Region | Title | System | Version | Edition | Languages | Serial | Status |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Sanitarium (Disc 1) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | 1.00.000 | Rerelease | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | 1.00.000 | Rerelease | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | 1.0.0.744 | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | 1.0.0.744 | Original | | | |
| The Secret of Googol 1: Reshaping Googol: Submarine / Tower | PC | 2.0 | Original | | | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PC | 2.0 | Original | | | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Serious Sam: The First Encounter | PC | 1.00 | Original | | | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Serious Sam: The Second Encounter | PC | 1.05 | Original | | | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Sherlock Holmes: Consulting Detective: Vol. I Sherlock Holmes: Consulting Detective: Vol. 1 | PC | | 5 ft. 10 PAK Vol. 2 | | | |
| Sid Meier's Alpha Centauri | PC | 1.0I | CD-ROM Classics | | | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV (Disc 2) (Play) | PC | | Original | | | |
| Silent Hill 4: The Room | PC | 1.0 | Original | | | |
| SimCity 2000 SimCity 2000: The Ultimate City Simulator | PC | | Bundle Version Creative Labs OEM | | | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| Spaguetti Party: La Familia Pomodoro | PC | | Covermount | | | |
| Spec Ops: Platinum Collection (Disc 2) | PC | 1.0 | Original | | | |
| Special Forces: Nemesis Strike (Disc 3) | PC | 1.0 | Original | | | |
| Spider-Man: Web of Shadows (Final Press Kit) | PC | | Press Kit | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| Spirit: Stallion of the Cimarron: Forever Free | PC | | Original | | | |
| Square Enix E3 2005 Media CD | PC | | Press Kit | | | |
| Star Trek Omnipedia | PC | | Original | | | |
| Star Trek: Klingon (Disc 1) (Installation) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Star Trek: Klingon (Disc 2) Star Trek: Klingon: The Ultimate Interactive Adventure | PC | | Original | | | |
| Starship Titanic (Disc 1) Douglas Adams: Starship Titanic | PC | 1.00.42b | Rerelease | | | |
| Super GameHouse Collection Super Collapse! / Super Glinx! / Super Nisqually | PC | | MacPlay | | | |
| Super Games for Windows: Volume II | PC | | Original | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| SuperBikes Racing SuperMoto Racing | PC | | Original, Covermount | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Smashing Reversi Reversi | PC | | Pocketware | | #11 | |
| Sid Meier's Civilization II | PC | 1.0 | Original | | 0-492-47-101 | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | 0-529-47-101 | |
| SimCity Classic | PC | 2.0 | Deluxe Edition | | 0002-000-0601B | |
| SimCity Classic | PC | 1.1 (Windows), 1.4 (Mac) | Scholastic | | 0002-000-0612-A | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Original, Maxis Collector's Series | | 0003-000-0612-A | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.00 | Windows 95 | | 0026-000-0601-A | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| SimTown | PC | 1.0 | Original | | 0037-000-0601-B | |
| SimTower SimTower: The Vertical Empire | PC | 1.0 | Original | | 0051-040-0601-A | |
| SimCity 2000 | PC | 1.2 | Bundle Version Diamond OEM | | 0059-031-0601-A | |
| SimCopter | PC | 1.0 | Original | | 0077-000-0601-A | |
| SimCopter SimCopter: Fly Missions in the Metropolis | PC | 1.01 | Original | | 0077-000-0601-B | |
| Scholastic's The Magic School Bus Explores Bugs | PC | 1.0.0.1 | Original, The Magic School Bus: Bonus Pack | | 0100 Part No. X05-52861, 1001 Part No. X08-51053 | |
| SimCity 2000 Special Edition | PC | | Original | | 0126-000-0601-A | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| SimCity 2000 Network Edition | PC | 1.0.42.0 | Original | | 0130-000-0601-A | |
