Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sacred (Disc 1) | PC | 1.2.0.10 | Original | | 28302-CD1 v1.0 | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samurai Shodown Anthology | PSP | 1.02 | Original | | ULUS 10401 … | |
| Scholastic's The Magic School Bus Explores in the Age of Dinosaurs | PC | 1.0.0.0 | Scholastic | | 0796 Part No. 91354 | |
| Schoolhouse Rock! Math Rock | PC | | Original | | 21010CD | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | 1.0 | Original, Scholastic | | 381681-CD, 381681-CD SP1 | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Scrabble | PC | | General Mills | | AM0703R72 | |
| Scrabble Complete | PC | | Original, Bundle Version Microgistix OEM | | 11290-CD, Part # 23970CD | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Seek & Find Adventures | PC | | Original | | | |
| Seek & Find Adventures 5 Pack | PC | | Original | | | |
| Seek and Destroy Seek & Destroy | PC | | Original | | EPSAD01 | |
| Sega Classics Arcade Collection | MCD | 1.00 | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sega Classics Arcade Collection | MCD | 1.01 | Bundled with Sega CD (Ecco the Dolphin / Sega Classics Arcade Collection Bundle) | | 4126 | |
| Sega Classics Collection | PS2 | 1.01 | Original | | SLUS 21009 | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega E3 2002 Art Disc | PC | | Press Kit | | | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega Saturn Bootleg II: On the Road Sega Screams Volume 1 | SS | 1.002 | Not for Resale | | 81068, 81075 | |
| Sega Saturn Choice Cuts | SS | 1.000 | Bundled with Sega Saturn | | 81600 | |
| Sega Smash Pack 2 | PC | | Original, Sonic Action 4 Pack | | 30107.101.US | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Smash Pack: Volume 1 | DC | 1.002 | Original, Bundled with DC | | 51146 | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Septerra Core: Legacy of the Creator | PC | 1.00 | Original | | CD-W58-1103-0 | |
| Serious Sam: The First Encounter | PC | 1.02 | Bundle Version Gainward OEM | | | |
| Sesame Street: Let's Make a Word! | PC | | Original, Software for the fun of it | | KES006 | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| Shadow Madness | PSX | | Demo | | SLUS-90031 | |
| Shadow of Destiny | PC | 1.0 | Original | | Part Number 23420 | |
| Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Original, East Meets West | | 04-12539CD | |
| Shadowrun Chronicles: Boston Lockdown | PC | 12.0.10093 | Cosmi | | DVDC6251 | |
| Shamrock Spring '97 Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shamrock's Fall '97 CD-ROM | PC | | | | | |
| Shattered Suns | PC | 1.0 | Original | | Part # CCS00003-1 | |
| Shaun White Snowboarding | PS3 | 01.01 | Original | | BLUS-30223 | |
| Sherlock Holmes and the Hound of the Baskervilles | PC | | Collector's Edition | | 33369101US | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Shivers | PC | 1.02 | Rerelease | | | |
| Shogo: Mobile Armor Division | PC | 2.2 | Interplay Rerelease | | CD-C95-1141-0 | |
| Shopmania | PC | | Original | | P/N 61227-CD | |
| Sid Meier's Alpha Centauri | PC | 1.0I | Original | | 105907 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Sid Meier's Civilization II | PC | 2.42a | Hasbro Rerelease | | Product # 99227 | |
| Sid Meier's Civilization III (Bonus CD) | PC | | Game of the Year Edition | | Part # 24356CD2 | |
| Sid Meier's Civilization III: Conquests | PC | 1.0 | Original, Scholastic | | CDR9704405 | |
| Sid Meier's Civilization III: Play the World | PC | 1.01f | Original | | Part # 24115CD | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization IV (Disc 3 & Manual) | PC | 1.61 | Game of the Year Edition | | 21712-1.3D | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 1) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.1 | |
| Sid Meier's Civilization IV: The Complete Edition | PC | 1.0.0.0 (109295) FINAL RELEASE | Original | | 31571-1 | |
| Sid Meier's Civilization IV: Warlords | PC | 2.0 | Original | | 21966-1 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Gettysburg! | PC | | CD-ROM Classics | | 1187707 | |
| Sid Meier's Gettysburg! | PC | 1.0 | Original | | 1015007 | |
| Silent Hunter III | PC | 1.4 | Encore | | | |
| Silent Steel | PC | 1.24.18.121 | Bundle Version Packard Bell OEM: Demo | | 170308 | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.01 | Rerelease | | | |
| SimAnt | PC | 2.0 | Classics, Maxis Collector's Series | | 0014-000-0612-A | |
| SimCity 2000 Network Edition | PC | 1.0.42.0 | Original | | 0130-000-0601-A | |
| SimCity 2000 Special Edition | PC | | CD-ROM Classics, Scholastic | | 10365, 1131107, 5710243CSP1, DP10 | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 2000: CD Collection | PC | 1.00 | Windows 95 | | 0026-000-0601-A | |
| SimCity 3000 | PC | 1.0.557.0 | Original | | 1500107 | |
| SimCity 3000 | PC | 1.0.557.0 | Rerelease | | 1230007, 1500127 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Original | | 1500907 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.610.0 | Original | | 1474007 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.1.610.0 | SimCity Box | | 1907317 | |
| SimCity Classic | PC | | CD-ROM Classics, 10 Sims for $20, Sim Mania Pack | | 1162907 | |
| SimCity Classic | PC | 2.0 | Deluxe Edition | | 0002-000-0601B | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection, Rerelease | | 1242617, 1246307 | |
| SimCopter | PC | 1.0 | Original | | 0077-000-0601-A | |
| SimCopter SimCopter: Fly Missions in the Metropolis | PC | 1.01 | Original | | 0077-000-0601-B | |
| SimCopter SimCopter: Fly Missions in the Metropolis | PC | 1.02 | CD-ROM Classics, 10 Sims for $20 | | 1119307, 1119317, 1641567 | |
| SimFarm SimFarm: SimCity's Country Cousin | PC | | Original, Maxis Collector's Series | | 0003-000-0612-A | |
| SimPark | PC | 1.1 | Rerelease, Scholastic | | 1126207, 5710372C SP1 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.932 | Original | | 1472607, 1472610 | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| The Sims Carnival: SnapCity | PC | 0.029 | SimCity Box | | 1907347 | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims | PC | 1.0 | Original | | 1500807 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457647 | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457657 | |
| The Sims: Double Deluxe (Bonus CD) | PC | | Double Deluxe, Mega Deluxe | | 1474107 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| SimTower SimTower: The Vertical Empire | PC | 1.0 | Original | | 0051-040-0601-A | |
| SimTown | PC | 1.00 | Rerelease | | 1126107 | |
| SimTunes | PC | 1.2nre | Kids Classics | | 1128707 | |
| Sin SiN | PC | 1.00 | Original | | 1000076.101.US | |
| Sin Episodes: Emergence SiN Episodes: Emergence | PC | | Original | | 984707 | |
| Slim Jim | PSX | | | | SCUS-94472 | |
| The Sly Collection | PS3 | 01.00 | Original | | BCUS-98246 | |
| Snapshot Adventures: Secret of Bird Island | PC | | Original | | P/N 61191-CD | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Bundled with Bluetooth Headset | | BCUS-98152 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Original | | BCUS-98183 | |
| SODA Off-Road Racing | PC | | All American Sports Series | | | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| The Software Toolworks CD Deluxe Pack 4 | PC | | Bundle Version OEM | | 2192610-590001/1034100, CDRM1170920 | |
| Soldier of Fortune | PC | 1.04 | Linux | | | |
| Soldier of Fortune | PC | 1.06 | Gold Edition | | 30173.101.US | |
| Soldier of Fortune | PC | 1.07f | Platinum Edition (Rerelease) | | 31761.101.US | |
| Soldier of Fortune II: Double Helix (Disc 1) | PC | | Original | | 31147.101.US | |
| Sonic & Knuckles Collection | PC | | Original, Jack in the Box | | 85037 | |
| Sonic & Knuckles Collection | PC | 1.0 | Expert Software, Sonic Action 4 Pack | | 6820 01, T-6820-02 | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | 1.0.0.9 | Original | | 35033.101.US | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | 1.0.0.9 | Original | | 35033.102.US | |
| Sonic CD | PC | 1.1 | Expert Software | | 6805 02 | |
| Sonic Gems Collection | GC | | Original, Player's Choice | | DL-DOL-G2XE-USA | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| Sonic's Schoolhouse | PC | 1.1 | Expert Software | | 6806 02 | |
| Sonny's Race for Chocolatey Taste | PC | | General Mills | | A38341 | |
| Space Colony | PC | | Interactive Demo | | | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | CD 7011 SPI | |
| Space Quest: Collection Series (Disc 1) | PC | | Original | | | |
| Space Quest: Collection Series (Disc 2) | PC | | Original | | | |
| SpaceStationSim | PC | 2.0.1.1 | Original | | | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spec Ops: Platinum Collection (Disc 2) | PC | 1.0 | Original | | | |
| Spec Ops: Ranger Assault | PC | | Covermount | | CDE30_CDA | |
| Spec Ops: Ranger Gold | PC | 1.0 | Original, Platinum Collection | | CD-RG-004 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 | |
| Speed / Space Adventure / Undersea Adventure | PC | | Bundle Version Packard Bell OEM | | 170159 Rev.1 | |
| Sports Champions / Medieval Moves: Deadmund's Quest Combo Disc | PS3 | 01.00 | Not for Resale | | BCUS-90490 | |
| Sportsman's Double Play | PC | 1.0.0 | Original | | | |
| Spy Fox 2: "Some Assembly Required" | PC | 1.0.0.1 | Original | | Part No. 04-17571CD | |
| Spy Fox in "Cheese Chase" | PC | 2.00 | Rerelease | | Part No. 04-15244CD | |
| Spy Fox in "Dry Cereal" | PC | | Demo | | | |
| Spy Fox in "Dry Cereal" | PC | 1.0 | Original | | 04-70281, Part # 0001407, Part No. 04-00000H1529 | |
| Spy Fox in "Dry Cereal" | PC | 2.00 | Original | | Part #04-00000H1407 | |
| Spy Fox in "Hold the Mustard" | PC | 1.0 | Original | | Part No. 04-17574CD | |
| Spy Fox: "Operation Ozone" | PC | | Original | | Part No. 04-22394CD | |
| Spyro 2: Ripto's Rage! / Crash Team Racing | PSX | | Demo | | SCUS 94632 | |
| Square Enix E3 2005 Media CD | PC | | Press Kit | | | |
| Squaresoft on PlayStation 1998 Collector's CD Vol. 1 | PSX | | | | SLUS-90028 | |
| Squaresoft on PlayStation 2000 Collector's CD Vol. 3 | PSX | | | | SLUS-90075 | |
| Squaresoft on PlayStation Collector's CD | PSX | | | | SCUS-94256 | |
| Star Trek Pinball | PC | 1.10 | Rerelease | | CD-C95-675-2 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Star Trek: Federation Compilation | | CD-C95-893-2 | |
| Star Trek: Armada | PC | 1.2 | Rerelease, Star Trek: Action Pack | | 1000913.101.US, 32257.102.US | |
| Star Trek: Away Team | PC | 1.00 | Original | | 30025.101.US | |
| Star Trek: Bridge Commander | PC | 1.0 | Original | | 31127.101.US | |
| Star Trek: Judgment Rites | PC | | Star Trek: Federation Compilation | | CD-C95-893-1 | |
