Region | Title | System | Version | Edition | Languages | Serial | Status |
| Star Wars: Pit Droids | PC | | Original | | 3513030 | |
| Star Wars: Math: Jabba's Game Galaxy | PC | | Original, Scholastic | | P/N CDR5077850 | |
| Star Wars: Jedi Knight: Dark Forces II: Pathways to the Force | PC | | Bundle Version Diamond OEM | | 646230, 75000202-100, CD-C95-829-DIA | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | 9521831 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Archive Series | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | 9521830 | |
| Star Wars: Galactic Battlegrounds: Clone Campaigns | PC | | Original | | 7111830 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | The Movie Collection | | 1292617, 8531031 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | Rerelease | | 8531031R, 8531031R1 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 1) | PC | | The Movie Collection | | 1292607, 8531030 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 1) | PC | | Rerelease | | 8531030R, 8531030R1 | |
| Star Trek: Starship Creator | PC | | Original, Deluxe | | | |
| Star Trek: Starship Creator (Add-On Pack) | PC | | Deluxe | | 0-671-31758-X | |
| Star Trek: Klingon (Disc 2) | PC | | Original | | | |
| Star Trek: Klingon (Disc 1) | PC | | Original | | | |
| Star Trek: Judgment Rites | PC | | Star Trek: Federation Compilation | | CD-C95-893-1 | |
| Star Trek: Judgment Rites | PC | | Original, Limited CD-ROM Collector's Edition | | CD-ICD-200-0, CD-ICD-728-2 | |
| Star Trek: Judgment Rites (Collector's Disc) | PC | | Limited CD-ROM Collector's Edition | | CD-ICD-200-1 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Star Trek: Federation Compilation | | CD-C95-893-2 | |
| Star Trek Online | PC | | Original | | 27872DV | |
| Star Trek Omnipedia | PC | | Original | | | |
| Star Control 3 | PC | | Original | | Part #:5000-00419 | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| Spy Fox: "Operation Ozone" | PC | | Original | | Part No. 04-22394CD | |
| Sports Illustrated Kids: Soccer | PC | | Wendy's Kids' Meal | | | |
| Sports Illustrated Kids: Basketball | PC | | Wendy's Kids' Meal | | | |
| Spore: Creepy & Cute Parts Pack | PC | | Original | | 1907607 | |
| Spore: Creature Creator | PC | | Original | | 1586407 | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| Spider-Man | PC | | Original | | 31131.101.US | |
| Spell It Deluxe | PC | | Original | | | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Spectre VR | PC | | Megapak 2 | | | |
| Spec Ops: Ranger Assault | PC | | Covermount | | CDE30_CDA | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spaguetti Party: La Familia Pomodoro | PC | | Covermount | | | |
| Spacebound Space Bound | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| South Park | PC | | Original | | | |
| Sonic R | PC | | Sonic Action 4 Pack, Twin Pack | | 682501.101.US | |
| Sonic R | PC | | Expert Software | | 682501.101.US | |
| Sonic CD | PC | | Original | | 85015 | |
| Sonic CD | PC | | Expert Software | | 6805 02 | |
| Sonic & Knuckles Collection | PC | | Original, Jack in the Box | | 85037 | |
| Soldier of Fortune II: Double Helix (Disc 1) | PC | | Original | | 31147.101.US | |
| The Software Toolworks CD Deluxe Pack 4 | PC | | Bundle Version OEM | | 2192610-590001/1034100, CDRM1170920 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Snowmobile Racing | PC | | Original | | 04-17527CD | |
| Snapshot Adventures: Secret of Bird Island | PC | | Original | | P/N 61191-CD | |
| Smashing Reversi Reversi | PC | | Pocketware | | #11 | |
| SiN Episodes: Emergence | PC | | Original | | 984707 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition, Scholastic | | 1403357 | |
| SimTheme Park Sim Theme Park | PC | | Sim Mania 2, The Kids Collection | | 1229827, 1641517 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| SimTheme Park (Bonus Rides and Attractions) Sim Theme Park | PC | | Gold Edition, Sim Mania 2 | | 1229817, 1403347, 1641527 | |
| The Sims: Vacation (Expansion Pack) | PC | | Original | | 1448807 | |
| The Sims: Vacation (Expansion Pack) | PC | | Expansion Collection Volume Three | | 1448807 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | | | | 1462617 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | | | | 1462607 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Expansion Collection Volume Two | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Original | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | | Expansion Collection Volume Two | | 1472007 | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe, Expansion Collection Volume One, Mega Deluxe | | 1446107 | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| SimLife | PC | | Scholastic | | 1111707, 7845126C SP1 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Rerelease, 10 Sims for $20 | | 11116, 1162207 | |
| SimEarth | PC | | Scholastic | | 5675434C, DP19 | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimCoaster | PC | | Original | | 1425707 | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection | | 1242617 | |
| SimCity Classic | PC | | CD-ROM Classics, 10 Sims for $20, Sim Mania Pack | | 1162907 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimAnt SimAnt: The Electronic Ant Colony | PC | | CD-ROM Classics, 10 Sims for $20 | | 1111407 | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Shogun: Total War (Disc 2) | PC | | Original | | 798717, 1224617 | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Shadoan (Disc 2) | PC | | Original | | CD-ICD-228-1 | |
| Shadoan (Disc 1) | PC | | Original | | CD-ICD-228-0 | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Sesame Street Search & Learn Adventures | PC | | Original, Software for the fun of it | | EOA844AE-CD, KES005 | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Smash Pack 2 | PC | | Original, Sonic Action 4 Pack | | 30107.101.US | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screamer | PC | | White Label | | | |
| Scratches | PC | | Original | | | |
| Scrabble Complete | PC | | Original, Monopoly & Scrabble Complete, Scrabble Complete/Jeopardy 2003 | | 11290-CD, Part # 23970CD | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Sci-Fi Pinball | PC | | Original | | | |
| Schoolhouse Rock! 1st & 2nd Grade (Disc 2) (2nd Grade) | PC | | Original | | 21330CD-2, SGE744AE-CD2 | |
| Scholastic's The Magic School Bus: Whales & Dolphins: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3, The Magic School Bus: Bonus Pack | | 0201 Part No. X06-15571 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| S!Zone for SimCity 2000 | PC | | Original | | | |