| Solitaire Master 2 | PC | 2.1 | Original | | 02-6306-10 | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67023 | |
| Scholastic's The Magic School Bus: Whales & Dolphins: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3, The Magic School Bus: Bonus Pack | | 0201 Part No. X06-15571 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Scholastic's The Magic School Bus Explores the Human Body | PC | 1.1.0.2 | Original | | 0396 Part No. 90612, Disc Assy. 299-056-002 | |
| Scholastic's The Magic School Bus Explores the Solar System | PC | 1.00.0000 | Original | | 0396 Part No. 90618, 1001 Part No. X08-51174, Disc Assy. 296-052-002 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original, The Magic School Bus: Bonus Pack | | 0396 Part No. 90626, Disc Assy. 451-052-012 | |
| Star Command Revolution | PC | 1.0 | Original | | 04-12257CD | |
| Snowmobile Racing | PC | | Original | | 04-17527CD | |
| Submarine Titans | PC | 1.0 | Original | | 04-21473CDA | |
| Survivor: The Interactive Game | PC | 1.0.0.17 | Original | | 04-22709CDSL | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| Scholastic's The Magic School Bus Explores in the Age of Dinosaurs | PC | 1.0.0.0 | Scholastic | | 0796 Part No. 91354 | |
| Scholastic's The Magic School Bus Explores the Rainforest | PC | 1.0 | Original | | 1001 Part No. X08-50154, CD SET 420-056-001 | |
| Strike Commander / Wing Commander: Privateer | PC | | Special CD-ROM Edition | | 1009121 | |
| Sid Meier's Gettysburg! | PC | 1.0 | Original | | 1015007 | |
| SimCity 2000 Special Edition | PC | | CD-ROM Classics, Scholastic | | 10365, 1131107, 5710243CSP1, DP10 | |
| Streets of SimCity | PC | 1.0 | Original | | 1040207 | |
| Sid Meier's Alpha Centauri | PC | 1.0I | Original | | 105907 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 1) | PC | 1.0 | Original | | 11001-1CDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 2) | PC | 1.0 | Original | | 11001-2CDA | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 3) | PC | 1.0 | Original | | 11001-3CDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| SimIsle: Missions in the Rainforest | PC | 1.034 | CD-ROM Classics, 10 Sims for $20 | | 1102017 | |
| SimAnt SimAnt: The Electronic Ant Colony | PC | | CD-ROM Classics, 10 Sims for $20 | | 1111407 | |
| SimEarth | PC | | Dual Jewel, 10 Sims for $20 | | 1111507 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Rerelease, 10 Sims for $20 | | 11116, 1162207 | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic | | 1111707, 7845126C SP1 | |
| SimLife SimLife: The Genetic Playground | PC | | Scholastic Clubs and Fairs | | 1111707, P1 | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| SimCopter SimCopter: Fly Missions in the Metropolis | PC | 1.02 | CD-ROM Classics, 10 Sims for $20 | | 1119307, 1119317, 1641567 | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| SimTown | PC | 1.00 | Rerelease | | 1126107 | |
| SimPark | PC | 1.1 | Rerelease, Scholastic | | 1126207, 5710372C SP1 | |
| Streets of SimCity | PC | 1.0 | CD-ROM Classics, 10 Sims for $20 | | 1127517 | |
| SimTunes | PC | 1.2nre | Kids Classics | | 1128707 | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| SimCity Classic | PC | | CD-ROM Classics, 10 Sims for $20, Sim Mania Pack | | 1162907 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | PC | 0.0.0.0 | Original | | 12241-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| SimTheme Park (Bonus Rides and Attractions) Sim Theme Park | PC | | Gold Edition, Sim Mania 2 | | 1229817, 1403347, 1641527 | |
| SimTheme Park Sim Theme Park | PC | | Sim Mania 2, The Kids Collection | | 1229827, 1641517 | |
| SimCity 3000 | PC | 1.0.557.0 | Rerelease | | 1230007, 1500127 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection, Rerelease | | 1242617, 1246307 | |
| Sid Meier's SimGolf | PC | 1.0 | Sim Mania 2 | | 1277387 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition, Scholastic | | 1403357 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| SimCoaster | PC | | Original | | 1425707 | |
