Vol. 4: Tateyama 山岳写真フォトCDシリーズVol.4[立山] | PHOTO-CD | | Original | | AS 0006 | |
| Sangaku Shashin Photo CD Series Vol. 5: Oze 山岳写真フォトCDシリーズVol.5[尾瀬] | PHOTO-CD | | Original | | AS 0007 | |
| Die Schönsten Hotels der Welt | PHOTO-CD | | Original | | 813 0060 | |
| Seikaku Shindan Game: Ukiyo-e Sumo-hen 性格診断ゲーム 浮世絵相撲編 | PHOTO-CD | | Original | | NPCD-1005 | |
| Sexy Bytes: Housewives 2 | PHOTO-CD | | Original | | | |
| Sexy Bytes: Lacquer & Leather | PHOTO-CD | | Original | | | |
| Sexy Bytes: Office Sex | PHOTO-CD | | Original | | | |
| Sexy Bytes: Outside Dreams | PHOTO-CD | | Original | | | |
| Sexy Bytes: Rolling Mountains | PHOTO-CD | | Original | | | |
| Sexy Bytes: Studio Girls 1 | PHOTO-CD | | Original | | | |
| Shiho Shashin-shuu SHIHO写真集 | PHOTO-CD | | Original | | FZ-JJ1YP0401 | |
| Shinpi no Sekai: El Hazard 神秘の世界 エルハザード | PHOTO-CD | | Original | | PIRW-1010 | |
| Snowboard "Trick x Trick" スノーボード”トリック×トリック” | PHOTO-CD | | Original | | AS 0003 | |
| Sotsugyou Genga-shuu 卒業原画集 | PHOTO-CD | | Original | | CRMP-1001 | |
| Souzou Sozai: Europe no Mado Vol. 2 創造素材 ヨーロッパの窓 Vol.2 | PHOTO-CD | | Original | | ERV2 | |
| Souzou Sozai: Umi Vol. 1 創造素材 海 Vol.1 | PHOTO-CD | | Original | | SEVI-1049 | |
| Space Shuttle スペースシャトル | PHOTO-CD | 1.1 | Original | | C02H | |
| Starry the Universe 大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Steelwood: Private Eye II 名探偵スチールウッドⅡ | PHOTO-CD | | Original | | PX-006 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| The Super Model Vol. 1: Gail McKenna ゲイル・マッケンナ | PHOTO-CD | | | | TPS-19011 | |
| Suppin Bishoujo Vol. 3 すっぴん美少女 vol.3 | PHOTO-CD | | Original | | SPN-003 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Serious Sam: The First Encounter | PALM | | Original | | | |
| Shooting Gallery | PALM | | Original | | | |
| SimCity for Palm OS Handhelds シムシティー フォーパーム | PALM | 1.5 | Original | | 42-031-003-01 | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| Star Soldier for Palm OS スターソルジャー for Palm OS | PALM | | Original | | HMGOT060015 | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| Soccer Addict: 2002 International Cup | PPC | 1.0.3b | Original | | | |
| Surasura Gaikokugo Kaiwa for Pocket PC すらすら外国語会話 for Pocket PC | PPC | | Original | | | |
| Secret of Video Architecture X68000画面表示仕様の秘密 | X68K | | Original | | | |
| Sugoi Dennou Club すごい電脳倶楽部 | X68K | | Original | | MKCD-0002 | |
| Suteki na Dennou Club すてきな電脳倶楽部 | X68K | | Original | | MKCD-0001 | |
| Science & Nature: Elements Science 1: Elements | ARCH | 1.00 | Original | | | |
| Science & Nature: Materials Science Series II: Materials | ARCH | 1.00 | Original | | | |
| Science: Electricity and Magnetism: Secondary Edition Science 3: Electricity and Magnetism | ARCH | 1.0 | Original | | | |
| Seashore Life | ARCH | 1.0 | Original | | | |
| Simon the Sorcerer | ARCH | | Original | | | |
| The Soft Rock Games Collection CD | ARCH | | Original | | | |
| The Soft Rock Software Collection | ARCH | Edition 1 | Original | | | |
| The StrongARM CD-ROM | ARCH | | Original | | | |
| Scooby-Doo: Viaje al Pasado | VFLASH | | Original | | 093087(SP) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093083(UK) | |
| Scooby-Doo! Les Civilisations Perdues | VFLASH | | Original | | 093085(FR) | |
| Shrek der Dritte: Die Suche nach Arthus | VFLASH | | Original | | 093144(GER) | |
| Shrek Le Troisième: En quête d'Artur | VFLASH | | Original | | 093145(FR) | |
| Shrek Tercero: ¿Dónde Está Arturo? | VFLASH | | Original | | 093147(SP) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093143(UK) | |
| Spider-Man: Angriff der Super-Schurken | VFLASH | | Original | | 093064(GER) | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 | |
| Salaryman Champ: Tatakau Salaryman サラリーマンチャンプ たたかうサラリーマン | KS573 | | Original | | A18 JA A02 | |
| Session Power Up Kit for DrumMania 2nd Mix / PercussionFreaks 2nd Mix | KS573 | | Original | | 912 *Z A01 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | | Original | | GV027-J1 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | Rev A | Original | | GV027-J1 | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 4.000 | Original | | GDX-0006C | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 5.000 | Original | | GDX-0006D | |
| Sega Network Taisen Mahjong MJ3 セガ・ネットワーク対戦麻雀MJ3 | CHIHIRO | 5.000 | Original | | GDX-0017D | |
| Sega Network Taisen Mahjong MJ3 Evolution セガ・ネットワーク対戦麻雀MJ3 EVOLUTION | CHIHIRO | 2.000 | Original | | GDX-0021A | |
| Sega Network Taisen Mahjong MJ3 Evolution-you Firmware Koushin Program セガ・ネットワーク対戦麻雀MJ3 EVOLUTION用ファームウェア更新プログラム | CHIHIRO | 1.000 | Original | | GDX-0023 | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega-Race TV セガ-レースTV | LINDBERGH | 1.002 | Lindbergh Yellow | | DVP-0044 | |
| StarHorse 2: Final Destination | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0086D | |
| Senko no Ronde 旋光の輪舞 | NAOMI | 1.001 | Original | | GDL-0030 | |
| Shikigami no Shiro II 式神の城II | NAOMI | 1.000 | Original | | GDL-0021 | |
| Slashout | NAOMI | 1.000 | Original | | GDS-0004 | |
| Sports Jam スポーツ・ジャム | NAOMI | 1.005 | Original | | GDS-0003 | |
| Street Fighter Zero 3 Upper | NAOMI | 1.001 | Original | | GDL-0002 | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 1.001 | Original | | GDL-0031 | |
| Super Shanghai 2005 スーパー上海2005 | NAOMI | 2.001 | Original | | GDL-0031A | |
| Sega Racing Classic | SRE | | RingWide | | DVR-0009A | |