Region | Title | System | Version | Edition | Languages | Serial | Status |
| Star Trek: Klingon Academy (Disc 5) | PC | | Original | | CD-C95-856-4 | |
| Star Trek: Klingon Academy (Disc 6) | PC | | Original | | CD-C95-856-5 | |
| Sid Meier's Civilization II | PC | 2.42a | Top 10 Games | | CD-C95-963-BS-E | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Original | | CD-ICD-016-0 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | | | CD-ICD-016-4 | |
| SimCity Enhanced CD-ROM | PC | | Original | | CD-ICD-041-0 | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.08 | | | CD-ICD-201-M9 | |
| SimCity Enhanced CD-ROM | PC | | Rerelease | | CD-ICD-204-0 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM | PC | | Star Trek: Federation Compilation | | CD-ICD-301-0 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Signature Series | | CD-ICD-301-0 | |
| SimCity Enhanced CD-ROM | PC | 1.0 | Rerelease | | CD-ICD-508-0 | |
| SimCity Enhanced CD-ROM | MAC | | MacPlay | | CD-MCR-041-0 | |
| The Skins Game at Bighorn | PC | | Original | | CD-MPC-126-0 | |
| Space Bunnies Must Die! | PC | | Original | | CD-RC004 | |
| Star Trek: Klingon Academy (Disc 1) | PC | | Original | | CD-W95-856-G1 | |
| Star Trek: Klingon Academy (Disc 2) | PC | | Original | | CD-W95-856-G2 | |
| Star Trek: Klingon Academy (Disc 3) | PC | | Original | | CD-W95-856-G3 | |
| Star Trek: Klingon Academy (Disc 4) | PC | | Original | | CD-W95-856-G4 | |
| Star Trek: Klingon Academy (Disc 5) | PC | | Original | | CD-W95-856-G5 | |
| Star Trek: Klingon Academy (Disc 6) | PC | | Original | | CD-W95-856-G6 | |
| Shadow Man: Rette deine Seele | PC | | Original | | CD194141.03-GER | |
| Shadow Man | PC | | Original | | CD194141.05-ITA | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | | Star Trek: Federation Compilation | | CD2-W95-846-G | |
| Spider-Man: Kampen om Evigt Liv | PC | | Book Bundle | | CDJ 8002 | |
| Swift Classics Card Games for Windows | PC | | Cosmi | | CDR 720 OD1, SJ 041001 G | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0.1.0 | Cosmi | | CDR285D1 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0.1.0 | Cosmi | | CDR285D2 | |
| SimCity 4 Deluxe Edition (Disc 1) | PC | 1.0 | Scholastic | | CDR5034957 | |
| SimCity 4 Deluxe Edition (Disc 2) | PC | 1.0 | Scholastic | | CDR5034957 | |
| Shogo: Mobile Armor Division | PC | 1.0 | Original | | CDR5051 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Spaceship Warlock | MAC | | Original | | CDRM 403300 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | 2 | Original | | CDRM 770000 | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Rerelease | | CDRM 835400 | |
| Sherlock Holmes: Consulting Detective: Vol. III | MAC | 3.0 | | | CDRM 835400 | |
| Space Quest IV: Roger Wilco and the Time Rippers Space Quest IV | PC | 1.0 | Original | | CDRM SQU344AE-CD | |
| Sherlock Holmes: Consulting Detective: Vol. I | PC | | Original | | CDRM1011460 | |
| Sherlock Holmes: Consulting Detective: Vol. III | PC | 4 | Original | | CDRM1061930 | |
| Super Huey III: Combat & Rescue / Spy Hunter/Sub Attack | PC | | Original | | CDRS409CD1 | |
| Syberia: Złota Edycja | PC | 1.0 | Kolekcja Klasyki | | CENEGA 396/PCDVD-ROM/2006 | |
| Sid Meier's Pirates! | PC | 1.0.2.0 (30927) | Kolekcja Klasyki | | CENEGA 564/PCDVD-ROM/2007 | |
| Sid Meier's Civilization II | PC | | Best of Infogrames | | CIV2PCB0GB/A | |
| Sid Meier's Civilization III | PC | 1.16f | Original | | CIVIL3PCD/A | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sid Meier's Colonization | MAC | | Original | | CLMC-60 | |
| Sid Meier's Colonization: Create a New Nation コロナイゼーション | PC | | Kanzen Nihongoban for Windows | | CLWC 66 | |
| Sensible Soccer 2006 | XBOX | | Original | | CM-091 | |
| Sticks 'n' Fire: Stop That Train | CDI | | Original | | CMC 24020-2CD-I | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Slipstream 5000 | PC | | Original | | CN000500028 | |
| Silver Gene: The Mutia Chronicle 1 シルバージーン the mutia chronicle 1 | PC | | Original | | CNDL-0002 | |
| SimCity 2000 | PC | 1.01 | Original | | CS090076 | |
| Su-27 Flanker: Squadron Commander's Edition | PC | | Software Pyramide | | CS090560X | |
| Super Solvers: Midnight Rescue! | PC | 1.1 | Rerelease | | CSM744AE-CD | |
| Super Solvers: Midnight Rescue! | PC | 1.12 | Rerelease | | CSM744BE-CD | |
| Summer Athletics: The Ultimate Challenge | XBOX360 | | Original | | CV-2004 | |
| Su-27 Flanker: Squadron Commander's Edition | PC | 1.0 | SoftKey | | D01028 | |
| SilverMoon | PC | | Designer's Collection 01 | | DC-KM001 | |
| Sumeragi no Miko-tachi (Disc 1) (Install Disc) すめらぎの巫女たち | PC | 1.0.0.1 | Original | | DCD-00531 | |
| Sumeragi no Miko-tachi (Disc 2) (Install Disc) すめらぎの巫女たち | PC | 1.0.0.1 | Original | | DCD-00532 | |
| SlamTilt Resurrection (Demon Table) | PC | | Dice | | DCG 003994 | |
| SlamTilt Resurrection (Pirate Table) | PC | | Dice | | DCG 003994 | |
| SimPark | PC | | Dice | | DCG 007091 | |
| SimGolf | PC | | Dice | | DCG 007107 | |
| SimAnt | PC | | Dice | | DCG 007220, DMM 007633 | |
| SimTunes | PC | | Dice | | DCG 007244 | |
| SimLife | PC | | Dice | | DCG 007282, DMM 007640 | |
| SimFarm | PC | | Dice | | DCG 007329, DMM 007695 | |
| SimTower: Das vertikale Imperium | PC | | Dice | | DCG 007350 | |
| Sim Town | PC | | Dice | | DCG 008678 | |
| Slipstream 5000 | PC | | Dice: ZOO Classics | | DCG 902796 | |
| Sangoku Rensenki: Otome no Heihou! (Disc 1) 三国恋戦記 ~オトメの兵法!~ | PC | | Original | | DD-0002-1 | |
| Sangoku Rensenki: Otome no Heihou! (Disc 2) 三国恋戦記 ~オトメの兵法!~ | PC | | Original | | DD-0002-2 | |
| Sierra/Coktel Multimedia Katalog | PC | | | | DEUTSCH PZZZ0520Z01Z1 | |
| Storage Manager: Memory Kanri Storage Manager メモリー管理 | 3DO | | Bundled with 3DO Memory Unit | | DFJN5018ZBZ | |
| STCC 2: Swedish Touring Car Championship | PC | 2.3 | Original | | DGN08903453 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
| Shissou, Yankee Tamashii. 疾走、ヤンキー魂。 | PC | | BB Games Online Game Fantasista | | disc_02 | |
| SmaBro DX Event-you Disc スマブラDX イベント用ディスク | GC | | Promo | | DL-DOL-D24J-DIS | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Taikenban | | DL-DOL-DM2J-DIS | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Serious Sam: Next Encounter | GC | | Original | | DL-DOL-G3BP-EUR | |
| The Sims ザ・シムズ | GC | | Original | | DL-DOL-G4PJ-JPN | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCP-EUR | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2D-NOE | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| Special Jinsei Game Special 人生ゲーム | GC | | Original | | DL-DOL-GLIJ-JPN | |
| Super Mario Sunshine 슈퍼 마리오 선샤인 | GC | | Original | | DL-DOL-GMSE-KOR | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | Rev 1 | Original | | DL-DOL-GMSJ-JPN | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Summoner: La Déesse Réincarnée | GC | | Original | | DL-DOL-GS2F-FRA | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Shaman King: Soul Fight シャーマンキング ソウルファイト | GC | Rev 1 | Original | | DL-DOL-GSEJ-JPN | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man | GC | | Original | | DL-DOL-GSMF-FRA | |
| Spider-Man スパイダーマン | GC | | Original | | DL-DOL-GSMJ-JPN | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSMP-UKV | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUP-EUR | |
| Slipstream 5000 | PC | | Dice | | DMM 000009 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 001631 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 001631 | |
| Sinbad the Seaman | PC | | Dice | | DMM 003550 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 011143 | |
| Superbike 2000 EA Sports: Superbike 2000 | PC | | Dice | | DMM 012774 | |
| SimCity Enhanced CD-ROM | PC | | Dice | | DMM 014129 | |
| Star Trek: Judgment Rites | PC | | Dice | | DMM 014150 | |
| Sin SiN | PC | 0.93 | Demo | | DMO-1000076.101.UK | |
| Sin SiN | PC | | Demo | | DMO-1000076.101.US | |
| Saddle Up: Time to Ride | PC | 1.00.000 | Original | | DPV1.0, PCO437CD | |
| Summer Athletics 2009 | XBOX360 | | Original | | DT-2006 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.0.5.0 | Rerelease | | DVD284D1, SJ102010 | |
| Star Wars: Republic Commando | PC | 1.01 | Cosmi | | DVD287D1, SJ032011 | |
| Seven Kingdoms: Conquest | PC | 1.00 | Original | | DVD580CD | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 7.000 | Lindbergh Red EX | | DVP-0049F | |
| Sega Network Taisen Mahjong MJ4 セガネットワーク対戦麻雀MJ4 | LINDBERGH | 8.003 | Lindbergh Red EX | | DVP-0049G | |
| Sega Network Taisen Mahjong MJ5 セガネットワーク対戦麻雀MJ5 | SRE | | Original | | DVR-0027 | |
| Sega Network Taisen Mahjong MJ5 Evolution セガネットワーク対戦麻雀MJ5 EVOLUTION | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083D | |
| Scholar Movie Magazine Soukan-gou スコラ MOVIE MAGAZINE 創刊号 | FMT | | Original | | DWDC 4815 | |
| Star Wars: Episode I: The Phantom Menace スター・ウォーズ エピソード1 ファントム・メナス | PC | | DigiCube PC | | DWOKD-00061 | |
| The Silent Service: Chinmoku no Kantai 沈黙の艦隊 | PC-98 | | Original | | DWPC3808 | |
| SD Gundam: GGeneration DA SDガンダム GジェネレーションDA | PC | 1.00 | DigiCube PC Series | | DWRMS-00158 | |
| Sega Rally 2: Sega Rally Championship (Install Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally 2: Sega Rally Championship (Play Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Desktop Accessories サクラ大戦3 ~巴里は燃えているか~ デスクトップアクセサリーズ | PC | | Tokubetsu Genteiban B | | DWWWC-50121~50123 | |
| The Simpsons: Road Rage | XBOX | | Original | | EA-019 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims | XBOX | | Original | | EA-047 | |
| The Sims: Bustin' Out 模擬市民 純屬意外 | XBOX | | Original | | EA-067 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| Les Simpson: Le Jeu | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| The Simpsons Game | XBOX360 | | Original | | EA-2057 | |
| Die Simpsons: Das Spiel | XBOX360 | | Original | | EA-2057 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| The Sims 2 | XBOX | | Original | | EA-907 | |
| SimCity Societies Destinations 模擬城市:度假天堂 | PC | | Original | | EA208707 | |
| Shogun: Total War: The Mongol Invasion | PC | | Original | | EAD08803486D | |
| Sid Meier's Gettysburg! | PC | 1.0 | Play The Games Vol. 2 | | EAG 08801356D | |
| Sid Meier's Gettysburg! | PC | 1.0 | Original | | EAG 08801356F | |
| Sid Meier's Alien Crossfire | PC | 4.0 | Original | | EAG08902814D | |
| Sid Meier's Alpha Centauri: Planetary Pack | PC | | Original | | EAG08903149D | |
| Superbike World Championship | PC | | | | EAX08801929D | |
| Sub Command (Disc 1) Sub Command: Akula Seawolf 688(I) | PC | 0.1.0.0 | Original | | EAX08803483D | |
| Sub Command (Disc 2) Sub Command: Akula Seawolf 688(I) | PC | 0.1.0.0 | Original | | EAX08803483D1 | |
| Sid Meier's SimGolf | PC | | Original | | EAX08803576D | |
| Singles 2: Wilde Zeiten | PC | | Original | | ECD008010M | |
| Das Schwarze Auge: Satinavs Ketten | PC | | Limitierte Erstauflage | | ECD008798M ECD008799M ECD008907K ECD900830D 23032012-00 | |
| Shinchou Mahjong 信長麻雀 | XBOX | | Original | | EF-001 | |
| Space Invada!! Type Shinai to Tama ga Denai. SPACE INVA打!! / SPACE INVADERS!! タイプしないとタマが出ない。 | PC | | Original | | EF-SIV01 | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Sega Touring Car Championship | PC | 1.0 | Xplosiv | | EI-1306 | |
| Sheep | PC | | Megapak 10 | | EI-1420 GERMAN | |
| Sega Marine Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1606 | |
| Space Empires V | PC | 1.20 | Original | | EI-2171 EUROPEAN | |
| Stranger | PC | | Original | | EI-2237 ML02 | |
| Strike Commander ストライクコマンダー | PC | 1.01 | Original | | EID-4001 | |
| Syndicate Wars シンジケートウォーズ | PC | | Original | | EMW-4021 | |
| Shin Theme Park: Yuuenchi o Tsukurou 新テーマパーク 遊園地をつくろう | PC | | Original | | EMW-4034 | |
| SimPeople シムピープル | PC | 1.0 | Original | | EMW-4061 | |
| SimCity 3000 Special Edition Upgrade Kit シムシティ3000 スペシャルエディション アップグレード・キット | PC | 2.0.958.0 | Original | | EMW-4071, EMW-4073, EMWV-707 | |
| SimCity 3000 Special Edition シムシティ3000 スペシャルエディション | PC | | Original | | EMW-4080 | |
| SimCity 4 (Disc 1) シムシティ4 | PC | 1.0.233.0 | Original | | EMW-4121 | |
| SimCity 4 (Disc 2) シムシティ4 | PC | 1.0.233.0 | Original | | EMW-4121 | |
| SimCity 4: Rush Hour: Expansion Pack シムシティ4 ラッシュ・アワー 拡張キット | PC | 1.1.613.0 | Original | | EMW-4131 | |
| The Sims 2 (Disc 1) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 2) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 3) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| The Sims 2 (Disc 4) ザ・シムズ2 | PC | 1.0.0.932 | Original | | EMW-4138 | |
| SimPeople: Magical Dream! (Data Set) (Disc 1) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Magical Dream! (Data Set) (Disc 2) シムピープル マジカルドリーム!データセット | PC | 1.1 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 1) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Pets & Gardening! (Data Set) (Disc 2) シムピープル ペット&ガーデニング!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 1) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Star Paradise! (Data Set) (Disc 2) シムピープル スター・パラダイス!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| SimPeople: Vacation! (Data Set) シムピープル バケーション!データセット | PC | 1.0 | SimPeople Kanzenban 3 | | EMW-4160 | |
| Shin Theme Park: Yuuenchi o Tsukurou 新テーマパーク 遊園地をつくろう | PC | | EA Best Selections | | EMWB-7007 | |
| SimCity 3000 シムシティ3000 | PC | | EA Best Selections | | EMWB-7048 | |
| Superbike 2000 | PC | | EA Best Selections | | EMWB-7053 | |
| Sid Meier's Alpha Centauri: Kanzenban シド・マイヤーズ アルファ・ケンタウリ 完全版 | PC | | EA Best Selections | | EMWB-7057 | |
| SimCity 2000 Special Edition シムシティ2000スペシャルエディション | PC | 1.0 | EA Best Selection | | EMWD-701 | |
| Shin Theme Park: Yuuenchi o Tsukurou 新テーマパーク 遊園地をつくろう | PC | | EA Best Selections | | EMWD-711 | |
| Strike Commander ストライク・コマンダー | PC-98 | | PC-98-you CD-ROM-ban | | ENP-7010 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 2) (Reading Adventure) | PC | | Original | | EPK-744AE-CD2 | |
| Souzou Sozai: Europe no Mado Vol. 2 創造素材 ヨーロッパの窓 Vol.2 | PHOTO-CD | | Original | | ERV2 | |
| Scudetto 5 Scudetto Championship Manager 5 | XBOX | | Original | | ES-026 | |
| SimCity 2000 Special Edition | PC | | SoftKey | | ESC744BB-CD | |
| Supermarket Mania | PC | | Original | | ESS772 | |
| Strong Bad's Cool Game for Attractive People | PC | 1.0.0.1 | Original | | EuroVideo-Artikel-Nummer 501883 | |
| Sam & Max Save the World Sam & Max: Season One | PC | | PC Game Bundle | | EuroVideo-Artikel-Nummer 502083 | |
