Region | Title | System | Version | Edition | Languages | Serial | Status |
| Space Griffon VF-9 スペースグリフォンVF‐9 | PSX | Rev 1 | Original | | SLPS 00012 | |
| Space Ace | 3DO | RE-1 | Original | | | |
| Star Trek: Deep Space Nine: The Fallen 星际迷航之外层空间九号:落日帝国 | PC | 338 | Original, Wo Yao Zhengban | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| Space Tripper Space Defender | PC | 1.4 | Pocketware | | #8 | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | Original | | | |
| Space Quest 6: Roger Wilco aux Frontières de l'Espace Intervertébral | PC | 1.11 | SierraOriginals | | S6460120Z12ZZ | |
| Spaceship Warlock | PC | 1.1.3 "MPC" | Ultimate Game Collection | | | |
| Space Quest: Collector's Edition Space Quest: 15th Anniversary Collector's Edition | PC | 1.032 | Original | | S343BBZZ12ZZZ | |
| Space Invaders Anniversary スペースインベーダー アニバーサリー | PS2 | 1.02 | Original | | SLPM 62354 | |
| Sega Ages 2500 Series Vol. 4: Space Harrier セガ・エイジス2500シリーズVol.4 ~スペース・ハリアー~ | PS2 | 1.02 | Original, Renkaban | | SLPM 62384 … | |
| Space Rebellion | PS2 | 1.01 | Original | | SLES-54593 | |
| Space Invaders Extreme スペースインベーダーエクストリーム | PSP | 1.01 | Original | | UCAS 40194 … | |
| Space Invaders Anniversary | PS2 | 1.01 | Original | | SLES-52313 … | |
| Space Channel 5: Special Edition (Disc 2) | PS2 | 1.01 | Original | | SLUS 20807 | |
| Space Channel 5 Part 2 スペースチャンネル5 パート2 | PS2 | 1.01 | Original, PlayStation 2 the Best | | SLPM 65096 … | |
| Space Channel 5 | PS2 | 1.01 | Original | | SCES-50611 | |
| Simple 2000 Series Vol. 52: The Chikyuu Shinryakugun: Space Raiders SIMPLE2000シリーズ Vol.52 THE 地球侵略群 SPACE RAIDERS | PS2 | 1.01 | Original | | SLPM 62496 | |
| Sega Ages: Space Harrier セガエイジス スペース・ハリアー | SS | 1.002 | Original, Gentei Special Set | | GS-9108, GS-9111 | |
| Space Jam | SS | 1.001 | Original | | T-8125H-50 | |
| Space Invaders スペース・インベーダー | SS | 1.001 | Original, Puzzle Bobble 2X & Space Invaders | | T-1107G, T-1111G | |
| Space Channel 5 スペース・チャンネル5 | DC | 1.001 | Original, Dorikore | | HDR-0029, HDR-0140 | |
| Space Channel 5 | DC | 1.001 | Original | | MK-51051-50 | |
| Space Jam | SS | 1.000 | Original | | T-8125H | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H-50 | |
| Space Channel 5 | DC | 1.000 | Original | | 51051 | |
| Space Channel 5 | DC | 1.000 | Sample | | 952-0083-50 | |
| Space Venus Starring Morning Musume. スペースヴィーナス starring モーニング娘。 | PS2 | 1.00 | Original | | SRPM 70201 | |
| Space Invaders: Invasion Day | PS2 | 1.00 | Original | | SLES-51746 | |
| Space Fishermen スペースフィッシャーメン | PS2 | 1.00 | Original | | SCPS 11025 | |
| Space Channel 5: Special Edition (Disc 1) | PS2 | 1.00 | Original | | SLUS 20806 | |
| Space Channel 5 Part 2 | PS2 | 1.00 | Original | | SCES-50612 | |
| StarFlyers Alien Space Chase | PC | 1.0 | Original | | 380853A-CD | |
| Star Trek: Deep Space Nine: The Fallen | PC | 1.0 | Original | | 0-671-57663-1, S5293110 | |
| Star Trek: Deep Space Nine: Harbinger: Holosuite Missions | PC | 1.0 | Original, Star Trek Emissary Gift | | CIENPCD043 | |
| Star Trek: Deep Space Nine: Harbinger (Disc 2) | PC | 1.0 | Original | | CD000802 | |
| Star Trek: Deep Space Nine: Harbinger (Disc 1) | PC | 1.0 | Original | | CD000801 | |
| Star Trek: Deep Space Nine: Harbinger (Disc 2) | PC | 1.0 | Original | | | |
| Star Trek: Deep Space Nine: Harbinger (Disc 1) | PC | 1.0 | Original | | | |
