Region | Title | System | Version | Edition | Languages | Serial | Status |
| Syphon Filter | PSX | Rev 1 | Original, Greatest Hits | | SCUS-94240 | |
| Suikoden | PSX | Rev 1 | Original | | SLUS-00292 | |
| Street Fighter Collection (Disc 2) | PSX | Rev 1 | Fighters Edge | | SLUS-00584 | |
| Street Fighter Collection (Disc 1) | PSX | Rev 1 | Fighters Edge | | SLUS-00423 | |
| Star Wars: Episode I: The Phantom Menace | PSX | Rev 1 | Original, Greatest Hits | | SLUS-00884 … | |
| Spyro: Year of the Dragon | PSX | Rev 1 | Original, Greatest Hits, Collectors' Edition | | SCUS-94467 … | |
| Spider-Man 2: Enter: Electro | PSX | Rev 1 | Original, Greatest Hits | | SLUS-01378 … | |
| Soul Blade | PSX | Rev 1 | Greatest Hits | | SLUS-00240 | |
| Sewer Shark | MCD | Rev 1 | Original | | T-6201 | |
| Sol-Feace | MCD | RE2 | Bundled with Sega CD | | 4130 | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Shock Wave | 3DO | RE1 | Original, Demo Disc (3DO Demo Disc Program) | | 7222 | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 2) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.2 | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 1) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.1 | |
| SharkPort: Code and Save Transfer Kit | PS2 | 2.21 | Unlicensed | | | |
| Sega Saturn Choice Cuts | SS | 2.000 | Bundled with Sega Saturn | | 81600 | |
| Syphon Filter: The Omega Strain | PS2 | 2.00 | Demo | | SCUS 97377 | |
| Soulcalibur III | PS2 | 2.00 | Original, Platinum, Platinum: The Best of PlayStation 2 | | SCES-53312 … | |
| SWAT 3: Close Quarters Battle (Disc 2) (Tactics Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| SWAT 3: Close Quarters Battle (Disc 1) (Play Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| Shin Sangoku Musou 2 真・三國無双2 | PS2 | 1.30 | Original, Koei 2002 Spring Pack, Koei Teiban Series, Mega Hits! | | SLPM 65053 … | |
| Shin Sangoku Musou 真・三國無双 | PS2 | 1.20 | Original, PlayStation 2 the Best, Koei 2002 Spring Pack, Koei Teiban Series | | SLPM 62005 … | |
| SharkPort: Code and Save Transfer Kit | PS2 | 1.2 | Unlicensed | | | |
| SharkPort: Code and Save Transfer Kit | PC | 1.10 | Original | | | |
| SuperLite 2000 Vol. 17: Hakoniwa Tetsudou: Blue Train Tokkyuu-hen SuperLite 2000 vol.17 箱庭鉄道 ~ブルートレイン・特急編~ | PS2 | 1.05 | Original, SuperLite 2000 Vol. 17 | | SLPM 62143 … | |
| Super Robot Taisen Impact スーパーロボット大戦IMPACT | PS2 | 1.05 | Original, PlayStation 2 the Best | | SCPS 55021 … | |
| Shin Sangoku Musou 2: Moushouden 真・三國無双2 猛将伝 | PS2 | 1.05 | Original, Koei Teiban Series | | SLPM 65170 … | |
| SharkPort: Code and Save Transfer Kit | PC | 1.04 | Original | | | |
| Star Wars: Episode III: Revenge of the Sith | PS2 | 1.03 | Original, Greatest Hits | | SLUS 21143 … | |
| Shin Sangoku Musou 3 真・三國無双3 | PS2 | 1.03 | Original, PlayStation 2 the Best, Shin Sangoku Musou 3 Treasure Box, Shin Sangoku Musou 3 Super Premium Box, Koei Teiban Series | | SLAJ 25011 … | |
| Star Wars: Battlefront | PS2 | 1.02 | Original, Greatest Hits | | SLUS 20898 … | |
| Sprint Cars: Road to Knoxville | PS2 | 1.02 | Original | | SLUS 21418 | |