| Star Trek: Judgment Rites (Collector's Disc) | PC | | Limited CD-ROM Collector's Edition | | CD-ICD-200-1 | |
| Star Trek: New Worlds | PC | 1.0 | Original | | | |
| Star Trek: Starfleet Academy: Strategic Command (Disc 1) | PC | 1.0 | Original | | CD-C95-1044-0 | |
| Star Trek: Starfleet Command | PC | 1.00.01 | Original | | CD-C95-637-0 | |
| Star Trek: Starfleet Command | PC | 1.02.01 | Gold Edition | | CD-W58-1177-0 | |
| Star Trek: Starfleet Command: Orion Pirates | PC | 2.5.0.0 | Original | | CD-C95-1290-0 | |
| Star Trek: Voyager: Elite Force | PC | 1.10 | Rerelease | | 1000912.101.US, 32097.101.US | |
| Star Trek: Voyager: Elite Force: Expansion Pack | PC | 1.20 | Star Trek: Action Pack | | 31151.101.US | |
| Star Trek: Voyager: Elite Force: Expansion Pack | PC | 1.20 | Original | | 31151.101.US | |
| Star Wars: Battlefront II | PC | 1.1 | Star Wars: Fan Favorites I (DVD-ROM) | | 9982131 V1.1.0.1 | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Original | | 635930 | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Rerelease, The LucasArts Archives Vol. III | | 8041834 | |
| Star Wars: Dark Forces | PC | 1.0 Build 1 | Original | | 633830 | |
| Star Wars: Dark Forces | PC | 1.0L Build 1 | Super Sampler Edition: LucasArts Archives Vol. II, The: Star Wars Collection | | 8031831 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Star Wars: Episode I: Insider's Guide (Disc 1) | PC | 1.0 | Original | | 3161830 | |
| Star Wars: Episode I: Insider's Guide (Disc 2) | PC | 1.0 | Original | | 3161831 | |
| Star Wars: Fall Force Gaming Preview Best Buy Preview CD | PC | 1.0 | | | 8330330 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 1) | PC | | The Movie Collection | | 1292607, 8531030 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 1) | PC | | Rerelease | | 8531030R, 8531030R1 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | The Movie Collection | | 1292617, 8531031 | |
| Star Wars: Galactic Battlegrounds Saga (Disc 2) | PC | | Rerelease | | 8531031R, 8531031R1 | |
| Star Wars: Galactic Battlegrounds: Clone Campaigns | PC | 1.0 | Original | | 7111830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Dark Forces II: Ambush at Altyr 5 | PC | 1.0 | Demo: Bundle Version OEM | | 647030, CD-C95-990-E | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | XBOX | | Original, Platinum Hits | | LA-020 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Star Wars: Math: Jabba's Game Galaxy | PC | | Original, Scholastic | | P/N CDR5077850 | |
| Star Wars: Pit Droids | PC | | Scholastic | | P/N 9401321C, WP1 | |
| Star Wars: Rebel Assault | PC | 1.02 | Original | | 632630, CDRM1132180 | |
| Star Wars: Rebel Assault | PC | 1.4 | Original | | 632630, CDRM1151470, DRS1151470 | |
| Star Wars: Rebel Assault: Super Sampler | PC | 1.4 | | | 636030, 636130 | |
| Star Wars: Rogue Squadron 3D | PC | 1.3 | Rerelease, CompUSA Exclusive | | 6521830R2 | |
| Star Wars: Rogue Squadron III: Rebel Strike (Limited Edition Preview Disc) | GC | | Demo | | DL-DOL-DLSE-USA | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | 1.0 | Bundle Version Diamond OEM | | 75000204-100 | |
| Star Wars: The Best of PC (Star Wars: Empire at War & Star Wars: Knights of the Old Republic) | PC | 1.0 | Original | | 8101830 | |
| Star Wars: The Force Unleashed II | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30534 … | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Original | | 635930 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051831 | |
| Star Wars: X-Wing: Collector's CD-ROM / Star Wars: X-Wing vs. TIE Fighter: Flight School | PC | | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061830 | |