| The Sims: House Party (Expansion Pack) | PC | 1.0 | Original | | 1431307, 1431317 | |
| Sid Meier's SimGolf | PC | 1.01 | Rerelease | | 1434917 | |
| The Sims Online (Disc 1) | PC | 1.0 | Original | | 1436707 | |
| The Sims Online (Disc 2) | PC | 1.0 | Original | | 1436717 | |
| The Sims: Hot Date (Expansion Pack) | PC | 1.1 | Original, Expansion Collection Volume Two, Mega Deluxe | | 1439827 | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe, Expansion Collection Volume One, Mega Deluxe | | 1446107 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| The Sims: Vacation (Expansion Pack) | PC | | Original | | 1448807 | |
| The Sims: Vacation (Expansion Pack) | PC | | Expansion Collection Volume Three | | 1448807 | |
| SimCity 4 (Disc 1) | PC | 1.0 | Original | | 1457307 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Original | | 1457317 | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457647 | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457657 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1459507 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume One | | 1459507 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | 1.0 | Original | | 1459517 | |
| The Sims: Unleashed (Expansion Pack) (Disc 2) | PC | 1.0 | Original, Expansion Collection Volume One | | 1459517 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | | | | 1462607 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume Three | | 1462607 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | | | | 1462617 | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | PC | 1.0 | Original, Expansion Collection Volume Three | | 1462617 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | | Expansion Collection Volume Two | | 1472007 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1472007 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Expansion Collection Volume Two | | 1472017 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 2) | PC | | Original | | 1472017 | |
| The Sims 2: Sneak Preview CD | PC | | Original | | 1472027 | |
| The Sims 2 (Disc 3) | PC | 1.0.0.1022 | Rerelease | | 1472606, 1472646, 1472686, 1527627 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.932 | Original | | 1472607, 1472610 | |
| The Sims 2 (Disc 2) | PC | 1.0.0.932 | Original | | 1472610, 1472617 | |
| The Sims 2 (Disc 4) | PC | 1.0.0.1022 | Rerelease | | 1472616, 1472656, 1472696, 1527637 | |
| The Sims 2 (Disc 2) | PC | 1.0 | Original | | 1472617 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.1022 | Rerelease | | 1472626, 1472666, 1472687 | |
| The Sims 2 (Disc 3) | PC | 1.0 | Original | | 1472627 | |
| The Sims 2 (Disc 2) | PC | 1.0.0.1022 | Rerelease | | 1472636, 1472676, 1472697, 1527617 | |
| The Sims 2 (Disc 4) | PC | 1.0.0.932 | Original | | 1472637 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.610.0 | Original | | 1474007 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.1.610.0 | Original | | 1474017 | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims 2 (Game Disk) | PC | 1.0.0.932 | Special DVD Edition | | 1488307 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | Original | | 1491707 | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | 1.1.0.230 | Original | | 1491717 | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | 1.1.0.230 | Original | | 1491717 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.286 | Rerelease | | 1491727 | |
| The Sims 2: University (Expansion Pack) (Disc 2) | PC | 1.1.0.286 | Rerelease | | 1491737 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.312 | Original | | 1497007 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | 1.2.0.312 | Original | | 1497017 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.377 | Rerelease | | 1497027 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 2) | PC | 1.2.0.377 | Rerelease | | 1497037 | |
