Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 3) | PC | 1.00.000 | Rerelease | | | |
| School Tycoon | PC | v1 | Original | | | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scratches | PC | | Original | | | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | CD-W58-1103-0 | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| ShadowCaster | PC | | CD-ROM Classics, Electronic Arts Presents | | 5393 | |
| Shannara | PC | 1.0 | Original | | | |
| Sheep | PC | 1.00.000 | Original | | | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| Shivers | PC | 1.02 | Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 1) | PC | 1.0.0.2 | Rerelease | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original, Rerelease | | | |
| Sid Meier's Civilization II | PC | 1.0 | Original | | 0-492-47-101 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition | | Part # 24356CD1 | |
| Silent Hill 3 (Disc 2) | PC | 1.0.0.1 | Original | | S2344320 | |
| Silent Hill 3 (Disc 3) | PC | 1.0.0.1 | Original | | S2344330 | |
| Silent Hill 3 (Disc 4) | PC | 1.0.0.1 | Original | | S2344340 | |
| Silent Hill 3 (Disc 5) | PC | 1.0.0.1 | Original | | S2344350 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2 (Game Disk) | PC | 1.0.0.932 | Special DVD Edition | | 1488307 | |
| The Sims 2 (Disc 2) | PC | 1.0.0.1022 | Rerelease | | 1472636, 1472676, 1472697, 1527617 | |
| The Sims 2 (Disc 3) | PC | 1.0.0.1022 | Rerelease | | 1472606, 1472646, 1472686, 1527627 | |
| The Sims 2 (Disc 4) | PC | 1.0.0.1022 | Rerelease | | 1472616, 1472656, 1472696, 1527637 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 1) | PC | 1.10.0.111 | Original, Slim Case | | 1536707 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original, Slim Case | | 1536717 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 1) | PC | 1.13.0.135 | Original, Slim Case | | 1537107 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 2) | PC | 1.13.0.135 | Original, Slim Case | | 1537117 | |
| The Sims 2: Glamour Life Stuff | PC | 1.5.0.121 | Original | | 1520807 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: IKEA Home Stuff | PC | 1.15.0.62 | Original | | 1578207 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.312 | Original | | 1497007 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | 1.2.0.312 | Original | | 1497017 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | Original | | 1526317 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | | | 1526317 | |
| The Sims 2: Seasons (Expansion Pack) (Disc 1) | PC | 1.7.0.145 | Original, Slim Case | | 1562107 | |
| The Sims 2: Seasons (Expansion Pack) (Disc 2) | PC | 1.7.0.145 | Original, Slim Case | | 1562117 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | Original | | 1491707 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.286 | Rerelease | | 1491727 | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | 1.1.0.230 | Original | | 1491717 | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | 1.1.0.286 | Rerelease | | 1491737 | |
| The Sims 3 | PC | 1.0.631.00001, 0.0.0.11195 | Original, The Sims 3: Deluxe | | 1539007 | |
| The Sims Life Stories | PC | 1.0.22.17622 | Original | | 1528207 | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims: Hot Date (Expansion Pack) | PC | 1.1 | Original, Expansion Collection Volume Two, Mega Deluxe | | 1439827 | |
| The Sims: House Party (Expansion Pack) | PC | 1.0 | Original | | 1431307, 1431317 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1472007 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Original | | 1472017 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume Three | | 1462607 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | 1.0 | Original, Expansion Collection Volume Three | | 1462617 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume One | | 1459507 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | 1.0 | Original, Expansion Collection Volume One | | 1459517 | |
