Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sam & Max Hit the Road | PC | | Softgold, Rerelease | | | |
| Scorcher | PC | | Original | | | |
| Secret Service: Wydanie Specjalne Alone in the Dark | PC | | | | | |
| The Settlers | PC | | eXtra Klasyka | | | |
| Shivers / Torin's Passage | PC | | | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 1) | PC | | Platin Edition | | | |
| SimCity Enhanced CD-ROM | PC | | White Label | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| Svenska CD Gamer: PC Gamer CD-ROM: Nr 11 Oktober 1997 | PC | | | | | |
| Świat Gier Komputerowych 1/03 (Disc 1) | PC | | | | | |
| Świat Gier Komputerowych 10/00 | PC | | | | | |
| Świat Gier Komputerowych 12/99 | PC | | | | | |
| Świat Przygód z Hugo 10/2006 | PC | | | | | |
| Świat Przygód z Hugo 2/2007 | PC | | | | | |
| Świat Przygód z Hugo 5/2007 | PC | | | | | |
| Świat Przygód z Hugo 9/2005 | PC | | | | | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Sudden Strike (Additional Missions) | PC | 1.0.0.1 | Original | | 04-22099CD2 | |
| Spy Fox in "Dry Cereal" | PC | 1.0 | Original | | 04-70281, Part # 0001407, Part No. 04-00000H1529 | |
| Scholastic's The Magic School Bus Explores in the Age of Dinosaurs | PC | 1.0.0.0 | Scholastic | | 0796 Part No. 91354 | |
| Star Trek: Armada | PC | 1.2 | Rerelease, Star Trek: Action Pack | | 1000913.101.US, 32257.102.US | |
| Strategy Challenges Collection 1 | PC | 1.04 | Original, OEM Bundle | | 102771 | |
| SimCopter SimCopter: Fly Missions in the Metropolis | PC | 1.02 | CD-ROM Classics, 10 Sims for $20 | | 1119307, 1119317, 1641567 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Soldier of Fortune II: Double Helix (Disc 1) | PC | | Original | | 31147.101.US | |
| Star Trek: Voyager: Elite Force: Expansion Pack | PC | 1.20 | Star Trek: Action Pack | | 31151.101.US | |
| Saturn Super Vol. 1 サターン・スーパー Vol.1 | SS | 1.000 | | | 610-6020-01 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Original | | 635930 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | 1.0 | Bundle Version Diamond OEM | | 75000204-100 | |
| Sports Champions 2 | PS3 | 01.00 | Original, Essentials, Promo | | BCES-01598 … | |
| Star Trek: Judgment Rites | PC | | Star Trek: Federation Compilation | | CD-C95-893-1 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Star Trek: Federation Compilation | | CD-C95-893-2 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Super Duper Arcade 2 | PC | | Original | | CS99ARC011, Part No. 04-17836CD | |
| SimCopter | PC | | Dice | | DCG 007268 | |
| SimTower: The Vertical Empire | PC | 1.0 | Dice | | DCG 007343 | |
| SimTown | PC | | Dice | | DCG 008661 | |
| Syberia | PC | SSV1.0 | Demo | | DEM379CD | |
| Shadowrun Chronicles: Boston Lockdown | PC | 12.0.10093 | Cosmi | | DVDC6251 | |
| Shogun: Total War | PC | | Demo | | EAX08901965DD1 | |
| Seiya Monogatari: Anearth Fantasy Stories 聖夜物語 | PCE | | Bundled with Book (Dengeki PC Engine Special Edition - Taikenban) | | HMD-0004 | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sonic the Hedgehog CD ソニック・ザ・ヘッジホッグCD | PC | 1.001 | Ultra 2000/Ultra Series | | MKW-160 | |
| SimCity 3000 | PC | | Bundle Version OEM | | MXX08801496BUD | |
| Spy Fox in "Cheese Chase" | PC | 2.00 | Rerelease | | Part No. 04-15244CD | |
| Spy Fox in "Hold the Mustard" | PC | 1.0 | Original | | Part No. 04-17574CD | |
| Super Duper Arcade 1 | PC | | Original | | Part No. 04-17834CD | |
| Spy Fox: "Operation Ozone" | PC | | Original | | Part No. 04-22394CD | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | 1.032 | Original | | S343BBZZ12ZZZ | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Square's Preview 5 | PSX | | Original, Sample (Asia) | | SCPS 45417 … | |
| Square Maniacs '98 スクウェアマニアックス’98 | PSX | | | | SLPM 80306 | |
| Das Schwarze Auge: Schatten über Riva | PC | 1.00 | Original | | SPI 032 | |
| Shock Price 500 Game Series: Shougi SHOCK PRICE 500 GAME SERIES 将棋 | PC | 1.0.2 | Rerelease | | SSRX 3027 | |
| Shock Price 500 Game Series: Shanghai Classic SHOCK PRICE 500 GAME SERIES 上海クラシック | PC | 1.00J | Original | | SSRX 3048 | |
| Shock Price 500 Game Series: Golf: Challenge at Mauna Lani Resort SHOCK PRICE 500 GAME SERIES ゴルフ チャレンジ アット マウナラニリゾート | PC | | Original | | SSRX 3072 | |
| Soukyuu Gurentai: Otokuyou 蒼穹紅蓮隊 御徳用 | SS | 1.000 | Original | | T-10626G | |