Region | Title | System | Version | Edition | Languages | Serial | Status |
| The Saboteur | XBOX360 | | Original | | EA-2191 | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Scene It? Box Office Smash! Scene It? Campione d'Incassi: Nuovissimi filmati e quiz sul cinema | XBOX360 | | Original | | MS-2144 | |
| Scene It? Ciak! Si Gira! Scene It? Ciak! Si Gira! Nuovissime domande e curiosità sul mondo del cinema | XBOX360 | | Original | | WR-2044 | |
| A Scene It? Lights, Cameraction! A Scene It? Luci, Camerazione! Il gioco a quiz sul cinema | XBOX360 | | Original | | MS-2098 | |
| Scratches: Graffi Mortali | PC | | Original | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| Secret Weapons of the Luftwaffe | PC | | Collezione CD-Rom by C.T.O. | | | |
| Shadow Watch | PC | | Original | | | |
| Shakii il Lupo Shakii the Wolf | PC | | Microforum | | | |
| Shareware Games: The Best of 1996: Luglio/Agosto 1996 | PC | | | | | |
| Sheep | PC | | Covermount, Absolute Gaming | | EI-1246 | |
| Sheep, Dog 'n' Wolf | PC | | | | 1008993 | |
| Sheep, Dog 'n' Wolf | PC | | Kellogg's | | | |
| Sherlock Holmes e il Re dei Ladri | PC | | FX Interactive (Rerelease) | | IT v.1.0 P - DVD | |
| Shogun: Total War (Disc 1) | PC | | Original | | EAX08801965D1 | |
| Shogun: Total War (Disc 2) | PC | | Original | | EAX08801965D2 | |
| Shogun: Total War (Manuale in formato PDF) | PC | | | | ZMAECA471SA | |
| Sid Meier's Civilization II Civilization II di Sid Meier | PC | | CD-ROM Classic Collection 5 | | MP591260DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization Sid Meier Presenta Civilization II: Conflitti in Civilization: Scenari | PC | | CD-ROM Classic Collection 5 | | MP 591 307 DO1R | |
| The Sims 2 (Bonus DVD) | PC | | Original, The Sims: Deluxe Edition | | MXX0PS04261D, MXX0PS04261D/GER | |
| Skylanders: Imaginators | XBOX360 | | | | AV-2352 | |
| Sleeping Dogs | XBOX360 | | Original | | SQ-2065 | |
| The Smurfs Les Schtroumpfs/Die Schlümpfe/Los Pitufos/I Puffi/De Smurfen | PSX | | Original, All Your Cartoon Favourites | | SLES-01749 … | |
| The Smurfs: The TeletransportSmurf | PC | | Original | | SCHTRGB5011 | |
| Softline Software World: Novembre 2000 (Disc A) | PC | | | | | |
| Software&Co.: Catalogo Interattivo 1997: Edizione 1 | PC | | | | | |
| Solaris 1.0.4. Solaris | PC | | Microforum | | | |
| Il Soldatino di Piombo | PC | | | | | |
| Sonic & Knuckles Collection | PC | | Xplosiv | | XP-1859 EUROPEAN, XP-1891, XP-1891 EUROPEAN | |
| SoulTrap Qualche gioco vi ha divertito. Pochi vi hanno appassionato. Solamente SoulTrap vi catturerà l'anima. | PC | | Microforum | | | |
| Space Ace | PC | | Jackson Libri | | | |
| Space Invaders Anniversary | PC | | Xplosiv | | XP-1879 EUROPEAN | |
| Spider-Man 2: The Game | PC | | Original | | 32581.101.IT | |
| Spycraft: La Grande Sfida (Disc 1) | PC | | | | | |
| Spycraft: La Grande Sfida (Disc 2) | PC | | | | | |
| Spycraft: La Grande Sfida (Disc 3) | PC | | | | | |
| Star Trek: Away Team | PC | | Original, Covermount | | 30025.101.UK | |
| Star Wars: X-Wing: Collector's CD-ROM Star Wars: X-Wing: CD-ROM Edition | PC | | Original, Collezione CD-Rom by C.T.O. | | | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Super Taxi Driver Corse pazze in città | PC | | Microforum | | | |
| Superbike Racing | PC | | FX Interactive | | IT v. 2 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Suzuki Alstare: Extreme Racing | PC | | Covermount | | | |
| Syyrah: The Warp Hunter Una pioggia di asteroidi minaccia la terra in questo nuovo divertentissimo puzzle-game "tetraedrico". | PC | | Microforum | | | |
| Starship Troopers | PC | 0.1.0.6 | Demo | | EI-1958 EUROPEAN | |