| Sam & Max: Im Theater des Teufels Sam & Max: The Devil's Playhouse | PC | | Original | | EuroVideo-Artikel-Nummer 502083 | |
| Silmarils Collection | PC | | Original | | EuroVideo-Artikel-Nummer: 502063 | |
| Seikimatsu Taimaden Tsumugi-chan SOS 世紀末退魔伝つむぎちゃんSOS | PC | | Original | | EXC-0011 | |
| Sid Meier's Civilization V シド・マイヤーズ シヴィライゼーションⅤ | PC | | Kakaku Kaiteiban | | FBG007W000A10 | |
| Star Wars: Yoda Stories + Star Wars: Screen Entertainment | PC | 1.0 | | | FD005, LUC629 | |
| Sherlock Holmes Versus Jack the Ripper | XBOX360 | | Original | | FE-2003 | |
| Sherlock Holmes: Crimes & Punishments | XBOX360 | | Original | | FE-2015 | |
| Sega Touring Car Championship | PC | | Fair Game: Quality Value | | FG-1306 EUROPEAN | |
| Suomiseikkailu | PC | | Original | | FI6 | |
| St. Shirobara Gakuen Petit Mahjong: Enami Rina no Maki 聖白薔薇学園プチ★MAHJONG ~江波理菜の巻~ | PC | | Original | | FIVD-002 | |
| Soreike! Anpanman: Tanoshii Eigo Asobi それいけ! アンパンマン ~たのしいえいごあそび~ | FMT | | Original | | FMB-3010 | |
| Sonic & All-Stars Racing Transformed | PC | | Rerelease | | FSGSEGAPC146AU | |
| Sharin no Kuni, Himawari no Shoujo 車輪の国、向日葵の少女 | XBOX360 | | Limited Edition | | FV-2017 | |
| Steins;Gate: Senkei Kousoku no Phenogram STEINS;GATE 線形拘束のフェノグラム | XBOX360 | | Limited Edition | | FV-2035 | |
| Super PC Engine Fan Deluxe: Special CD-ROM Vol. 1 | PC-FX | | | | FXTIM003 | |
| Super PC Engine Fan Deluxe: Special CD-ROM Vol. 2 | PC-FX | | | | FXTIM004 | |
| Shimada Youko: Quatre 島田陽・子カトル | PHOTO-CD | | Original | | FZ-JJ1YP0501 | |
| Shock Wave: Operation JumpGate ショック・ウェーブ ~オペレーション・ジャンプゲート~ | 3DO | | Demo-CD | | FZ-JJ9DSV-5D | |
| Scramble Cobra: Premium Version スクランブル・コブラ プレミアム・バージョン | 3DO | | Not for Sale | | FZ-JJ9PSC-5H | |
| Secre Fuumin no Omochabako セクレ・フーミンのおもちゃ箱 | 3DO | | Original | | FZ-SJ2651 | |
| Seimei Handan 姓名判断 | 3DO | | Original | | FZ-SJ4053 | |
| Sanzennen Shokudou: Shoku Culture Simulation Game 三千年食堂 食カルチャーシミュレーションゲーム | MAC | | Original | | G012JAP-M | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.11 | Rerelease | | GAG744BE-CD | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Shin Sangoku Musou 3: Fan Disc 「真・三國無双3」ファンディスク | PC | | Hibaihin | | GCITY-65248 | |
| Shikigami no Shiro II 式神の城II | NAOMI | 1.000 | Original | | GDL-0021 | |
| SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 4.000 | Original | | GDX-0006C | |
| Sega Network Taisen Mahjong MJ2 セガ・ネットワーク対戦麻雀MJ2 | CHIHIRO | 5.000 | Original | | GDX-0006D | |
| Sega Network Taisen Mahjong MJ3 セガ・ネットワーク対戦麻雀MJ3 | CHIHIRO | 5.000 | Original | | GDX-0017D | |
| Sega Network Taisen Mahjong MJ3 Evolution セガ・ネットワーク対戦麻雀MJ3 EVOLUTION | CHIHIRO | 2.000 | Original | | GDX-0021A | |
| Sega Network Taisen Mahjong MJ3 Evolution-you Firmware Koushin Program セガ・ネットワーク対戦麻雀MJ3 EVOLUTION用ファームウェア更新プログラム | CHIHIRO | 1.000 | Original | | GDX-0023 | |
| Steam Heart's Perfect Collection: Hybrid CD-ROM スチームハーツ パーフェクトコレクション HYBRID CD-ROM | PC | | Original | | GIGA-970430 | |
| Sumida Yuki: Photo CD Portfolio 墨田ユキ フォトCDポートフォリオ | PHOTO-CD | | Original | | GLS-PH-08 | |
| Search and Rescue: Vietnam MedEvac | PC | | Original | | GLS00239 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Sega Ages: Memorial Selection Vol. 1 セガエイジス メモリアル・セレクションVOL.1 | SS | 1.002 | Original | | GS-9135 | |
| Sakura Taisen: Hanagumi Taisen Columns サクラ大戦 ~花組対戦コラムス~ | SS | 1.000 | Original | | GS-9138 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 2.000 | Original | | GS-9188 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sesamstrasse: Auf die Krümel, fertig, los! | PC | | Rerelease | | GSL854AG-CD | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | | Original | | GV027-J1 | |
| Susume! Taisen Puzzle-dama 進め!対戦ぱずるだま | KSGV | Rev A | Original | | GV027-J1 | |
| Seiryuu Densetsu: Monbit 聖竜伝説モンビット | PCE | Rev 4 | Original | | HCD1018 | |
| Seiya Monogatari: Anearth Fantasy Stories 聖夜物語 | PCE | Rev 2 | Original | | HCD5071 | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.010 | Genteiban | | HDR-0031 | |
| Sakura Taisen: Hanagumi Taisen Columns 2 サクラ大戦 ~花組対戦コラムス2~ | DC | 1.000 | Original | | HDR-0046 | |
| Sega Marine Fishing セガマリンフィッシング | DC | 1.003 | Original | | HDR-0104 | |
| Samba de Amigo Ver. 2000 | DC | 1.001 | Original | | HDR-0131 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Sakura Taisen 3 Movie Disc サクラ大戦3 ~巴里は燃えているか~ サクラ大戦3 ムービーディスク | DC | 1.002 | Original | | HDR-0136 | |
| Sakura Taisen Kinematron Hanagumi Mail サクラ大戦 キネマトロン 花組メール | DC | 1.008 | Original | | HDR-0136 | |
| Softkey Home/Family Bundle | PC | | Original | | HFB344CB-CD | |
| The Smurfs | PC | | 2nd Edition | | HFSMURPC52FGDEIP/A | |
| Stormovik: SU-25 Soviet Attack Fighter Stormovik | PC | | Hit Squad / Euro Power Pack | | HITDANCD001 | |
| Shuttle: The Space Flight Simulator Shuttle | PC | 1.01 | Hit Squad / Euro Power Pack | | HITDANCD015 | |
| Soft de Hard na Monogatari 2 ソフトでハードな物語2 | FMT | | Original | | HMA-214 | |
| Shijou Saikyou no Video Bible: The Greatest Video Bible in the World 史上最強のビデオバイブル | FMT | | Original | | HMA-251 | |
| Suikoden: Tenmei no Chikai 水滸伝・天命の誓い | FMT | | with Soundware | | HMB-108 | |
| Shooting Towns シューティング・タウンズ | FMT | | Original | | HMB-118 | |
| SimCity シム・シティ | FMT | Rev A | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121A | |
| Sangokushi II 三國志Ⅱ | FMT | | with Soundware | | HMB-159 | |
| Sim Sports Diving: Soreyuke! Diving それゆけ!ダイイビング | FMT | | Original | | HMB-161 | |
| Shanghai 上海 | FMT | | Original | | HMB-192 | |
| Shougaku Ongaku (5·6-nensei-you) 小学音楽(5·6年生用) | FMT | Rev A | Original | | HMB-512A | |
| Shiki o Irodoru: Nihon no Shouka: Haru 四季を彩る 日本の唱歌 春 | FMT | | Original | | HMC-101 | |
| Shiki o Irodoru: Nihon no Shouka: Natsu 四季を彩る 日本の唱歌 夏 | FMT | | Original | | HMC-102 | |
| Shiki o Irodoru: Nihon no Shouka: Aki 四季を彩る 日本の唱歌 秋 | FMT | | Original | | HMC-103 | |
| Shiki o Irodoru: Nihon no Shouka: Fuyu 四季を彩る 日本の唱歌 冬 | FMT | | Original | | HMC-104 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev A | Original | | HMC-139A | |
| Silent Möbius: Case: Titanic サイレント・メビウス | FMT | | Original | | HMC-143 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | Rev 1 | Original | | HMC-157 | |
| Schwarzschild シュヴァルツシルト | FMT | | Original | | HMC-171 | |
| Super Shanghai: Dragon's Eye スーパー上海 ~ドラゴンズ・アイ ~ | FMT | | Original | | HMC-181 | |
| Super Collection 1: Game Technopolis (Himitsu no Hanazono & Kimi dake ni Ai o... +) スーパー・コレクション① (秘密の花園&キミだけに愛を…+) | FMT | | Original | | HMD-134 | |
| Shuukan Shounen Magazine History 週刊少年マガジンヒストリー | FMT | 1.0 | Original | | HMD-151 | |
| The Secret of Monkey Island モンキー・アイランド | FMT | | Original | | HMD-155 | |
| Steepia スティーピア | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 25 | | HMD-179 | |
| Speech Trainer V1.0 L10 スピーチ・トレーナー | FMT | | Original | | HMD-224 | |
| Strike Commander ストライク・コマンダー | FMT | | Original | | HMDC-1915 | |
| Super Real Mahjong PII & PIII+ スーパーリアル麻雀 PⅡ&PⅢ+ | FMT | | Ving Marty Taiou Vol. 1 | | HME-111 | |
| Steepia Lite スティーピア ライト | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 34 | | HME-118 | |
| Shinc | FMT | | Original | | HME-131 | |
| Secre Volume I: Naoko Iijima SECRE VOLUME ① 「飯島 直子」 | FMT | | Original | | HME-168 | |
| Super Collection 2: Game Technopolis (IV: Tesera & Hatsukoi Monogatari +) スーパー・コレクション② (Ⅳ~テセラ~&初恋物語+) | FMT | | Original | | HME-184 | |
| Secre Volume 3: Fumie Hosokawa SECRE VOLUME ③ 「細川 ふみえ」 | FMT | | Original | | HME-191 | |
| Secre Volume 4: Hitomi Fujisaki SECRE VOLUME ④ 「藤崎 仁美」 | FMT | | Original | | HME-196 | |
| Software Contest Nyuusen Sakuhinshuu 3 ソフトウェア・コンテスト 入選作品集 3 | FMT | | Original | | HME-200 | |
| Secre Volume 5: Tina Gushiken SECRE VOLUME ⑤ 「具志堅 ティナ」 | FMT | | Sample | | HME-204 | |
| Secre Volume 6: Reiko Kato SECRE VOLUME ⑥ 「かとう れいこ」 | FMT | | Original | | HME-205 | |
| Secre Volume 7: Reiko Chiba SECRE VOLUME ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 | |
| Shangrlia 2 シャングリラ2 | FMT | | Original | | HME-220 | |
| Schwarzschild IV: The Cradle End シュヴァルツシルトⅣ -THE CRADLE END- | FMT | | Original | | HME-223 | |
| Sid Meier's Railroad Tycoon レイルロード・タイクーン デラックス | FMT | | Original | | HME-245 | |
| Secre Demo Disk | FMT | | Hibaihin | | HME-921 | |
| Super Real Mahjong PIV スーパーリ・アル麻雀PⅣ | FMT | | Ving Marty Taiou Vol. 7 | | HMF-138 | |
| Syndicate シンジケート | FMT | | Original | | HMF-163 | |
| SimFarm シムファーム | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 48 | | HMF-170 | |
| Sayaka + Miho 沙也香/美穂 | FMT | | Original | | HMF-179 | |
| SimCity 2000 シム・シティ2000 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 52 | | HMF-191 | |
| SimFarm: SimCity's Country Cousin シムファーム | FMT | | Demo | | HMF-920 | |
| Star Soldier for Palm OS スターソルジャー for Palm OS | PALM | | Original | | HMGOT060015 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 1) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 2) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Starry Sky: After Summer Portable: Etsuran Shite Please: Etsu Plea 2 Starry☆Sky ~After Summer~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.01 | Shokai Genteiban | | HONEY-006, … | |
| Starry Sky: After Autumn Portable: Etsuran Shite Please: Etsu Plea 2 Starry☆Sky ~After Autumn~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.00 | Shokai Genteiban | | HONEY-007, … | |
| Starry Sky: After Winter Portable Starry★Sky ~スタ・スカ~ ~After Winter~ Portable | PSP | 1.01 | Shokai Genteiban | | HONEY-008, … | |
| Starry Sky: After Winter Portable: Etsuran Shite Please: Etsu Plea 2 Starry★Sky ~スタ・スカ~ ~After Winter~ Portable 閲覧してプリーズ"えつぷりっ2" | PSP | 1.00 | Shokai Genteiban | | HONEY-008, … | |
