| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Scooter Pro | PC | | Original |  | APWCDR1001 |  |
| Scorcher | PC | | Original | | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
 | Scorcher | PC | | Original | | 04-11264CD | |
| Score 4 | PC | | Original | | | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| Scrabble
Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble | PC | | Rerelease | | 99002 | |
| Scrabble
Scrabble: CD-ROM Crossword Game | PC | | Scholastic, Classic Value Series | | 99002 | |
| Scrabble
Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002 | |
| Scrabble
Scrabble: CD-ROM Crossword Game | PC | | Rerelease | | 99002, 99002● | |
| Scrabble
Scrabble: CD-ROM Crossword Game | PC | | Original | | 99002 | |
| Scrabble | PC | 2.0 | Rerelease | | 99182, Product# 99182 | |
| Scrabble Complete | PC | | Original, Bundle Version Microgistix OEM | | 11290-CD, Part # 23970CD | |
| Scrabble Complete | PC | 2.0 | Rerelease | | Part # 26022CDA | |
 | Scrabble Interactive: 2005 Edition | PC | 1.0 | Covermount: Special Edition | | | |
| Scrabble Interactive: 2005 Edition | PC | 1.0.0.0 | Ubisoft eXclusive / Focus Essential | | ESS624 | |
| Scrabble Interactive: 2007 Edition | PC | 1.1.0 | Ubisoft eXclusive / Focus Essential | | ESS760 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scratches: Director's Cut | PC | | Original | | | |
| Scratches: Director's Cut | PC | | Rerelease | | | |
| Screamer | PC | | | | | |
| Screamer | PC | | Original | | | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Original | | | |
| Screamer | PC | | Original | | | |
 | Screamer 2 | PC | | Covermount | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2
Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
 | Screamer Rally | PC | | Sold Out Software | | | |
 | Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| Screaming Skies | PC | 1.01 | Original | | | |
 | Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited (Asset Disc) | PC | | Press Kit | | | |
 | Scribblenauts Unlimited | PC | | Original | | 2000079870, 5000145356 | |
| The Scroll | PC | | | | | |
| Scud: Industrial Evolution | PC | | Original | | 129-7 | |
| SD Qlympics
Olympic Challenge | PC | | Grabit | | GDL031 | |
| Sea Dogs | PC | 1.06 | Green Pepper | | | |
| Sea Dogs: An Epic Adventure at Sea | PC | 1.06 | Original | | | |
| Sea Plane Adventures
Sea Plane Adventures for FS2002/2004 | PC | | Original | | | |
| Seal of Evil | PC | | Original | | 904066DVD | |
| Search and Rescue
Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
 | Search and Rescue 4: Coastal Heroes | PC | | Original | | | |
| Search and Rescue: Vietnam MedEvac | PC | | Original | | GLS00239 | |
| Search for the Golden Dolphin
Search for the Golden Dolphin: An Interactive 3-D Adventure | PC | | | | | |
| Season Ticket Baseball 2003 | PC | 1.0 | Original | | 04-23416CDSL | |
| SeaWorld Adventure Parks Tycoon | PC | | Original | | 31711.101.US | |
| SeaWorld Adventure Parks Tycoon 2
SeaWorld Adventure Parks Tycoon 3D | PC | 1.0 | Original | | 35077.101.US | |
 | Second Life: The Official Guide | PC | | Book Bundle | | CD ID #MD02993a, Part #0999008684 | |
| Secret Agent Barbie | PC | 1.0c | Original | | S7127810 | |
| Secret Files: Tunguska | PC | 1.03 | Original, Xplosiv | | ECD008099M 00060722-01, ECD900019D 00060810-01, XP-2221 3026412 | |
| Secret Files: Tunguska (Disc 1) (Play Disc) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 2) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 3) | PC | 1.0 | Original | | | |
| Secret Files: Tunguska (Disc 4) | PC | 1.0 | Original | | | |
| The Secret Island of Dr. Quandary | PC | | Softkey | | PDQ944AB-CD | |
| The Secret Island of Dr. Quandary | PC | | CD-ROM Ten Pak | | | |
| The Secret Island of Dr. Quandary | PC | 1.0 | SoftKey | | PDQ944AE-CD | |
| The Secret of Margrave Manor | PC | | Original | | | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge
The Monkey Island Bounty Pack: The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | 1.0 | LucasArts Classics: The Monkey Island Bounty Pack | | 3000012.101.UK | |
| The Secret of the Silver Earring
Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of the Silver Earring (Disc 1)
Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2)
Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| Secret Service | PC | 1.0 | Original | | 35635.101.UK, 35635.101.US | |
| Secret Service: Security Breach | PC | 1.1 | Original | | 31035.101.US | |
 | Secret Weapons of the Luftwaffe | PC | | Collezione CD-Rom by C.T.O. | | | |
| Secret Weapons over Normandy (Disc 1) | PC | 1.0 | Original | | 2101830 | |
| Secret Weapons over Normandy (Disc 2) | PC | 1.0 | Original | | 2101831 | |
| Secret Weapons over Normandy (Disc 3) | PC | 1.0 | Original | | 2101832 | |
| Secret Weapons over Normandy (Disc 4) (Play Disc) | PC | 1.0 | Original | | 2101833 | |
| The Secrets of Alamût (Disc 1)
The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Alamût (Disc 2)
The Secrets of Alamût: The Legend 2 | PC | | | | | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 2) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Atlantis (Disc 3) | PC | | Original | | PC0549CD SNY 2.0 | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 1) | PC | | Original | | ref. 3760137140273 | |
| Secrets of Great Art | PC | 1.1 | Original | | P/N 61218-CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 1) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 2) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the Ark: A Broken Sword Game (Disc 3) | PC | 1.0 | Original | | PCO535CD | |
| Secrets of the East | PC | | Scholastic | | P/N CDR9909538 | |
| Secrets of the Luxor (Disc 1) | PC | | Original | | | |
| Secrets of the Luxor (Disc 2) | PC | | Original | | | |
| Section Z
Capcom Classics: Section Z | PC | 1.0 | PDA | | | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 Press Kit 2005
2005 E3 Press Kit | PC | | Press Kit | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Genesis Classic Collection: Gold Edition | PC | 1.0.019 | Original | | | |
| Sega Mega Drive Classic Collection: Złota Edycja | PC | 1.0.019 | Platynowa Kolekcja | | P_37010_04A_PL | |
| Sega Press Materials | PC | | Press Kit | | | |
 | Sega Puzzle Pack | PC | | Original | | 673-01815 | |
| Sega Puzzle Pack | PC | | Expert Software | | 682701.101.US | |
| Sega Rally 2 (Install Disc)
Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Play Disc)
Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