| Space Siege | PC | 1.0 | Original | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SoftKey, SierraOriginals | | CDRM SQU344AE-CD, S4840220012ZZ | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | CD 7011 SPI | |
| Space Quest Collection | PC | 1.0 | Original, Sierra Classic Collection | | | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.0 | Original | | S329430 | |
| Space Invaders | PC | 1.0 | Original | | 1000916.101.US | |
| SuperLite 1500 Series: Space Chaser 2000 SuperLite 1500 シリーズ スペースチェイサー2000 | PSX | | Original | | SLPM 86661 | |
| Starwinder: The Ultimate Space Race | PSX | | Original | | SLUS-00094 | |
| Starwinder: The Ultimate Space Race スターワインダー | PSX | | Original | | SLPS 00988 | |
| Star Trek: Deep Space Nine: The Fallen | PC | | Original | | | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Spacebound Space Bound | PC | | Original | | | |
| Space Sniper Maya (Disc 2) スペーススナイパー マヤ | PC | | Original | | GOR-0004 2/2 | |
| Space Sniper Maya (Disc 1) スペーススナイパー マヤ | PC | | Original | | GOR-0004 1/2 | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | 3DO | | Original | | | |
| Space Shot | PSX | | Original | | SLUS-01308 | |
| Space Rogue スペース・ローグ | FMT | | Original | | HMB-180 | |
| Space Raiders | GC | | Original | | DL-DOL-GIJE-USA | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | PC | | | | S6460520212ZZ | |
| Space Pirates | 3DO | | Original | | ALG595001 | |
| Space Jam | PSX | | Original | | SLUS-00243 | |
| Space Jam | PSX | | Original | | SLES-00284 | |
| Space Invaders: The Original Game スペース・インベーダー | PCE | | Original | | NAPR-1050 | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Space Invaders Anniversary | PC | | Xplosiv | | XP-1879 | |
| Space Invaders 2000 スペースインベーダー2000 | PSX | | Original | | SLPM 86153 | |
| Space Invaders | PSX | | Original | | SLUS-00928 | |
| Space Invaders スペースインベーダー | PSX | | Original | | SLPS 00940 | |
| Space Invaders スペースインベーダー | PC | | Yuuyuu 1,480-yen (Publishing Distribution) | | KMK-1210, MKY-055 | |
| Space Invaders | PSX | | Original | | SLES-02144 | |
| Space Invaders | PC | | Covermount | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Hulk: Vengeance of the Blood Angels | PSX | | Original | | SLUS-00205 | |
| Space Hulk: Vengeance of the Blood Angels | PSX | | Original | | SLES-00207 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | | |
| Space Griffon VF-9 | PSX | | Original | | SLUS-00153 | |
| Space Griffon VF-9 スペースグリフォンVF‐9 | PSX | | Original, Sample | | SLPS 00012 | |
| Space Debris | PSX | | Original, Promo | | SCES-02432 | |
| Space Colony | PC | | Interactive Demo | | | |
| Space Chimps | WII | | Original | | RVL-RP9X-EUU | |
| Space Chimps | WII | | Original | | RVL-RP9P-EUR | |
| The Space Bar (Disc 3) | PC | | Original | | | |
| The Space Bar (Disc 2) | PC | | Original | | | |
| The Space Bar (Disc 1) | PC | | Original | | | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Space Adventure Cobra: Kokuryuuou no Densetsu コブラ ~黒竜王の伝説~ | PCE | | Original | | HCD8004 | |
| Space Adventure Cobra II: Densetsu no Otoko コブラⅡ ~伝説の男~ | PCE | | Original | | HCD1014 | |
| Space Ace | AJCD | | Original | | | |
| Space Ace | 3DO | | Original | | | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| Space Ace | PC | | Jackson Libri | | | |
| Space Ace | CDI | | Original, For Demonstration Only | | 810 0073, 818 0017 | |
| Simple 1500 Series Vol. 73: The Invaders: Space Invaders 1500 SIMPLE1500シリーズ Vol.73 THE インベーダー ~スペースインベーダー1500~ | PSX | | Original | | SLPM 86900 | |