Region | Title | System | Version | Edition | Languages | Serial | Status |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Gold Edition | | | |
| S³: Silent Storm: Sentinels | PC | 1.1 | Gold Edition | | | |
| The Saboteur | PC | 1.0 | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| Scarface: The World Is Yours | PC | 1.00.1 | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Shadow Man | PC | | Original | | | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | | |
| Silent Hill 4: The Room | PC | 1.0 | Original | | | |
| South Park | PC | | Original | | | |
| Space Colony | PC | | Original | | | |
| State of Emergency | PC | 1.00.0008 | Original | | | |
| Street Fighter IV | PC | 1.00.3013 | Original, Limited Edition | | | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Stronghold 2 (Disc 2) (Play) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| SWAT 4 (Disc 1) | PC | 1.0 | Original | | | |
| SWAT 4 (Disc 1) | PC | 31973 | Original | | | |
| SWAT 4: The Stetchkov Syndicate | PC | | Original | | | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 1) | PC | 1.0 | Original | | 11001-1CDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| SpellForce | PC | 1.52.64763 | Platinum Edition | | 11121-1DDA | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scrabble: Champion Edition | PC | 1.0S | Rerelease | | 11191B-CD | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Shield: The Game | PC | 1.0.0.0 | | | 11451-1DDA | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| Spore | PC | | Original | | 1535207 | |
| Spore | PC | 1.00.000 | Original | | 1535207 | |
| The Sims: Pet Stories | PC | | Original | | 1536507 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 1) | PC | 1.10.0.111 | Original, Slim Case | | 1536707 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original, Slim Case | | 1536717 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original | | 1536717 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 1) | PC | 1.13.0.135 | Original, Slim Case | | 1537107 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| SimCity Societies | PC | 1.0 | Original | | 1574507 | |
| The Sims Castaway Stories | PC | 1.0 | Original | | 1575007 | |
| The Sims 2: Kitchen & Bath Interior Design Stuff | PC | | Original | | 1578007 | |
| The Sims 2: Kitchen & Bath Interior Design Stuff | PC | 1.14.0.72 | Original | | 1578007 | |
| The Sims 2: IKEA Home Stuff | PC | 1.15.0.62 | Original | | 1578207 | |
| Spore: Creature Creator | PC | | Original | | 1586407 | |
| The Sims Carnival: BumperBlast | PC | 1.0.10 | Original | | 1586907 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe The Sims 2: Store Edition | PC | 2.0 | Rerelease | | 1597037 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | Original | | 1672907 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | | | 1672927 | |
| The Sims 2: University Life Collection | PC | 2.0 | Original | | 1685207 | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| The Sims Carnival: SnapCity | PC | 0.029 | SimCity Box | | 1907347 | |
| The Sims 2: Apartment Life (Expansion Pack) | PC | 1.16.0.179 | Original, Slim Case | | 1907807 | |
| Spore | PC | 1.0 | Galactic Edition | | 1908007 | |
| The Sims 2: Mansion & Garden Stuff | PC | 1.17.0.66 | Original | | 1918007 | |
| Syndicate | PC | | Original | | 1922907 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Katy Perry Sweet Treats | PC | | Original | | 1979807 | |
| The Sims 3: University Life (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 1980803301 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| S²: Silent Storm (Disc 1) | PC | 1.2 | Original | | 28015-CD1 | |
| SpellForce: The Order of Dawn (Disc 1) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD1 v1.0 F, 28017-SM1 v1.0 F | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization IV: Colonization | PC | 1.0.0.0 (109295) | Original | | 31491-1 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: Battlefront (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3241830 | |
| Star Wars: Republic Commando (Disc 1) (Play Disc) | PC | | Original | | 3251830 | |