| Soccer Life! We are Challengers to Europe サッカー選手育成シミュレーション サッカーライフ! We are challengers to EUROPE | PS2 | 1.02 | Original | | SLPS 20350 | |
| Soccer Kantoku Saihai Simulation: Formation Final サッカー監督采配シミュレーション FORMATION FINAL | PS2 | 1.02 | Original | | SLPM 65372 | |
| Simple 2000 Series Vol. 18: The Party Sugoroku SIMPLE2000シリーズ Vol.18 THE パーティーすごろく | PS2 | 1.02 | Original | | SLPM 62272 | |
| Shadow the Hedgehog | PS2 | 1.02 | Original, Greatest Hits | | SLUS 21261 … | |
| Saka Tsuku 2002: J.League Pro Soccer Club o Tsukurou! サカつく2002 ~J.LEAGUEプロサッカークラブをつくろう!~ | PS2 | 1.02 | Original | | SLPM 65109 | |
| Suzuki TT Superbikes: Real Road Racing | PS2 | 1.01 | Original | | SLUS 20912 | |
| Stuntman | PS2 | 1.01 | Original | | SLUS 20250 | |
| Star Wars: Battlefront II | PS2 | 1.01 | Original | | SLUS 21240 | |
| Spider-Man: Friend or Foe | PS2 | 1.01 | Original | | SLUS 21600 | |
| Sphinx and the Shadow of Set Sphinx and the Cursed Mummy | PS2 | 1.01 | Demo | | SLUS 29057 | |
| Simple 2000 Series Vol. 39: The Boku no Machi-zukuri: Matching Maker++ SIMPLE2000シリーズ Vol.39 THE ぼくの街づくり ~街ingメーカー+ + ~ | PS2 | 1.01 | Original | | SLPM 62398 | |
| Shin Sangoku Musou 3: Moushouden 真・三國無双3 猛将伝 | PS2 | 1.01 | Original, PlayStation 2 the Best, Shin Sangoku Musou 3: Empires & Moushouden Premium Box, Shin Sangoku Musou 3 Super Premium Box, Koei Mega Pack, Koei Teiban Series | | SLAJ 25023 … | |
| Seek and Destroy | PS2 | 1.01 | Original | | SLUS 20606 | |
| Samurai Kanzenban 侍 完全版 | PS2 | 1.01 | PlayStation 2 the Best | | SLPM 74405 | |
| Sega Flash Vol. 4 | SS | 1.003 | Bundled with Magazine | | 610-6288D | |
| Sega Saturn Bootleg II: On the Road Sega Screams Volume 1 | SS | 1.002 | Not for Resale | | 81068, 81075 | |
| S.T.A.L.K.E.R. | PC | 1.0000 | Original | | K 851646 DB | |
| Sotsugyou II: Neo Generation 卒業Ⅱ -Neo generation- | SS | 1.000 | Original | | T-5301G | |
| Saturn Super Vol. 5 サターン・スーパー Vol.5 | SS | 1.000 | | | 610-6020-006 | |
| Syphon Filter: Dark Mirror | PS2 | 1.00 | Demo | | SCUS 97620 | |
| Super PickUps | PS2 | 1.00 | Original | | SLUS 21450 | |
| Steambot Chronicles | PS2 | 1.00 | Demo | | SLUS 29188 | |
| State of Emergency 2 | PS2 | 1.00 | Trade Demo | | SLUS-28056 | |
| Star Wars: Jedi Starfighter | PS2 | 1.00 | Trade Demo | | SLUS - 280 … | |
| SSX on Tour | PS2 | 1.00 | Demo | | SLUS 29161 | |
| SSX 3 | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20772 … | |
| Square Enix Sampler Disc Volume Two: Front Mission 4 Playable Demo | PS2 | 1.00 | | | SLUS 29098 | |
| SpyHunter | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20056 … | |
| Soulcalibur II | PS2 | 1.00 | Original, Greatest Hits, Namco Classic Fighter Collection | | SLUS 20643 … | |
| Sonic Riders | PS2 | 1.00 | Demo | | SLUS 29179 | |
| SOCOM: U.S. Navy SEALs: Combined Assault | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97545 | |
| SOCOM 3: U.S. Navy SEALs | PS2 | 1.00 | Demo | | SCUS 97475 | |
| Sly 2: Band of Thieves | PS2 | 1.00 | Demo | | SCUS 97457 | |
| SingStar '90s | PS2 | 1.00 | Original | | SCUS 97626 | |
| The Sims 2: Castaway | PS2 | 1.00 | Original | | SLUS 21664 | |
| The Sims 2 | PS2 | 1.00 | Demo | | SLUS 29173 | |
| The Sims 2 | PS2 | 1.00 | Original, Greatest Hits | | SLUS 21265 … | |
| Sonic Heroes (Disc 2) | PC | 1.0 | Sold Out Software | | SOC000939-1 | |
| Sonic Heroes (Disc 1) | PC | 1.0 | Sold Out Software | | SOC000939 | |
| Star Trek: Voyager: Elite Force | PC | 0.28 | Original, Collector's Edition | | 1000912.101.US | |
| Syphon Filter 3 | PSX | | Original, Greatest Hits | | SCUS-94640 | |
| Syphon Filter 3 | PSX | | Demo | | SCUS-94661 | |
| Syphon Filter 2 (Disc 2) | PSX | | Original, Greatest Hits | | SCUS-94451 … | |
| Syphon Filter 2 (Disc 1) | PSX | | Original, Greatest Hits | | SCUS-94451 | |
| Syphon Filter 2 | PSX | | Demo | | SCUS-94393 | |
| Syphon Filter | PSX | | Demo | | SCUS-94362 | |
| Syphon Filter | PSX | | Original | | SCUS-94240 | |
| Syndicate Wars | PSX | | Original | | SLUS-00262 | |
| Sydney 2000 | PSX | | Original | | SLUS-01177 | |
| Swagman | PSX | | Original | | SLUS-00151 | |
| Surf Riders | PSX | | Original | | SLUS-01190 | |
| Superstar Dance Club: #1 Hits!!! | PSX | | Original | | SLUS-01493 | |
| SuperLite 1500 Series: Castrol Honda Super Bike Racing SuperLite 1500 シリーズ ~Castrol HONDA スーパーバイクレーシング~ | PSX | | Original | | SLPM 86489 | |
| SuperLite 1500 Series: Card II SuperLite 1500 シリーズ カードII | PSX | | Original | | SLPM 86298 | |
| SuperCross Circuit | PSX | | Demo | | SCUS-94396 | |
| SuperCross Circuit | PSX | | Original | | SCUS-94453 | |
| Super Real Mahjong PIV Custom スーパー・リアル麻雀PⅣカスタム | PCE | | Original | | NXCD3027 | |
| Super Puzzle Fighter II Turbo | PSX | | Original | | SLUS-00418 | |
| Super Mahjong Taikai SUPER 麻雀大会 | PCE | | Original | | KOCD2002 | |
| Super Daisenryaku SUPER 大戦略 | PCE | | Original | | MCCD 0001 | |
| Super Bubble Pop | PSX | | Original | | SLUS-01528 | |
| Suikoden II | PSX | | Original | | SLUS-00958 | |
| Suikoden | PSX | | Original | | SLUS-00292 | |
| Stuart Little 2 | PSX | | Original, Greatest Hits | | SCUS-94669 | |
| Strikers 1945 | PSX | | Original | | SLUS-01337 | |
| Striker Pro 2000 | PSX | | Original | | SLUS-01078 | |
| Striker 96 | PSX | | Original | | SLUS-00210 | |
| Strike Point | PSX | | Original | | SLUS-00139 | |
| Strider 2 | PSX | | Original | | SLUS-01163 | |
| Strider | PSX | | Original | | SLUS-01142 | |
| Street Sk8er 2 | PSX | | Original | | SLUS-01083 | |
| Street Sk8er | PSX | | Original | | SLUS-00818 | |
| Street Racquetball | PSX | | Original | | SLUS-01450 | |
| Street Racer | PSX | | Original | | SLUS-00099 | |
| Street Fighter: The Movie | PSX | | Original | | SLUS-00041 | |
| Street Fighter Zero 3 ストリートファイターZERO3 | PSX | | Original, CapKore | | SLPM 86877 … | |
| Street Fighter EX2 Plus | PSX | | Original | | SLUS-01105 | |
| Street Fighter EX Plus Alpha | PSX | | Original, Fighters Edge | | SLUS-00548 | |
| Street Fighter Collection 2 | PSX | | Fighters Edge | | SLUS-00746 | |
| Street Fighter Collection (Disc 2) | PSX | | Original | | SLUS-00584 | |
| Street Fighter Collection (Disc 1) | PSX | | Original | | SLUS-00423 | |
| Street Fighter Alpha: Warriors' Dreams | PSX | | Original, Fighters Edge | | SLUS-00197 | |
| Street Fighter Alpha 3 | PSX | | Greatest Hits, Fighters Edge | | SLUS-00821 … | |
