Region | Title | System | Version | Edition | Languages | Serial | Status |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Sid Meier's Civilization III Complete (Disc 1) (Install/Play) | PC | | Rerelease, Sid Meier's Civilization Chronicles | | 31074-1.3 | |
| Sid Meier's Civilization IV (Disc 1) | PC | | Original, Sid Meier's Civilization Chronicles | | 31074-1.6 | |
| Sid Meier's Civilization IV (Disc 1) (Install) | PC | | Original | | | |
| Sid Meier's Civilization IV: Colonization | PC | | Original | | 31491-1 | |
| Sid Meier's Civilization V | PC | | Original, Special Edition | | 31817-1 | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| SimCity 3000 Unlimited | PC | | Rerelease | | 1446307, 1641507 | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| SimCoaster | PC | | Original | | 1425707 | |
| SimCoaster | PC | | Sim Mania 2, The Kids Collection, Rerelease | | 1242617, 1246307 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Family Fun Stuff | PC | | Original | | 1515807 | |
| The Sims 2: H&M Fashion Stuff | PC | | Original | | 1536607 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims | PC | | Bundle Version Gateway OEM | | 1500827 | |
| The Sims: House Party (Expansion Pack) | PC | | Double Deluxe, Expansion Collection Volume One, Mega Deluxe | | 1446107 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | | Expansion Collection Volume Two | | 1472007 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | | | | 1462607 | |
| The Sims: Vacation (Expansion Pack) | PC | | Original | | 1448807 | |
| The Sims: Vacation (Expansion Pack) | PC | | Expansion Collection Volume Three | | 1448807 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition, Scholastic | | 1403357 | |
| SimTheme Park Sim Theme Park | PC | | Sim Mania 2, The Kids Collection | | 1229827, 1641517 | |
| SimTheme Park Sim Theme Park | PC | | Gold Edition | | 1403337 | |
| SiN Episodes: Emergence | PC | | Original | | 984707 | |
| South Park | PC | | Original | | | |
| Spacebound Space Bound | PC | | Original | | | |
| Spear of Destiny | PC | | Ultimate Game Collection | | | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Spintires Spintires: Offroad Truck Simulator | PC | | Original | | | |
| Spore | PC | | Original | | 1535207 | |
| Spore: Creature Creator | PC | | Original | | 1586407 | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| Star Wars: Republic Commando | PC | | Original | | 3258130, 3258130R | |
| Star Wars: Republic Commando (Disc 1) (Play Disc) | PC | | Original | | 3251830 | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| State of Decay: Year-One Survival Edition | PC | | Original | | | |
| Stronghold 2 (Disc 2) (Play) Firefly Studios' Stronghold 2 | PC | | Original | | | |
| Super Lucky's Tale (Disc 1) | PC | | Original | | | |
| Super Lucky's Tale (Disc 2) | PC | | Original | | | |
| SWAT 4: The Stetchkov Syndicate | PC | | Original | | | |
| Syberia Collectors Edition: I & II | PC | | Original | | 16660-DVD | |
| Syndicate | PC | | Original | | 1922907 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| The Sims Carnival: SnapCity | PC | 0.029 | SimCity Box | | 1907347 | |
| The Sims 3: Late Night (Expansion Pack) | PC | 0.2.0.125 | Original, The Sims 3 Starter Pack | | 1915003301 | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| Star Trek: Voyager: Elite Force | PC | 0.28 | Original, Collector's Edition | | 1000912.101.US | |
| The Saboteur | PC | 1.0 | Original | | | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Sanity: Aiken's Artifact | PC | 1.0 | Original, Best Buy | | | |
| Secret Files: Tunguska (Disc 1) (Play Disc) | PC | 1.0 | Original | | | |
| Shadow of Destiny | PC | 1.0 | Original | | Part Number 23420 | |
| Shadowgrounds Survivor | PC | 1.0 | Original | | 000152 DVD | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| Shogun: Total War (Disc 1) | PC | 1.0 | Original | | 798707 | |
| Sid Meier's SimGolf | PC | 1.0 | Sim Mania 2 | | 1277387 | |
| Silent Hill 2 (Disc 1) | PC | 1.0 | Original | | Part Number 23429/23435-1 | |
| Silent Hill 4: The Room | PC | 1.0 | Original | | | |
| Silent Hunter III | PC | 1.0 | Original | | 681953-DVD | |
| SimCity | PC | 1.0 | Original, Limited Edition | | 1971403401 | |
| SimCity 4 (Disc 1) | PC | 1.0 | Original | | 1457307 | |
| SimCity 4 (Disc 2) | PC | 1.0 | Original | | 1457317 | |
