Region | Title | System | Version | Edition | Languages | Serial | Status |
| Scaler | XBOX | | Original | | TT-122 | |
| Scarface: The World Is Yours | XBOX | | Original | | VU-063 | |
| Scooby-Doo! Mystery Mayhem | XBOX | | Original | | TQ-014 | |
| Scooby-Doo! Unmasked | XBOX | | Original | | TQ-247 | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | XBOX | | Original | | AV-080 | |
| Second Sight | XBOX | | Original | | CM-071 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Serious Sam II | XBOX | | Original | | TT-013 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| ShellShock: Nam '67 | XBOX | | Original | | ES-019 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shikigami no Shiro 式神の城 | XBOX | | Original, Shokai Genteiban | | MP-002 | |
| Shikigami no Shiro Evolution 式神の城 EVOLUTION | XBOX | | Blue Version, Red Version | | KI-001 | |
| Shin Sangoku Musou 2 真・三國無双2 | XBOX | | Original | | KO-003 | |
| Shin Sangoku Musou 3 真・三國無双3 | XBOX | | Original | | KO-004 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shrek 2 シュレック 2 | XBOX | | Original, World Collection | | AV-055 | |
| Sid Meier's Pirates! | XBOX | | Original | | TT-143 | |
| Silent Hill 2: Saigo no Uta サイレントヒル2 最期の詩 | XBOX | | Original | | KT-001 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| The Simpsons: Hit & Run | XBOX | | Original, Classics | | VU-021 | |
| The Simpsons: Hit & Run | XBOX | | Original, Platinum Hits, World Collection | | VU-021 | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| Sneak King | XBOX | | Original | | MS-211 | |
| SNK vs. Capcom: SVC Chaos | XBOX | | Original | | SN-001 | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Sonic Heroes | XBOX | | Original, Classics | | SE-043 | |
| Sonic Mega Collection Plus ソニック メガコレクション プラス | XBOX | | Original, Classics | | SE-060 | |
| Soulcalibur II | XBOX | | Original | | NM-003 | |
| Soulcalibur II | XBOX | | Original, Platinum Hits | | NM-003 | |
| Spartan: Total Warrior | XBOX | | Demo | | SE-138 | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man 2 | XBOX | | Original | | AV-043 | |
| Spider-Man 2 스파이더맨 2 | XBOX | | Original | | AV-043 | |
| Splat Magazine Renegade Paintball | XBOX | | Original | | TT-147 | |
| SpyHunter | XBOX | | Platinum Hits | | MW-004 | |
| SpyHunter 2 | XBOX | | Original | | MW-027 | |
| Spyro: A Hero's Tail | XBOX | | Original | | VU-052 | |
| SSX on Tour | XBOX | | Original | | EA-130 | |
| SSX Tricky | XBOX | | Original, Classics | | EA-004 | |
| Stake: Fortune Fighters | XBOX | | Original | | MD-004 | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Star Wars: Battlefront | XBOX | | Original | | LA-017 | |
| Star Wars: Battlefront | XBOX | | Original, Classics, Platinum Hits | | LA-017 | |
| Star Wars: Battlefront II | XBOX | Rev 1 | Platinum Hits | | LA-026 | |
| Star Wars: Battlefront II | XBOX | | Original | | LA-026 | |
| Star Wars: Episode III: Revenge of the Sith | XBOX | | Original, Platinum Hits | | LA-023 | |
| Star Wars: Jedi Knight II: Jedi Outcast | XBOX | | Original | | AV-021 | |
| Star Wars: Jedi Knight II: Jedi Outcast | XBOX | | Original | | LA-009 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original, World Collection | | LA-011 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original, Classics | | LA-003 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Knights of the Old Republic | XBOX | Rev 1 | Platinum Hits | | LA-003 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | XBOX | | Original | | LA-020 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | XBOX | | Original, Platinum Hits | | LA-020 | |
| Star Wars: Obi-Wan | XBOX | | Original | | AV-015 | |
| Star Wars: Obi-Wan | XBOX | | Original | | EA-034 | |
| Star Wars: Obi-Wan | XBOX | | Original, Platinum Hits | | LA-001 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| Star Wars: Starfighter Special Edition | XBOX | | Original, Platinum Hits | | LA-002 | |
| Star Wars: The Clone Wars + Tetris Worlds | XBOX | | Bundled with Xbox: Limited Edition Package, Promotional Offer | | XL-013 | |
| Starsky & Hutch | XBOX | | Original | | EM-005 | |
| Steel Battalion | XBOX | | Original | | CC-002 | |
| Stolen | XBOX | | Original | | HP-001 | |
| Street Fighter Anniversary Collection ストリートファイター アニバーサリーコレクション | XBOX | | Original | | CC-015 | |
| Stubbs the Zombie in Rebel Without a Pulse | XBOX | | Original | | AY-002 | |
| Sudeki 魔幻戰士 | XBOX | | Original | | MS-010 | |
| The Suffering | XBOX | | Original | | MW-021 | |
| The Suffering: Ties That Bind | XBOX | | Original | | MW-044 | |
| Super Monkey Ball Deluxe | XBOX | | Original | | SE-056 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Syberia | XBOX | | Original | | MI-006 | |