| Street Fighter Alpha 2 | PSX | | Original | | SLUS-00258 | |
| Streak Hoverboard Racing | PSX | | Original | | SLUS-00629 | |
| Str.at.e.s. 8: Riddle Wrangler! | PSX | | Original | | LSP-030108 … | |
| Str.at.e.s. 7: Riddle Roundup! | PSX | | Original | | LSP-030107 … | |
| Str.at.e.s. 6: Analogy-ology! | PSX | | Original | | LSP-030106 … | |
| Str.at.e.s. 5: Parallel Lives! | PSX | | Original | | LSP-030105 … | |
| Str.at.e.s. 4: Titlerama! | PSX | | Original | | LSP-030104 … | |
| Str.at.e.s. 3: Title This! Title That! | PSX | | Original | | LSP-030103 … | |
| Str.at.e.s. 2: Matchamania! | PSX | | Original | | LSP-030102 … | |
| Str.at.e.s. 1: Match-A-Batch | PSX | | Original | | LSP-030101 … | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Steel Reign | PSX | | Original | | SCUS-94902 | |
| Steel Harbinger | PSX | | Original | | SLUS-00093 | |
| StationMaster 2/2001 Xploder Playnation Xploder Blaze | PSX | | Unlicensed | | | |
| StationMaster 1/2002 Xploder | PSX | | Unlicensed | | | |
| Station 7 | PSX | | | | SLED-01969 | |
| Station 5 | PSX | | | | SLED-01782 | |
| Starwinder: The Ultimate Space Race | PSX | | Original | | SLUS-00094 | |
| Starfighter Sanvein | PSX | | Original | | SLUS-01302 | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| Starblade α | PSX | | Original | | SLUS-00057 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PSX | | Original, Greatest Hits | | SLUS-00386 … | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PSX | | Original, Greatest Hits | | SLUS-00381 … | |
| Star Wars: Masters of Teräs Käsi | PSX | | Original | | SLUS-00562 | |
| Star Wars: Episode I: The Phantom Menace | PSX | | Original | | SLUS-00884 | |
| Star Wars: Episode I: The Phantom Menace | PSX | | Trade Demo | | SLUS-80884 | |
| Star Wars: Episode I: Jedi Power Battles | PSX | | Original, Greatest Hits | | SLUS-01046 | |
| Star Wars: Demolition | PSX | | Demo | | SLUS-90088 | |
| Star Wars: Demolition | PSX | | Original | | SLUS-01183 | |
| Star Wars: Dark Forces | PSX | | Original, Greatest Hits | | SLUS-00297 … | |
| Star Trek: Invasion | PSX | | Original | | SLUS-00924 | |
| Star Sweep | PSX | | Original | | SLUS-01307 | |
| Star Ocean: The Second Story & Hello Charlie!! スターオーシャン セカンドストーリー & ハローチャーリー!! | PSX | | Taikenban | | SLPM 80274 | |
| Star Ocean: The Second Story (Disc 2) | PSX | | Original | | SCUS-94421 | |
| Star Ocean: The Second Story (Disc 1) | PSX | | Original | | SCUS-94421 | |
| Star Gladiator: Episode I: Final Crusade | PSX | | Original, Fighters Edge | | SLUS-00372 | |
| Star Fighter | PSX | | Original | | SLUS-00241 | |
| Squaresoft on PlayStation Collector's CD | PSX | | | | SCUS-94256 | |
| Squaresoft on PlayStation 2000 Collector's CD Vol. 3 | PSX | | | | SLUS-90075 | |
| Squaresoft on PlayStation 1998 Collector's CD Vol. 2 (Final Fantasy VIII Demo) | PSX | | Demo | | SLUS-90029 | |
| Squaresoft on PlayStation 1998 Collector's CD Vol. 1 | PSX | | | | SLUS-90028 | |
| Square's Preview Extra: FF VII Sample & SIGGRAPH '95 Works | PSX | | Demo | | SLPM 80048 | |
| Spyro: Year of the Dragon | PSX | | Original | | SCUS-94467 | |
| Spyro: Year of the Dragon | PSX | | Demo | | SCUS-94615 | |
| Spyro x Sparx: Tondemo Tours スパイロxスパークス ~トンでもツアーズ~ | PSX | | Taikenban | | PCPX 96191 | |
| Spyro the Dragon | PSX | | Demo | | SCUS-94439 | |
| Spyro the Dragon | PSX | | Demo, Toys R Us Test Drive | | SCUS-94290 | |
| Spyro the Dragon | PSX | | Original, Greatest Hits, Collectors' Edition | | SCUS-94228 … | |
| Spyro 2: Ripto's Rage! / Crash Team Racing | PSX | | Demo | | SCUS 94632 | |
| Spyro 2: Ripto's Rage! | PSX | | Demo | | SCUS-94460 | |
| Spyro 2: Ripto's Rage! | PSX | | Original, Greatest Hits, Collectors' Edition | | SCUS-94425 … | |
| Spot Goes to Hollywood | PSX | | Original | | SLUS-00014 | |
| Sports Superbike 2 | PSX | | Original | | SLUS-01459 | |
| Sports Car GT | PSX | | Original | | SLUS-00655 | |
| Spin Jam | PSX | | Original | | SLUS-01250 | |
| Spider: The Video Game | PSX | | Original | | SLUS-00230 | |
| Spider-Man 2: Enter: Electro | PSX | | Original | | SLUS-01378 | |
| Spider-Man | PSX | | Original, Greatest Hits | | SLUS-00875 … | |
| Spice World | PSX | | Original | | SLUS-00723 | |
| Speedball 2100 | PSX | | Original | | SLUS-01218 | |
| Speed Racer | PSX | | Original | | SLUS-00613 | |
| Speed Punks | PSX | | Demo | | SCUS-94572 | |
| Speed Punks | PSX | | Original | | SCUS-94563 | |
| Spec Ops: Stealth Patrol | PSX | | Original | | SLUS-01131 | |
| Spec Ops: Ranger Elite | PSX | | Original | | SLUS-01299 | |
| Spec Ops: Covert Assault | PSX | | Original | | SLUS-01420 | |
| Spec Ops: Airborne Commando | PSX | | Original | | SLUS-01447 | |
| Spawn: The Eternal | PSX | | Preview Version | | SCUS-94204 | |
| Spawn: The Eternal | PSX | | Original | | SCUS-94204 | |
| Space Shot | PSX | | Original | | SLUS-01308 | |
| Space Jam | PSX | | Original | | SLUS-00243 | |
| Space Invaders | PSX | | Original | | SLUS-00928 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Hulk: Vengeance of the Blood Angels | PSX | | Original | | SLUS-00205 | |
| Space Griffon VF-9 | PSX | | Original | | SLUS-00153 | |
| Soviet Strike | PSX | | Original | | SLUS-00061 | |
| South Park: Chef's Luv Shack | PSX | | Original | | SLUS-00997 | |
| South Park Rally | PSX | | Original | | SLUS-00984 | |
| South Park | PSX | | Original | | SLUS-00936 | |
| Soumatou 蒼魔灯 | PSX | | Taikenban | | SLPM 80507 | |
| Soulmaster ソウルマスター | PSX | | Original, Koei the Best | | SLPM 86170 … | |
| Soul of the Samurai | PSX | | Original | | SLUS-00822 | |
| Soul Blade | PSX | | Original | | SLUS-00240 | |
| Soukou Kihei Votoms: Koutetsu no Gunzei 装甲騎兵ボトムズ 鋼鉄の軍勢 | PSX | | Shokai Seisan Genteiban (Disc 1) | | SLPS 02313 | |
| Soukaigi (Disc 3) 双界儀 | PSX | | Original | | SLPS 01293 | |
| Soukaigi (Disc 2) 双界儀 | PSX | | Original | | SLPS 01292 | |
| Soukaigi (Disc 1) 双界儀 | PSX | | Original | | SLPS 01291 | |
| Sorcerer's Maze | PSX | | Original | | SLUS-01495 | |
| Sol Divide | PSX | | Original | | SLUS-01519 | |
| Snowboarding | PSX | | Original | | SLUS-01287 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | PSX | | Original | | SLUS-01093 | |
| The Smurfs | PSX | | Original | | SLUS-01008 | |
| Smurf Racer! | PSX | | Original | | SLUS-01359 | |
| Small Soldiers | PSX | | Original | | SLUS-00781 | |
| Slotter Mania 9: Gokunetsu 30 Phi! Haibi & Splash Seven スロッターマニア9 極熱30φ!ハイビ&スプラッシュセブン | PSX | | Original | | SLPS 03533 | |
| Slotter Mania 7: Gekiatsu! Siosai-musume Seizoroi DX + Apache A スロッターマニア7 激熱!シオサイ姫勢揃いDX+アパッチA | PSX | | Original | | SLPS 03511 | |
| Slots | PSX | | Original | | SLUS-01555 | |
| Slomanny'j mech Chast' 2: Dy'myashheesya zerkalo (Disc 4) Сломанный меч Часть 2: Дымящееся зеркало | PC | | Original | | | |
| Slomanny'j mech Chast' 2: Dy'myashheesya zerkalo (Disc 3) Сломанный меч Часть 2: Дымящееся зеркало | PC | | Original | | | |
| Slim Jim | PSX | | | | SCUS-94472 | |
| Sled Storm & Medal of Honor Demo CD | PSX | | | | SLUS-90072 | |
| Sled Storm | PSX | | Original, Greatest Hits, Collectors' Edition | | SLUS-00955 … | |
| Slamscape | PSX | | Original | | SLUS-00080 | |
| Slam 'n Jam '96 featuring Magic & Kareem | PSX | | Original | | SLUS-00022 | |
| Slam 'n Jam '95 | 3DO | | Original | | | |
| Slam 'n Jam '95 | 3DO | | Original | | 60140-C | |
| Skydiving Extreme | PSX | | Original | | SLUS-01392 | |
| Skullmonkeys | PSX | | Original | | SLUS-00601 | |
| Skullmonkeys | PSX | | Original, Promo | | SLES-01090 | |
| Skeleton Warriors | PSX | | Original | | SLUS-00209 | |
| SimTheme Park Sim Theme Park | PSX | | Original | | SLUS-01069 | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Simpsons Wrestling | PSX | | Original | | SLUS-01227 | |
| Simple 1500 Jitsuyou Series Vol. 02: Katei no Fuusui SIMPLE1500実用シリーズ Vol.02 家庭の風水 | PSX | | Original | | SLPS 02843 | |
| SimCity 2000 | PSX | | Original, Greatest Hits | | SLUS-00113 … | |
| Silverload | PSX | | Original | | SLUS-00050 | |
| Silhouette Mirage | PSX | | Original | | SLUS-00728 … | |
| Silent Hill | PSX | | Trade Demo | | SLUS-80707 | |
| Silent Hill | PSX | | Demo | | SLUS-90050 | |
| Silent Hill | PSX | | Original, Greatest Hits | | SLUS-00707 … | |
| Silent Hill サイレントヒル | PSX | | Trial Version | | SLPM 80363 | |
| Silent Hill | PSX | | Demo | | SLED-01735 | |
| Silent Bomber | PSX | | Original | | SLUS-00902 | |
| Sidewinder 2: Let's Dance in the Sky サイドワインダー2 | PSX | | Original, PlayStation the Best | | SLPS 00954 … | |
| Shrek Treasure Hunt | PSX | | Original | | SLUS-01463 | |
| Shockwave Assault (Disc 2) (Shockwave: Operation Jumpgate) | PSX | | Original | | SLUS-00137 | |
| Shockwave Assault (Disc 1) (Shockwave: Invasion Earth) | PSX | | Original | | SLUS-00028 | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shock Wave: Operation JumpGate | 3DO | | Original | | | |
| Shock Wave ショックウェーブ | PSX | | Original | | SLPS 00419 | |
| Shipwreckers! | PSX | | Original | | SLUS-00558 | |
| Shipwreckers! | PSX | | Demo | | SLUS-90013 | |
| Shin Sedai Robot Senki: Brave Saga 新世代ロボット戦記 BRAVE SAGA | PSX | | Brave Charge Box | | SLPS 01755 | |
| Shin Samurai Spirits: Haoumaru Jigokuhen ~ Samurai Shodown II 真サムライ・スピリッツ ~覇王丸地獄変~ | NGCD | | Original | | NGCD-063, NGCD-063E | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Shellshock | PSX | | Original | | SLUS-00031 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Sheep | PSX | | Original | | SLUS-01298 | |
