Region | Title | System | Version | Edition | Languages | Serial | Status |
| Extreme Pinball 梦幻弹子球 | PC | 1.0 | Original | | 7642, E3595CED | |
| The Elder Scrolls V: Skyrim | PC | | Original | | DIS-41506-ENG | |
| Escape from Monkey Island (Disc 1) | PC | 1.0 | Original | | 1101830, 41022.101.UK | |
| Enemy Territory: Quake Wars | PC | 1.0 | Original, Limited Collector's Edition | | 32885.101.EU, 32885.101.US, 33117.101.EU | |
| Emperor: Battle for Dune (Disc 4) (Ordos Disc) | PC | 1.04 | Original | | 1418137, WWE08903445D4 | |
| Emperor: Battle for Dune (Disc 3) (Harkonnen Disc) | PC | 1.04 | Original | | 1418127, WWE08903445D3 | |
| Emperor: Battle for Dune (Disc 2) (Atreides Disc) | PC | 1.04 | Original | | 1418117, WWE08903445D2 | |
| Emperor: Battle for Dune (Disc 1) (Install Disc) | PC | 1.04 | Original | | 1418107, WWE08903445D | |
| Enter the Matrix (Disc 3) | PC | 1.0.0.1 | Original, Collector's Edition | | IJKK-006-3, Part# 24394CD3 | |
| Enter the Matrix (Disc 2) | PC | 1.0.0.1 | Original, Collector's Edition | | IJKK-006-2, Part# 24394CD2 | |
| Enter the Matrix (Disc 1) | PC | 1.0.0.1 | Original, Collector's Edition | | IJKK-006-1, Part# 24394CD1 | |
| Enter the Matrix (Play Disc) | PC | 1.0.0.1 | Original, Collector's Edition | | IJKK-006-4, Part# 24394CD4 | |
| Extreme PaintBrawl 2 | PC | | Original | | 21229.101.US | |
| Extreme PaintBrawl | PC | | Original | | 21175.101.US | |
| Extreme Bullrider | PC | 1.0.0.1 | Original | | 21215.101.US | |
| European Air War | PC | | Rerelease | | 04-17590CD | |
| Escape from Monkey Island (Disc 2) | PC | 1.0 | Original | | 1101831, 1101831R1 | |
| Escape from Monkey Island (Disc 1) | PC | | Original | | 1101830R1 | |
| Eragon (Disc 4) | PC | 1.0 | Original | | | |
| Eragon (Disc 3) | PC | 1.0 | Original | | | |
| Eragon (Disc 2) | PC | 1.0 | Original | | | |
| Eragon (Disc 1) (Play) | PC | 1.0 | Original | | | |
| Eradicator | PC | 1.0 | Original | | 5000-00445 | |
| Epic Pinball Epic Pinball: The Complete Collection | PC | 2.1 | Rerelease | | P/N 7225 | |
| Enemy Engaged: Apache/Havoc | PC | 1.1C | Rerelease, Dual Jewel | | CD-C95-1054-1 | |
| Empire Earth: The Art of Conquest Expansion | PC | 1.00.2657 | Original | | | |
| Empire Earth | PC | 1.0 | Original | | | |
| The Elder Scrolls: Chapter One: Arena | PC | 1.07 | Original | | | |
| The Elder Scrolls IV: Shivering Isles | PC | 1.2.0201 | Original | | | |
| The Elder Scrolls IV: Oblivion: Game of the Year Edition (Disc 2) (Shivering Isles/Knights of the Nine) | PC | 1.2.0416 | Original | | 31283-1.2 | |
| The Elder Scrolls IV: Oblivion: Game of the Year Edition (Disc 1) | PC | 1.1.425 | Original | | 31283-1.1 | |
| The Elder Scrolls IV: Oblivion | PC | 1.0.228 | Collector's Edition | | | |
| The Elder Scrolls III: Tribunal | PC | 1.3.1029 | The Elder Scrolls III: Morrowind: Game of the Year Edition | | | |
| The Elder Scrolls III: Morrowind | PC | 1.2.0722 | Game of the Year Edition | | | |
| The Elder Scrolls III: Morrowind | PC | 1.00.417 | Original, Collector's Edition | | | |
| The Elder Scrolls III: Bloodmoon | PC | 1.6.1820 | The Elder Scrolls III: Morrowind: Game of the Year Edition | | | |
| The Elder Scrolls Construction Set | PC | 1.20 | Original, Collector's Edition | | | |
| The Elder Scrolls Construction Set | PC | | The Elder Scrolls III: Morrowind: Game of the Year Edition | | | |
| Eidos Demos Volume 8 | PC | | | | | |
| Eidos Demos Volume 7 | PC | | | | | |
| Eidos Demos Volume 6 | PC | | | | | |
| Eidos Demos Volume 5 | PC | | | | | |
| Eidos Demos Volume 4 | PC | | | | | |
| Eidos Demos Volume 1 | PC | | PC Game Bundle | | | |
| Earthworm Jim: Special Edition | PC | | Original | | CDD-3114-01-U3 | |
| Earthworm Jim: Special Edition | PC | | Bundle Version Micron OEM | | | |
| EarthSiege 2 | PC | | Original | | | |
| EarthSiege Metaltech: EarthSiege | PC | | Original | | S630430 | |
| Earth 2160 | PC | 1.3.7.0 | Cosmi (DVD-ROM) | | SJ022508, SJ100509 | |
| Enemy Engaged: RAH-66 Comanche Versus KA-52 Hokum | PC | 1.0 | Original | | EI-1194 | |