Region | Title | System | Version | Edition | Languages | Serial | Status |
| Super Mario Galaxy 2 超級瑪利歐銀河2 | WII | | Original | | RVL-SB4W-CHT-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCU-AUS-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Original | | RVL-SS4U-AUS-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Original | | RVL-SS3U-AUS-B0 | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| SimCity Creator | WII | Rev 1 | Original | | RVL-R4CP-AUS | |
| Super Karts | WII | Rev 1 | Original | | RVL-SN6P-EUR-B0 | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYY-USA-B0 | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPY-BRA-B0 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCX-CAN-B0 | |
| The Saddle Club | WII | | Original | | RVL-SSLP-EUR-B0 | |
| Safar'Wii | WII | | Original | | RVL-RD6P-EUR-B0 | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWP-EUR | |
| Safecracker | WII | | Original | | RVL-RQFP-EUR | |
| Sakura Wars: So Long, My Love | WII | | Original | | RVL-SAKP-UKV-E0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | Rev 1 | Original | | RVL-R3XP-EUR | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSP-EUR | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59P-EUR-E0 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCP-EUR | |
| Science Papa | WII | | Original | | RVL-RZEP-EUR-B0 | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| Scrabble Interactive | WII | | Original | | RVL-RVHP-EUR-B0 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| Secret Files 2: Puritas Cordis | WII | | | | RVL-RZFP-EUR | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUP-EUR | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85P-EUR-B0 | |
| Shakedown: Hawaii | WII | | Original | | RVL-SEVP-EUR-B0 | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDP-EUR-B0 | |
| SimCity Creator | WII | | Beta | | | |
| SimCity Creator | WII | | Original | | RVL-R4CP-EUR | |
| The Simpsons Game Los Simpson: El Videojuego / I Simpson: Il Videogioco | WII | | Original | | RVL-RSNX-EUS | |
| The Sims 2: Castaway | WII | | Beta | | | |
| The Sims 2: Castaway | WII | Rev 1 | Original | | RVL-R42P-EUR | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PP-EUR | |
| Skate City Heroes | WII | | Original | | RVL-RHUP-EUR-B0 | |
| The Sky Crawlers: Innocent Aces | WII | | Original | | RVL-RQRP-EUR-B0 | |
| Skylanders: Giants | WII | | Booster Pack | | RVL-SKYZ-EUZ-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXI-EUZ-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXI-EUZ-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8D-FAH-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skyscraper | WII | | Original | | RVL-R3KP-UKV-B1 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDP-EUR | |
| The Smurfs Party Pack | WII | | Original | | RVL-S7SP-EUR-B0 | |
| Sniper Elite | WII | | Original | | RVL-SSNP-EUR-B0 | |
| So Blonde: Back to the Island | WII | | Original | | RVL-RVJP-EUR-B0 | |
| Sonic and the Black Knight | WII | | Original | | RVL-RENP-EUR | |
| Space Camp | WII | | Original | | RVL-RIYP-EUR | |
| Speed | WII | | Original | | RVL-SPEP-EUR-B0 | |
| Speed 2 | WII | | Bundled with Wii Wheel | | RVL-SQPP-EUR-B0 | |
| Spellbound Party | WII | | Original | | RVL-SPBP-EUR-B0 | |
| Spider-Man 3 | WII | | Original | | RVL-RS3X-EUR | |
| Spider-Man 3 | WII | Rev 1 | Original | | RVL-RS3P-UKV | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOP-UKV | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOX-EUR | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48P-EUR | |
| SPRay | WII | | Original | | RVL-RYIP-EUR-B0 | |
| Sprint Cars | WII | | Original | | RVL-SN8P-EUR-B0 | |
| Spy Fox in "Dry Cereal" Spy Fox: Dry Cereal | WII | | Original | | RVL-RDLP-EUR | |
| Squeeballs Party | WII | | Original | | RVL-R6YP-EUR-B0 | |
| Star Trek: Conquest | WII | | Original | | RVL-RTJP-EUR | |
| Star Wars: The Force Unleashed II | WII | | Beta | | | |
| Step to the Beat | WII | | Original | | RVL-RY6P-EUR-B0 | |
| Story Hour: Adventures | WII | | Original | | RVL-R3AP-EUR | |
| Story Hour: Fairy Tales | WII | | Original | | RVL-R4FP-EUR | |
| Street Football | WII | | Original | | RVL-R8KP-EUR-B0 | |
| Stunt Flyer: Hero of the Skies | WII | | Original | | RVL-SSTP-EUR-B0 | |
| Sudoku Ball: Detective | WII | | Original | | RVL-R9SP-EUR | |
| Summer Athletics | WII | Rev 1 | Original | | RVL-RUMP-EUR | |
| Summer Athletics 2009 | WII | | Original | | RVL-R9MP-EUR-B0 | |
| Summer Challenge: Athletics Tournament | WII | | Original | | RVL-RE6P-EUR-B0 | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJP-EUR-B0 | |
| Super Karts | WII | | Original | | RVL-SN6P-EUR-B0 | |
| Super Swing Golf | WII | | Original | | RVL-R2PP-EUR-B0 | |
| Super Truck Racer | WII | | Original | | RVL-SN7P-EUR-B0 | |
| Supersonic Racer | WII | | Original | | RVL-SRSP-EUR-B0 | |
| Surf's Up | WII | | Original | | RVL-RXUX-EUU | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPP-EUR-B2 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Survivor | WII | | Original | | RVL-RLNP-UKV-B0 | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Les Simpson: Le Jeu | WII | | Original | | RVL-RSNF-FRA | |
| The Spirit of the Wolf | WII | | Original | | RVL-SLPP-EUR-B0 | |
| Scene It? Ganz großes Kino! | WII | | Original | | RVL-SSCD-NOE-B0 | |
| Die Simpsons: Das Spiel | WII | | Original | | RVL-RSND-NOE | |
| Scene It? Ciak! Si Gira! Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCI-ITA-B0 | |
| Samba de Amigo サンバDEアミーゴ | WII | | Original | | RVL-R3BJ-JPN | |
| Samurai Spirits: Rokuban Shoubu サムライスピリッツ 六番勝負 | WII | | Original | | RVL-RSSJ-JPN | |
| Sangokushi 11 with Power-Up Kit 三國志11 with パワーアップキット | WII | | Original | | RVL-R35J-JPN | |
| Sangokushi 11 with Power-Up Kit 三國志11 with パワーアップキット | WII | Rev 1 | Koei the Best | | RVL-R35J-JPN-1 | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ | WII | | Original | | RVL-SD9J-JPN-B0 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: Scad Hammers SDガンダム スカッドハンマーズ | WII | | Original | | RVL-RSDJ-JPN | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2) 戦国BASARA2 | WII | | Original | | RVL-RBSJ-1-JPN | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2: Heroes) 戦国BASARA2 英雄外伝 | WII | | Original | | RVL-RBSJ-0-JPN | |
| Sengoku Basara 3 戦国BASARA3 | WII | | Original | | RVL-SB3J-JPN-B0 | |
| Sengoku Basara 3: Utage 戦国BASARA3 宴 | WII | | Original | | RVL-S3HJ-JPN-B0 | |
| Sengoku Musou 3: Moushouden 戦国無双3 猛将伝 | WII | | Original | | RVL-S5QJ-JPN-E0 | |
| Sengoku Musou: Katana 戦国無双 KATANA | WII | | Original | | RVL-RS5J-JPN | |
| Shanghai 上海 | WII | | Original | | RVL-RS8J-JPN | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | | Original | | RVL-SHIJ-JPN-B0 | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-SHIJ-JPN-B0 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | | Original | | RVL-REKJ-JPN-1 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-REKJ-JPN-1 | |
| Sharuui Takoron しゃるうぃ~☆たころん | WII | | Original | | RVL-RTKJ-JPN | |
| Shikakui Atama o Maruku Suru. Wii シカクいアタマをマルくする。 Wii | WII | | Original | | RVL-R4MJ-JPN | |
| Shikigami no Shiro III 式神の城Ⅲ | WII | | Original | | RVL-RS4J-JPN | |
| Shin Chuuka Taisen: Michael to Meimei no Bouken 新・中華大仙 ~マイケルとメイメイの冒険~ | WII | | Original | | RVL-RTDJ-JPN | |
| SimAnimals シムアニマル | WII | | Original | | RVL-R4AJ-JPN | |
| SimAnimals: Africa シムアニマル アフリカ | WII | | Original | | RVL-R7AJ-JPN-B0 | |
| SimCity Creator シムシティ クリエイター | WII | | Original | | RVL-R4CJ-JPN | |
| I Simple 2000 Series Wii Vol. 1: The Table Game: Mahjonggo, Shougi, Card, Hanafuda, Reversi, Gomoku Narabe SIMPLE2000シリーズWii Vol.1 THE テーブルゲーム ~麻雀・囲碁・将棋・カード・花札・リバーシ・五目ならべ~ | WII | | Original | | RVL-RZ8J-JPN | |
| Simple 2000 Series Wii Vol. 2: The Party Game SIMPLE2000シリーズWii Vol.2 THE パーティーゲーム | WII | | Original | | RVL-RZ9J-JPN | |
| Simple Wii Series Vol. 1: The Minna de Kart Race SIMPLE Wii シリーズ Vol.1 THE みんなでカート・レース | WII | | Original | | RVL-RZ2J-JPN | |
| Simple Wii Series Vol. 2: The Minna de Bass Tsuri Taikai SIMPLE Wii シリーズ Vol.2 THE みんなでバス釣り大会 | WII | | Original | | RVL-RZ3J-JPN | |
| Simple Wii Series Vol. 3: Asonde Oboeru: The Party Casino SIMPLE Wii シリーズ Vol.3 遊んで覚える THE パーティー・カジノ | WII | | Original | | RVL-RZ4J-JPN | |
| Simple Wii Series Vol. 4: The Shooting Action SIMPLE Wii シリーズ Vol.4 THE シューティング・アクション | WII | | Original | | RVL-RZ5J-JPN | |
| Simple Wii Series Vol. 5: The Block Kuzushi SIMPLE Wii シリーズ Vol.5 THE ブロックくずし | WII | | Original | | RVL-RZ6J-JPN | |
| Simple Wii Series Vol. 6: The Wai Wai Combat SIMPLE Wii シリーズ Vol.6 THE ワイワイ・コンバット | WII | | Original | | RVL-RZ7J-JPN | |
| Skate It スケート イット | WII | | Original | | RVL-RVSJ-JPN | |
| Sky Crawlers: Innocent Aces スカイ・クロラ イノセン・テイセス | WII | | Original | | RVL-RQRJ-JPN | |
| Skylanders: Spyro no Daibouken スカイランダーズ スパイロの大冒険 | WII | | Starter Pack | | RVL-SSPJ-JPN-B0 | |
| Sonic Colors ソニック カラーズ | WII | | Original | | RVL-SNCJ-JPN-B0 | |
| Sonic Riders: Shooting Star Story ソニックライダーズ シューティングスターストーリー | WII | | Original | | RVL-RS9J-JPN | |
| Sonic to Ankoku no Kishi ソニックと暗黒の騎士 | WII | | Original | | RVL-RENJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Taikenban | | RVL-DSRJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Original | | RVL-RSRJ-JPN | |
| Sonic World Adventure ソニック ワールドアドベンチャー | WII | | Original | | RVL-RSVJ-JPN | |
| Soulcalibur Legends ソウルキャリバーレジェンズ | WII | | Original | | RVL-RSLJ-JPN | |
| Speed Racer スピード・レーサー | WII | | Original | | RVL-R3PJ-JPN | |
| Spider-Man 3 スパイダーマン3 | WII | | Original | | RVL-RS3J-JPN | |
| Spore: Kimi ga Tsukuru Hero スポア キミがつくるヒーロー | WII | | Original | | RVL-RQOJ-JPN-B0 | |
| SSX Blur SSXブラー | WII | | Original | | RVL-RSXJ-JPN | |
| Star Wars: The Force Unleashed スター・ウォーズ フォース アンリーシュド | WII | | Original | | RVL-RSTJ-JPN | |
| Sugoro Chronicle: Migite ni Ken o Hidarite ni Saikoro o スゴロクロニクル ~右手に剣を左手にサイコロを~ | WII | | Original | | RVL-RDUJ-JPN | |
| Sukeban Shachou Rena Wii: Neko Shachou, Tsukaeru Shain Daiboshuu. 女番社長レナWii 猫社長、つかえる社員大募集。 | WII | | Original | | RVL-R4YJ-JPN-B0 | |
| Super Mario Stadium: Family Baseball スーパーマリオスタジアム ファミリーベースボール | WII | | Original | | RVL-RMBJ-JPN | |
| Super Monkey Ball Athletic スーパーモンキーボール アスレチック | WII | | Original | | RVL-SMBJ-JPN-B0 | |
| Super Monkey Ball: Uki Uki Party Daishuugou スーパーモンキーボール ウキウキパーティー大集合 | WII | | Original | | RVL-RSMJ-JPN | |
| Super Paper Mario スーパーペーパーマリオ | WII | Rev 1 | Original | | RVL-R8PJ-JPN | |
| Super Robot Taisen Neo スーパーロボット大戦ネオ | WII | | Original | | RVL-RRWJ-JPN-B0 | |
| Super Sentai Battle: Ranger Cross スーパー戦隊バトル レンジャークロス | WII | | Original | | RVL-SRJJ-JPN-B0 | |
| Survival Kids Wii サバイバルキッズWii | WII | | Original | | RVL-RKZJ-JPN | |
| Suzumiya Haruhi no Gekidou 涼宮ハルヒの激動 | WII | | Chou DX Pack | | RVL-RHHJ-JPN | |