| Shanghai: True Valor | PSX | | Original | | SLUS-00795 | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shadow Tower | PSX | | Original | | SLUS-00863 | |
| Shadow Master | PSX | | Original | | SLUS-00545 | |
| Shadow Man | PSX | | Original | | SLUS-00895 | |
| Shadow Madness (Disc 2) | PSX | | Original | | SLUS-00718 | |
| Shadow Madness (Disc 1) | PSX | | Original | | SLUS-00468 | |
| Shadow Madness | PSX | | Demo | | SLUS-90031 | |
| Setup Utility for DTL-H1500 (Version 1.1) | PSX | | Original | | | |
| Sesame Street: Elmo's Number Journey | PSX | | Original, Twin Pack | | SLUS-00622 … | |
| Sesame Street: Elmo's Letter Adventure | PSX | | Original, Twin Pack | | SLUS-00621 … | |
| Sesame Street Sports | PSX | | Original | | SLUS-01180 | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Sentinel Returns | PSX | | Original | | SLUS-00604 | |
| Sentient | PSX | | Original | | SCUS-94110 | |
| Sega Classic Arcade Collection: Limited Edition セガクラシック | MCD | | Original | | G-6012 | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PSX | | Original | | LSP-020780 … | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PSX | | Original | | LSP-020650 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PSX | | Original | | LSP-020450 … | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PSX | | Original | | LSP-020280 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 2b: Reshaping Googol: Under the Ocean | PSX | | Original | | LSP-020170 … | |
| The Secret of Googol 2a: Reshaping Googol: The Castle | PSX | | Original | | LSP-020180 … | |
| The Secret of Googol 1b: Reshaping Googol: The Tower | PSX | | Original | | LSP-020150 … | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| SD Gundam: GCentury SDガンダム ジーセンチュリー | PSX | | Original | | SCPS 45034 … | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| Scrabble | PSX | | Original | | SLUS-00903 | |
| Scooby-Doo and the Cyber Chase | PSX | | Demo | | SLUS-90098 | |
| Scooby-Doo and the Cyber Chase | PSX | | Original, Greatest Hits | | SLUS-01396 … | |
| Sangokushi V 三國志Ⅴ | PSX | | Original | | SLPS 00703 | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLUS-00505 | |
| Samurai Shodown: Warriors Rage | PSX | | Original | | SLUS-01039 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Sammy Sosa Softball Slam | PSX | | Original | | SLUS-01064 | |
| Sammy Sosa High Heat Baseball 2001 | PSX | | Original | | SLUS-01063 | |
| Saltwater Sportfishing | PSX | | Original | | SLUS-01397 | |
| Sakuma-shiki Jinsei Game さくま式人生ゲーム | PSX | | Original | | SLPS 01740 | |
| Saiyuki: Journey West | PSX | | Original | | SLUS-01381 | |
| SaGa Frontier 2 | PSX | | Original | | SLUS-00933 | |
| SaGa Frontier | PSX | | Original | | SCUS-94230 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLUS-01208 | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Saban's Power Rangers: Lightspeed Rescue | PSX | | Original | | SLUS-01114 | |
| Saban's Power Rangers Zeo: Full Tilt Battle Pinball | PSX | | Original | | SLUS-00256 | |
| S.C.A.R.S. | PSX | | Original | | SLUS-00692 | |