| SimCity 3000 | PC | 1.0.557.0 | Original | | 1500107 | |
| The Sims | PC | 1.0 | Original | | 1500807 | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Scholastic | | 1500907 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Original | | 1500907 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: Glamour Life Stuff | PC | 1.5.0.121 | Original | | 1520807 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | Original | | 1526317 | |
| The Sims 2: Pets (Expansion Pack) (Disc 2) | PC | 1.6.0.259 | | | 1526317 | |
| The Sims Life Stories | PC | 1.0.22.17622 | Original | | 1528207 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 1) | PC | 1.10.0.111 | Original, Slim Case | | 1536707 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original, Slim Case | | 1536717 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 1) | PC | 1.13.0.135 | Original, Slim Case | | 1537107 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 2) | PC | 1.13.0.135 | Original, Slim Case | | 1537117 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| The Sims 3 | PC | 1.0.631.00001, 0.0.0.11195 | Original, The Sims 3: Deluxe | | 1539007 | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| The Sims 2: Seasons (Expansion Pack) (Disc 1) | PC | 1.7.0.145 | Original, Slim Case | | 1562107 | |
| The Sims 2: Seasons (Expansion Pack) (Disc 2) | PC | 1.7.0.145 | Original, Slim Case | | 1562117 | |
| SimCity Societies | PC | 1.0 | Original | | 1574507 | |
| The Sims 2: IKEA Home Stuff | PC | 1.15.0.62 | Original | | 1578207 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | | | 1672927 | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.610.0 | SimCity Box | | 1907317 | |
| The Sims Carnival: SnapCity | PC | 0.029 | SimCity Box | | 1907347 | |
| The Sims 2: Apartment Life (Expansion Pack) | PC | 1.16.0.179 | Original, Slim Case | | 1907807 | |
| The Sims 3: Late Night (Expansion Pack) | PC | 0.2.0.125 | Original, The Sims 3 Starter Pack | | 1915003301 | |
| The Sims 2: Mansion & Garden Stuff | PC | 1.17.0.66 | Original | | 1918007 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| SimCity | PC | 1.0 | Original, Limited Edition | | 1971403401 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Rerelease | | 2054130 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | | Original | | 2061830 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | 1.0A | Collector Series, Rerelease | | 2064130, 8051832 | |
| The Secret of Monkey Island | PC | 2.3 | Original, Bundle Version OEM | | 2147010-590001 / I 042 | |
| Sid Meier's Civilization IV (Disc 3 & Manual) | PC | 1.61 | Game of the Year Edition | | 21712-1.3D | |
| Sid Meier's Civilization IV: Warlords | PC | 2.0 | Original | | 21966-1 | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | 1.08 | Rerelease | | 3091830 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | 1.0 | Original | | 3091830, CDRM1361630 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | 1.08 | Rerelease | | 3091831 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | 1.0 | Original | | 3091831, CDRM1361640 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 2) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.7 | |
| Star Trek: Bridge Commander | PC | 1.0 | Original | | 31127.101.US | |
| Spider-Man | PC | | Original | | 31131.101.US | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 1) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.1 | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 2) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.2 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 1) | PC | 1.7.4.0 | Original | | 31183-1.1 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 2) | PC | 1.7.4.0 | Original | | 31183-1.2 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 3) | PC | 1.7.4.0 | Original | | 31183-1.3 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | 3121830 | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization IV: Colonization | PC | 1.0.0.0 (109295) | Original | | 31491-1 | |
| Sid Meier's Civilization IV: The Complete Edition | PC | 1.0.0.0 (109295) FINAL RELEASE | Original | | 31571-1 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Star Wars Galaxies: An Empire Divided (Disc 1) | PC | 1.00 | Collector's Edition | | 3181830 | |
| Star Wars Galaxies: An Empire Divided (Disc 2) | PC | 1.00 | Collector's Edition | | 3181831 | |
| Star Wars Galaxies: An Empire Divided (Disc 3) | PC | 1.00 | Collector's Edition | | 3181832 | |
| Spider-Man (Disc 1) | PC | 1.0 | Original | | 32249.101.US | |
| Spider-Man (Disc 2) | PC | 1.0 | Original | | 32249.102.US | |
| Star Wars: Republic Commando (Disc 1) (Play Disc) | PC | | Original | | 3251830 | |
| Star Wars: Republic Commando (Disc 2) | PC | | Original | | 3251831 | |
| Spider-Man 2: The Game | PC | 1.0 | Original | | 32581.101.US | |
| Star Wars: Republic Commando | PC | | Original | | 3258130, 3258130R | |
| Spider-Man: Web of Shadows | PC | 1.0 | Original | | 33211.101.EF, 33211.101.US | |
| Strange Cases: The Tarot Card Mystery / Strange Cases: The Lighthouse Mystery | PC | | The Best of Big Fish Games | | 33364101US | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | 1.0 | Original, Scholastic | | 381681-CD, 381681-CD SP1 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.003 | Original | | 51019 | |
| Samba de Amigo | DC | 1.001 | Original | | 51092 | |
| SimEarth | PC | | Scholastic | | 5675434C, DP19 | |
| Silent Hunter II Silent Hunter II: WWII U-Boat Combat Simulator | PC | 1.00.06 | Original | | 610465-CD | |
| Star Wars: Screen Entertainment | PC | | Original, The LucasArts Archives Vol. I | | 633630 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Original | | 635930 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Dark Forces II: Ambush at Altyr 5 | PC | 1.0 | Demo: Bundle Version OEM | | 647030, CD-C95-990-E | |
| Star Wars: Rogue Squadron 3D: Elite Missions | PC | 1.0 | Bundle Version OEM | | 6528030, CD-C951912-LOE | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | Original | | 7101830 | |
| Star Wars: Galactic Battlegrounds: Clone Campaigns | PC | 1.0 | Original | | 7111830 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 1) | PC | 1.00.55911 | Original | | 7131830 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 2) | PC | 1.00.55911 | Original | | 7131831 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | 1.0 | Bundle Version Diamond OEM | | 75000204-100 | |
| Sid Meier's Civilization IV (Disc 1) | PC | 1.61 | Game of the Year Edition | | 77875-1.1REA | |
| Sid Meier's Civilization IV (Disc 2) | PC | 1.61 | Game of the Year Edition | | 77875-1.2REA | |
| Sega Rally Championship | SS | 1.006 | Original, Sega Saturn NetLink Bundle | | 80012, 81207 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031832 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031834 | |
| Star Wars: Making Magic | PC | QA1.03 | Star Wars Masterpieces | | 8031835 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031836 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051831 | |
| Star Wars: X-Wing: Collector's CD-ROM / Star Wars: X-Wing vs. TIE Fighter: Flight School | PC | | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061830 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | 1.0.0.1 | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061831 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | Demo (LucasArts Archives Vol. IV, The: Star Wars Collection II) | | 8061833 | |
| Star Wars: Yoda Stories / Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0.0.1 | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061834 | |
| Sega Saturn Bootleg II: On the Road Sega Screams Volume 1 | SS | 1.002 | Not for Resale | | 81068, 81075 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Sega Touring Car Championship | SS | 1.001 | Original, Sample | | 81216 | |