| Star Wars: Yoda Stories | PC | 1.0 | Original | | 3111830 | |
| Star Wars: Yoda Stories | PC | 1.0 | Original | | 3111830 | |
| Star Wars: Yoda Stories / Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0.0.1 | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061834 | |
| StarCraft | PC | 1.05 | StarCraft Battle Chest | | S7154921 | |
| Starflight II Starflight 2: Trade Routes of the Cloud Nebula | PC | | Top Ten Pak II | | 7588 | |
| StarFlyers Alien Space Chase | PC | 1.0 | Original | | 380853A-CD | |
| StarFlyers: Royal Jewel Rescue | PC | 1.0 | Original | | 381547A-CD | |
| Stellar Forces Stellar Forces Expansion Pak: Over 50 Add-On Levels for StarCraft | PC | 2.0 | Original | | | |
| Still Life (Disc 1) (Install) | PC | 1.0 | Original | | PCO461CD | |
| Stonekeep | PC | 1.2 | Original | | CD-ICD-045-0 | |
| Strange Cases: The Tarot Card Mystery / Strange Cases: The Lighthouse Mystery | PC | | The Best of Big Fish Games | | 33364101US | |
| Strategy Challenges Collection 1 | PC | 1.04 | Original, OEM Bundle | | 102771 | |
| Street Fighter Anniversary Collection | PS2 | 1.02 | Original | | SLUS 20949 | |
| Street Fighter Collection (Disc 1) | PSX | | Original | | SLUS-00423 | |
| Street Fighter Collection (Disc 1) | SS | 1.000 | Original | | T-1222H | |
| Street Fighter Collection (Disc 1) | PSX | Rev 1 | Fighters Edge | | SLUS-00423 | |
| Street Fighter Collection (Disc 2) | PSX | | Original | | SLUS-00584 | |
| Street Fighter Collection (Disc 2) | SS | 1.000 | Original | | T-1222H | |
| Street Fighter Collection (Disc 2) | PSX | Rev 1 | Fighters Edge | | SLUS-00584 | |
| Street Fighter Collection 2 | PSX | | Fighters Edge | | SLUS-00746 | |
| Streets of SimCity | PC | 1.0 | Original | | 1040207 | |
| Streets of SimCity | PC | 1.0 | CD-ROM Classics, 10 Sims for $20 | | 1127517 | |
| Strike Commander | PC | | Original | | RVL 13-004-0046 | |
| Strike Commander / Wing Commander: Privateer | PC | | Special CD-ROM Edition | | 1009121 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.1 | Original | | | |
| Stronghold FireFly Studios' Stronghold | PC | 1.2 | Original, Maximum Strategy | | | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.1 | Rerelease | | | |
| Stuart Little Learning Adventures: His Adventures in Wordland (Disc 2) | PC | 1.0 | Original | | 381676-CD2 | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Sudden Strike (Additional Missions) | PC | 1.0.0.1 | Original | | 04-22099CD2 | |
| The Sum of All Fears | PC | 1.0.12.0 | Original | | 650362-CD | |
| Summoner (Disc 1) | PC | 1.00 | Original | | | |
| Summoner (Disc 2) | PC | 1.00 | Original | | | |
| Super Collapse! II | PC | 1.33 | Original | | | |
| Super Duper Arcade 1 | PC | | Original | | Part No. 04-17834CD | |
| Super Duper Arcade 2 | PC | | Original | | CS99ARC011, Part No. 04-17836CD | |
| Super GameHouse Collection Super Collapse! / Super Glinx! / Super Nisqually | PC | | MacPlay | | | |
| Super Scattergories | PC | | General Mills | | A50040 | |
| Super Solitaire 15 | PALM | | Rerelease | | 332-0204-10 | |
| Super Solvers: Spellbound! | PC | 1.12 | Rerelease | | SBO744CE-CD | |
| SuperBikes Racing SuperMoto Racing | PC | | Original, Covermount | | | |
| SWAT 4: The Stetchkov Syndicate | PC | | Original | | | |
| Sword of the Stars | PC | 1.0.12 | Original | | P/N 21133-5 | |
| Syberia (Bonus CD) | PC | 1.0 | Game of the Year Edition | | PCO379CDB | |
| Syberia | PC | SSV1.0 | Demo | | DEM379CD | |
| Syndicate Plus | PC | | Original | | | |