| Star Wars: Republic Commando | PC | | Original | | 3258130, 3258130R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3261830 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 1.0 | Rerelease | | 3261830R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 2.00.424 | Original | | 3261830R1 v2.1.0.0 | |
| Star Wars: Battlefront II (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3281830 | |
| Star Wars: Battlefront II | PC | 1.0 | Original | | 3281930 | |
| Star Wars: Battlefront II | PC | 1.0 | DVD-ROM | | 3282030 | |
| Singularity | PC | 1.0 | Original | | 33309101US | |
| Spider-Man: Shattered Dimensions | PC | | Original | | 33355101US | |
| Skylanders: Spyro's Adventure | PC | 1.0 | Starter Pack | | 33366010US | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Original | | 3381830 | |
| Star Wars: The Force Unleashed II | PC | 1.0 | Original | | 3411830 | |
| ShellShock 2: Blood Trails | PC | 1.0 | Original | | 5000026211 | |
| Section 8 | PC | | Original | | 50027-LBL | |
| Star Wars: Episode III: Revenge of the Sith: Activity Center (Disc 1) | PC | 1.0 | Original | | 682967-CD1 | |
| Star Wars: Episode III: Revenge of the Sith: Activity Center (Disc 2) | PC | 1.0 | Original | | 682967-CD2 | |
| Silent Hunter: Wolves of the Pacific | PC | 1.2.0.0 | Original | | 683438-DVD1 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 1) | PC | 1.00.55911 | Original | | 7131830 | |
| Star Wars: Empire at War: Forces of Corruption | PC | 1.00.55911 | Original | | 7131930 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| Star Wars: The Best of PC (Star Wars: Empire at War & Star Wars: Knights of the Old Republic) | PC | 1.0 | Original | | 8101830 | |
| Star Wars: Empire at War | PC | 1.00.35517 | Demo | | 8330730 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Original, Collector's Edition | | 8541830 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Rerelease | | 8541830R | |
| Star Wars: Empire at War (Bonus Disc) | PC | | Original, Collector's Edition | | 8541832 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Original | | 9551830 | |
| Star Wars: Republic Commando | PC | 1.0 | Star Wars: Fan Favorites I | | 9982132 V1.01.0.1 | |
| Star Wars: Knights of the Old Republic | PC | 1.3.1.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982530 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | PC | 2.2.0.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982531 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| Star Defender III | PC | | Original | | CD001697 | |
| Star Wars: The Force Unleashed II | PC | 1.1 | Cosmi | | DVD248D1 v 1.1.0.1 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.0.5.0 | Rerelease | | DVD284D1, SJ102010 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Cosmi | | DVD288D1 | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| Spy Kids: Mega Mission Zone | PC | 3.6.27 | Original | | H3343 | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| ShellShock: Nam '67 | PC | 1.00 | Original | | MSHOCPUS01 | |
| Sword of the Stars | PC | 1.0.12 | Original | | P/N 21133-5 | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| Supreme Commander | PC | 1.0.3189 | Original, Gold Edition | | part # 109050 | |
| Sid Meier's Civilization III: Play the World | PC | 1.01f | Original | | Part # 24115CD | |
| Sid Meier's Pirates! (Disc 2) | PC | 1.0.0.0 (16296) | Original | | Part # 24810CD2 | |
| Shadow of Destiny | PC | 1.0 | Original | | Part Number 23420 | |
| Silent Hill 2 (Disc 1) | PC | 1.0 | Original | | Part Number 23429/23435-1 | |
| The Secrets of Atlantis (Disc 1) | PC | | Original | | PC0549CD SNY 2.0 | |
| Sherlock Holmes: Nemesis (Disc 1) | PC | 1.00.0777 | Original | | PCO589CD1, SNY 1.0 | |
| The Sting! | PC | v2.0e | Original | | ROTHESTING0004USLAB | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Silent Hill 3 (Disc 1) | PC | 1.0.0.1 | Original | | S2344310 | |
| Soldiers of Anarchy | PC | | Original | | S5280010 | |
| The Simpsons: Hit & Run (Disc 1) | PC | 1.0 | Original | | S7213210 | |
| The Spiderwick Chronicles | PC | 1.0 | Original | | S7270810 | |
| Switchball | PC | | Original | | S7275110 | |
| Street Fighter IV | PC | 1.0.0.1 | Original | | SYX26084GM | |