| Suzumiya Haruhi no Heiretsu 涼宮ハルヒの並列 | WII | | Original | | RVL-R44J-JPN | |
| Swing Golf Pangya 2nd Shot! スイングゴルフ パンヤ 2ndショット! | WII | | Original | | RVL-R2PJ-JPN | |
| Samurai Spirits: 6beonui Seungbu 사무라이 스피리츠 6번의 승부 | WII | | Original | | RVL-RSSK-KOR | |
| SimCity Namanui Dosi 심시티 나만의 도시 | WII | | Original | | RVL-R4CK-KOR | |
| Sin Junghwa-daeseon: Michaelgwa Meimeiui Moheom 신중화대선 ~마이클과 메이메이의 모험~ | WII | | Original | | RVL-RTDK-KOR | |
| Soulcalibur Legends 소울 칼리버 레전즈 | WII | | Original | | RVL-RSLK-KOR | |
| SSX Blur SSX 블러 | WII | | Original | | RVL-RSXK-KOR | |
| Super Mario Collection 슈퍼 마리오 컬렉션 | WII | | Super Mario Bros. 25th Anniversary | | RVL-SVMK-KOR-B0 | |
| Super Paper Mario 슈퍼 페이퍼 마리오 | WII | | Original | | RVL-R8PK-KOR | |
| Swing Golf Pangya 2nd Shot! 스윙골프 팡야 2nd 샷! | WII | | Original | | RVL-R2PK-KOR | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXX-LTN-E0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8X-LTN-E0 | |
| Het Studio 100 Speeleiland | WII | | Original | | RVL-SPWH-HOL-B0 | |
| Scene It? Estrellas en la Pantalla Gigante | WII | | Original | | RVL-SSCS-ESP-B0 | |
| Shin Chan: Las Nuevas Aventuras para Wii! | WII | | Original | | RVL-RC4S-ESP | |
| Supervivientes | WII | | Original | | RVL-RV7S-ESP | |
| Skylanders: Spyro's Adventure | WII | Rev 1 | Starter Pack | | RVL-SSPX-SCN-B0 | |
| Skylanders: Spyro's Adventure | WII | Rev 2 | Starter Pack | | RVL-SSPX-SCN-B1 | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPX-SCN-B2 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXY-SCN-E0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8V-SCN-E0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8V-EUR-B0 | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| The Sims 3 | WII | | Beta | | | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| Six Flags Fun Park | WII | | Original | | RVL-R6FE-USA | |
| Skate It | WII | | Beta | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| Skylanders: SuperChargers Racing | WII | | Starter Pack | | RVL-SKNE-USA-B0 | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |
| Space Station Tycoon | WII | | Prototype | | | |
| Speed | WII | | Original | | RVL-SPEE-USA-B0 | |
| Speed Zone | WII | | Original | | RVL-RZSE-USA-B0 | |
| Spider-Man: Friend or Foe | WII | | Original | | RVL-RFOE-USA | |
| The Spiderwick Chronicles | WII | | Original | | RVL-R48E-USA | |
| SPRay | WII | | Beta | | | |
| SPRay | WII | | Original | | RVL-RYIE-USA | |
| Spy Games: Elevator Mission | WII | | Original | | RVL-RECE-USA-B0 | |
| Spyborgs | WII | | Beta | | | |
| Squeeballs Party | WII | | Original | | RVL-R6YE-USA-B0 | |
| SSX Blur | WII | | Beta | | | |
| SSX Blur | WII | | Original | | RVL-RSXE-USA | |
| Story Hour: Adventures | WII | | Original | | RVL-R3AE-USA | |
| Story Hour: Fairy Tales | WII | | Original | | RVL-R4FE-USA | |
| Storybook Workshop | WII | | Original | | RVL-R4VE-USA-B0 | |
| Summer Sports 2: Island Sports Party | WII | | Original | | RVL-RI6E-USA-B0 | |
| Summer Sports: Paradise Island | WII | | Original | | RVL-RSUE-USA | |
| Summer Stars 2012 | WII | | Original | | RVL-SSJE-USA-B0 | |
| Super Fruit Fall | WII | | Original | | RVL-RF4E-USA | |
| Super PickUps | WII | | Original | | RVL-RQUE-USA-B0 | |
| Super Swing Golf | WII | | Original | | RVL-RPYE-USA | |
| Super Swing Golf Season 2 | WII | | Original | | RVL-R2PE-USA | |
| Surf's Up | WII | | Original | | RVL-RXUE-USA | |
| Survivor | WII | | Original | | RVL-RLNE-USA-B0 | |
| Swords | WII | | Original | | RVL-SSZE-USA-B0 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NP-UKV-B0 | |