| The Sims: Vacation (Expansion Pack) | PC | | Expansion Collection Volume Three | | 1448807 | |
| Soulbringer (Disc 1) | PC | 1.0.0.1 | Dual Jewel, Rerelease | | CD-C95-1306-3 | |
| Soulbringer (Disc 2) | PC | 1.0.0.1 | Original, Dual Jewel | | CD-C95-1077-1, CD-C95-1306-4 | |
| Space Quest 6: Roger Wilco: The Spinal Frontier Space Quest 6: Roger Wilco in The Spinal Frontier | PC | 1.11 | Original | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| SpellForce: The Order of Dawn (Disc 1) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD1 v1.0 F, 28017-SM1 v1.0 F | |
| SpellForce: The Order of Dawn (Disc 2) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD2 v1.0 E, 28017-SM2 v1.0 F | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| Star Control 3 | PC | | Original | | Part #:5000-00419 | |
| Star Trek: Armada | PC | 1.2 | Rerelease, Star Trek: Action Pack | | 1000913.101.US, 32257.102.US | |
| Star Trek: Judgment Rites | PC | | Original, Limited CD-ROM Collector's Edition | | CD-ICD-200-0, CD-ICD-728-2 | |
| Star Trek: Starfleet Academy (Disc 1) | PC | 0.99 | Original | | CD-H95-069-0 | |
| Star Trek: Starfleet Academy (Disc 2) | PC | 0.99, 1.1 | Original | | CD-H95-069-1, CD-MCR-069-1 | |
| Star Trek: Starfleet Academy (Disc 3) | PC | 0.99, 1.1 | Original | | CD-H95-069-2, CD-MCR-069-2 | |
| Star Trek: Starfleet Academy (Disc 4) | PC | 0.99, 1.1 | Original | | CD-H95-069-3, CD-MCR-069-3 | |
| Star Trek: Starfleet Academy (Disc 5) | PC | 0.99, 1.1 | Original | | CD-H95-069-4, CD-MCR-069-4 | |
| Star Trek: Voyager: Elite Force | PC | 1.10 | Rerelease | | 1000912.101.US, 32097.101.US | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Rerelease, The LucasArts Archives Vol. III | | 8041834 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: Knights of the Old Republic (Disc 2) | PC | 1.0.0.0 | Original | | 3191831 | |
| Star Wars: Knights of the Old Republic (Disc 3) | PC | 1.0.0.0 | Original | | 3191832 | |
| Star Wars: Knights of the Old Republic (Disc 4) | PC | 1.0.0.0 | Original | | 3191833 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051831 | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft: Brood War (Expansion Set) | PC | 1.04 | Original | | S03995 | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67023 | |
| Stephen King's F13 Stephen King's F13: Ctrl,Alt, ...Shiver | PC | | Original | | | |
| Still Life (Disc 1) (Install) | PC | 1.0 | Original | | PCO461CD | |
| Still Life (Disc 2) (Play) | PC | 1.0 | Original | | PCO461CD | |
| Strike Commander / Wing Commander: Privateer | PC | | Special CD-ROM Edition | | 1009121 | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 1) | PC | 1.0 | Original | | 11001-1CDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 2) | PC | 1.0 | Original | | 11001-2CDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 3) | PC | 1.0 | Original | | 11001-3CDA | |
| Summoner (Disc 1) | PC | 1.00 | Original | | | |
| Summoner (Disc 2) | PC | 1.00 | Original | | | |
| Syberia (Disc 1) | PC | 1.0 | Original | | PC37920JC | |
| Syberia (Disc 2) | PC | 1.0 | Original | | PC37920JC | |
| Syberia II (Disc 1) | PC | 1.0 | Original | | 71702221 | |
| Syberia II (Disc 2) B. Sokal Syberia II | PC | 1.0 | Original, Viva Media Adventure Anthology | | 71702321 | |
| System Shock 2 | PC | 1.15 | Original | | 796907 | |
| The Sims 2: Celebration! Stuff | PC | 1.8.0.64 | Original | | 1564707, MXX08005556D | |
| Siege of Avalon Anthology | PC | 1.7.1.0913 | Rerelease | | | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SoftKey, SierraOriginals | | CDRM SQU344AE-CD, S4840220012ZZ | |
| StarCraft | PC | 1.0 | Original | | 630235 | |