| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Sphinx and the Cursed Mummy | GC | | Original |      | DL-DOL-GXPP-EUR, DL-DOL-GXPP-NOE | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
 | Sonic Adventure DX: Director's Cut | GC | | Original, Player's Choice |  | DL-DOL-GXSE-USA | |
| Sonic Adventure DX: Director's Cut | GC | Rev 1 | Original, Player's Choice | | DL-DOL-GXSP-EUR | |
| Surf's Up | GC | | Original | | DL-DOL-GXUE-USA |  |
 | Super Mario Stadium: Miracle Baseball
スーパーマリオスタジアム ミラクルベースボール | GC | | Original | | DL-DOL-GYQJ-JPN | |
| SD Gundam: Gashapon Wars
ＳＤガンダム ガシャポンウォーズ | GC | | Taikenban | | DL-DOL-PGPJ-JPN | |
| SuperPower | PC | 2 | Demo | | DMCD35310 | |
| Slipstream 5000 | PC | | Dice | | DMM 000009 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 001631 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 001631 | |
| Sinbad the Seaman | PC | | Dice |  | DMM 003550 | |
| Sentinel Returns | PC | | Dice | | DMM 005448 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 011143 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 011143 | |
| Solar Crusade | PC | | Dice | | DMM 011396 | |
| Superbike 2000
EA Sports: Superbike 2000 | PC | | Dice |  | DMM 012774 | |
| SimCity Enhanced CD-ROM | PC | | Dice | | DMM 014129 | |
| Star Trek: Judgment Rites | PC | | Dice | | DMM 014150 | |
 | Solar Crusade | PC | | Dice | | DMM 031419 | |
| S.T.O.R.M. (Disc 1) | PC | | Dice | | DMM 031730 | |
| Sin
SiN | PC | 0.93 | Demo | | DMO-1000076.101.UK | |
| Sin
SiN | PC | | Demo | | DMO-1000076.101.US | |
| Shaftdiver
シャフトダイバー | PC | 1.0 | Original | | DNAS-SDVR | |
| Summer Athletics | XBOX360 | | Original | | DT-2002 | |
| Summer Athletics 2009 | XBOX360 | | Original | | DT-2006 | |
| SDevTC: Version 2.4 | PC | 2.4 | Original | | DTL-S2200 | |
| Street Fighter V | PC | | Original | | DV1-97242-00EUR | |
| Street Fighter 30th Anniversary Collection | PC | | Original |    | DV1-97251-00EUR | |
| Street Fighter IV | PC | 1.00.3013 | Original, Software Pyramide | | DV197115-00EUR | |
| Street Fighter X Tekken | PC | 1.0.0.0 | Original |   | DV97162-00EUR | |
| The Stalin Subway: Red Veil
The Stalin Subway 2: Red Veil | PC | 1.0.0.1 | Original | | DVD 60866 | |
| Star Wars: The Force Unleashed II | PC | 1.1 | Cosmi | | DVD248D1 v 1.1.0.1 | |
| Star Wars: Battlefront | PC | 1.2 | Cosmi | | DVD282D1; SJ032011 | |
| Star Wars: Battlefront II | PC | 1.1 | Cosmi (DVD-ROM) | | DVD283D1 | |
| Star Wars: Empire at War: Gold Pack | PC | | Cosmi | | DVD284D1 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Cosmi | | DVD284D1, SJ102010 | |
| Star Wars: Republic Commando | PC | 1.01 | Cosmi | | DVD287D1, SJ032011 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | | Cosmi | | DVD288D1 SJ102010 | |
| Star Wars: The Clone Wars: Republic Heroes | PC | 1.0 | Cosmi | | DVD288D1 | |
| SpellForce: Universe (Disc 2) | PC | 2.00 | Original | | DVD563CD | |
| SpellForce: Universe (Disc 1) | PC | 1.52 | Original | | DVD564CD | |
| Seven Kingdoms: Conquest | PC | 1.00 | Original | | DVD580CD | |
| The Secret of the Silver Earring
Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| Shadowrun Chronicles: Boston Lockdown | PC | 12.0.10093 | Cosmi | | DVDC6251 | |
| Sega Network Casino Club STD
セガネットワークカジノクラブ ＳＴＤ | LINDBERGH | 4.000 | Lindbergh Yellow | | DVP-0016C | |
 | Sega-Race TV
セガ－レースＴＶ | LINDBERGH | 1.002 | Lindbergh Yellow | | DVP-0044 | |
| Sega Network Taisen Mahjong MJ4
セガネットワーク対戦麻雀ＭＪ４ | LINDBERGH | 2.000 | Lindbergh Red EX | | DVP-0049A | |
| Sega Network Taisen Mahjong MJ4
セガネットワーク対戦麻雀ＭＪ４ | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ4
セガネットワーク対戦麻雀ＭＪ４ | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega Network Casino Club Ver. 2
セガネットワークカジノクラブ Ｖｅｒ． ２ | LINDBERGH | 1.000 | Lindbergh Yellow | | DVP-0053 | |
| Sega Network Casino Club Ver. 3
セガネットワークカジノクラブ Ｖｅｒ． ３ | LINDBERGH | 1.000 | Lindbergh Yellow | | DVP-0073 | |
| Sega Network Taisen Mahjong MJ4 Evolution
セガネットワーク対戦麻雀ＭＪ４ Ｅｖｏｌｕｔｉｏｎ | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |
| StarHorse 2: Fifth Expansion | LINDBERGH | 2.000 | Lindbergh StarHorse 2 | | DVP-0082A | |
| StarHorse 2: Fifth Expansion | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0082D | |
| StarHorse 2: Final Destination | LINDBERGH | 1.001 | Lindbergh StarHorse 2 | | DVP-0086 | |
| StarHorse 2: Final Destination | LINDBERGH | 5.000 | Lindbergh StarHorse 2 | | DVP-0086D | |
| StarHorse 2: Final Destination | LINDBERGH | 6.000 | Lindbergh StarHorse 2 | | DVP-0086E | |
 | Sega Racing Classic | SRE | | RingWide | | DVR-0009A | |
| Sega Network Taisen Mahjong MJ5
セガネットワーク対戦麻雀ＭＪ５ | SRE | | Original | | DVR-0027 | |
| Sega Network Taisen Mahjong MJ5
セガネットワーク対戦麻雀ＭＪ５ | SRE | 3.01.00 | Original | | DVR-0027J | |
| StarBoat
スターボート | SRE | 1.01.00 | Original | | DVR-0036A | |
| Sega Network Taisen Mahjong MJ5 Evolution
セガネットワーク対戦麻雀ＭＪ５ ＥＶＯＬＵＴＩＯＮ | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 R Evolution
セガネットワーク対戦麻雀ＭＪ５ Ｒ ＥＶＯＬＵＴＩＯＮ | SRE | | Original | | DVR-0083 | |
| Sega Network Taisen Mahjong MJ5 R Evolution
セガネットワーク対戦麻雀ＭＪ５ Ｒ ＥＶＯＬＵＴＩＯＮ | SRE | | Original | | DVR-0083D | |
| StarHorse 3 Season I: A New Legend Begins | SRE2 | 1.50.00 | Original | | DVR-5002F | |
| StarHorse 3 Season V: Exceed the Limit (No. 1) | SRE2 | 1.21.00 | Original | | DVR-5051J | |
| Sega Net Mahjong MJ Arcade
セガＮＥＴ麻雀ＭＪ Ａｒｃａｄｅ | SRE | 12.50.00 | Original | | DVR-5055AD | |
| Sega Net Mahjong MJ Arcade
セガＮＥＴ麻雀ＭＪ Ａｒｃａｄｅ | SRE | 12.60.00 | Original | | DVR-5055AF | |
| Sega Net Mahjong MJ Arcade
セガＮＥＴ麻雀ＭＪ Ａｒｃａｄｅ | SRE | | Original | | DVR-5055D | |
| StarHorse 3 Season VII: Great Journey (No. 1) | SRE2 | 1.00.00 | Original | | DVR-5060 | |
| StarHorse 3 Season VII: Great Journey (No. 1) | SRE2 | 1.10.00 | Original | | DVR-5060C | |
| StarHorse 3: SH4-you User Data Uploader
ＳｔａｒＨｏｒｓｅ３ ＳＨ４用ユーザーデータ アップローダー | SRE2 | 1.99.00 | Original | | DVR-5061 | |
| Scholar Movie Magazine Soukangou
スコラ ＭＯＶＩＥ ＭＡＧＡＺＩＮＥ 創刊号 | FMT | | Original | | DWDC 4815 | |
| Sensual Angels
センシャル・エンジェル | FMT | | DCCS (FM Towns Release), PC-9821 Release | | DWDC3813 | |
| Shamhat: The Holy Circlet
シャムハト －Ｔｈｅ Ｈｏｌｙ Ｃｉｒｃｌｅｔ－ | FMT | | FM-Towns Sen'you, FM-Towns Marty Sen'you | | DWFS3010, DWFT 3012 | |
| The Silent Service: Chinmoku no Kantai
沈黙の艦隊 | FMT | | Original | | DWFT2802 | |
| SimClassics Vol. 1: SimTown / SimSafari
シムクラシック ｖｏｌ．１ シムタウン／シムサファリ | PC | | DigiCube PC | | DWOKD-00042 | |
| SimCity 3000
シムシティ３０００ | PC | 1.0.557.0 | Original, DigiCube PC, Shokaiban | | DWOKD-00046, EMW-4047 | |
| Star Wars: Episode I: The Phantom Menace
スター・ウォーズ エピソード１ ファントム・メナス | PC | | DigiCube PC | | DWOKD-00061 | |
| Sangokushi III
三國志Ⅲ | PC | 1.0 | Koei Teiban Series | | DWOKD-00071 | |
| SimPeople Deluxe
シムピープル デラックス | PC | | DigiCube PC | | DWOKD-00085 | |
| Suikoden: Tenmei no Chikai
水滸伝 天命の誓い | PC | 1.0 | DigiCube PC, Koei Teiban Series | | DWOKM-00043, KN10-14103 | |
| The Silent Service: Chinmoku no Kantai
沈黙の艦隊 | PC-98 | | Original | | DWPC3808 | |
| SD Gundam: GGeneration DA
ＳＤガンダム ＧジェネレーションＤＡ | PC | 1.00 | DigiCube PC Series | | DWRMS-00158 | |
| Sega Rally 2: Sega Rally Championship (Install Disc)
セガラリー２ | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally 2: Sega Rally Championship (Play Disc)
セガラリー２ | PC | | DigiCube PC | | DWRPD-00081 | |
| Sequence Palladium
シークエンス パラディウム | PC | | DigiCube, Media Kite Great Series | | DWRPM-00089, MKW-182 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | DigiCube PC | | DWRPS-00055 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Desktop Accessories
サクラ大戦３ ～巴里は燃えているか～ デスクトップアクセサリーズ | PC | | Tokubetsu Genteiban B | | DWWWC-50121~50123 | |
| Spiele der Welt | PC | | Original | | DZEM013-96800A | |
| Space Hulk | PC | | Original | | E2105CCD | |
| Syndicate Plus | PC | | CD-ROM Classics | | E2825CCD | |
| Syndicate Plus
Syndicate+ | PC | | CD-ROM Classics: RComp | | E2825CCD | |
| SSN-21 Seawolf | PC | | EA CD-ROM Classics | | E3205CXD | |
| Space Hulk: Vengeance of the Blood Angels | PC | | Original | | E348EDED | |
| Shockwave Assault | PC | | Original | | E354WCED | |
| Syndicate
シンジケート | 3DO | | Original | | E3D-7025 | |
| System Shock | MAC | | Original | | EA 568407 | |
| Syndicate Wars | PC | | | | EA 768207 | |