| System Catalog: Kigyou-muke System no Goannai System Catalog 企業向けシステムのご案内 | 3DO | | Hibaihin | | HOU-013DO01 | |
| Sports Island Freedom | XBOX360 | | Original | | HU-2015 | |
| Shinma Kourin 神魔降臨 | PC | | Original | | ICCD-005 | |
| Silicon Scream シリコンスクリーム | PC | | Original | | ID NO.9430-17-01 | |
| Sentimental Graffiti (Disc 1) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01A | |
| Sentimental Graffiti (Disc 2) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01B | |
| Slam Tennis | XBOX | | Original | | IG-017 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Shadow Ops: Red Mercury | XBOX | | Demo | | IG-037 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-037 | |
| Sega Soccer Slam | XBOX | | Original | | IG-041 | |
| Shadow Ops: Red Mercury | XBOX | | Original | | IG-065 | |
| Saints Row | XBOX360 | | Demo | | IM-2024 | |
| Sheep | PC | 1.0.0.1 | Original | | IMG 008 | |
| A Sombra do Zorro | PC | | Original | | INFOG 095 | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Satsui no Shoumei: In the 1st Degree: Making CD-ROM 殺意の証明 イン ザ ファースト ディグリー メイキングCD-ROM | PC | | Hibaihin | | IP-081M | |
| Sherlock Holmes e il Re dei Ladri | PC | | FX Interactive (Rerelease) | | IT v.1.0 P - DVD | |
| Silmarils Collection | PC | 1.6 | Just for Games: Just for Gamers | | JFG10-SICO-OBL | |
| SBK 09: Superbike World Championship | PC | 1.0 | Just For Gamers | | JFG10-SSWC-OBL | |
| StarCruiser II for CD-ROM スタークルーザー Ⅱ for CD‐ROM | FMT | | Original | | JH-006 | |
| Samurai Spirits サムライ・スピリッツ | FMT | | Original | | JH-012 | |
| SpellForce: Platinum Edition | PC | 1.5 | SpellForce Universe | | JOW 009PC LAB1 | |
| Ski Racing 2005 Ski Racing 2005 featuring Hermann Maier | XBOX | | Original | | JW-005 | |
| Ski Racing 2006 Ski Racing 2006 featuring Hermann Maier | XBOX | | Original | | JW-010 | |
| Sherlock Holmes Versus Jack the Ripper Sherlock Holmes vs. Jack the Ripper | XBOX360 | | Original | | JW-2003 | |
| S²: Silent Storm (Disc 1) | PC | 1.1 | Original | | JW002243 | |
| S²: Silent Storm (Disc 2) | PC | 1.1 | Original | | JW002243 | |
| Sega Smash Pack II | PC | | Bundle Version Tiny OEM | | KDGT44 | |
| Sequence Palladium 2 Mania Kit | PC | | Original | | KGD-0060 | |
| Symphonic Rain シンフォニック=レイン | PC | 1.0.0.2 | Original | | KGD-04040 | |
| Sequence Palladium 2: Yami no Shousei シークエンス・パラディウム2 ~闇の笑声~ | PC | | Rerelease | | KGD-04080 | |
| Symphonic Rain Aizouban シンフォニック=レイン愛蔵版 | PC | 1.1.0.6 | Original, Aizouban | | KGD-05050 / KGD-055545 | |
| Sequence Palladium Premium Digital Novel | PC | | PC Game Bundle | | KGD-06021 | |
| Sequence Palladium シークエンス パラディウム | PC | | Original | | KGDP004 | |
| Sequence Palladium Aizouban シークエンス パラディウム 愛蔵版 | PC | | Original | | KGDP075 | |
| Shikigami no Shiro II 式神の城Ⅱ | XBOX | | Original | | KI-002 | |
| Shoujo Kakumei Utena: La Maison de Chu Chu 少女革命ウテナ メゾン・ド・チュチュ | PC | | Original | | KIRA 19 | |
| Saints Row IV: Ultra Super Ultimate Deluxe Edition セインツロウ フォー ウルトラ・スーパー・アルティメット・デラックス・エディション | XBOX360 | | Original | | KM-2038 | |
| Silent Hill 2: Restless Dreams | XBOX | | Platinum Hits | | KN-004 | |
| Shadow of Memories | XBOX | | Original | | KN-014 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Suikoden: Tenmei no Chikai 水滸伝・天命の誓い | PC | 1.0 | Original | | KN10-14103 | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | | Original | | KN11-15101 | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | 1.0 | Value Set Series | | KN11-15101 | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | 1.0 | Original | | KN11-15102 | |
| Senshi no Ketsudan: Combat Force 戦士の決断 コンバット フォース | PC | 1.0 | Original | | KN12-12201 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Shin Sangoku Musou 4: Empires 真・三國無雙4 Empires | XBOX360 | | Original | | KO-2003 | |
| Sengoku Musou 2 with Moushouden 戦国無双2 with 猛将伝 | XBOX360 | | Original | | KO-2005 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Shin Sangoku Musou 5: Empires 真・三國無雙5 Empires | XBOX360 | | Original | | KO-2023 | |
| Shin Sangoku Musou 5: Empires 真・三國無双5 Empires | XBOX360 | | Original | | KO-2023 | |
| Shin Hokuto Musou 真・北斗無双 | XBOX360 | | Original | | KO-2047 | |
| Shin Sangoku Musou 4: Digital Figure 真・三國無双4 デジタルフィギュア | PC | 1.0 | Shin Sangoku Musou 4: Digital Figure with Original Sound Track | | KOEI-21350-01 | |
| Shin Sangoku Musou 5 真・三國無双5 | PC | | Original | | KOEI-29516 | |
| Sengoku Musou 2 戦国無双2 | PC | 1.0 | Original | | KOEI-30130 | |
| Shoot the Bullet for Busy Person. Tengu Without Increased Scarlet Devil Mansion 忙しい人のための文花帖 ~紅魔館マシマシ天狗ヌキ~ | PC | | Original | | KSG-0005 | |
| Starlight Scramble: Ren'ai Kouhosei ―スターライトスクランブル―恋愛候補生 | PC | | Original | | KSGW60146 | |
| Shin Sangoku Musou 6 with Moushouden (Game Disc) 真・三國無双6 with 猛将伝 | PC | 1.0.0.0 | Original | | KTGS-44830A | |
| Shin Sangoku Musou 6 with Moushouden (Installation Disc 1) 真・三國無双6 with 猛将伝 | PC | 1.0.0.0 | Original | | KTGS-44830B | |
| Shin Sangoku Musou 6 with Moushouden (Installation Disc 2) 真・三國無双6 with 猛将伝 | PC | 1.0.0.0 | Original | | KTGS-44830C | |
| Shin Sangoku Musou 7 with Moushouden (Disc 1) 真・三國無双7 with 猛将伝 | PC | 1.00 | Original | | KTGS-65293A | |
| Shin Sangoku Musou 7 with Moushouden (Disc 2) 真・三國無双7 with 猛将伝 | PC | 1.00 | Original | | KTGS-65293B | |
| Shin Sangoku Musou 7 with Moushouden (Disc 3) 真・三國無双7 with 猛将伝 | PC | 1.00 | Original | | KTGS-65293C | |
| Shin Sangoku Musou 7 with Moushouden (Disc 4) 真・三國無双7 with 猛将伝 | PC | 1.00 | Original | | KTGS-65293D | |
| SegaSaturn: SGL Tool Kit: Sega 3D Game Library | SS | 1.000 | Original | | L15-1000 | |
| SegaSaturn: Movie Tools: Cinepak for Sega Saturn | SS | | Hybrid Version | | L17-1000 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando スター・ウォーズ リパブリックコマンド | XBOX | | Original | | LA-025 | |
| Star Wars: Episode I: The Phantom Menace スターウォーズ:エピソードI: ファントムメナス | PC | | Original | | LAMW-4002 | |
| Star Wars: Starfighter | PC | | EA Best Selections | | LAMWB-7003 | |
| Star Wars: Episode I: The Phantom Menace スターウォーズ:エピソードI: ファントムメナス | PC | | EA Best Selections | | LAMWB-7005 | |
| St. Jeremiah Gakuen for Windows 聖エレミヤ学園 FOR WINDOWS | PC | | Original | | LNR0001 | |
| SBK 08: Superbike World Championship | XBOX360 | | Original | | LS-2001 | |
| SBK 09: Superbike World Championship | XBOX360 | | Original | | LS-2004 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK 2011: FIM Superbike World Championship | XBOX360 | | Original | | LS-2021 | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Star Wars: Episode I: Racer | PC | | M6 Multimedia | | M6MMC3 | |
| Super Meat Boy: Ultra Edition | PC | | Original | | MAMG052 | |
| Shiken ni Deru!? Haruno-chan 試験に出る!?はるのちゃん | PC | | Original | | MAY-20112 | |
| Scudetto 4: Championship Manager: Stagione 2002-2003 | PC | 4.0.4 | Original | | MCHM4PIT81 | |
| StarFighter 3000 スターファイター3000 | PC | | Original | | MDC-7035 | |
| Sleeping Dogs | PC | | Limited Edition | | MDOGSVMB01 | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.0 | Original | | MEM744AE-CD | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744CE-CD | |
| Syberia II | XBOX | | Original | | MI-008 | |
| Still Life | XBOX | | Original | | MI-011 | |
| Still Life | XBOX | | Original | | MI-011 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Sniper Elite | XBOX | | Original | | MI-013 | |
| Shido Karakuri Enban 支奴唐繰円盤 | PC | 8.5.1.102 | Shokai Gentei Box | | MII-003 | |
| School Rumble: Neru Musume wa Sodatsu.: DTA Daisuki Tenma Accessory スクールランブル ねる娘は育つ。 DTA<大好き 天満アクセサリー> | PC | | DX Pack | | MII-012 | |
| Sonic CD | PC | | Original | | MK 85015-50 | |
| Sega Rally Championship PC | PC | 2.11 | Original | | MK 85048MX-50 | |
| Serious Sam HD | XBOX360 | | Promo | | MK-2004 | |
| The Serious Sam Collection | XBOX360 | | Original | | MK-2010 | |
| Sega Bass Fishing | DC | 1.020 | Original | | MK-51006-50 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Worldwide Soccer 2000 | DC | 1.300 | Original | | MK-51031-50 | |
| Skies of Arcadia (Disc 1) | DC | 1.000 | Original | | MK-51052-50 | |
| Skies of Arcadia (Disc 2) | DC | 1.000 | Original | | MK-51052-50 | |
| Sonic Shuffle | DC | 1.000 | Original | | MK-51060-50 | |
| Sega Worldwide Soccer 2000: Euro Edition SWWS 2000: Euro Edition | DC | 1.030 | Original | | MK-51083-50 | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | MK-51117-50 | |
| Sonic Adventure 2 | DC | 1.002 | Beta | | MK-5111750 | |
| Sonic & Knuckles Collection | PC | | Audio CD Bundle | | MK-85037-50D | |
| Sega Worldwide Soccer '98: Club Edition | SS | 1.003 | Original | | MK81123-50 | |
| Suteki na Dennou Club すてきな電脳倶楽部 | X68K | | Original | | MKCD-0001 | |
| Sugoi Dennou Club すごい電脳倶楽部 | X68K | | Original | | MKCD-0002 | |
| Seal: Travelers of Destiny SEAL~運命の旅人~ | PC | | Original | | MKD-1390 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | MKW-031 | |
| Sonic & Knuckles Collection ソニック&ナックルズ コレクション | PC | | Ultra 2000/Ultra Series | | MKW-051 | |
| Sonic R ソニックR | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Super Air Combat スーパーエアーコンバット 蒼空の覇者 | PC | | Ultra 2000/Ultra Series | | MKW-158 | |
| Sekai Saikyou Ginsei Igo 世界最強銀星囲碁 | PC | 2.2 | Great Series | | MKW-161 | |
| Sega Memorial Selection: Dear 80's Videogame Best 3 | PC | | Ultra 2000/Ultra Series | | MKW-183 | |
| Sunsoft Classic Games 1 サンソフト クラシック ゲームズ1 | PC | | Ultra 2000/Ultra Series | | MKW-190 | |
| Shin Samurai Spirits: Haoumaru Jigokuhen 真サムライ・スピリッツ ~覇王丸地獄変~ | PC | | Ultra 2000/Ultra Series | | MKW-266 | |
| Sorcerian Forever ソーサリアン・フォーエバー | PC | | Ultra 2000/Ultra Series | | MKW-274 | |
| Sudden Strike Forever サドン・ストライク ~フォーエバー~ | PC | 1.0.0.1 | Ultra 2000/Ultra Series | | MKW-307 | |
| Sudden Strike Forever サドンストライク ~フォーエバー~ | PC | | Yuu Yuu 1980yen | | MKY-045 | |
| Sunsoft Classic Games 1 サンソフト クラシック ゲームズ1 | PC | | Original | | MKY-081 | |
| Stacked with Daniel Negreanu | XBOX | | Original | | MM-001 | |
| SimTown: The Town You Build Yourself! シムタウン | MAC | | Original | | MMC-4093 | |
| Star Command Revolution | PC | | Budget | | MMICDR 5082 | |
| Speedboat Attack | PC | 0.9.9.0 | Budget | | MMICDR 5097 | |
| Speedboat Attack | PC | 0.9.9.0 | Budget | | MMICDR 5097 | |
| SPQR: The Emperor's Darkest Hour | PC | | Original | | MMICDR 5188 | |
| Settlers II, The: Veni, Vidi, Vici | PC | | Budget | | MMICDR 5803 | |
| Seijo Vampire 聖女ヴァンパイア | PC | | Original | | MMM-7881 | |
| The Sims 2: Teen Style Stuff | PC | | Original | | MMX08005156D | |
| Sid Meier's Civilization | PC | 474.03 | Rerelease | | MP 190128D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 1) | PC | 1.0 | Original | | MP 193 459 DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 2) | PC | 1.0 | Original | | MP 193 459 DO2R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization Sid Meier Presenta Civilization II: Conflitti in Civilization: Scenari | PC | | CD-ROM Classic Collection 5 | | MP 591 307 DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 1) | PC | 1.0 IT | CD-ROM Classic Collection 7 | | MP 593 459 DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 2) | PC | 1.0 IT | CD-ROM Classic Collection 7 | | MP 593 459 DO2R | |
| Star Trek: Generations (Disc 1) | PC | | Original | | MP191 261 DO1R | |
| Star Trek: Generations (Disc 2) | PC | | Original | | MP191 261 DO2R | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Star Trek: Generations (Disc 1) | PC | | Star Trek: Federation Compilation | | MP391 261 DO1R | |
| Star Trek: Generations (Disc 2) | PC | | Star Trek: Federation Compilation | | MP391 261 DO2R | |
| Star Trek: Generations (Disc 1) | PC | | Original | | MP391 264 DO1R | |
| Star Trek: Generations (Disc 2) | PC | | Original | | MP391 264 DO2R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP391 307 DO1R | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | MP391 435 DO1R | |
| Sid Meier's CivNet | PC | | Gigapack Vol. 1 | | MP391226D O IR | |
| Sid Meier's CivNet | PC | 1.0 | Original | | MP391226DO1R | |
| Sid Meier's Civilization II | PC | | Original | | MP391260DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 1) | PC | 1.0 | Original | | MP393 459 DO1R | |
| Star Trek: The Next Generation: Klingon Honor Guard (Disc 2) | PC | 1.0 | Original | | MP393 459 DO2R | |
| Star Trek: Generazioni (Disc 1) | PC | 1.00 | CD-ROM Classic Collection | | MP591 261 DO1R | |
| Star Trek: Generazioni (Disc 2) | PC | 1.00 | CD-ROM Classic Collection | | MP591 261 DO2R | |
| Sid Meier's Civilization II Civilization II di Sid Meier | PC | | CD-ROM Classic Collection 5 | | MP591260DO1R | |
| Super Bean | PC | | SelectSoft (CD-R) | | MPSI 44459 | |
| Sid Meier's Civilization II | PC | | Original | | MPX91260DO1R | |
| Sid Meier's Civilization II | PC | 1.02 | Original | | MPX91260DO1R | |
| The Ship | PC | | Original | | MPY883AS-DVD | |
| Shadow President Shadow President: The Simulation of Presidential World Power! | PC | | Gold Medal 12 CD Pack | | MQ 13-004-116 | |
| Spectre VR Classic | PC | | Original | | MQ 13-004-120 | |
| Street Sports: Jammit | PC | | Super 16 CD Pak Volume 2 | | MQ 13-004-166 | |
| Shikigami no Shiro EX 式神の城EX | PC | | Original | | MQD-3790 | |
| Syberia (Disc 1) シベリア | PC | 1.0.0.23 | Original | | MQT0057 | |
| Syberia (Disc 2) シベリア | PC | 1.0.0.23 | Original | | MQT0057 | |
| Sudeki: Sennen no Akatsuki no Monogatari Sudeki ~千年の暁の物語~ | XBOX | | Original | | MS-010 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future 세가 GT 2002 + 젯 셋 라디오 퓨처 · 噴射小子 未來版 | XBOX | | Bundled with Xbox | | MS-061 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| A Scene It? Lights, Cameraction! A Scene It? Luci, Camerazione! Il gioco a quiz sul cinema | XBOX360 | | Original | | MS-2098 | |
| Scene It? Luces, Cámara, ¡Acción! Scene It? Bright Lights! Big Screen! | XBOX360 | | Bundled with 4 Controllers | | MS-2098 | |
| Scene It? Box Office Smash! Scene It? Campione d'Incassi: Nuovissimi filmati e quiz sul cinema | XBOX360 | | Original | | MS-2144 | |
| Scene It? Grandes Éxitos de Taquilla | XBOX360 | | Original | | MS-2144 | |
| Scene It? Kinohits | XBOX360 | | Bundled with 4 Controllers | | MS-2144 | |
| Space Dynagon Kai スペース大納言(改 | PC | | Original | | MSCD-0026 | |
| Space Bunnies Must Die! | PC | | Demo | | MSDE-37216 | |
| Souko Mania 2 倉庫マニア2 | PC | | Original | | MSDJ-02012 | |
| Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka! 政界立志伝~君は日本のリーダーになれるか!~ | PC | | | | MSDJ-99094 | |