| Star Wars: Fall Force Gaming Preview Best Buy Preview CD | PC | 1.0 | | | 8330330 | |
| Star Wars: Empire at War | PC | 1.00.35517 | Demo | | 8330730 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Original, Collector's Edition | | 8541830 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Rerelease | | 8541830R | |
| Star Wars: Empire at War (Disc 2) | PC | 1.00.36493 | Original, Collector's Edition | | 8541831 | |
| Star Wars: Empire at War (Disc 2) | PC | 1.00.36493 | Rerelease | | 8541831R | |
| Slam Tilt Pinball | PC | 1.0 | Expert Software | | 8694 01 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Original | | 9551830 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0.1 | Rerelease | | 9551830R1 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0 | Original | | 9551831 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0.1 | Rerelease | | 9551831R, 9551831R1 | |
| Sin Episodes: Emergence SiN Episodes: Emergence | PC | | Original | | 984707 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Stubbs the Zombie in Rebel Without a Pulse | XBOX | | Original | | AY-002 | |
| Sports Champions / Medieval Moves: Deadmund's Quest Combo Disc | PS3 | 01.00 | Not for Resale | | BCUS-90490 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Bundled with Bluetooth Headset | | BCUS-98152 | |
| Sports Champions | PS3 | 01.01 | Bundled with PlayStation Move | | BCUS-98177 | |
| Sports Champions | PS3 | 01.01 | Original, Bundled with PlayStation Move | | BCUS-98177 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Original | | BCUS-98183 | |
| Sly Cooper: Thieves in Time | PS3 | 01.02 | Original | | BCUS-98247 | |
| Sports Champions 2 | PS3 | 01.00 | Original | | BCUS-98278 | |
| Sid Meier's Civilization III | PC | 1.07f | Small Box Release | | BIPCIV3CDRV1 | |
| Spider-Man: Web of Shadows 스파이더 맨: 웹 오브 쉐도우 | PS3 | 01.00 | Original | | BLKS 20086 … | |
| Stuntman: Ignition | PS3 | 01.02 | Original | | BLUS-30073 | |
| Sid Meier's Civilization Revolution | PS3 | 01.01 | Original | | BLUS-30130 | |
| Silent Hill: Homecoming | PS3 | 01.00 | Original | | BLUS-30169 | |
| Score International Baja 1000: The Official Game | PS3 | 01.00 | Original | | BLUS-30230 | |
| SBK: Superbike World Championship | PS3 | 01.01 | Original | | BLUS-30236 | |
| Ski-Doo Snowmobile Challenge | PS3 | 01.04 | Original | | BLUS-30272 | |
| Stormrise | PS3 | 01.00 | Original | | BLUS-30328 | |
| Spider-Man: Shattered Dimensions | PS3 | 01.01 | Original | | BLUS-30499 | |
| SBK 09: Superbike World Championship SBK: Superbike World Championship | PS3 | 01.01 | Original | | BLUS-30519 | |
| The Sims 3 | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30609 … | |
| SBK X: Superbike World Championship | PS3 | 01.00 | Original | | BLUS-30683 | |
| Spider-Man: Edge of Time | PS3 | 01.00 | Original | | BLUS-30760 | |
| Sonic & All-Stars Racing Transformed | PS3 | 01.01 | Bonus Edition | | BLUS-30839 | |
| Sherlock Holmes: Crimes & Punishments | PS3 | 01.01 | Original | | BLUS-31412 | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | CD 7011 SPI | |
| Star Trek: Starfleet Academy: Strategic Command (Disc 1) | PC | 1.0 | Original | | CD-C95-1044-0 | |
| Star Trek: Starfleet Academy: Strategic Command (Disc 2) | PC | 1.0 | Original | | CD-C95-1044-1 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Interplay Rerelease | | CD-C95-1141-0 | |
| Star Trek: Starfleet Command II: Empires at War (Disc 1) | PC | 1.0.0.2 | Original | | CD-C95-1185-0 | |
| Star Trek: Starfleet Command II: Empires at War (Disc 2) | PC | 1.0.0.2 | Original | | CD-C95-1185-1 | |
| Star Trek: Starfleet Command: Orion Pirates | PC | 2.5.0.0 | Original | | CD-C95-1290-0 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Dual Jewel | | CD-C95-1298-0 | |
| Star Trek: Klingon Academy | PC | 1.0 | Interactive Demo | | CD-C95-856-D1 | |
| Star Trek: Starfleet Academy: Cadet Briefing | PC | 0.99 | Star Trek: Federation Compilation | | CD-C95-893-0 | |
| Star Trek: Judgment Rites | PC | | Star Trek: Federation Compilation | | CD-C95-893-1 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Star Trek: Federation Compilation | | CD-C95-893-2 | |
| Star Trek: Judgment Rites | PC | | Original, Limited CD-ROM Collector's Edition | | CD-ICD-200-0, CD-ICD-728-2 | |
| Star Trek: Judgment Rites (Collector's Disc) | PC | | Limited CD-ROM Collector's Edition | | CD-ICD-200-1 | |
| Sid Meier's Civilization III: Conquests | PC | 1.0 | Original, Scholastic | | CDR9704405 | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Syberia | PC | SSV1.0 | Demo | | DEM379CD | |
| Sonic Gems Collection | GC | | Original, Player's Choice | | DL-DOL-G2XE-USA | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| Super Mario Strikers | GC | | Original, Best Seller | | DL-DOL-G4QE-USA | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2E-USA | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSE-USA | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Spider-Man | GC | | Original | | DL-DOL-GSME-USA | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUE-USA | |
| Sphinx and the Cursed Mummy | GC | | Original | | DL-DOL-GXPE-USA | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Original | | GAG744AE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Original | | GAG744AE-CD | |
| Spy Kids: Mega Mission Zone | PC | 3.6.27 | Original | | H3343 | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| Str.at.e.s. 2: Matchamania! | PSX | | Original | | LSP-030102 … | |
| Str.at.e.s. 4: Titlerama! | PSX | | Original | | LSP-030104 … | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744BE-CD | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sneak King | XBOX | | Original | | MS-211 | |
| Startopia | PC | 1.00 | Original | | MSTARPUS01 | |
| Soulcalibur II | XBOX | | Original, Platinum Hits | | NM-003 | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Sporting Clays: Interactive Shooting Simulation | PC | 1.0 | Original | | P/N 7407 | |
| Sid Meier's Civilization III: Play the World | PC | 1.01f | Original | | Part # 24115CD | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition | | Part # 24356CD1 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Pirates! (Disc 1) | PC | 1.0.0.0 (16296) | Original | | Part # 24810CD1 | |
| Sid Meier's Pirates! (Disc 2) | PC | 1.0.0.0 (16296) | Original | | Part # 24810CD2 | |
| Spy Fox 2: "Some Assembly Required" | PC | 1.0.0.1 | Original | | Part No. 04-17571CD | |
| Spy Fox in "Hold the Mustard" | PC | 1.0 | Original | | Part No. 04-17574CD | |
| Shadow of Destiny | PC | 1.0 | Original | | Part Number 23420 | |
| Silent Hill 2 (Disc 1) | PC | 1.0 | Original | | Part Number 23429/23435-1 | |
| Silent Hill 2 (Disc 2) | PC | 1.0 | Original | | Part Number 23429/23435-2 | |
| Silent Hill 2 (Disc 3) | PC | 1.0 | Original | | Part Number 23429/23435-3 | |
| Sid Meier's Civilization II | PC | 2.42a | Hasbro Rerelease | | Product # 99227 | |
| Stuart Little: Big City Adventures Stuart Little: Big City Adventures CD-ROM Game | PC | | Original | | Product # 99716 | |
| Strike Commander | PC | | Original | | RVL 13-004-0046 | |
| Sin & Punishment: Star Successor | WII | | Original | | RVL-R2VE-USA-B0 | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Speed Racer: The Videogame | WII | | Original | | RVL-R3PE-USA | |
| Spider-Man: Web of Shadows | WII | | Original | | RVL-R3SE-USA | |
| The Sims 2: Castaway | WII | | Original | | RVL-R42E-USA | |
| SimAnimals | WII | | Original | | RVL-R4AE-USA | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PE-USA | |
| Super Paper Mario | WII | | Original | | RVL-R8PE-USA | |
| Super Paper Mario | WII | Rev 1 | Original | | RVL-R8PE-USA | |
| Super Paper Mario | WII | Rev 2 | Original, Nintendo Selects | | RVL-R8PE-USA, RVL-R8PE-USA-B0 | |
| Super Mario Galaxy | WII | | Original, Nintendo Selects | | RVL-RMGE-USA, RVL-RMGE-USA-B0 | |
