Region | Title | System | Version | Edition | Languages | Serial | Status |
| EQ One | PSX | | Unlicensed | | | |
| Equalizer Game Wizard for Harry Potter and the Philosopher's Stone | PSX | | Unlicensed | | | |
| Eurasia Express Satsujin Jiken ユーラシアエクスプレス殺人事件 | PSX | | Taikenban | | SLPM 80336 | |
| Euro Demo 06 Official UK PlayStation Magazine CD 6 | PSX | | | | SCES-00184 | |
| Euro Demo 13 | PSX | | | | SCED-00776 | |
| Euro Demo 15 | PSX | | | | SCED-00778 | |
| Euro Demo 53 Official UK PlayStation Magazine CD 53 | PSX | | | | SCED-01827 | |
| Euro Demo 75 Official UK PlayStation Magazine 75 | PSX | | | | SCED-03452 | |
| Every Child Can Succeed 2 | PSX | | Original | | LSP-990192 … | |
| ESPN NHL Hockey | PS2 | 1.02 | Original | | SLUS 20728 | |
| ESPN Winter X Games Snowboarding | PS2 | 1.10 | Original | | SLUS 20089 | |
| EverQuest: Online Adventures | PS2 | 1.00 | Beta | | SLUS 28021 | |
| EverQuest: Online Adventures | PS2 | 1.00 | Original | | SLUS 20470 | |
| EverQuest: Online Adventures | PS2 | 1.00 | Beta | | SLUS 28026 | |
| Ecco the Dolphin: Defender of the Future | DC | 1.000 | Original | | 51033 | |
| Eidos Demos Volume 4 | PC | | | | | |
| Eidos Free Playable Demos! | PC | | | | | |
| The Elder Scrolls Adventures: Redguard (Disc 1) (Install Disc) | PC | | Original | | | |
| The Elder Scrolls Adventures: Redguard (Disc 2) (Play Disc) | PC | | Original | | | |
| E3 2005 Game Play B-Roll DVD (Disc 2) | PC | | Press Kit | | | |
| Electronic Gaming Monthly: Volume 1 | PC | | Original | | | |
| Electronic Gaming Monthly: Volume 2 | PC | | Original | | | |
| Electronic Gaming Monthly: Volume 3 | PC | | Original | | | |
| Electronic Gaming Monthly: Volume 5 | PC | | Original | | | |
| The Experience Disc Version 1.0 | XBOX360 | | Kiosk Demo | | XK-2017 | |
| The Experience Disc Version 1.5 | XBOX360 | | Kiosk Demo | | XK-2025 | |
| The Experience Disc Version 5.0 | XBOX360 | | Kiosk Demo | | XK-2114 | |
| ESPN Fitness Pros: Step Aerobics | 3DO | 1.0 | Original | | SEF-01-3DO | |
| ESPN Golf: Lower Your Score with Tom Kite: Shot Making (Disc 1) | 3DO | 1.0 | Original | | | |
| ESPN Golf: Lower Your Score with Tom Kite: Shot Making (Disc 2) | 3DO | 1.0 | Original | | | |
| ESPN Golf: Lower Your Score with Tom Kite: Shot Making (Disc 3) | 3DO | 1.0 | Original | | | |
| A ESPN Let's Go Skiing with Picabo Street. J. Kitt & Holly Flanders | 3DO | 1.0 | Original | | SSK-01-3DO | |
| Earth Rhythms | CDI | | Original | | 310690222-2 | |
| Effacer | CDI | | Original, Demonstration Disc | | 310-690-248-2, 310690248-2 | |
| Enkhuizer Almanak 1997 | CDI | | Original | | 90 5094 001 | |
| eScape | CDI | | Original, Head Crash: Limited Edition Triple Pack | | 810 0117 | |
| Escape from CyberCity | CDI | | Original, Demonstration Disc, Nur für Demonstrationszwecke | | 310-690-071-2, 310690071-2, 690 071-2, 690 0712, 810 0005, 812 0043, 813 0041, 815 0029 | |
| Exit 7: The Harley-Davidson Experience on CD-i | CDI | | | | | |