| Region | Title | System | Version | Edition | Languages | Serial | Status |
 | S.C.A.R.S. | PC | 1.0 | | | |  |
 | S.T.O.R.M. (Disc 1) | PC | | Original | | PC-CD 92000-4 |  |
 | S.T.O.R.M. (Disc 2) | PC | | Original | | PC-CD 92000-4 |  |
 | S.T.O.R.M. (Disc 3) | PC | | Original | | PC-CD 92000-4 |  |
 | Sacrifice: Uzuki no Kubiwa サクリファイス ~疼きの首輪~ | PC | | Original | | CNDL-0001 |  |
 | Saga: Gniew Wikingów | PC | 1.0.0.1 | eXtra Klasyka | | |  |
 | Saint Eyes セイントアイズ | PC | | Shokai Genteiban | | |  |
 | Sakamoto Ryouma: Ishin Kaikoku 坂本竜馬 ~維新開国~ | SS | 1.002 | Original | | T-19709G |  |
 | Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 |  |
 | Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 |  |
 | Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 |  |
 | Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 |  |
 | Sakura Taisen Teikokukagekidan Taiin Meibo サクラ大戦 帝国華撃団隊員名簿 | SS | 1.000 | Hibaihin | | SKR-00468 |  |
 | Sam & Max Hit the Road | PC | | White Label: Doubles | | |  |
 | Same Game FX | PC-FX | | Bundled with PC-FXGA | | |  |
 | Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | |  |
 | Samurai Shodown | MCD | | Original | | T-60175-50 |  |
 | Samurai Shodown | MCD | | Original | | T-60175 |  |
 | Samurai Spirits サムライ・スピリッツ | FMT | | Original | | JH-012 |  |
 | Samurai Spirits: Amakusa Kourin サムライ・スピリッツ ~天草降臨~ | SS | 1.001 | Hibaihin | | 610-6730 |  |
 | The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 |  |
 | Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | |  |
 | Sangoku Engi x Sangoku Seishi 三國演義×三國正史 | PC | 1.0 | Original | | RON003 |  |
 | Sangokushi II 三國志Ⅱ | PC | 1.0 | Original | | KN11-98101 |  |
 | Sangokushi Koumeiden 三國志孔明伝 | PC | | Original | | KN11-15101 |  |
 | Sangokushi: Returns 三國志 リターンズ | PC | 1.0 | Kikan Gentei Hatsubai | | |  |
 | Sanguo Mahjong Fengyun 三國麻將風雲 | PC | | Original | | |  |
 | Sanguozhi V 三國志Ⅴ | SS | 1.000 | Zhongwenban | | T-7606H-11, T-7606H-16 |  |
 | Sanguozhi Yingjiezhuan 三國志英傑伝 | SS | 1.000 | Zhongwenban | | T-7603H-11, T-7603H-16 |  |
 | Saturn Super Henshuubu Hen: Taikenban Saturn Soft Taizen サターン・スーパー 編集部 編 体験版サターンソフト大全 | SS | 1.000 | | | 610-6020-04 |  |
 | Saturn Super Vol. 11 Furoku CD-ROM サターン・スーパー Vol.11 付録CD‐ROM | SS | 1.000 | | | 610-6020-12 |  |
 | Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | | | 610-6020-02 |  |
 | Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | | | 610-6020-02 |  |
 | Saturn Super Vol. 2 サターン・スーパー Vol.2 | SS | 1.000 | | | 610-6020-02 |  |
 | Saturn Super Vol. 3 サターン・スーパー Vol.3 | SS | 1.001 | | | 610-6020-03 |  |
 | Saturn Super Vol. 3 サターン・スーパー Vol.3 | SS | 1.001 | | | 610-6020-03 |  |
 | Saturn Super Vol. 3 サターン・スーパー Vol.3 | SS | 1.001 | | | 610-6020-03 |  |
 | Saturn Super Vol. 6 サターンスーパー Vol.6 | SS | 1.000 | | | 610-6020-07 |  |
 | Saturn Super Vol. 7 サターン・スーパー Vol.7 | SS | 1.000 | | | 610-6020-08 |  |
 | Saturn Super Vol. 7 サターン・スーパー Vol.7 | SS | 1.000 | | | 610-6020-08 |  |
 | Saturn Super Vol. 8 サターン・スーパー Vol.8 | SS | 1.000 | | | 610-6020-09 |  |
 | Savage Warriors | PC | 1.0 | Original | | 2205110-S90001/1055SA |  |
 | Scarab S.C.A.R.A.B. | PC | | Original | | EAE08801181D |  |
 | Scarab S.C.A.R.A.B. | PC | | Original | | 7545 |  |
 | Schleichfahrt | PC | | | | |  |
 | Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 |  |
 | Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 |  |
 | Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 |  |
 | Schwarzschild GX: Sabita Sousei シュヴァルツシルトGX ~錆びた蒼星~ | PC-98 | | Original | | 9531-77-01 |  |
 | Schwarzschild GXR: Toki no Tsukaibito シュヴァルツシルトGXR 時現の遣人 | PC | | Original | | ID NO.9674-68-01 |  |
 | Scissors 'n' Stones | PC | | Original | | |  |
 | Screamer | PC | | Award Winners No. 1 | | EI-1041 |  |
 | Screamer | PC | | Sold Out Extreme | | |  |
 | Screamer 2 | PC | | Original | | |  |
 | Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 |  |
 | Screamworld Bonus CD Welcome to Screamworld | PC | | | | |  |
 | SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 |  |
 | Il Secondo Disco de Le Favole di Esopo | CDI | | Original | | 815 0046 |  |
 | Secre Volume 7: Reiko Chiba SECRE VOLUME ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 |  |
 | The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | |  |
 | Seek and Destroy Seek & Destroy | CD32 | | Original | | |  |
 | Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H |  |
 | Sega Ages: Space Harrier セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 |  |
 | Sega Ages: Space Harrier セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 |  |
 | Sega Entertainment's Arcade Sampler | PC | | | | |  |
 | Sega Family Fun Pak | PC | | Original | | |  |
 | Sega Internet-Selain | SS | 1.012 | Bundled with Net Link Internet Modem | | 80124 |  |
 | Sega Puzzle Pack | PC | | Original | | 85091 |  |
 | Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 |  |
 | Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 |  |
 | Sega Rally Championship | PC | 1.0 | Original | | 85048 |  |
 | Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | |  |
 | Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 |  |
 | Sega Touring Car Championship | PC | 1.0 | Original | | 85067 |  |
 | Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 |  |
 | Sega Worldwide Soccer PC | PC | | Grabit | | GDL074 |  |
 | Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka! 政界立志伝~君は日本のリーダーになれるか!~ | PC | | | | MSDJ-99094 |  |
 | Seikimatsu Taimaden Tsumugi-chan SOS 世紀末退魔伝つむぎちゃんSOS | PC | | Original | | EXC-0011 |  |
 | Sengoku Blade: Sengoku Ace Episode II 戦国ブレード | SS | 1.002 | Mihonhin | | ST-14410G |  |
 | Sensible Soccer | MCD | | Original | | T-93185-50 |  |
 | Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | |  |
 | Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | |  |
 | Sentimental Graffiti (Disc 1) (Game Disc) センチメンタル・グラフィティ | SS | 1.003 | Original | | T-20106G |  |
 | Sentimental Graffiti (Disc 2) (Second Window) センチメンタル・グラフティ | SS | 1.000 | Original | | T-20106G |  |
 | Sento Monogatari Sono I 「占都物語」そのⅠ | SS | 1.000 | Original | | T-6801G |  |
 | Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | |  |
 | Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | |  |
 | The Settlers II: Złota Edycja | PC | 1.51 | eXtra Klasyka | | |  |
 | The Settlers III (Disc 1) | PC | | Revival | | REV036 |  |
 | The Settlers III (Disc 2) | PC | | Revival | | REV036 |  |
 | The Settlers III: Złota Edycja (Disc 1) | PC | | Nowa eXtra Klasyka | | |  |
 | The Settlers III: Złota Edycja (Disc 2) | PC | | Nowa eXtra Klasyka | | |  |
 | Sewer Shark | MCD | | Original | | T-93015-50 |  |
 | Sewer Shark | MCD | | Bundled with Sega CD | | 4101 |  |
 | The Shadow of the Third Moon | ACD | 1.1 | Original | | |  |
 | Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 |  |
 | Shadow Warrior Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 |  |
 | Shakunetsu no Bishoujo: Touno Maiko 灼熱の美少女 遠野舞子 | PHOTO-CD | | Original | | PLP-5005 |  |
 | Shanghai Gensoutan: Teito Kitan Gaiden (Disc Otsu) 上海幻想譚 ~帝都奇譚外伝~ | PC | | Original | | |  |
 | Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK |  |