Region | Title | System | Version | Edition | Languages | Serial | Status |
| Star Trek Online | PC | | Original | | 27872DV | |
| Star Wars: Knights of the Old Republic Collection | PC | 1.0.3.0 | Original | | | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Cosmi | | DVD288D1 | |
| Star Wars: The Force Unleashed II | PC | 1.0 | Original | | 3411830 | |
| Star Wars: The Force Unleashed II | PC | 1.1 | Cosmi | | DVD248D1 v 1.1.0.1 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | PC | 0.0.0.0 | Original | | 12241-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| Star Wars: The Old Republic (Disc 1) | PC | 1.0.0.0 | Original | | 1957807 | |
| Star Wars: The Old Republic (Disc 2) | PC | 1.0.0.0 | Original | | 1957817 | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| The Stronghold Collection | PC | | Original | | 31684-1 | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Supreme Commander | PC | 1.0.3189 | Original, Gold Edition | | part # 109050 | |
| Supreme Commander 2 | PC | | Original | | | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| Syndicate | PC | | Original | | 1922907 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| Splash Lake | PCE | | Original | | TGXCD1025 | |
| Super Air Zonk: Rockabilly-Paradise | PCE | | Original | | TGXCD1042 | |
| SydMead's TerraForming | PCE | | Original | | TGXCD1040 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Sonic Riders | XBOX | | Original | | SE-135 | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man | XBOX | Rev 1 | Platinum Hits | | AV-006 | |
| Splashdown | XBOX | | Original | | IG-027 | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Star Wars: Episode III: Revenge of the Sith | XBOX | | Original, Platinum Hits | | LA-023 | |
| Star Wars: Jedi Knight II: Jedi Outcast | XBOX | | Original | | LA-009 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Jedi Starfighter | XBOX | | Original | | LA-005 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Knights of the Old Republic | XBOX | Rev 1 | Platinum Hits | | LA-003 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | XBOX | | Original, Platinum Hits | | LA-020 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| Star Wars: Starfighter Special Edition | XBOX | | Original, Platinum Hits | | LA-002 | |
| Star Wars: The Clone Wars + Tetris Worlds | XBOX | | Bundled with Xbox: Limited Edition Package, Promotional Offer | | XL-013 | |
| Super Monkey Ball Deluxe | XBOX | | Original | | SE-056 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| ShellShock 2: Blood Trails | XBOX360 | | Original | | SC-2021 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Ski-Doo Snowmobile Challenge | XBOX360 | | Original | | VG-2001 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Swap Force | XBOX360 | | Original | | AV-2281 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Sleeping Dogs | XBOX360 | | Original, Ultimate Action Triple Pack | | SQ-2065 | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Sonic Unleashed | XBOX360 | | Original, Platinum Hits | | SE-2066 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Street Fighter IV: The Ties That Bind (Bonus Disc) | XBOX360 | | Xbox 360 Game Bundle | | | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| The Second AMUC CD | ACD | | | | CDRM1251610 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 01) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 02) | 3DO | | Original | | | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Starblade | 3DO | | Original | | FZ-SC5351 | |
| Starblade 스타블레이드 | 3DO | | Original | | FZ-SM5351, GDT-GA221 | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Syndicate | 3DO | | Original | | | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Scooby-Doo! | IXL | 2.0.0 | Original | | R9709 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SiN Gold | MAC | | MacPlay | | | |
| SiN Gold | MAC | 1.1.1 | Original | | | |
| Space Ace CD-ROM (For Macintosh Computers) Don Bluth's Space Ace | MAC | | Original | | | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Star Trek: Elite Force II (Disc 1) | MAC | | Original | | 10440-1CDA | |
| Star Trek: Elite Force II (Disc 2) | MAC | | Original | | 10440-2CDA | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disk) | MAC | | Original | | P/N 04-17512CD2 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Wars: Dark Forces | MAC | 1.1 | Original | | 3062130 | |
| Star Wars: Dark Forces (Special Edition: 3 Playable Levels) | MAC | 1.2 | LucasArts Macintosh Archives Vol. I, The | | 8022134 | |
| Star Wars: Jedi Knight II: Jedi Outcast | MAC | 1.03 | Original | | 10200-1CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | | Original | | 11610-1DDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims: Complete Collection | MAC | 2.9.1 | Original | | 11370-1DDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 310690304-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Sudoku | GAMEWAVE | | Original | | G230 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |