Region | Title | System | Version | Edition | Languages | Serial | Status |
| SHADOW: War of Succession | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shock Wave: Operation JumpGate | 3DO | | Original | | | |
| SimTheme Park Sim Theme Park | PSX | | Original | | SLUS-01069 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | 063636, T162035 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| A Sombra do Zorro | PC | | Original | | INFOG 095 | |
| Space Pirates | 3DO | | Original | | ALG595001 | |
| Spyro 2: Ripto's Rage! | PSX | | Original, Greatest Hits, Collectors' Edition | | SCUS-94425 … | |
| Surgical Strike | MCD | | Sega CD 32X (Disc 2) | | 4435, 157036 | |
| Surgical Strike | MCD | | Original | | 4435 | |
| Space Ace | 3DO | RE-1 | Original | | | |