Region | Title | System | Version | Edition | Languages | Serial | Status |
| Syndicate Plus | PC | | CD-ROM Classics | | E2825CCD | |
| Supercars International | PC | | Hit Squad | | HITSQDUK 026 | |
| Superbike 2001 | PC | | Original, EA Classics | | EAX08903308D, EAX08903632D1 | |
| Supaplex | PC | | Action Replay | | | |
| Stunt Driver | PC | 1.1 | Action Sixteen | | | |
| Stonekeep | PC | 1.2 | Original | | CD-ICD-045-0 | |
| Star Trek: Judgment Rites | PC | | White Label, White Label: Doubles | | | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | White Label, White Label: Doubles, Star Trek: Federation Compilation | | CD-ICD-301-0 | |
| Star Legions Trevor Sorensen's Star Legions | PC | 1.0 | Action Replay | | | |
| Star Control Collection | PC | | Original, Rerelease | | 7094 | |
| Stack Up | PC | | Original | | | |
| Sonic Riders | PC | 1.0 | Sonic PC Collection | | SEGA-PC051, SEGA-PC051-EU | |
| Sonic Mega Collection Plus | PC | 1.00.0000 | Sonic PC Collection | | SEGA-PC033, SEGA-PC033-EU | |
| Sonic Heroes (Disc 2) | PC | | Sonic PC Collection | | SEGA-PC008/2, SEGA-PC008/2-EU | |
| Sonic Heroes (Disc 1) | PC | | Sonic PC Collection | | SEGA-PC008/1, SEGA-PC008/1-EU | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | 1.009 | Sonic PC Collection | | SEGA-PC002-EU, SEGA-PC002/2-EU | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | 1.009 | Sonic PC Collection | | SEGA-PC002-EU, SEGA-PC002/1-EU | |
| Smok Wawelski | PC | | Covermount | | SELL 0132 | |
| Slam Tilt | PC | | Original | | | |
| Skoki Narciarskie 2005 | PC | | Covermount | | | |
| Skoki Narciarskie 2004 | PC | | Covermount | | | |
| Skoki Narciarskie 2003: Polski Orzeł: Złota Edycja | PC | 2.1.G | Covermount | | | |
| Skoki Narciarskie 2003: Polski Orzeł | PC | 0.1 | Covermount | | | |
| Skoki Narciarskie 2001: Polski Zwycięzca | PC | 1.03e | Covermount | | | |
| Shadoworlds | PC | | Buzz | | | |
| Shadowlands | PC | | Original, 10 Pack CD-ROM Series, Action CD-ROM 5 Pak | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Sensible Soccer: European Club Edition | PC | | Original | | | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Rally 2 (Disc 2) (Play Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-2 | |
| Sega Rally 2 (Disc 1) (Install Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-1 | |
| Sega Rally | PC | 3.2.0.3 | Original, TopSeller | | | |
| Sega Rally (Uaktualnienie Wersji Polskiej) | PC | | Original, TopSeller | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge The Monkey Island Bounty Pack: The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | 1.0 | LucasArts Classics: The Monkey Island Bounty Pack | | 3000012.101.UK | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |