Region | Title | System | Version | Edition | Languages | Serial | Status |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | Beta 8 | Beta (CD-R) | | | |
| Slam 'n Jam '95 | 3DO | | Beta (CD-R) | | | |
| Scramble Cobra | 3DO | | Beta (CD-R) | | | |
| Star Fighter | 3DO | | Bundled with Magazine | | | |
| Syndicate | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SE3851G | |
| Super Raiden スーパー雷電 | PCE | Rev 1 | Original | | HCD2023 | |
| Super Darius II スーパー・ダライアスⅡ | PCE | Rev 1 | Original | | NAPR-1031 | |
| Sumida Yuki: Photo CD Portfolio 墨田ユキ フォトCDポートフォリオ | PHOTO-CD | | Original | | GLS-PH-08 | |
| Strider Hiryuu ストライダー飛竜 | PCE | | Original | | NAPR-1041 | |
| Strahl | 3DO | | Original | | FZ-SM4651 | |
| Steam·Heart's スチーム・ハーツ | PCE | | Original | | GLCD6002 | |
| Starblade 스타블레이드 | 3DO | | Original | | FZ-SM5351, GDT-GA221 | |
| Starblade | 3DO | | Original | | FZ-SC5351 | |
| Star Wars: Rebel Assault | 3DO | | Original | | | |
| Star Parodier スター・パロジャー | PCE | | Original | | HCD2024 | |
| Star Fighter | 3DO | | Original | | | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | 3DO | | Original | | | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Ace | 3DO | | Original | | | |
| Sotsugyou II Special: Neo Generation 卒業ⅡSPECIAL | 3DO | | Original | | FZ-SJ7451 | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| Slopestyle: An Interactive Learning Cube | 3DO | | Original | | | |
| Slayer | 3DO | | Original | | | |
| Slam 'n Jam '95 | 3DO | | Original | | | |
| Slam 'n Jam '95 | 3DO | | Original | | 60140-C | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Short Warp: Warp's Short Game Collection ショート・ワープ | 3DO | | Original | | FZ-SJ2357 | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shiho Shashin-shuu SHIHO写真集 | PHOTO-CD | | Original | | FZ-JJ1YP0401 | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Sex | 3DO | | Original | | | |
| Sewer Shark | 3DO | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| School Mates Collection | PHOTO-CD | | Original | | SJ-0001 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program), DMI Sample Pressing | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| Shock Wave | 3DO | RE1 | Original, Demo Disc (3DO Demo Disc Program) | | 7222 | |
| The Super Model: Gail McKenna スーパー・モデル ゲイル・マッケンナ | 3DO | | Original, Mihonban | | TPS-18012 | |
| Star Control II | 3DO | | Original, Not for Resale | | | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |