Region | Title | System | Version | Edition | Languages | Serial | Status |
| A Survey of Western Art: The Electronic Library of Art | VIS | | Original | | 25-6153 | |
| SmartKids Challenge One | VIS | | Original | | 25-6176 | |
| Sherlock Holmes: Consulting Detective: Vol. II | VIS | | Original | | 25-6184 | |
| Sherlock Holmes: Consulting Detective: Vol. I | VIS | | Original | | 25-6183 | |
| The Secrets of Hosea Freeman | VIS | | Original | | 25-6144 | |
| Search for the Sea | VIS | | Original | | 25-6143 | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Sudoku | GAMEWAVE | | Original | | G230 | |
| Space Invaders XL | NUON | | Original | | 11109 | |
| Shrek the Third: The Search for Arthur | VFLASH | | Original | | 093140(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | Rev 1 | Original | | 093080(US) | |
| Scooby-Doo! Ancient Adventure | VFLASH | | Original | | 093080(US) | |
| Socket Low Power SDIO WLAN | PPC | Release 142 D | Original | | P/N 6210-00142 D | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| ShadowGate Classic | PPC | 1.0.0.4 | Original | | 5053626 | |
| SwiftWare | PALM | | Cosmi | | PDA060501, PDAMC1 | |
| Super Solitaire 15 | PALM | | Rerelease | | 332-0204-10 | |
| Super Game Pak | PALM | | Ultimate Game Collection, Cosmi | | PDA102501, PDA634D1 | |
| Sudoku Master | PALM | | Original | | 3340R-2006-03-CDA-US | |
| Sudoku Deluxe Sudoku Pack | PALM | 2.1 | Original | | P/N: 750-3009-CD-B | |
| Strike It Rich! $trike It Rich! | PALM | 1.00 Build 0524c | Original | | | |
| Street Maps & Vacation Planner | PALM | | Cosmi | | PDA051501, PDA631D1 | |
| SocketScan | PALM | Release 108K | Original | | P/N 6210-00108 K | |
| Scrabble: Crossword Game | PALM | | Original | | 358-1001-10 | |
| Scrabble: Crossword Game | PALM | | Original | | 358-0901-10 | |
| Sundance Channel: Sept. 2000 | PHOTO-CD | | | | | |
| Space Ace | AJCD | | Original | | | |
| Saucer Wars | AJCD | | Unlicensed (CD-R) | | | |
| Surf City | CDI | | Original, Demonstration Disc | | 310-690-131-2, 310690131-2 | |
| Super Stories: My Favorite Things | CDI | | | | | |
| Super Stories: Mom is Going to Stop It | CDI | | | | | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Striker Pro | CDI | | Original, Demonstration Disc | | 310-690-143-2, 310690143-2 | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| The Story of Jonah | CDI | 2.04 | Original, FPD | | 310-690-067-2, 310690067-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Stickybear Preschool | CDI | | Pre-Release Demonstration Disc | | 310-690-257-2 | |
| Stickybear Preschool | CDI | | Original, Demonstration Disc | | 310-690-257-2, 310690257-2 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| Stickybear Family Fun | CDI | | Original | | 310690258-2 | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 310690304-2 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 310690304-2 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Space Ranger | CDI | | Unlicensed | | OGCDI-1180 | |
| Space Ace | CDI | | Original, Demonstration Disc | | 310-690-059-2, 310690059-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| Sliver (Disc 2) | CDI | | Original | | 310690309-2 | |
| Sliver (Disc 1) | CDI | | Original | | 310690309-2 | |
| Skin Style | CDI | | Original | | | |
| ShowMaster | CDI | 1.0 | Demo | | | |
| Shorelines | CDI | | | | | |
| Shark Alert | CDI | | Original, Demonstration Disc | | 310-690-278-2, 310690278-2 | |
| Shari Lewis Lamb Chop's Play-Along! Action Songs | CDI | | Original | | 310690289-2 | |
| Self Selling Disc | CDI | 3.1 | | | 310-690-049-2 | |
| Self Selling Disc | CDI | 3.1 | | | | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Sargon Chess | CDI | | Original, Original: Longbox | | 310690030-2 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | MAC | | Original | | 12240-1DDA2 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | MAC | | Original | | 12240-1DDA | |
| Star Wars: Mac Pack | MAC | | Original | | 12300-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Star Wars: Knights of the Old Republic | MAC | 1.03 | Original | | 10660-1DDA | |
| Star Wars: Jedi Knight Gold Pack | MAC | | Original | | 12280-1DDA | |
| Star Wars: Empire at War | MAC | 1.05 | Original | | 11490-1DDA | |
| Star Wars: Battlefront | MAC | 1.2 | Original | | 10900-1DDA | |
| The Sims: Party Pack | MAC | | Original | | 10790-1DDA | |
| The Sims 2: University (Expansion Pack) | MAC | | Original | | 11110-1DDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| The Sims 2: Open For Business (Expansion Pack) | MAC | | Original | | 11390-1DDA | |
| The Sims 2: Nightlife (Expansion Pack) | MAC | | Original | | 11330-1DDA | |
| The Sims 2: Bon Voyage (Expansion Pack) | MAC | | Original | | 11780-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| The Sims 2 | MAC | | Rerelease | | 10880-1DDA | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| Sid Meier's Civilization IV: Beyond the Sword | MAC | | Original | | 12090-1DDA | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization III Complete | MAC | 1.22 | Original | | 11180-1DDA | |
| System Shock | MAC | | Original | | EA 568407 | |
| Syndicate | MAC | | Original | | 7558 | |
| Stellaluna | MAC | | Original | | 2069-1-01 | |
| Star Wars: X-Wing: Collector's CD-ROM | MAC | 1.01 | Original | | 2052130 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | MAC | 1.0 | Original | | 2062130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault | MAC | 1.06 | LucasArts Macintosh Archives Vol. I, The | | 8022132 | |
| Star Wars: Rebel Assault | MAC | 1.01 | Original | | 634630 | |
| Star Wars: Rebel Assault | MAC | | Original | | 634630, CDRM1208410 | |
| Star Wars: Rebel Assault | MAC | | Demo | | CDRM1209730 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | MAC | 1.0.1 | Original | | 10610-2CDA | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | MAC | 1.0.1 | Original | | 10610-1CDA | |
| Star Wars: Jedi Knight II: Jedi Outcast | MAC | 1.03 | Original | | 10200-1CDA | |
| Star Wars: Dark Forces (Special Edition: 3 Playable Levels) | MAC | 1.2 | LucasArts Macintosh Archives Vol. I, The | | 8022134 | |
| Star Wars: Dark Forces | MAC | 1.1 | Original | | 3062130 | |
| Star Trek: Voyager: Elite Force | MAC | | Original | | | |
| Star Trek: The Next Generation: Klingon Honor Guard (Install Disk) | MAC | | Original | | P/N 04-17512CD2 | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Trek: Starfleet Academy (Disc 1) | MAC | 1.1 | Original | | CD-MCR-069-0 | |
| Star Trek: Elite Force II (Disc 2) | MAC | | Original | | 10440-2CDA | |
| Star Trek: Elite Force II (Disc 1) | MAC | | Original | | 10440-1CDA | |
| Star Fighter | MAC | | | | 03239-001 | |
| Spycraft: The Great Game (Disc 3) | MAC | | Original | | CDM-3110-103-U3 | |
| Spycraft: The Great Game (Disc 2) | MAC | | Original | | CDM-3110-102-U3 | |
| Spycraft: The Great Game (Disc 1) | MAC | | Original | | CDM-3110-101-US | |
| Spectre VR CD | MAC | | Original | | | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Space Shuttle | MAC | | Original | | CDRM1087300 | |
| The Space Bar (Disc 3) | MAC | | Original | | 115-7F | |
| The Space Bar (Disc 2) | MAC | | Original | | 115-7E | |
| The Space Bar (Disc 1) | MAC | 1.0 | Original | | 115-7H | |
| The Space Bar (Disc 1) | MAC | | Original | | 115-7D | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Solitaire Mania | MAC | | Original | | PART NO. 05SMM-01 | |
| Solid State Pinball: Crystal Caliburn Crystal Caliburn | MAC | | Original | | | |
| The Software Toolworks Presents: Maniac Sports | MAC | | Original | | 2200820-590001 / I034100 | |
| Sinkha | MAC | | Original | | | |
| SiN Gold | MAC | 1.1.1 | Original | | | |
| SiN Gold | MAC | | MacPlay | | | |
| Sin Gold SiN Gold | MAC | | Shooter Pack, MacPlay | | | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| The Sims: Vacation (Expansion Pack) | MAC | | Original | | | |
| The Sims: Superstar (Expansion Pack) (Disc 2) | MAC | | Original | | 10430-2CDA | |
| The Sims: Superstar (Expansion Pack) (Disc 1) | MAC | | Original | | 10430-1CDA | |
| The Sims: Livin' Large (Expansion Pack) | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims: Hot Date (Expansion Pack) | MAC | | Original | | 10150-1CDA | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | | | | |
| The Sims | MAC | | The Sims & The Sims: Livin' Large Expansion Pack | | | |
| The Sims 2: Pets (Expansion Pack) | MAC | | Original | | 11500-1CDA | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| SimCity 4 (Disc 2) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 4 (Disc 1) | MAC | 1.0 | Original | | 10350-1CDA | |
| SimCity 3000 | MAC | 1.0.557 | Original | | 1500607 | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| A Silly Noisy House | MAC | | Original | | CDAC 014500 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Alpha Centauri | MAC | RELEASE 4.0 | Original | | | |
| Shrek 2 | MAC | | Original | | 10700-1CDA | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Shanghai: Double Pack | MAC | | Original | | 1000029-102-U3 | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Sesame Street: Let's Make A Word! | MAC | | Original | | 9281 | |
| Scrabble: Crossword Game | MAC | 1.0.0.52 | Original | | P/N 10328-5 | |
| Schoolhouse Rock! Grammar Rock | MAC | | Original | | 9227 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| The Scavenger Hunt Adventure Series: Africa | MAC | | Original | | | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| The San Diego Zoo Presents... The Animals! | MAC | Version 1 | Bundle Version OEM | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Scooby-Doo! | IXL | 2.0.0 | Original | | R9709 | |
| Scooby-Doo! | IXL | 1.0.0 | Original | | R9709 | |
| Syndicate | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Strahl | 3DO | | Original | | FZ-SM4651 | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Star Control II | 3DO | | Original, Not for Resale | | | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | 3DO | | Original | | | |
| Space Pirates | 3DO | | Original | | ALG595001 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | Beta 8 | Beta (CD-R) | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Ace | 3DO | RE-1 | Original | | | |
| Space Ace | 3DO | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| Slopestyle: An Interactive Learning Cube | 3DO | | Original | | | |
| Slayer | 3DO | | Original | | | |
| Slayer | 3DO | | 3DO Action Pak | | | |
| Slam 'n Jam '95 | 3DO | | Beta (CD-R) | | | |
| Slam 'n Jam '95 | 3DO | | Original | | 60140-C | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Shock Wave | 3DO | RE1 | Original, Demo Disc (3DO Demo Disc Program) | | 7222 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Sex | 3DO | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Sports: Football | CD32 | | | | | |
| Surf's Up | XBOX360 | | Original | | US-2041 | |
| Supreme Commander | XBOX360 | | Original | | AY-2001 | |
| Superman Returns | XBOX360 | | Original | | EA-2029 | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Street Fighter IV: The Ties That Bind (Bonus Disc) | XBOX360 | | Xbox 360 Game Bundle | | CC-2033 | |
| Stoked: Big Air Edition | XBOX360 | | Original | | DE-2005 | |
| Stoked | XBOX360 | | Original | | DE-2003 | |
| Star Wars: The Clone Wars: Republic Heroes | XBOX360 | | Original | | LA-2018 | |
| Star Trek: Legacy | XBOX360 | | Original | | BS-2002 | |
| Star Trek | XBOX360 | | Original | | NM-2139 | |
| Star Ocean: The Last Hope (Disc 3) | XBOX360 | | Original | | SQ-2013 | |
| Star Ocean: The Last Hope (Disc 2) | XBOX360 | | Original | | SQ-2013 | |
| Star Ocean: The Last Hope (Disc 1) | XBOX360 | | Original | | SQ-2013 | |
| SSX | XBOX360 | | Original | | EA-2413 | |
| The Spiderwick Chronicles | XBOX360 | | Bundled with Audiobook | | VU-2022 | |
| Spider-Man: Web of Shadows | XBOX360 | | Original | | AV-2069 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Spider-Man: Friend or Foe | XBOX360 | | Original | | AV-2042 | |
| Spectral Force 3 | XBOX360 | | Original | | AT-2003 | |
| Space Chimps | XBOX360 | | Original | | BT-2004 Version: 1. | |
| South Park: The Stick of Truth | XBOX360 | | Original, Platinum Hits | | US-2245 | |
| Sonic's Ultimate Genesis Collection | XBOX360 | | Platinum Hits | | SE-2064 | |
| Sonic Unleashed | XBOX360 | | Original, Platinum Hits | | SE-2066 | |
| Soldier of Fortune: Payback | XBOX360 | | Original | | AV-2050 | |
| Snoopy's Grand Adventure | XBOX360 | | Original | | AV-2338 | |
| Sniper Elite V2 | XBOX360 | | Original | | FO-2024 | |
| Sniper Elite III | XBOX360 | | Original | | FO-2051 | |
| The Smurfs 2 | XBOX360 | | Original | | US-2237 | |
| Sleeping Dogs | XBOX360 | | Original, Ultimate Action Triple Pack | | SQ-2065 | |
| Skylanders: Trap Team | XBOX360 | | Original | | AV-2321 | |
| Skylanders: Swap Force | XBOX360 | | Starter Pack | | AV-2281 | |
| Skylanders: SuperChargers | XBOX360 | | Original | | AV-2335 | |
| Skylanders: Imaginators | XBOX360 | | Original | | AV-2352 | |
| Ski-Doo Snowmobile Challenge | XBOX360 | | Original | | VG-2001 | |
| Skate. | XBOX360 | | Original | | EA-2067 | |
| Skate 2 | XBOX360 | | Original | | EA-2175 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | XBOX360 | | Original | | JW-2003 | |
| Shaun White Snowboarding | XBOX360 | | Target Limited Edition | | US-2078 | |
| Shaun White Skateboarding | XBOX360 | | Original | | US-2095 | |
| Shadowrun | XBOX360 | | Original | | MS-2006 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| Scene It? Bright Lights! Big Screen! | XBOX360 | | Original | | WR-2037 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| Saw II: Flesh & Blood | XBOX360 | | Original | | KN-2082 | |
| Saw | XBOX360 | | Original | | KN-2050 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Spartan: Total Warrior | XBOX | | Review | | | |
| SX Superstar | XBOX | | Original | | AC-016 | |
| SWAT: Global Strike Team | XBOX | | Original | | VV-037 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Superman Returns | XBOX | | Original | | EA-160 | |
| Super Monkey Ball Deluxe | XBOX | | Original | | SE-056 | |
| Super Bubble Pop | XBOX | | Original | | JA-004 | |
| The Suffering | XBOX | | Original | | MW-021 | |
| Stubbs the Zombie in Rebel Without a Pulse | XBOX | | Original | | AY-002 | |
| Strike Force Bowling | XBOX | | Original | | CV-008 | |
| Street Hoops | XBOX | | Original | | AV-003 | |
| Street Fighter Anniversary Collection | XBOX | | Original | | CC-015 | |
| Still Life | XBOX | | Original | | MI-011 | |
| Steel Battalion | XBOX | | Original | | CC-002 | |
| State of Emergency | XBOX | | Original | | TT-006 | |
| Starsky & Hutch | XBOX | | Original | | EM-005 | |
| Star Wars: The Clone Wars + Tetris Worlds | XBOX | | Bundled with Xbox: Limited Edition Package, Promotional Offer | | XL-013 | |
| Star Wars: The Clone Wars | XBOX | | Original | | LA-004 | |
| Star Wars: Starfighter Special Edition | XBOX | | Original, Platinum Hits | | LA-002 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| Star Wars: Obi-Wan | XBOX | | Original, Platinum Hits | | LA-001 | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | XBOX | | Original, Platinum Hits | | LA-020 | |
| Star Wars: Knights of the Old Republic | XBOX | Rev 1 | Platinum Hits | | LA-003 | |
| Star Wars: Knights of the Old Republic | XBOX | | Original | | LA-003 | |
| Star Wars: Jedi Starfighter | XBOX | | Original | | LA-005 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Jedi Knight II: Jedi Outcast | XBOX | | Original | | LA-009 | |
| Star Wars: Episode III: Revenge of the Sith | XBOX | | Original, Platinum Hits | | LA-023 | |
| Star Wars: Battlefront II | XBOX | Rev 1 | Platinum Hits | | LA-026 | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| SSX Tricky | XBOX | | Platinum Hits | | EA-004 | |
| SSX on Tour | XBOX | | Original | | EA-130 | |
| SSX 3 | XBOX | | Original | | EA-060 | |
| SRS: Street Racing Syndicate | XBOX | | Original | | NM-019 | |
| SpyHunter: Nowhere to Run | XBOX | | Original | | MW-055 | |
| SpyHunter 2 | XBOX | | Original | | MW-027 | |
| SpyHunter | XBOX | | Platinum Hits | | MW-004 | |
| Spy vs. Spy | XBOX | | Original | | TT-124 | |
| Splashdown | XBOX | | Original | | IG-027 | |
| Spikeout: Battle Street | XBOX | | Original | | SE-041 | |
| Spider-Man | XBOX | Rev 1 | Platinum Hits | | AV-006 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Speed Kings | XBOX | | Original | | AC-011 | |
| Spawn: Armageddon | XBOX | | Original | | NM-012 | |
| Spartan: Total Warrior | XBOX | | Demo | | SE-138 | |
| Spartan: Total Warrior | XBOX | | Original | | SE-139 | |
| Soulcalibur II | XBOX | | Original, Platinum Hits | | NM-003 | |
| Soulcalibur II | XBOX | | Demo | | NM-003 | |
| Sonic Riders | XBOX | | Original | | SE-135 | |
| Sonic Heroes | XBOX | | Platinum Family Hits | | SE-043 | |
| Soldier of Fortune II: Double Helix | XBOX | | Original | | AV-027 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sneakers | XBOX | | Original | | MS-035 | |
| Sneak King | XBOX | | Original | | MS-211 | |
| Smashing Drive | XBOX | | Original | | NM-001 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Shrek Super Party | XBOX | | Original | | TM-004 | |
| Shrek | XBOX | | Original | | TM-001 | |
| Showdown: Legends of Wrestling | XBOX | | Original | | AC-029 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shattered Union | XBOX | | Original | | TT-131 | |
| Shadow the Hedgehog | XBOX | | Original | | SE-134 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| Sega Soccer Slam | XBOX | | Original | | SE-020 | |
| Sega GT Online | XBOX | | Original | | SE-033 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 | XBOX | | Original | | SE-003 | |
| Secret Weapons over Normandy | XBOX | | Original | | LA-006 | |
| SeaBlade | XBOX | | Original | | VU-023 | |
| Scooby-Doo! Night of 100 Frights | XBOX | | Original | | TQ-031 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| SydMead's TerraForming | PCE | | Original | | TGXCD1040 | |
| Super Air Zonk: Rockabilly-Paradise | PCE | | Original | | TGXCD1042 | |
| Splash Lake | PCE | | Original | | TGXCD1025 | |
| SimEarth: The Living Planet | PCE | | Original | | TGXCD1036 | |
| Sherlock Holmes: Consulting Detective: Vol. II | PCE | | Original | | TGXCD1039 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Shape Shifter | PCE | | Original | | TGXCD1021 | |
| Shadow of the Beast | PCE | | Original | | TGXCD1018 | |
| Syndicate | PC | | Original | | 1922907 | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| Supreme Commander | PC | 1.0.3189 | Original, Gold Edition | | part # 109050 | |
| Supreme Commander | PC | | Original | | P/N: 120904-B | |
| The Stronghold Collection | PC | | Original | | 31684-1 | |
| Street Fighter IV | PC | 1.00.3013 | Original, Limited Edition | | | |
| StarCraft II: Wings of Liberty | PC | | Original | | | |
| StarCraft II: Wings of Liberty | PC | | Original, Collector's Edition | | | |
| StarCraft II: Legacy of the Void (Disc 2) | PC | | Original | | | |
| StarCraft II: Legacy of the Void (Disc 1) | PC | | Original | | | |
| StarCraft II: Heart of the Swarm | PC | | Original | | | |
| Star Wars: The Old Republic (Disc 2) | PC | 1.0.0.0 | Original | | 1957817 | |
| Star Wars: The Old Republic (Disc 1) | PC | 1.0.0.0 | Original | | 1957807 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | PC | 0.0.0.0 | Original | | 12241-1DDA | |
| Star Wars: The Force Unleashed II | PC | 1.1 | Cosmi | | DVD248D1 v 1.1.0.1 | |
| Star Wars: The Force Unleashed II | PC | 1.0 | Original | | 3411830 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Cosmi | | DVD288D1 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Original | | 3381830 | |
| Star Wars: Knights of the Old Republic Collection | PC | 1.0.3.0 | Original | | | |
| Star Trek: Starfleet Academy | PC | 1.15 | Bundle Version OEM (DVD-ROM) | | CD-DVD-069-GQE | |
| Star Trek Online | PC | | Original | | 27872DV | |
| Spider-Man: Web of Shadows | PC | 1.0 | Original | | 33211.101.EF, 33211.101.US | |
| Spider-Man: Shattered Dimensions | PC | | Original | | 33355101US | |
| SpellForce: Universe (Disc 2) | PC | 2.00 | Original | | DVD563CD | |
| Spec Ops: The Line | PC | | Premium Edition | | 41152-1 | |
| South Park: The Fractured But Whole (Disc 2) | PC | | Gold Edition | | UBP60802045-DISC2 | |
| South Park: The Fractured But Whole (Disc 1) | PC | | Gold Edition | | UBP60802045-DISC1 | |
| Sniper: Ghost Warrior 3 (Disc 4) | PC | | Season Pass Edition | | TCIU01221UND4 | |
| Sniper: Ghost Warrior 3 (Disc 3) | PC | | Season Pass Edition | | TCIU01221UND3 | |
| Sniper: Ghost Warrior 3 (Disc 2) | PC | | Season Pass Edition | | TCIU01221UND2 | |
| Sniper: Ghost Warrior 3 (Disc 1) | PC | | Season Pass Edition | | TCIU01221UND | |
| Sniper: Ghost Warrior | PC | | Original | | L0001US | |
| Skylanders: Spyro's Adventure | PC | 1.0 | Starter Pack | | 33366010US | |
| Singularity | PC | 1.0 | Original | | 33309101US | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| The Sims 3: University Life (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 1980803301 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Outdoor Living Stuff | PC | 7.0.55.010001 | Original | | 1950307 | |
| The Sims 3: Late Night (Expansion Pack) | PC | 0.2.0.125 | Original, The Sims 3 Starter Pack | | 1915003301 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| The Sims 3 | PC | 1.0.631.00001, 0.0.0.11195 | Original, The Sims 3: Deluxe | | 1539007 | |
| The Sims 2: Double Deluxe The Sims 2: Store Edition | PC | 2.0 | Rerelease | | 1597037 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Shift 2: Unleashed | PC | | Limited Edition | | 1948307 | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| Sam & Max: Season Two | PC | 1.5.0.0 | Original | | | |
| Sam & Max: Season One | PC | 1.0 | Original | | | |
| Saints Row: The Third (Disc 1) | PC | | Original | | | |
| Saints Row 2 | PC | | Original | | | |
| Sacred 2: Fallen Angel (Disc 3) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 2) | PC | | Beta | | | |
| Sacred 2: Fallen Angel (Disc 1) | PC | | Beta | | | |
| Sacred 2 (Disc 2) | PC | | Original | | | |
| Sacred 2 (Disc 1) | PC | | Original | | | |
| The Saboteur | PC | 1.0 | Original | | | |
| Syberia Collectors Edition: I & II | PC | | Original | | 16660-DVD | |
| Sword of the Stars: Ultimate Collection | PC | 1.6.7 | Original | | | |
| Sword of the New World: Granado Espada | PC | 2.1.18 | | | | |
| Surface: Mystery of Another World | PC | | Collector's Edition | | 33418010US | |
| Supreme Commander (Bonus Disc) | PC | | Original | | | |
| Stronghold 3 Gold Stronghold 3: Gold | PC | | Original | | 50080-LBL | |
| Stronghold 3 | PC | | Original | | 50070-LBL | |
| Strong Bad's Cool Game for Attractive People | PC | 1.5.0.0 | Original | | | |
| Stories: The Path of Destinies (Installation Disc) | PC | 0.0.18092 | Collector's Edition, GameTrust Collection | | | |
| Still Life 2 | PC | 1.0 | Original | | 16740-DVD | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Best Edition | | | |
| Steins;Gate | PC | System 1.20 / Script 1.11 | Limited Edition | | | |
| State of Decay: Year-One Survival Edition | PC | | Original | | | |
| Starship Troopers | PC | 0.3.2.69 | Original | | P/N 21121-5 | |
| Stardew Valley | PC | 1.4.5 | Fangamer | | | |
| Star Wars: The Old Republic (Disc 3) | PC | 1.0.0.0 | Original | | 1957827 | |
| Star Wars: The Best of PC (Star Wars: Empire at War & Star Wars: Knights of the Old Republic) | PC | 1.0 | Original | | 8101830 | |
| Star Wars: Republic Commando | PC | 1.01 | Cosmi | | DVD287D1, SJ032011 | |
| Star Wars: Republic Commando | PC | 1.0 | Star Wars: Fan Favorites I | | 9982132 V1.01.0.1 | |
| Star Wars: Republic Commando | PC | 1.0 | Star Wars: Fan Favorites I | | 9982132R V1.01.1.1 | |
| Star Wars: Republic Commando | PC | | Original | | 3258130, 3258130R | |
| Star Wars: Knights of the Old Republic II: The Sith Lords | PC | 2.2.0.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982531 | |
| Star Wars: Knights of the Old Republic | PC | 1.3.1.0 | Star Wars: Knights of the Old Republic Collection (DVD-ROM) | | 9982530 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.0.5.0 | Rerelease | | DVD284D1, SJ102010 | |
| Star Wars: Empire at War | PC | 1.00.35517 | Demo | | 8330730 | |
| Star Wars: Battlefront II | PC | 1.1 | Star Wars: Fan Favorites I (DVD-ROM) | | 9982131R V1.1.1.1 | |
| Star Wars: Battlefront II | PC | 1.1 | Rerelease (DVD-ROM) | | 3288130, 3288130R | |
| Star Wars: Battlefront II | PC | 1.1 | Star Wars: Fan Favorites I (DVD-ROM) | | 9982131 V1.1.0.1 | |
| Star Wars: Battlefront II | PC | 1.1 | Cosmi (DVD-ROM) | | DVD283D1 | |
| Star Wars: Battlefront II | PC | 1.0 | DVD-ROM | | 3282030 | |
| Star Wars: Battlefront | PC | 1.2 | Cosmi | | DVD282D1; SJ032011 | |
| Star Wars: Battlefront | PC | 1.2 | Star Wars: Fan Favorites I | | 9982130 V1.01.0.1 | |
| Star Wars: Battlefront | PC | 1.2 | Rerelease | | 3248130, 3248130R | |
| Star Wars Galaxies: The Complete Online Adventures (Disc 1) | PC | | Original | | 8131830 | |
| Star Trek: Legacy | PC | 1.0 | Original | | | |
| The Stanley Parable (Installation Disc) | PC | | IndieBox | | | |
| Spycraft: The Great Game | PC | | Enhanced DVD-ROM Edition | | | |
| Spore: Galactic Adventures | PC | 1.0 | Original | | 1535407 | |
