Region | Title | System | Version | Edition | Languages | Serial | Status |
| Exploring Our Solar System | CDI | | Original | | 080600 | |
| Explorations of Space | CDI | | | | | |
| Exit 7: The Harley-Davidson Experience on CD-i | CDI | | | | | |
| Evolution (Change through Natural Selection) | CDI | | Original | | 085582 | |
| Evoluon: Philips Competence Centre: An Interactive Journey Through the Evoluon Philips Competence Centre: The Evoluon | CDI | | | | 8180069 | |
| Everything You Ever Wanted to Know About CD-i | CDI | | For Demonstration Only | | | |
| Everything You Always Wanted to Ask John Hawkins | CDI | | Prototype | | | |
| Everything You Always Wanted to Ask John Hawkins | CDI | | Prototype | | | |
| The European School | CDI | | Original | | 819 0041 | |
| European Party | CDI | 1.05 | Original | | 810 0094 | |
| The European CD-i Association: CD-i Presentation | CDI | | Original | | 2020.009 | |
| Eureka: Gutenberg: L'Imprimerie et Ses Précurseurs | CDI | | Beta | | | |
| Etoiles et Galaxies: Astronomie Flammarion | CDI | 2.01 | Original | | 812 0091 | |
| Essentials: The New Shape of Home Shopping | CDI | | Original | | | |
| Escape from CyberCity | CDI | | Original, Demonstration Disc, Nur für Demonstrationszwecke | | 310-690-071-2, 310690071-2, 690 071-2, 690 0712, 810 0005, 812 0043, 813 0041, 815 0029 | |
| Escape from CyberCity | CDI | | Automatische Versie | | | |
| eScape | CDI | | Original, Head Crash: Limited Edition Triple Pack | | 810 0117 | |
| Ernte der Sonne: Vincent van Gogh Ernte der Sonne | CDI | | Original | | 813 0012 | |
| ERM Produktcatalogus: Voorjaar 1995 | CDI | | | | | |
| ERM Produktcatalogus: Najaar 1995 (Nr 3) | CDI | | | | | |
| ERM Produktcatalogus: Najaar 1994 | CDI | | | | | |
| Ennio Morricone: Vidi Aquam id est Benacum | CDI | | | | VDNA 01 | |
| Enkhuizer Almanak 1997 | CDI | | Original | | 90 5094 001 | |
| Enkhuizer Almanak 1997 | CDI | | Beta | | | |
| English Interactive (Disc 23) (Units 67-69) | CDI | | | | | |
| English Interactive (Disc 22) (Units 64-66) | CDI | | | | | |
| English Interactive (Disc 21) (Units 61-63) | CDI | | | | | |
| English Interactive (Disc 20) (Units 58-60) | CDI | | | | | |
| English Interactive (Disc 19) (Units 55-57) | CDI | | | | | |
| English Interactive (Disc 18) (Units 52-54) | CDI | | | | | |
| English Interactive (Disc 17) (Units 49-51) | CDI | | | | | |
| English Interactive (Disc 16) (Units 46-48) | CDI | | | | | |
| English Interactive (Disc 15) (Units 43-45) | CDI | | | | | |
| English Interactive (Disc 14) (Units 40-42) | CDI | | | | | |
| English Interactive (Disc 13) (Units 37-39) | CDI | | | | | |
| English Interactive (Disc 12) (Units 34-36) | CDI | | | | | |
| English Interactive (Disc 11) (Units 31-33) | CDI | | | | | |
| English Interactive (Disc 10) (Units 28-30) | CDI | | | | | |
| English Interactive (Disc 09) (Units 25-27) | CDI | | | | | |
| English Interactive (Disc 08) (Units 22-24) | CDI | | | | | |
| English Interactive (Disc 07) (Units 19-21) | CDI | | | | | |
| English Interactive (Disc 06) (Units 16-18) | CDI | | | | | |
| English Interactive (Disc 05) (Units 13-15) | CDI | | | | | |
| English Interactive (Disc 04) (Units 10-12) | CDI | | | | GIT-PA09 | |
| English Interactive (Disc 03) (Units 7-9) | CDI | | | | GIT-PA08 | |
| English Interactive (Disc 02) (Units 4-6) | CDI | | | | GIT-PA07 | |
| English Interactive (Disc 01) (Units 1-3) | CDI | | | | GIT-PA06 | |
| Engineering 6.0 | CDI | | Demo | | | |
| Engineering 5.0 | CDI | | Demo | | | |
| Engineering 2.9 | CDI | | Glass Master | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 2001 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 2000 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 1999 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 1998 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 1997 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 1996 | CDI | | Original | | | |
| Enciclopedia Elettronica Multimediale Grolier: Edizione 1994 | CDI | | Original | | | |
| The Emperor's New Clothes | CDI | | Original | | 310690042-2 | |
| The Emperor's New Clothes | CDI | | Original | | 310690042-2, 699 042-2 | |
| Elsevier's Interactive Anatomy: Volume 2-III (Elbow Joint & Cubital Fossa) | CDI | | | | | |
| Elsevier's Interactive Anatomy: Volume 2-II (Hand & Wrist) | CDI | | Original | | | |
| Elsevier's Interactive Anatomy: Volume 2-I (Shoulder Joint & Axilla) | CDI | | Original | | | |
| Elsevier's Interactive Anatomy: Volume 1-II (Temporal Bone & Posterior Cranial Fossa) | CDI | | | | | |
| Elsevier's Interactive Anatomy: Volume 1-I (Paranasal Sinuses & Anterior Skull Base) | CDI | | Original | | | |
| Electronic Art Gallery: Funkausstellung Berlin 1991 | CDI | | Original | | | |
| Effectief Communiceren I: School Version | CDI | | Beta | | | |
| Effacer | CDI | | Original, Demonstration Disc | | 310-690-248-2, 310690248-2 | |
| Ecosystems: Nature in Balance AIMS: Ecosystems: Nature in Balance | CDI | | Original | | 085599 | |
| Ecolauto: No 5: Tests Codoroute Ecolauto: N°5: Tests Codoroute | CDI | | Original | | T5-01 | |
| Ecolauto: No 4: Tests Codoroute Ecolauto: N°4: Tests Codoroute | CDI | | Original | | 4-1-12-96 | |
| Ecolauto: No 3: Cours de Formation B Ecolauto: N° 3: Cours de Formation B | CDI | | Original | | 3-2-6-94 | |
| Ecolauto: Moto 1 DV: Maniabilité CD-i Moto I DV: Maniabilité Sécurité: Digital Vidéo | CDI | | Original | | 1-1-01-96 | |
| Ecolauto: Groupe Lourd No 2: Question Écrites Ecolauto: Groupe Lourd N° 2: Question Écrites | CDI | | Original | | GL-2-1-01-95 | |
| Ecolauto: Groupe Lourd No 1: Épreuve Orale Ecolauto: Groupe Lourd N° 1: Épreuve Orale | CDI | | Original | | GL-1-1-12-94 | |
| Ecolauto: DV No 4: Cours de Formation B Ecolauto: DV N° 4: Cours de Formation B | CDI | | Original | | 4-1-5-94 | |
| Ecolauto: DV No 4: Cours de Formation B Ecolauto: DV N° 4: Cours de Formation B | CDI | | Original | | 4-2-7-94 | |
| ECCO Electronic Coaching: Messegespräche | CDI | | Original | | | |
| ECCO Electronic Coaching: Erst Stirbt das Image... | CDI | | Original | | | |
| ECCO Electronic Coaching: Ein Meeting Jagt das Andere | CDI | | Original | | | |
| Easy Driver (Disc 4) | CDI | 1.04 | Original | | Artikel-Nr. 8106 | |
| Easy Driver (Disc 3) | CDI | 1.04 | Original | | Artikel-Nr. 8106 | |
| Easy Driver (Disc 2) | CDI | 1.04 | Original | | Artikel-Nr. 8106 | |
| Easy Driver (Disc 1) | CDI | 1.04 | Original | | Artikel-Nr. 8106 | |
| Easy Biker | CDI | 1.04 | Original | | Artikel-Nr. 8108 | |
| Easy Biker | CDI | 1.01 | Original | | Artikel-Nr. 8108 | |
| Earth: A Multimedia Guide to Changing Environment | CDI | | Original | | 779461000224 | |
| Earth Rhythms: Daichi no Hibiki アース・リズム ~大地の響き~ | CDI | | Sample | | PCIM-00036 | |
| Earth Rhythms | CDI | | Original | | 310690222-2 | |
| Earth Command | CDI | | Original | | 310690291-2 | |
| Earth Command | CDI | 1.10 | Original | | 814 0040 | |
| Earth Command Earth Command: Die Zukunft unserer Welt liegt in Ihrer Hand | CDI | 1.07 | Original | | 813 0033 | |
| Earth Command | CDI | 1.07 | Original | | 812 0072 | |
| Earth Command | CDI | 1.14 | Original | | 810 0072 | |
| E-Z Play Today Keyboard | CDI | 1.05 | Original | | 810 0137 | |
| E-Cat No 3 E-Cat N° 3 | CDI | | Original | | | |
| E-Cat No 2 E-Cat N° 2 | CDI | | Original | | | |
| E-Cat No 1 E-Cat N° 1 | CDI | | Original | | 818 0061 | |