| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | |  |
| Samurai Shodown | MCD | | Original |  | T-60175-50 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
 | Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sensible Soccer | MCD | | Original |    | T-93185-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| Sonic MegaMix | MCD | | Unlicensed | | | |
 | Sonic the Hedgehog CD
ソニック・ザ・ヘッジホッグＣＤ | MCD | | Sample | | SG-6021 | |
| Space Ace | MCD | | Demo | | | |
| Starblade | MCD | | Original | | 4284-50 | |
| Super Strike Trilogy | MCD | | Unlicensed | | | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Surgical Strike | MCD | | Original | | 4435-50, 670-6783-50 | |
| Syndicate | MCD | | Original | | T-88065-50 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
 | Stupid Invaders (Disc 1) | DC | 1.000 | Original | | T-17711D-09 | |
| Stupid Invaders (Disc 2) | DC | 1.000 | Original | | T-17711D-09 | |
![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]")