| Spore: Creepy & Cute Parts Pack | PC | | Original | | 1907607 | |
| Spore | PC | 1.00.000 | Original | | 1535207 | |
| Spore | PC | 1.0 | Galactic Edition | | 1908007 | |
| Spore | PC | | Original | | 1535207 | |
| The Spiderwick Chronicles | PC | 1.0 | Original | | S7270810 | |
| Spider-Man: Friend or Foe | PC | | Original | | 33167.101.US | |
| Spider-Man 3 | PC | | Original | | 33121.101.US | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| SpellForce | PC | 1.52.64763 | Platinum Edition | | 11121-1DDA | |
| Space Siege | PC | 1.0 | Original | | | |
| Space Engineers | PC | | Limited Edition | | | |
| Space Ace | PC | | Original | | | |
| South Park: The Stick of Truth | PC | | Original | | 689058-DVD | |
| South Park: The Fractured But Whole (Disc 3) | PC | | Gold Edition | | UBP60802045-DISC3 | |
| Sonic and the Secret Rings Comic Book DVD from Archie Comics | PC | | | | | |
| Sniper: Art of Victory | PC | | Original | | | |
| Sniper Elite | PC | | Original | | 40009 | |
| Sins of a Solar Empire: Trinity | PC | | | | | |
| Sins of a Solar Empire: Trinity | PC | | Rerelease | | | |
| Sins of a Solar Empire | PC | 1.165 | Game of the Year Edition | | | |
| Sins of a Solar Empire | PC | 1.00 | Original | | | |
| Sins of a Solar Empire | PC | | Rerelease | | | |
| Singularity | PC | | Press Kit | | | |
| Sin Episodes: Emergence SiN Episodes: Emergence | PC | | Original | | 984707 | |
| The Sims: Pet Stories | PC | | Original | | 1536507 | |
| The Sims Medieval: Pirates & Nobles | PC | 2.0.109.00001 | Original | | 1962507 | |
| The Sims Life Stories | PC | 1.0.22.17622 | Original | | 1528207 | |
| The Sims Castaway Stories | PC | 1.0 | Original | | 1575007 | |
| The Sims 4: Island Living | PC | | Original, Rerelease | | 3765703401, 3765703402 | |
| The Sims 4: Discover University (Expansion Pack) | PC | | Original | | 3765903401 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims 3: Town Life Stuff | PC | | Original | | 1957907 | |
| The Sims 3: Seasons (Expansion Pack) | PC | | Original, Limited Edition | | 1978303301 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Master Suite Stuff | PC | 11.0.84.014001 | Original | | 1962307 | |
| The Sims 3: Katy Perry Sweet Treats | PC | | Original | | 1979807 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 3: Hidden Springs | PC | | Original, The Sims 3: Worlds Bundle | | 1979707 | |
| The Sims 3: Fast Lane Stuff | PC | 5.0.44.008001 | Original | | 1950207 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 3: Diesel Stuff The Sims 3: Diesel for Successful Living Stuff | PC | 14.0.48.017001 | Original | | 1968807 | |
| The Sims 2: University Life Collection | PC | 2.0 | Original | | 1685207 | |
| The Sims 2: Mansion & Garden Stuff | PC | 1.17.0.66 | Original | | 1918007 | |
| The Sims 2: Fun with Pets Collection | PC | 2.1 | Original | | 1685607 | |
| The Sims 2: Double Deluxe | PC | | Original | | 1597007 | |
| The Sims 2: Double Deluxe (Bonus DVD) | PC | | Original | | 1597027 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | | | 1672927 | |
| The Sims 2: Deluxe | PC | 1.0.0.1068 | Original | | 1672907 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | The Sims 2: Double Deluxe | | 1597017 | |
| The Sims 2: Deluxe (Bonus DVD) | PC | | Original | | 1672917 | |
| The Sims 2: Best of Business Collection | PC | 2.0 | Original | | 1685507 | |
| The Sims 2: Apartment Life (Expansion Pack) | PC | 1.16.0.179 | Original, Slim Case | | 1907807 | |
| The Sims 2 (Game Disk) | PC | 1.0.0.932 | Special DVD Edition | | 1488307 | |
| The Sims 2 (Bonus Disk) | PC | | Special DVD Edition | | 1488317 | |