| SimCity Societies | PC | 1.0 | Original | | 1574507 | |
| SimCity Societies Destinations | PC | 1.0 | SimCity Box | | 1907307 | |
| The Simpsons: Hit & Run (Disc 1) | PC | 1.0 | Original | | S7213210 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims | PC | 1.0 | Original | | 1500807 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims | PC | 1.0 | Original | | 1500827 | |
| The Sims: Deluxe Edition (Disc 1) | PC | 1.0 | Original, Double Deluxe, Mega Deluxe | | 1457647 | |
| The Sims: House Party (Expansion Pack) | PC | 1.0 | Original | | 1431307, 1431317 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| The Sims: Livin' Large (Expansion Pack) | PC | 1.0 | Original | | 1422707 | |
| The Sims: Makin' Magic (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1472007 | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume Three | | 1462607 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original | | 1459507 | |
| The Sims: Unleashed (Expansion Pack) (Disc 1) | PC | 1.0 | Original, Expansion Collection Volume One | | 1459507 | |
| Singularity | PC | 1.0 | Original | | 33309101US | |
| Slave Zero | PC | 1.0 | Original | | 46031-301SZR | |
| Space Siege | PC | 1.0 | Original | | | |
| Spider-Man: Web of Shadows | PC | 1.0 | Original | | 33211.101.EF, 33211.101.US | |
| Spore | PC | 1.0 | Galactic Edition | | 1908007 | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | 1535407 | |
| Star Wars: Battlefront (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3241830 | |
| Star Wars: Battlefront II (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3281830 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Original | | 9551830 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 1.0 | Rerelease | | 3261830R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords (Disc 1) (Play Disc) | PC | 1.0 | Original | | 3261830 | |
| Star Wars: The Best of PC (Star Wars: Empire at War & Star Wars: Knights of the Old Republic) | PC | 1.0 | Original | | 8101830 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Original | | 3381830 | |
| Star Wars: The Force Unleashed II | PC | 1.0 | Original | | 3411830 | |
| StarLancer (Disc 1) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67021 | |
| StarLancer (Disc 2) Microsoft StarLancer | PC | 1.0 | Original, Microsoft Action Pack | | 0200 Part Number X05-67023 | |
| Still Life (Disc 2) (Play) | PC | 1.0 | Original | | PCO461CD | |
| Stronghold FireFly Studios' Stronghold | PC | 1.0 | Original | | | |
| Stronghold Crusader FireFly Studios' Stronghold Crusader | PC | 1.0 | Original | | | |
| Stubbs the Zombie in Rebel Without a Pulse (Disc 1) | PC | 1.0 | Original | | 11001-1CDA | |
| Syberia (Disc 1) | PC | 1.0 | Original | | PC37920JC | |
| Syberia (Disc 2) | PC | 1.0 | Original | | PC37920JC | |
| Syberia II (Disc 1) | PC | 1.0 | Original | | 71702221 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: Knights of the Old Republic (Disc 1) (Play Disc) | PC | 1.0.0.0 | Original | | 3191830 | |
| Star Wars: The Old Republic (Disc 1) | PC | 1.0.0.0 | Original | | 1957807 | |
| Sid Meier's Civilization IV: Colonization | PC | 1.0.0.0 (109295) | Original | | 31491-1 | |
| Sid Meier's Pirates! (Disc 2) | PC | 1.0.0.0 (16296) | Original | | Part # 24810CD2 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.1022 | Rerelease | | 1472626, 1472666, 1472687 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | | | 1672927 | |
| The Sims 2 (Game Disk) | PC | 1.0.0.932 | Special DVD Edition | | 1488307 | |
| The Sims 2 (Disc 1) | PC | 1.0.0.932 | Original | | 1472607, 1472610 | |
| Sword of the Stars | PC | 1.0.12 | Original | | P/N 21133-5 | |
| The Sum of All Fears | PC | 1.0.12.0 | Original | | 650362-CD | |
| The Sims Life Stories | PC | 1.0.22.17622 | Original | | 1528207 | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| Supreme Commander | PC | 1.0.3189 | Original, Gold Edition | | part # 109050 | |
| The Sims 3 | PC | 1.0.631.00001, 0.0.0.11195 | Original, The Sims 3: Deluxe | | 1539007 | |
| Shogun: Total War: Warlord Edition (Disc 1) | PC | 1.00 | Original | | 1430707 | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| Startopia | PC | 1.00 | Original | | MSTARPUS01 | |
| Sheep | PC | 1.00.000 | Original | | | |
| Spore | PC | 1.00.000 | Original | | 1535207 | |
| Street Fighter IV | PC | 1.00.3013 | Original, Limited Edition | | | |
