| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Saint Eyes
セイントアイズ | PC | | Shokai Genteiban | | |  |
 | Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
 | Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Screamworld Bonus CD
Welcome to Screamworld | PC | | | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
 | Sega Worldwide Soccer PC | PC | | Grabit | | GDL074 | |
| The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | DigiCube PC | | DWRPS-00055 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | PC Game Best Series Mega Hit | | | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | | |
| Silver Gene: The Mutia Chronicle 1
シルバージーン ｔｈｅ ｍｕｔｉａ ｃｈｒｏｎｉｃｌｅ 1 | PC | | Original | | CNDL-0002 | |
| Simone
Simone: A 64-Bit Memory Game | AJCD | | Unlicensed | | | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
 | Soft-World Magazine No. 139: November 2000
軟體世界雜誌社 ＭｅｇａＤｉｓｃ 第１３９期 | PC | | | | | |
| Software of the Month Club: Volume 245 (Software Showcase) | PC | | | | | |
 | Sonic 3D: Flickies Island | PC | | ValuSoft | | THQ70487.101 | |
| Sonic R
ソニックＲ | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Soul Ride | PC | | | | | |
| Soundtracks of Lipstick Adv.EX
リップスティックアドベンチャーＥＸ サウンドトラック | PC | | PC Game Bundle | | F&C-106 | |
| Souzou Sozai: Umi Vol. 1
創造素材 海 Ｖｏｌ．１ | PHOTO-CD | | Original | | SEVI-1049 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Starblade | MCD | | Original | | 4284-50 | |
| Starry the Universe
大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Style Game Magazine July 2000
新遊戲時代 ２０００．０７ | PC | | | | | |
| Suppin Bishoujo Vol. 3
すっぴん美少女 ｖｏｌ．３ | PHOTO-CD | | Original | | SPN-003 | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Surgical Strike | MCD | | Original | | 4435-50, 670-6783-50 | |
| Sanguo Mahjong Fengyun
三國麻將風雲 | PC | | Original |  | | |
| Sanguozhi V
三國志Ⅴ | SS | 1.000 | Zhongwenban | | T-7606H-11, T-7606H-16 | |
| Sanguozhi Yingjiezhuan
三國志英傑伝 | SS | 1.000 | Zhongwenban | | T-7603H-11, T-7603H-16 | |
 | Shiluo Dadi
失落大地 | PC | 1.00.000 | Original | | | |
 | Spellcross: Poslední Bitva | PC | | Covermount |  | | |
 | S.C.A.R.S. | PC | 1.0 | |  | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | PC-CD 92000-4 | |
| S.T.O.R.M. (Disc 2) | PC | | Original | | PC-CD 92000-4 | |
| S.T.O.R.M. (Disc 3) | PC | | Original | | PC-CD 92000-4 | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Scarab
S.C.A.R.A.B. | PC | | Original | | EAE08801181D | |
| Scarab
S.C.A.R.A.B. | PC | | Original | | 7545 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scissors 'n' Stones | PC | | Original | | | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Sold Out Extreme | | | |
 | Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| SD Qlympics
Olympic Challenge | PC | | Grabit | | GDL031 | |
| Seek and Destroy
Seek & Destroy | CD32 | | Original | | | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 (Disc 2)
Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship
Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship PC
セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Sewer Shark | MCD | | Original | | T-93015-50 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.03 | Original | | CD-ICD-201-2 | |
| Shellshock | PC | | Kixx | | | |
| Shellshock | PC | | Original | | | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shrak
Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Collector's Edition | | | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Colonization
Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Ski Racing: Extreme Edition
Sierra Sports Ski Racing '99: Extreme Edition | PC | 1.0.0.14 | Sierra Originals: Sports | | S0014001 | |
| Sky Target: Daredevil Air Force
スカイ・ターゲット | PC | 1.0.06.19 us | PCHome | | 506-9890 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]")