| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Saint Eyes
セイントアイズ | PC | | Shokai Genteiban | | |  |
 | Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
 | Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Screamworld Bonus CD
Welcome to Screamworld | PC | | | | | |
 | Secret Service CD 55 (Strona A) | PC | | | | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
 | Sega Worldwide Soccer PC | PC | | Grabit | | GDL074 | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | DigiCube PC | | DWRPS-00055 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | PC Game Best Series Mega Hit | | | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silver Gene: The Mutia Chronicle 1
シルバージーン ｔｈｅ ｍｕｔｉａ ｃｈｒｏｎｉｃｌｅ 1 | PC | | Original | | CNDL-0002 | |
| Simone
Simone: A 64-Bit Memory Game | AJCD | | Unlicensed | | | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
 | Soft-World Magazine No. 139: November 2000
軟體世界雜誌社 ＭｅｇａＤｉｓｃ 第１３９期 | PC | | | | | |
| Software of the Month Club: Volume 245 (Software Showcase) | PC | | | | | |
 | Sonic 3D: Flickies Island | PC | | ValuSoft | | THQ70487.101 | |
| Sonic R
ソニックＲ | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Soul Ride | PC | | | | | |
| Soundtracks of Lipstick Adv.EX
リップスティックアドベンチャーＥＸ サウンドトラック | PC | | PC Game Bundle | | F&C-106 | |
| Souzou Sozai: Umi Vol. 1
創造素材 海 Ｖｏｌ．１ | PHOTO-CD | | Original | | SEVI-1049 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Starblade | MCD | | Original | | 4284-50 | |
| Starry the Universe
大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Style Game Magazine July 2000
新遊戲時代 ２０００．０７ | PC | | | | | |
| Suppin Bishoujo Vol. 3
すっぴん美少女 ｖｏｌ．３ | PHOTO-CD | | Original | | SPN-003 | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Original | | T162045 | |
| Surgical Strike | MCD | | Original | | 4435-50, 670-6783-50 | |
| Świat Przygód z Hugo 5/2004 | PC | | | | | |
| Sanguo Mahjong Fengyun
三國麻將風雲 | PC | | Original |  | | |
| Sanguozhi IV
三國志Ⅳ | SS | 1.003 | Zhongwenban | | T-7601H-11, T-7601H-16 | |
| Sanguozhi V
三國志Ⅴ | SS | 1.000 | Zhongwenban | | T-7606H-11, T-7606H-16 | |
 | Sanguozhi VIII
三国志Ⅷ | PC | 1.0 | Original | | | |
| Sanguozhi Yingjiezhuan
三國志英傑伝 | SS | 1.000 | Zhongwenban | | T-7603H-11, T-7603H-16 | |
| Shiluo Dadi
失落大地 | PC | 1.00.000 | Original | | | |
| Shouhuzhe Zhi Jian (Disc 1)
守护者之剑 | PC | | Original | | | |
| Shouhuzhe Zhi Jian (Disc 2)
守护者之剑 | PC | | Original | | | |
 | Spellcross: Poslední Bitva | PC | | Covermount |  | | |
 | S.C.A.R.S. | PC | 1.0 | |  | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | PC-CD 92000-4 | |
| S.T.O.R.M. (Disc 2) | PC | | Original | | PC-CD 92000-4 | |
| S.T.O.R.M. (Disc 3) | PC | | Original | | PC-CD 92000-4 | |
| Salamander Deluxe Pack Plus
沙羅曼蛇 ＤＥＬＵＸＥ ＰＡＣＫ ＰＬＵＳ | SS | 1.010 | Original | | T-9520G | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| Sandwarriors | PC | 1.11 | Original | | CD-ICD-297-0 | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Saturn Bomberman | SS | 1.003 | Original | | 81070 | |
| Scarab
S.C.A.R.A.B. | PC | | Original | | EAE08801181D | |
| Scarab
S.C.A.R.A.B. | PC | | Original | | 7545 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
 | Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| SD Qlympics
Olympic Challenge | PC | | Grabit | | GDL031 | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| Secrets of Tatjana | CDI | | Original, Demonstration Disc | | 810 0046 | |
| Seek and Destroy
Seek & Destroy | CD32 | | Original | | | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Puzzle Pack | PC | | Original | | 673-01815 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 (Disc 2)
Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship
Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Rally Championship PC
セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Touring Car Championship | SS | 1.001 | Original, Sample | | 81216 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