| Starship Troopers | PC | 0.2.2.55 | Original | | EI-1957 EUROPEAN | |
| The Saboteur | PS3 | 01.00 | Original | | BLES-00743 | |
| Scene It? Ciak! Si Gira! Scene It? Ciak! Si Gira! Nuovissime domande e curiosità sul mondo del cinema | PS3 | 01.00 | Original | | BLES-00782 | |
| Score International Baja 1000: World Championship Off Road Racing | PS3 | 01.00 | Original | | BLES-00421 | |
| Shadows of the Damned | PS3 | 01.00 | Original | | BLES-01276 | |
| Shaun White Skateboarding | PS3 | 01.00 | Original | | BLES-01004 | |
| The Sims 3: Pets | PS3 | 01.00 | Original, Limited Edition | | BLES-01368 | |
| SingStar A Tutto Pop | PS3 | 01.00 | Original | | BCES-00345 | |
| SingStar Frozen: Il Regno di Ghiaccio | PS3 | 01.00 | Original | | BCES-02111 | |
| SingStar Intro | PS3 | 01.00 | Original | | BCES-00622 | |
| SingStar Vasco | PS3 | 01.00 | Original | | BCES-00722 | |
| SingStar Vol. 3 | PS3 | 01.00 | Original | | BCES-00267 | |
| Skate 2 | PS3 | 01.00 | Original | | BLES-00461 | |
| SOCOM: Special Forces | PS3 | 01.00 | Original | | BCES-00938 … | |
| Soldier of Fortune: Payback | PS3 | 01.00 | Original | | BLES-00189 | |
| Sonic Generations | PS3 | 01.00 | Original, Essentials, Collector's Edition | | BLES-01236 … | |
| Splatterhouse | PS3 | 01.00 | Original | | BLES-01120 | |
| Sports Champions 2 | PS3 | 01.00 | Original, Essentials, Promo | | BCES-01598 … | |
| Stormrise | PS3 | 01.00 | Original | | BLES-00513 | |
| Syndicate | PS3 | 01.00 | Original | | BLES-01371 … | |
| SBK 08: Superbike World Championship | PS3 | 01.01 | Original | | BLES-00368 | |
| SBK X: Superbike World Championship | PS3 | 01.01 | Original | | BLES-00774 … | |
| Shaun White Skateboarding | PS3 | 01.01 | Original | | BLES-01003 | |
| ShellShock 2: Blood Trails | PS3 | 01.01 | Original | | BLES-00408 | |
| Silent Hill: Downpour | PS3 | 01.01 | Original, Promo | | BLES-01446 | |
| Silent Hill: HD Collection | PS3 | 01.01 | Original | | BLES-01504 | |
| SingStar Cantautori Italiani | PS3 | 01.01 | Original | | BCES-01023 | |
| SingStar Vol. 2 | PS3 | 01.01 | Original | | BCES-00234 | |
| Skylanders: Swap Force | PS3 | 01.01 | Starter Pack | | BLES-01860 | |
| Sonic & Sega All-Stars Racing | PS3 | 01.01 | Original, Essentials | | BLES-00750 … | |
| Spec Ops: The Line | PS3 | 01.01 | Original | | BLES-01157 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition | PS3 | 01.01 | Essentials | | BLES-00678 … | |
| De Snipers: Invisible, Silentadly | PS3 | 01.02 | Original | | BLES-01327 | |
| Sonic & All-Stars Racing Transformed | PS3 | 01.02 | Original, Essentials, Limited Edition | | BLES-01646 … | |
| Spider-Man 3 | PS3 | 01.02 | Collector's Edition | | BLES-00062 | |
| Summer Stars 2012 | PS3 | 01.02 | Original | | BLES-01528 | |
| Ski-Doo Snowmobile Challenge | PS3 | 01.06 | Original | | BLES-01486 | |
| Sentinel: Il Regno delle Illusioni (Disc 1) | PC | 1.0 | | | | |
| Sentinel: Il Regno delle Illusioni (Disc 2) | PC | 1.0 | | | | |
| The Sims Life Stories | PC | 1.0 | Original | | MXX07705229D | |
| Sonic Heroes (Disc 2) | PC | 1.0 | Original | | SEGA-PC008, SEGA-PC008/2 | |
| Sonic Heroes (Disc 1) | PC | 1.0 | Original | | SEGA-PC008/1 | |
| Spider-Man: Web of Shadows | PC | 1.0 | Original | | 33211.101.EU | |
| Spore: Creepy & Cute Parts Pack | PC | 1.0 | Original | | MXX09206558D | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | MXX09206599D | |
| Stranger | PC | 1.0 | Original | | ECD632004D ITA | |
| Syberia (Disco 1) | PC | 1.0 | Covermount | | | |
| Syberia (Disco 2) | PC | 1.0 | Covermount | | | |
| Syberia II (Disc 1) | PC | 1.0 | Covermount | | | |