| Star Wars: Empire at War | PC | 1.00.35517 | Demo | | 8330730 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Rerelease | | 8541830R | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Original, Collector's Edition | | 8541830 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 1) | PC | 1.00.55911 | Original | | 7131830 | |
| Sid Meier's SimGolf | PC | 1.01 | Rerelease | | 1434917 | |
| Sid Meier's Civilization III: Play the World | PC | 1.01f | Original | | Part # 24115CD | |
| SpellForce: The Order of Dawn (Disc 1) | PC | 1.05 | Original, Store Manager Copy | | 28017-CD1 v1.0 F, 28017-SM1 v1.0 F | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| The Sims: Hot Date (Expansion Pack) | PC | 1.1 | Original, Expansion Collection Volume Two, Mega Deluxe | | 1439827 | |
| Stronghold FireFly Studios' Stronghold | PC | 1.1 | Original | | | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.230 | Original | | 1491707 | |
| The Sims 2: University (Expansion Pack) (Disc 1) | PC | 1.1.0.286 | Rerelease | | 1491727 | |
| Shadowrun | PC | 1.1.1.0 | Original | | 0307 Part No. X13-37194-01 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.1.610.0 | Original | | 1474017 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 1) | PC | 1.10.0.111 | Original, Slim Case | | 1536707 | |
| The Sims 2: Bon Voyage (Expansion Pack) (Disc 2) | PC | 1.10.0.111 | Original, Slim Case | | 1536717 | |
| The Sims 2: Teen Style Stuff | PC | 1.11.0.44 | Original | | 1537007 | |
| The Sims 2: FreeTime (Expansion Pack) (Disc 1) | PC | 1.13.0.135 | Original, Slim Case | | 1537107 | |
| System Shock 2 | PC | 1.15 | Original | | 796907 | |
| The Sims 2: IKEA Home Stuff | PC | 1.15.0.62 | Original | | 1578207 | |
| The Sims 2: Apartment Life (Expansion Pack) | PC | 1.16.0.179 | Original, Slim Case | | 1907807 | |
| The Sims 2: Mansion & Garden Stuff | PC | 1.17.0.66 | Original | | 1918007 | |
| Sweet Tooth To Go Sweet Tooth Deluxe | PC | 1.1R | Original | | 1586807 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.312 | Original | | 1497007 | |
| The Sims 2: Nightlife (Expansion Pack) (Disc 1) | PC | 1.2.0.377 | Rerelease | | 1497027 | |
| Sid Meier's Civilization III | PC | 1.29f | Game of the Year Edition | | Part # 24356CD1 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| The Sims 2: Open for Business (Expansion Pack) | PC | 1.3.0.249 | Original | | 1515707 | |
| Star Wars: Knights of the Old Republic | PC | 1.3.1.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982530 | |
| SWAT 3: Close Quarters Battle | PC | 1.4 | Elite Edition | | | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| The Sims 2: Glamour Life Stuff | PC | 1.5.0.121 | Original | | 1520807 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| The Sims 2: Pets (Expansion Pack) (Disc 1) | PC | 1.6.0.259 | Original | | 1526307 | |
| S.T.A.L.K.E.R.: Call of Pripyat | PC | 1.6.02 | Collector's Edition | | | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization IV (Disc 1) | PC | 1.61 | Game of the Year Edition | | 77875-1.1REA | |
| The Sims 2: Seasons (Expansion Pack) (Disc 1) | PC | 1.7.0.145 | Original, Slim Case | | 1562107 | |
| Sid Meier's Civilization IV: Gold Edition (Disc 1) | PC | 1.7.4.0 | Original | | 31183-1.1 | |
| Sid Meier's Civilization IV: Warlords | PC | 2.0 | Original | | 21966-1 | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| SWAT 3: Close Quarters Battle (Play CD) | PC | 2.0 | Tactical Game of the Year Edition | | | |
| SWAT 3: Close Quarters Battle (Disc 1) (Play Disc) | PC | 2.0 | Tactical Game of the Year Edition: SWAT 4 | | | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Scholastic | | 1500907 | |
| SimCity 3000 Unlimited | PC | 2.0.949.0 | Original | | 1500907 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | PC | 2.2.0.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982531 | |
| System Shock 2 | PC | 2.3 | Classics | | 1203807 | |
| System Shock 2 시스템 쇼크 2 | PC | 2.3 | Rerelease, EA Classix, Gagyeok Pagoe! | | 796917 | |
| Sherlock Holmes: The Awakened | PC | 3.0 | Original | | Art. Number PF0903/US2 | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | 3.0 | Original | | | |
| Sid Meier's Civilization IV: Beyond the Sword (Disc 1) | PC | 3.0.3.1 (77541) | Rerelease | | 31173-1.1 | |
| Spy Kids: Mega Mission Zone | PC | 3.6.27 | Original | | H3343 | |
| The Sting! | PC | v2.0e | Original | | ROTHESTING0004USLAB | |