| Smarty Pants: Trivia Fun for Everyone! | WII | | Original | | RVL-RP2E-USA | |
| Spider-Man 3 | WII | | Original | | RVL-RS3E-USA | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Super Monkey Ball: Banana Blitz | WII | | Original | | RVL-RSME-USA | |
| The Simpsons Game | WII | | Original | | RVL-RSNE-USA | |
| Solitaire & Mahjong | WII | | Original | | RVL-RSOE-USA-B0 | |
| Showtime Championship Boxing | WII | | Original | | RVL-RSYE-USA | |
| Summer Athletics: The Ultimate Challenge | WII | | Original | | RVL-RU3E-USA, RVL-RU3E-USA-B0 | |
| The Sims 3 | WII | | Original | | RVL-S3ME-USA-B0 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Super Mario Galaxy 2 | WII | | Original, Nintendo Selects | | RVL-SB4E-USA-B0 | |
| Spider-Man: Shattered Dimensions | WII | | Original | | RVL-SPDE-USA-B0 | |
| Spider-Man: Edge of Time | WII | | Original | | RVL-SQME-USA-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS3E-USA-B0 | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Bundled with Wii Remote Cover | | RVL-SS4E-USA-B0 | |
| Super Mario All-Stars | WII | | Original, Nintendo Selects | | RVL-SVME-USA-B0 | |
| The Simpsons: Hit & Run (Disc 1) | PC | 1.0 | Original | | S7213210 | |
| The Simpsons: Hit & Run (Disc 2) | PC | 1.0 | Original | | S7213220 | |
| The Simpsons: Hit & Run (Disc 3) | PC | 1.0 | Original | | S7213230 | |
| Spyro 2: Ripto's Rage! / Crash Team Racing | PSX | | Demo | | SCUS 94632 | |
| Syphon Filter: The Omega Strain | PS2 | 1.00 | Original | | SCUS 97264 | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.02 | Original, Greatest Hits | | SCUS 97275 … | |
| SOCOM II: U.S. Navy SEALs | PS2 | 1.00 | Beta | | SCUS 97366 | |
| Syphon Filter: The Omega Strain | PS2 | 2.00 | Demo | | SCUS 97377 | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97464 | |
| SOCOM: U.S. Navy SEALs: Combined Assault | PS2 | 1.00 | Original, Greatest Hits | | SCUS 97545 | |
| SOCOM: U.S. Navy SEALs: Combined Assault | PS2 | 1.00 | Demo | | SCUS 97560 | |
| Syphon Filter: Dark Mirror | PS2 | 1.00 | Demo | | SCUS 97620 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Slim Jim | PSX | | | | SCUS-94472 | |
| Syphon Filter: Dark Mirror | PS2 | 1.01 | Original | | SCUS-97362 | |
| Sly 3: Honor Among Thieves | PS2 | 1.00 | Demo | | SCUS-97527 | |
| Sonic Adventure: Limited Edition | DC | 1.002 | Limited Edition, Hollywood Video Rental | | SDC-51014 | |
| Star Wars: Super Bombad Racing | PS2 | 1.03 | Original | | SLUS 20043 | |
| The Simpsons: Road Rage | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20305 … | |
| Spider-Man | PS2 | 2.01 | Greatest Hits | | SLUS 20336 … | |
| SWAT: Global Strike Team | PS2 | 1.00 | Original | | SLUS 20433 | |
| Star Ocean: Till the End of Time (Disc 1) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20488 … | |
| The Simpsons: Hit & Run | PS2 | 1.01 | Original | | SLUS 20624 … | |
| Spider-Man 2 | PS2 | 1.01 | Original, Greatest Hits | | SLUS 20776 … | |
| The Sims: Bustin' Out | PS2 | 1.00 | Original | | SLUS 20842 | |
| Silent Hill 4: The Room | PS2 | 1.00 | Original | | SLUS 20873 … | |
| Samurai Warriors | PS2 | 1.00 | Original | | SLUS 20878 | |
| Star Ocean: Till the End of Time (Disc 2) | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20891 … | |
| Shin Megami Tensei: Nocturne | PS2 | 1.01 | Original | | SLUS 20911 | |
| Sonic Mega Collection Plus | PS2 | 1.00 | Original, Greatest Hits | | SLUS 20917 … | |
| Smash Court Tennis: Pro Tournament 2 | PS2 | 1.00 | Original | | SLUS 20933 | |
| Shin Megami Tensei: Digital Devil Saga | PS2 | 1.00 | Original | | SLUS 20974 | |
| Shonen Jump's One Piece: Grand Battle | PS2 | 1.00 | Original | | SLUS 20975 | |
| The Shield: The Game | PS2 | 1.01 | Original | | SLUS 21040 | |
| SnoCross 2 featuring Blair Morgan | PS2 | 1.04 | Original | | SLUS 21130 | |
| Shin Megami Tensei: Digital Devil Saga 2 | PS2 | 1.00 | Original | | SLUS 21152 | |
| Samurai Western | PS2 | 1.01 | Original | | SLUS 21187 | |