Region | Title | System | Version | Edition | Languages | Serial | Status |
| Secret Service CD 59 (Strona B) | PC | | | | | |
| Secret Service CD 59 (Strona A) | PC | | | | | |
| Secret Service CD 58 (Strona B) | PC | | | | | |
| Secret Service CD 58 (Strona A) | PC | | | | | |
| Secret Service CD 57 (Strona B) | PC | | | | | |
| Secret Service CD 57 (Strona A) | PC | | | | | |
| Secret Service CD 56 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 55 (Strona A) | PC | | | | | |
| Secret Service CD 54 (Strona B) | PC | | | | | |
| Secret Service CD 54 (Strona A) | PC | | | | | |
| Secret Service CD 51 (Strona A) | PC | | | | | |
| Secret Service CD 48 (Strona A) | PC | | | | | |
| Secret Service CD 46 | PC | | | | | |
| Secret Service CD 41 | PC | | | | | |
| Seaman 2: Pekin Genjin Ikusei Kit シーマン2 ~北京原人育成キット~ | PS2 | 1.00 | Taikenban | | SLPM 61163 | |
| ScreamRide | XBOX360 | | Original | | MS-2726 | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer | PC | | White Label | | | |
| Scrabble Interactive: 2005 Edition | PC | 1.0 | Covermount: Special Edition | | | |
| Scrabble Complete | PC | 2.0 | Rerelease | | Part # 26022CDA | |
| Scrabble | PC | 2.0 | Rerelease | | 99182, Product# 99182 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo and the Cyber Chase | PSX | | Demo | | SLUS-90098 | |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| Sci-Fi Saturday Arcade | PC | 1.0 | Covermount | | TS055 | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0000 | Original | | 0396 Part No. 90618, 1001 Part No. X08-51174, Disc Assy. 296-052-002 | |
| Scholastic's The Magic School Bus Explores the Rainforest | PC | 1.0 | Original, Bundle Version OEM | | 0297 Part No. 91323, 1001 Part No. X08-50154, CD SET 420-056-001 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.1.0.2 | Original | | 0396 Part No. 90612, Disc Assy. 299-056-002 | |
| Scholastic's The Magic School Bus Explores in the Age of Dinosaurs | PC | 1.0.0.0 | Scholastic | | 0796 Part No. 91354 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| SBK X: Superbike World Championship | PS3 | 01.00 | Original | | BLUS-30683 | |
| SBK 08: Superbike World Championship | PC | | Covermount | | | |
| Saw | PS3 | 01.00 | Original | | BLUS-30358 | |
| Savage: The Battle for Newerth | PC | | Bundle Version ASUS OEM | | V471 | |
| Savage Warriors | PC | 1.0 | Megapak 4 | | 2205110-590001/1055SA | |
| Saturn Super Vol. 10 Furoku CD-ROM サターン・スーパー Vol.10 付録CD‐ROM | SS | 1.000 | | | 610-6020-11 | |
| Saturn Super Vol. 1 サターン・スーパー Vol.1 | SS | 1.000 | | | 610-6020-01 | |
| Saturn Bomberman Fight!! サターン・ボンバーマン・ファイト!! | SS | 0.300 | Taikenban | | 610-6801 | |
| SAS: Anti-Terror Force | PC | | | | | |
| Saru! Get You! Million Monkeys サルゲッチュ ミリオンモンキーズ | PS2 | 1.00 | Taikenban | | PCPX 98041 | |
| Santa Claus Saves the Earth | PSX | | Original | | SLES-04023 | |
| Sanmi Ittai 三位一体 | PSX | | Taikenban | | SLPM 80065 | |
| Sanguozhi V 三国志Ⅴ | PC | 1.0 | Baibian Zhenbaoxiang 2 | | | |
| Sanguozhi IV 三國志Ⅳ | SS | 1.003 | Zhongwenban | | T-7601H-11, T-7601H-16 | |
| Sangokushi III 三國志Ⅲ | PCE | | Original | | KOCD3003 | |
| Sangoku Musou 三國無双 | PSX | | Tentou Taikenban CD-ROM | | SLPM 80085 | |
| Samuraj Po-Xi Super Zabawa | PC | | | | | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Sampler Disc for PSP Vol. 1 | PSP | 1.00 | Demo | | UCJB-98301 | |
| Samidare 五月雨 | PC | 1.05 | Original | | PNB-001 | |
| Samba de Amigo サンバDEアミーゴ | DC | 1.000 | Original | | HDR-0063 | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Sakurazaka Shouboutai 桜坂消防隊 | PS2 | 1.00 | Taikenban | | SLPM 60241 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.001 | Tokubetsu-ban (Standalone, Bundled with Mogitate SegaSaturn Vol. 2) | | 610-6864 | |
| Saishuu Densha 最終電車 | PSX | | Taikenban | | SLPM 80215 | |
| Saints Row: The Third | XBOX360 | | Original, The Full Package (Disc 2) | | TQ-2213 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Saints Row: Gat out of Hell | PS3 | 01.00 | Original | | BLUS-31496 | |
| Saints Row IV | PS3 | 01.00 | Original, Commander in Chief Edition | | BLUS-31205 | |
| Saint Seiya: Meiou Hades Juunikyuu-hen 聖闘士星矢 ~冥王ハーデス十二宮編~ | PS2 | 1.00 | Taikenban | | SLPM 61158 | |
| Safecracker | PC | | Action-Games | | 80271 | |
| Sacrifice | PC | 0492.10.25 | Original | | CD-C95-1041-0, CD-C95-1041-E | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |
| Sacrifice | PC | | Bundle Version ASUS OEM | | CD-C951041-AS2E | |
| Sacred 3 | PS3 | 01.02 | Original | | BLUS-30876 | |
| Sabre Team | CD32 | | Original | | | |
| The Saboteur | PS3 | 01.00 | Original | | BLUS-30407 | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | A541W3GD[1] | |
| S.T.A.L.K.E.R.: Clear Sky BGamer 168 | PC | 1.5.10 | Covermount | | | |
| S.L.A.I.: Steel Lancer Arena International S.L.A.I.: Phantom Crash | PS2 | 0.11 | Beta | | SLUS 29132 | |
| S.L.A.I.: Steel Lancer Arena International S.L.A.I.: Phantom Crash | PS2 | 0.11 | Beta Trial Code | | TLES-52940 | |
| S.C.A.R.S. | PSX | | Demo | | SLED-01415 | |