| Syberia II (Disc 2) | PC | 1.0 | Covermount | | | |
| SWAT 4: The Stetchkov Syndicate | PC | 1.0.0 | Gold Edition (Covermount) | | | |
| Il Signore dell'Olimpo: Zeus | PC | 1.0.0.0 | Original | | S0021675 | |
| Il Signore dell'Olimpo: Zeus | PC | 1.0.0.0 | Il Signore dell'Olimpo: Zeus Gold: BestSeller Series | | S1001038 | |
| Skateboard Park Tycoon World Tour 2003 | PC | 1.0.0.1 | Xplosiv | | XP-2118 EUROPEAN | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | 1.0.0.9 | Original | | SEGA-PC002-EU/1 | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | 1.0.0.9 | Original | | SEGA-PC002-EU/2 | |
| Supreme Commander | PC | 1.0.3189 | Original | | 86622, 86646, 88893 | |
| SWAT 4 (Disc 1) | PC | 1.0.31973.0 | Gold Edition (Covermount) | | | |
| SWAT 4 (Disc 2) | PC | 1.0.31973.0 | Gold Edition (Covermount) | | | |
| The Settlers: Rise of an Empire | PC | 1.0.4140 | Original, Bundle Version LG OEM | | 300007676 | |
| SingStar Italian Party | PS2 | 1.00 | Original | | SCES-54869 | |
| SingStar Pop Hits | PS2 | 1.00 | Original | | SCES-54571 … | |
| SingStar R&B | PS2 | 1.00 | Original | | SCES-54762 … | |
| SingStar top.it | PS2 | 1.00 | Original | | SCES-54077 | |
| Speed Haste | PC | 1.00 | Original | | A5475CXD | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 2) | PC | 1.00 | LucasArts Classic | | 41177.102.IT | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 1) | PC | 1.00 | LucasArts Classic | | 41177.101.IT | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.00 | LucasArts Classic | | 41177.103.IT | |
| StarCraft | PC | 1.00 | BestSeller Series, Covermount | | | |
| Sensible Soccer 2006 | PC | 1.00.0000 | Original | | MSS1CDEU00 | |
| Shadowrun | PC | 1.00.0000 | Original | | 0407 Parte n. X13-57732-01 IT | |
| Shrek 2 | PC | 1.00.0000 | DreamWorks Action Pack | | 32585.101.IT | |
| Silent Hunter II | PC | 1.00.06 | Original, Covermount | | | |
| Scarface: The World Is Yours | PC | 1.00.1 | BestSeller Series | | S1004050 | |
| SingStar '80s | PS2 | 1.01 | Original | | SCES-53605 | |
| Sinbad: Legend of the Seven Seas | PC | 1.01.000 | Original, Best of Atari | | 1009929 | |
| The Secrets of Da Vinci: Il Manoscritto Proibito (Disc 1) | PC | 1.02 | Original | | | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 2) | PC | 1.02 | Original | | | |
| SuperTest | CDI | 1.03 | Original | | 810 0168 | |
| Supreme Snowboarding | PC | 1.033 | Pringles | | VG-1012 | |
| StarCraft: Brood War (Expansion Set) | PC | 1.05 | BestSeller Series, Covermount | | S0014798 | |
| The Suffering | PC | 1.1.0.1 | Covermount | | | |
| Safari Kongo | PC | 1.2 | Original | | | |
| The Sims: House Party (Expansion Pack) | PC | 1.3 | Original | | 62092, MXX08803522D | |
| STCC: Swedish Touring Car Championship | PC | 1.32 | Covermount | | | |
| Scudetto 2 | PC | 1.48 | CD-ROM Classic Collection 3 | | | |
| SpellForce: The Order of Dawn (Disc 1) (Installa/Esegui CD) | PC | 1.52.61407 | Original | | ROSPELLFOR0027LAB1 | |
| SpellForce: The Order of Dawn (Disc 2) (Installa CD) | PC | 1.52.61407 | Original | | ROSPELLFOR0027LAB2 | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 2) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 1) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| Star Wars: Rebel Assault | PC | 1.7 | Collezione CD-Rom by C.T.O. | | | |
| Il Signore di Atlantide: Poseidon | PC | 2.0 | Il Signore dell'Olimpo: Zeus Gold: BestSeller Series | | S1001037 | |
| Seven Kingdoms: Ancient Adversaries | PC | 2.00 | Original, 2in1 Pack | | | |
| Sacred: Edizione Oro | PC | 2.24 | FX Interactive | | IT v.2.0.2.64 P - DVD | |
| Sacred: Edizione Oro | PC | 2.24 | FX Interactive | | IT v.2.0.2.64 P - DVD | |