Region | Title | System | Version | Edition | Languages | Serial | Status |
| Syphon Filter 3 | PSX | | Platinum, Press Kit | | SCES-03698 … | |
| Syphon Filter 3 (Press CD) | PC | | Press Kit | | | |
| Synthelabo: Cardio-Vasculaire Dausse 1995: Cours de Perfectionnement en Imagerie Cardiaque | CDI | | Original | | | |
| Syndicate | 3DO | | Original | | | |
| Syndicate | 3DO | | Bundled with Magazine (Demo) | | | |
| Syberia | XBOX | | Original | | MI-006 | |
| Swiss Click | CDI | | Original | | | |
| Swagman | PSX | | Demo | | SLED-00665 | |
| SVO: Opleiding voor de Vleessector: Hygiëne en Verse Voeding SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| SVO: Opleiding voor de Vleessector: Het Bewerken van Varkensvlees SVO Opleiding voor de Vleessector te Utrecht | CDI | | Original | | | |
| SuperTest | CDI | 1.01 | Beta | | 810 0168 | |
| Superman Returns | XBOX | | Original | | EA-160 | |
| Super Mario's Wacky Worlds | CDI | 0.11 | Prototype | | | |
| Stuntman: Ignition | PS2 | 1.01 | Original | | SLES-54820 | |
| Strip-Poker Pro | CDI | | Original | | 8120142 | |
| Striker Pro | CDI | 1.14 | Original | | 810 0186, 810 0187, 811 0044 | |
| Striker 96 | PSX | Rev 1 | Original | | SLES-00023 … | |
| Stretch-Top System: Wasserbett-Information Stretch-Top System: Waterbed-Information | CDI | | Original | | | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Stomach in Motion | CDI | | Original | | WIM 060792 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Stickybear Reading Stickybear Leyendo | CDI | | Original, Demonstration Disc | | 310-690-083-2, 310690083-2, 816 0040 | |
| Stickybear Preschool | CDI | 1.03 | Beta | | 690 2572 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Sticks 'n' Fire: Stop That Train | CDI | | Original | | CMC 24020-2CD-I | |
| Stichting voor de Technische Wetenschappen: Jaarverslag 91 Technology Foundation: Annual Report 91 | CDI | | Original | | 2036.001 | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Steel Panthers | PC | 1.1 | Megapak 6 | | | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Starsky & Hutch | PC | | Nestlé | | | |
| Stars on CD-I: Rob Peetoom | CDI | | Original | | | |
| Stars on CD-i: Ad Peters | CDI | | Original | | | |
| Starblade | 3DO | | Original, Not for Resale | | FZ-SE5351, FZ-SG5351 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | | Original | | | |
| Star Wars: Screen Entertainment | MAC | | Mac Game Bundle | | | |
| Star Wars: Rebellion | PC | | | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | | Original | | | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | | Original | | | |
| Star Wars: Rebel Assault | PC | | | | | |
| Star Wars: Galactic Battlegrounds (Disc 2) (Jeu) | PC | | Original | | | |
| Star Wars: Galactic Battlegrounds (Disc 1) (Installation) | PC | | Original | | | |
| Star Wars: Episode I: Racer | PC | | Original | | | |
| Star Wars: Episode I: La Menace Fantôme | PC | | Original | | | |
| Star Wars: Dark Forces | PC | | | | | |
| Star Trek VI: The Undiscovered Country (Disc 2) | CDI | | Original | | 811 1007 | |
| Star Trek VI: The Undiscovered Country (Disc 1) | CDI | | Original | | 811 1007 | |
| Star Fighter | 3DO | | Original | | | |
| Standaard Interactieve Encyclopedie | CDI | | Demonstratie-Exemplaar | | 818 0081 | |
| St. Petersbourg et les Trésors de l'Ermitage: The Art of the Czars | CDI | | Original | | 812 0056 | |
| SpyHunter: Nowhere to Run | PC | | Original | | | |
| Spy Fox: "Operation Milkshake" | PC | | Rerelease | | | |
| Sport Freaks | CDI | | Original | | 819 1033 | |
| Spirou | PC | | Promo | | SPIROM65511 | |
| Spirou | PC | | Original | | SPIROM65511 | |
| Spine Sense: The Interactive Back Protection Program | CDI | | Original | | | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Spider-Man | MAC | | Original | | | |
| Spider-Man | PC | | Original | | 31131.101.US | |
| Spider-Man | PC | | Original | | 31131.101.UK | |
| Sphinx and the Cursed Mummy Sphinx et la Malédiction de la Momie | PS2 | 1.00 | Demo | | SLED-51832 | |
| Speed Devils: Online Racing | DC | 1.003 | Original | | T-17713D-50 | |
| Space Quest 6: Roger Wilco in the Spinal Frontier | MAC | | Original | | S4330250Z12ZZ | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H-50 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | | |
| Space Hulk | PC | | Original | | E2105CCD | |
| Space Ace | CDI | | Original, For Demonstration Only | | 810 0073, 818 0017 | |
| Sortilèges: Rage of Mages II Rage of Mages II: Necromancer | PC | | Original | | | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Sonic Adventure DX: Director's Cut (Disc 2) | PC | | Original | | SEGA-PC002-EU | |
| Sonic Adventure DX: Director's Cut (Disc 1) | PC | | Original | | SEGA-PC002-EU | |
| Somewhere: Une Envie de Naturel | CDI | | | | | |
| Solitaire | CDI | | Prototype | | | |
| The Smurfs: The TeletransportSmurf | PC | | Original | | SCHTRGB5011 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| Smilde | CDI | | Original | | | |
| Skin Style | CDI | | Original | | | |
| Sipa Image: First Image Catalog on CD-I | CDI | | Original | | | |
| SimCity | CDTV | | Original | | 91133 | |
| Silhouette: CD-i Demo Version | CDI | | Original | | | |
| Sid Meier's Colonization | MAC | | Original | | CLMC-60 | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Shock Wave | 3DO | | Original | | | |
| Shipwreck | CDI | | Original | | 811 0025 | |
| Shining Wisdom | SS | 1.000 | Original | | MK81381-50 | |
| Shellshock | SS | 1.000 | Original | | T-11502H-09 | |
| Sheep, Dog 'n' Wolf | PC | | Kellogg's | | | |
| Shaolin's Road | CDI | | Original | | SHAOLM24011 | |
| Shadow of the Colossus | PS2 | 1.01 | Demo | | SCED-53962 | |
| Shadow Master | PC | | Original | | | |
| Les Shadoks: Le Jeu: La Promenade | PC | | Original | | PCMCSHAD97FCD1 | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Sewer Shark | 3DO | | Original | | | |
| The Settlers IV | PC | | Original | | | |
| Serum-Werk Bernburg AG: Veterinärpharmaka: Vol. 1 | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Selling You to You and Taking Personal Control | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Self Selling Disc | CDI | 01 | Original | | | |
| Secret Mission | CDI | 1.07 | Original | | 812 0053 | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scotland Yard Interactive | CDI | 1.09 | Original | | 813 0042 | |
| Scotland Yard Interactif | CDI | 1.04 | Original | | 812 0070 | |
| Scooby-Doo! Le Mystere du Parc Fantome | PC | | Original | | | |
| Les Schtroumpfs: Le Téléportaschtroumpf | PC | | Original | | SCHTRFR5011 | |
| Scarface: The World Is Yours | XBOX | | Original | | VU-063 | |
| Scan & Teach: Thema 7-12: Klasse 3 | CDI | | Original | | | |
| Scan & Teach: Thema 1-6: Klasse 3 | CDI | | Original | | | |
| Say What You Want | CDI | | Original | | | |
| Sargon Chess | CDI | | Beta | | 310-690-030-2 | |
| Sargon Chess | CDI | | Original | | 310690030-2, 690 030-2, 690 0302, 699 030-2, 812 0024, 814 0042 | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Sandy's Circus Adventure | CDI | | Original, Demonstration Disc | | 310-690-022-2, 310690022-2, 699 022-2 | |
| Sailing | CDI | | Original, Demonstration Disc | | 310-690-101-2, 310690101-2 | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |