Region | Title | System | Version | Edition | Languages | Serial | Status |
| Strife | PC | 1.2 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.2 | Original | | | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.2 | Rerelease | | 381427-CD3 | |
| Super Solvers: Spellbound! | PC | 1.2 | Bonus CD | | SRS744AE-CD | |
| Silent Hunter: Wolves of the Pacific | PC | 1.2.0.0 | Original | | 683438-DVD1 | |
| Sacred (Disc 1) | PC | 1.2.0.10 | Original | | 28302-CD1 v1.0 | |
| Sacred (Disc 2) | PC | 1.2.0.10 | Original | | 28302-CD2 v1.0 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.312 | Original | | 1497007 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | 1.2.0.312 | Original | | 1497017 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.377 | Rerelease | | 1497027 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | 1.2.0.377 | Rerelease | | 1497037 | |
| Steel Beasts | PC | 1.2.2.6 | Gold Edition | | 23952CD | |
| SimCity 3000 | PC | 1.2.673.0 | Rerelease | | 1500117 | |
| Star Trek: Voyager: Elite Force: Expansion Pack | PC | 1.20 | Star Trek: Action Pack | | 31151.101.US | |
| Star Trek: Voyager: Elite Force: Expansion Pack | PC | 1.20 | Original | | 31151.101.US | |
| Starball | PC | 1.20 | Original | | | |
| Silent Steel | PC | 1.24.18.121 | Bundle Version Packard Bell OEM: Demo | | 170308 | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition | | Part # 24356CD1 | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition (Rerelease) | | | |
| Sid Meier's Civilization III | PC | 1.29f | Scholastic | | P/N CDR9640733 | |
| SimCity 2000: CD Collection | PC | 1.2cj | Windows | | 0026-000-0601-A | |
| SimTunes | PC | 1.2nre | Kids Classics | | 1128707 | |
| Sorry! | PC | 1.3 | Original | | 99040 | |
| Star Wars: Rogue Squadron 3D | PC | 1.3 | Rerelease, CompUSA Exclusive | | 6521830R2 | |
| Star Wars: Rogue Squadron 3D | PC | 1.3 | Rerelease | | 6521830 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.3 | Demo | | | |
| Super Solvers: Spellbound! | PC | 1.3 | Adventure Workshop: 4th-6th Grade: 5th Edition | | 383332-CD4 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| Star Wars: Knights of the Old Republic | PC | 1.3.1.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982530 | |
| Star Miner: Battle for Supremacy Asteroid Miner | PC | 1.30 FULL | Pocketware | | #9 | |
| Silent Hunter: Commander's Edition | PC | 1.31 | Original | | 2211110-590004 | |
| Silent Hunter: Commander's Edition | PC | 1.31 | Ultimate Wargame Collection Volume 2: World War II | | 379280-CD2 | |
| Super Collapse! II | PC | 1.33 | Original | | | |
| Silent Hunter III | PC | 1.4 | Encore | | | |
| Space Tripper Space Defender | PC | 1.4 | Pocketware | | #8 | |
| Spear of Destiny | PC | 1.4 | Original | | | |
| Star Wars: Rebel Assault | PC | 1.4 | Original | | 632630, CDRM1151470 | |
| Star Wars: Rebel Assault: Super Sampler | PC | 1.4 | | | 636030, CDRM1221330 | |
| SWAT 3: Close Quarters Battle | PC | 1.4 | Elite Edition | | | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| Silent Hunter 4: Wolves of the Pacific Silent Hunter 4: Wolves of the Pacific: U-Boat Missions | PC | 1.5 | Gold Edition | | 684589-DVD1 | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| The Sims 2: Glamour Life Stuff | PC | 1.5.0.121 | Original | | 1520807 | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| SpellForce | PC | 1.52.64763 | Platinum Edition | | 11121-1DDA | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| Sports Car GT | PC | 1.52US | CD-ROM Classics | | 1187207 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | Original | | 1526317 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | | | 1526317 | |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| Sid Meier's Civilization IV (Disc 3 & Manual) | PC | 1.61 | Game of the Year Edition | | 21712-1.3D | |
| Sid Meier's Civilization IV (Disc 1) | PC | 1.61 | Game of the Year Edition | | 77875-1.1REA | |
| Sid Meier's Civilization IV (Disc 2) | PC | 1.61 | Game of the Year Edition | | 77875-1.2REA | |
| The Sims 2: Seasons (Expansion Pack) (Disc 1) | PC | 1.7.0.145 | Original, Slim Case | | 1562107 | |
| The Sims 2: Seasons (Expansion Pack) (Disc 2) | PC | 1.7.0.145 | Original, Slim Case | | 1562117 | |
| Siege of Avalon Anthology | PC | 1.7.1.0913 | Rerelease | | | |
| Space Rangers | PC | 1.7.2 | Cinemaware Marquee | | 02-1506-12 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 1) | PC | 1.7.4.0 | Original | | 31183-1.1 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 2) | PC | 1.7.4.0 | Original | | 31183-1.2 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 3) | PC | 1.7.4.0 | Original | | 31183-1.3 | |
| Star Wars: Rebel Assault | PC | 1.72 | Star Wars Masterpieces | | 8031833 | |
| Star Wars: Rebel Assault | PC | 1.72 | The LucasArts Archives Vol. II: Star Wars Collection | | 8031833 | |
| Sacred (Disc 1) | PC | 1.8 | Rerelease | | 10153-CD1 | |
| Sacred (Disc 2) | PC | 1.8 | Rerelease | | 10153-CD2 | |
| The Sims 2: Celebration! Stuff | PC | 1.8.0.64 | Original | | 1564707 | |
| Squad Assault: Second Wave | PC | 1.80 | Original | | | |
| Silent Steel | PC | 1.82.42.100 | DVD-ROM | | | |
| SpaceChem | PC | 1011 | Original | | | |
| SpaceChem | PC | 1012 | Limited Edition | | | |
| Star Trek: Deep Space Nine: The Fallen (Demo and Trailer) | PC | 11-2000-a | Demo | | | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| Shadowrun Chronicles: Boston Lockdown | PC | 12.0.10093 | Cosmi | | DVDC6251 | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| Scrabble | PC | 2.0 | Rerelease | | 99182, Product# 99182 | |
| Scrabble Complete | PC | 2.0 | Rerelease | | Part # 26022CDA | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 2: Reshaping Googol: Castle / Ocean | PC | 2.0 | Original | | | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PC | 2.0 | Original | | | |
| The Secret of Googol 4: The Googol Counting Fair: Corral / Fun House | PC | 2.0 | Original | | | |
| The Secret of Googol 5: Googolfest: Party Isle / Toy Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| The Secret of Googol 7: Eggs All Around: Egg Trek / Balloon Picnic | PC | 2.0 | Original | | | |
| The Secret of Googol 8: Googol Gulch: General Store / Math Arcade | PC | 2.0 | Original | | | |
| Sesame Street Reading is Fun! Toddler (Disc 1) (Grover's Travels) | PC | 2.0 | Original | | SRF844AE-CD-1 | |
| Sesame Street Reading is Fun! Toddler (Disc 2) (The Three Grouchketeers) | PC | 2.0 | Original | | SRF844AE-CD-2 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 1) (Elmo's Preschool) | PC | 2.0 | | | SPC844AE-CD-1 | |
| Sesame Street: Elmo's Preschool Deluxe (Disc 2) (Search & Learn Adventures) | PC | 2.0 | | | SPC844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 1) (Art Workshop) | PC | 2.0 | Original | | STO844AE-CD-1 | |
| Sesame Street: Toddlers Deluxe (Disc 2) (Letters) | PC | 2.0 | Original | | STO844AE-CD-2 | |
| Sesame Street: Toddlers Deluxe (Disc 3) (Numbers) | PC | 2.0 | Original | | STO844AE-CD-3 | |
| Shrak Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Sid Meier's Civilization IV: Warlords | PC | 2.0 | Original | | 21966-1 | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| SimCity Classic | PC | 2.0 | Deluxe Edition | | 0002-000-0601B | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| The Sims 2: Double Deluxe The Sims 2: Store Edition | PC | 2.0 | Rerelease | | 1597037 | |
| The Sims 2: University Life Collection | PC | 2.0 | Original | | 1685207 | |
| Solitaire Master 2 | PC | 2.0 | Original | | 11-2806-10 | |
| Solitaire: 50 Complete Games! | PC | 2.0 | Rerelease | | 10-0990-10 | |
| Space Ace CD-ROM Don Bluth's Space Ace | PC | 2.0 | | | SANSARL-01 | |
| Sport Image: World Cup 1994 | PC | 2.0 | SoftKey | | WCF344AE-CD | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Stella Gets a New Brain! | PC | 2.0 | Original | | AR-4602 | |
| Stellar Forces Stellar Forces Expansion Pak: Over 50 Add-On Levels for StarCraft | PC | 2.0 | Original | | | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | 10049 | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | SBW744DE-CD | |
| Storybook Weaver Deluxe | PC | 2.0 | Rerelease | | #SBW744BE-CD | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Original | | | |
| Str.at.e.s. 1: Match-A-Batch | PC | 2.0 | Rerelease | | | |
| Sudden Strike II | PC | 2.0 | Original | | CDR8000/US2 | |
| SWAT 3: Close Quarters Battle (Play CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Tactics CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Disc 1) (Play Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| SWAT 3: Close Quarters Battle (Disc 2) (Tactics Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| Systemax Ultimate Software Collection (Disc 22) (Richard Scarry's: Busy Town) | PC | 2.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| SimCity 3000 Unlimited | PC | 2.0.949 | Scholastic | | 1500907 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Scholastic | | 1500907 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Original | | 1500907 | |
| Shanghai: Great Moments | PC | 2.00 | Bundle Version Canon OEM | | | |
| Solitaire Deluxe | PC | 2.00 | Original | | CD-C95-080-0 | |
| SpellForce: Universe (Disc 2) | PC | 2.00 | Original | | DVD563CD | |
| Spy Fox in "Cheese Chase" | PC | 2.00 | Rerelease | | Part No. 04-15244CD | |
| Spy Fox in "Dry Cereal" | PC | 2.00 | Original | | Part #04-00000H1407 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 2.00.424 | Original | | 3261830R1 v2.1.0.0 | |
| Star Wars: X-Wing Alliance (Disc 1) | PC | 2.02a | Original | | 2091830, 2091830R1 | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 2.02a | Original | | 2091831, 2091831R1 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0A | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088131 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0A | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | 2088131R1 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| Solitaire Master 2 | PC | 2.1 | Original | | 02-6306-10 | |
| Storybook Weaver Deluxe | PC | 2.1 | Rerelease | | SBW744EE-CD | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Shogo: Mobile Armor Division | PC | 2.2 | Bundle Version Creative Labs OEM | | 1713310341 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Dual Jewel | | CD-C95-1298-0 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Interplay Rerelease | | CD-C95-1141-0 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | PC | 2.2.0.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982531 | |
| Sacred Gold (Disc 1) | PC | 2.24 | Original | | 10130-CD1 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| The Secret of Monkey Island | PC | 2.3 | Original | | 2147010-590001 / I 042 | |
| System Shock 2 | PC | 2.3 | Classics | | 1203807 | |
| System Shock 2 시스템 쇼크 2 | PC | 2.3 | Rerelease, EA Classix, Gagyeok Pagoe! | | 796917 | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Rerelease | | 0-492-47-101 | |
| Sid Meier's Civilization II | PC | 2.42a | Risk: Gold Edition | | Product # 99227 | |
| Sid Meier's Civilization II | PC | 2.42a | Infogrames Rerelease | | | |
| Sid Meier's Civilization II | PC | 2.42a | Hasbro Rerelease | | Product # 99227 | |
| Star Trek: Starfleet Command: Orion Pirates | PC | 2.5.0.0 | Original | | CD-C95-1290-0 | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sammy's Science House | PC | 3.0 | Southwestern Kids' Collection | | R2522/8612a.7.01 | |
| Scooby-Doo 2: Monsters Unleashed | PC | 3.0 | Original | | | |
| Sesame Street Toddler: Elmo's Art Workshop (Disc 2) | PC | 3.0 | Rerelease | | STL744AE-CD2 | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Storybook Weaver Deluxe 2004 | PC | 3.0 | Original | | 483050-CD | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 1) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.1 | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 2) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.2 | |
| Sesame Street: Elmo's Preschool (Disc 1) (Elmo's Preschool) | PC | 3.1 | Original | | P/N 379663-CD1 | |
| Sesame Street: Elmo's Preschool (Disc 2) (Search & Learn Adventures) | PC | 3.1 | Original | | P/N 379663-CD2 | |
| Sid Meier's Colonization Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Spy Kids: Mega Mission Zone | PC | 3.6.27 | Original | | H3343 | |
| SWAT 4 (Disc 1) | PC | 31973 | Original | | | |
| SWAT 4 (Disc 2) | PC | 31973 | Original | | | |
| Sid Meier's Railroad Tycoon | PC | 455.03 | RomZōn! | | 0-447-40-101 | |
| The Sims 3: Fast Lane Stuff | PC | 5.0.44.008001 | Original | | 1950207 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 5.1 | 5 ft. 10 PAK Vol. 2 | | CD 7012 SPI | |
| The Sims 3: Outdoor Living Stuff | PC | 7.0.55.010001 | Original | | 1950307 | |
| Stellar 7 | PC | 7.3 | 5 ft. 10 Pak Vol. I | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | Beta 3 | Beta | | | |
| Starship Tycoon | PC | Build 2.24 | Original | | | |
| System Shock | PC | F1.6C / F1.6S | Original | | | |
| System Shock | PC | F1.6C / F1.6S | CD-ROM Classics, Rerelease | | 5497 | |
| Star Wars: Making Magic | PC | QA1.03 | Star Wars Masterpieces | | 8031835 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | PC | Rev A | Bundle Version OEM | | RVL 13-004-073 | |
| Syberia (Demo CD) | PC | SSV1.0 | Demo | | DEM379CD | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Best Edition | | | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Limited Edition | | | |
| School Zone Math: Grade 2 | PC | v.5 | Original | | 08032 | |
| School Zone Phonics: Grades 2-3 | PC | v.5 | Original | | 08064 | |
| School Tycoon | PC | v1 | Original | | | |
| The Sting! | PC | v2.0e | Original | | ROTHESTING0004USLAB | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | | |
| The San Diego Zoo Presents... The Animals! | PC | Version 2 PB | Original | | 170121 | |
| Star Wars: Rebel Assault II: Encounter on Dreighton | PC | WD1.09 | Star Wars Masterpieces, Bundle Version OEM | | 644030 | |