Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sacred 2: Fallen Angel | XBOX360 | | Original | | KM-2001 | |
| Sacred 3 | XBOX360 | | Original | | KM-2023 | |
| Saints Row 2 | XBOX360 | | Original, Classics, Platinum Hits, Promo, Saints Row Double Pack | | TQ-2044 | |
| Saints Row IV | XBOX360 | | Original, Commander in Chief Edition | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 1) (Installation Disc) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 2) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Saints Row: The Third | XBOX360 | | Original, The Full Package (Disc 2) | | TQ-2157 | |
| Saints Row: The Third: The Full Package (Disc 1) (DLC Installer) | XBOX360 | | Original | | TQ-2157 | |
| Samurai Warriors 2 | XBOX360 | | Original | | KO-2005 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| ScreamRide | XBOX360 | | Original | | MS-2726 | |
| Section 8 | XBOX360 | | Original | | GP-2004 | |
| Sega Rally Revo Sega Rally | XBOX360 | | Original | | SE-2022 | |
| Sesame Street: Once Upon a Monster | XBOX360 | | Original | | WR-2060 | |
| Shadows of the Damned | XBOX360 | | Original | | EA-2346 | |
| Shift 2: Unleashed | XBOX360 | | Original, Limited Edition | | EA-2356 | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | XBOX360 | | Original | | KO-2028 | |
| Silent Hill: Downpour | XBOX360 | | Original, Promo | | KN-2083 | |
| Silent Hill: HD Collection | XBOX360 | | Original | | KN-2117 | |
| The Sims 3 | XBOX360 | | Original, Classics | | EA-2274 | |
| Singularity | XBOX360 | | Original | | AV-2031 | |
| Skate 3 | XBOX360 | | Original, Platinum Hits | | EA-2278 | |
| Skylanders: Giants | XBOX360 | | Booster Pack | | AV-2266 | |
| Skylanders: Spyro's Adventure | XBOX360 | | Starter Pack | | AV-2219 | |
| Sniper Elite III: Ultimate Edition | XBOX360 | | Original | | FO-2051 | |
| Sniper Elite V2: Silver Star Edition Sniper Elite V2: Game of the Year Edition | XBOX360 | | Original | | FO-2024 | |
| Sniper: Ghost Warrior | XBOX360 | | Original, Sniper: Ghost Warrior Double Pack | | CY-2001 | |
| Sniper: Ghost Warrior 2 | XBOX360 | | Original, Limited Edition, Sniper: Ghost Warrior Double Pack, Bulletproof Steelbook Edition | | CY-2004 | |
| Sonic & All-Stars Racing Transformed | XBOX360 | | Original | | SE-2141 | |
| Sonic & Sega All-Stars Racing with Banjo-Kazooie | XBOX360 | | Original | | SE-2069 | |
| Sonic Free Riders | XBOX360 | | Original | | SE-2125 | |
| Sonic the Hedgehog | XBOX360 | | Original, Platinum Family Hits | | SE-2006 | |
| Soulcalibur IV | XBOX360 | | Original, Classics, Promo, SoulCalibur IV / Tekken 6 | | NM-2016 | |
| Spec Ops: The Line | XBOX360 | | Original, 2K Rogues and Outlaws Collection | | TT-2115 | |
| Spider-Man 3 | XBOX360 | | Original | | AV-2018 | |
| Spider-Man: Edge of Time | XBOX360 | | Original | | AV-2226 | |
| Splatterhouse | XBOX360 | | Original | | NM-2032 | |
| Split/Second Split/Second: Velocity | XBOX360 | | Original | | BV-2023 | |
| Star Wars: The Force Unleashed II | XBOX360 | | Original, Platinum Hits | | LA-2034 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | XBOX360 | | Original | | LA-2002 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | XBOX360 | | Original | | LA-2002 | |
| Stormrise | XBOX360 | | Original | | SE-2054 | |
| Stuntman: Ignition | XBOX360 | | Original | | TQ-2036 | |
| Super Street Fighter IV: Arcade Edition スーパーストリートファイターⅣ アーケードエディション | XBOX360 | | Original, Platinum Collection | | CC-2044 | |
| Supreme Commander 2 | XBOX360 | | Original | | SQ-2019 | |