Region | Title | System | Version | Edition | Languages | Serial | Status |
| S!Zone for SimCity 2000 | PC | | Original | | | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0007lab1 | |
| S²: Silent Storm (Disc 1) | PC | | Gold Edition | | ROSILENTST0006lab1 | |
| S²: Silent Storm (Disc 2) | PC | | Gold Edition | | ROSILENTST0006lab2 | |
| S³: Silent Storm: Sentinels | PC | | Gold Edition | | ROSILENTST0004lab, ROSILENTST0006lab3 | |
| SAAR + AMOK PD CD-ROM Überarbeitete Version 12/93 | ACD | | Original | | | |
| SAAR AMOK II Oktober 1994 | ACD | | Original | | | |
| Saban's Power Rangers Zeo Versus the Machine Empire | PC | | Original | | | |
| Saban's Power Rangers: Time Force | PC | | Original | | | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLES-03730 … | |
| Saban's Power Rangers: Time Force | PSX | | Original | | SLUS-01351 | |
| Saban's Power Rangers: Time Force | PC | | PC Fun Club, THQ Double Pack (Focus Essential) | | ESS589, PFC024/D | |
| Saber Marionette J: Battle Sabers セイバーマリオネットJ バトルセイバーズ | PSX | | Shokai Genteiban | | SLPS 00738 | |
| Saber Marionette J: Battle Sabers セイバーマリオネットJ バトルセイバーズ | PSX | | Original | | SLPS 00739 | |
| Sable Maze: Forbidden Garden & Twelve Fears | PC | | Original | | 33528010US | |
| Sable Maze: Sullivan River / Norwich Caves | PC | | | | 33471010US | |
| Sabrina l'Apprentie Sorcière et l'Horloge Cosmique | PSX | | Original | | SLES-03628 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLES-03561 | |
| Sabrina the Teenage Witch: A Twitch in Time! | PSX | | Original | | SLUS-01208 | |
| The Sacred Mirror of Kofūn (Disc 1) (Installation) | PC | | | | CKOF1096-1A | |
| The Sacred Mirror of Kofūn (Disc 2) | PC | | | | CKOF1096-2A | |
| The Sacred Mirror of Kofūn (Disc 3) | PC | | | | CKOF1096-3A | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |
| Saddle Up with Pippa Funnell: Equestrian Champion | PC | | Original | | 782650-CF | |
| SaGa Frontier サガフロンティア | PSX | | Original, PSone Books, Ultimate Hits | | SCPS 45102 … | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Disc 1) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| Saga Heroes of Might and Magic I-III (Disc 2) (Heroes of Might and Magic III) | PC | | eXtra Klasyka Next | | | |
| The Sagara Family (Game Disc) | PC | | Original | | GC-026 | |
| The Sagara Family (Install Disc) | PC | | Original | | GC-026 | |
| Die Sage von Nietoom | PC | | Original | | | |
| Saibara Rieko no Mahjong Toriatama Kikou 西原理恵子の麻雀鳥頭紀行 | PSX | | Original | | SLPS 02611 | |
| Saikyou Ginsei Mahjong 最強銀星麻雀 | PSX | | Original | | SLPS 03461 | |
| Saikyou Kareshi: Dynamic Darling 最強彼氏 | MAC | | Original | | | |
| Sail with Columbus | VIS | | Original | | 25-6181 | |
| Saint Hermit Studios E3 2001 Press Kit | PC | | Press Kit | | | |
| Saints Row | XBOX360 | | Demo | | IM-2024 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Saints Row IV | XBOX360 | | Original, Commander in Chief Edition | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 1) (Installation Disc) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 2) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row IV: Ultra Super Ultimate Deluxe Edition セインツロウ フォー ウルトラ・スーパー・アルティメット・デラックス・エディション | XBOX360 | | Original | | KM-2038 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Saishuu Densha 最終電車 | PSX | | Taikenban | | SLPM 80215 | |
| Sakamoto Ryouma: Ishin Kaikoku 坂本竜馬・維新開国 | PSX | | Original | | SLPS 01152 | |
| Sakkyoku surun da mon: Dance Remix-hen 作曲するんだもん ダンスリミックス編 | PSX | | Original | | SLPS 02808 | |
| Sakuma-shiki Jinsei Game さくま式人生ゲーム | PSX | | Original | | SLPS 01740 | |
| Sakura Flamingo Archives サクラフラミンゴアーカイヴス | XBOX360 | | Original | | NQ-2002 | |
| Sakura no Mori 櫻の杜 | FMT | | PC-9821 Release | | | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02557 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02558 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02559 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02554 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02555 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Play Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | | Shokai Genteiban | | 673-02556 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 1) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03911 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 2) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03912 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 3) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03913 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 4) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03914 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 5) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03915 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 6) サクラ大戦3 ~巴里は燃えているか~ | PC | | Shokai Genteiban | | 673-03916 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Desktop Accessories サクラ大戦3 ~巴里は燃えているか~ デスクトップアクセサリーズ | PC | | Tokubetsu Genteiban B | | DWWWC-50121~50123 | |
| Sakura Taisen Monogatari: Mysterious Paris: Special Disc サクラ大戦物語 ~ミステリアス巴里~ Special Disc | PC | | Promo | | | |
| Sakura Taisen: Denmaku Club 2 サクラ大戦 電幕倶楽部2 | PC | | Gouka Genteiban | | 673-01444 | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| Salaryman Kintarou サラリーマン金太郎 | PC | | Original | | SCR90402 | |
| Salaryman Kintarou: Dai-2-kan Netsuai Roman-hen サラリーマン金太郎 第2巻 熱愛浪漫篇 | PC | | Original | | SCR90403 | |
| Salaryman Kintarou: Dai-3-kan Touhoku Dotou-hen サラリーマン金太郎:第3巻東北怒涛篇 | PC | | Original | | | |
| Salaryman Kintarou: The Game サラリーマン金太郎 THE GAME | PSX | | Original | | SLPS 02806 | |
| Salaryman Settai Mahjong サラリーマン接待麻雀 | PSX | | Original | | SLPS 03175 | |
| Salvage Yard Simulator | PC | | Original | | | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.AU | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | | Kixx XL | | | |
| Sam & Max Hit the Road | PC | | Softgold, Rerelease | | | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.IT | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives: Adventure Collection | | | |
| Sam & Max Hit the Road | PC | | Original | | 634031 | |
| Sam & Max Hit the Road | PC | | Original | | 634430 | |
| Sam & Max Hit the Road | PC | | The LucasArts Archives Vol. I | | | |
| Sam & Max Hit the Road | MAC | | Original | | 8022133 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Sam & Max Save the World Sam & Max: Season One | PC | | PC Game Bundle | | EuroVideo-Artikel-Nummer 502083 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Sam & Max: Beyond Time and Space | PC | | Original | | | |
| Sam & Max: Beyond Time and Space | PC | | Original | | 27898CD | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Im Theater des Teufels Sam & Max: The Devil's Playhouse | PC | | Original | | EuroVideo-Artikel-Nummer 502083 | |
| Sam & Max: This Time It's Virtual! | PC | | Limited Run Games | | | |
| Samantha Swift and the Golden Touch Samantha Swift Bundle | PC | | Original | | | |
| Samantha Swift and the Roses of Athena | PC | | Play + Smile | | | |
| Samba de Amigo | WII | | Original | | RVL-R3BP-EUR | |
| Samba de Amigo サンバDEアミーゴ | WII | | Original | | RVL-R3BJ-JPN | |
| Samba de Amigo | WII | | Original | | RVL-R3BE-USA | |
| Same or Different | PC | | Book Bundle | | 08028 | |
| Samgukji II 2000 Plus 三國志Ⅱ 2000 PLUS | PC | | Original | | | |
| Sammy Sosa High Heat Baseball 2001 | PSX | | Original | | SLUS-01063 | |
| Samogonki Самогонки | PC | | Original | | | |
| Samorost 2: Zvezdanutoe priklyuchenie (Igrovoj disk) Саморост 2. Звезданутое приключение | PC | | Podarochnoe izdanie | | | |
| Sampras Extreme Tennis | PSX | | Original | | SLES-00217 | |
| Sampras Extreme Tennis サンプラス・エクストリーム・テニス | PSX | | Original | | SLPS 00594 | |
| Samurai Deeper Kyou サムライ・ディーパー・キョウ | PSX | | Shokai Seisan Gentei Shiyou | | SLPS 03505 | |
| Samurai Dou 3 侍道3 | XBOX360 | | Original | | SD-2044 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCP-EUR | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown サムライ・ショーダウン | 3DO | | Original | | FZ-SJ3155 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| Samurai Shodown | 3DO | | Original | | | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSP-EUR | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Shodown II Samurai Spirits | PC | | All You Can Play: 10 Action-Games | | | |
| Samurai Shodown II Samurai Spirits | PC | | Original | | | |
| Samurai Shodown II | PC | | Dual Jewel | | CD-C95-1302-0 | |
| Samurai Shodown II | PC | | Original | | CD-C95-1166-0 | |
| Samurai Shodown III | PSX | | Original | | SCES-00563 | |
| Samurai Shodown III: Blades of Blood | PSX | | Original | | SCUS-94206 | |
| Samurai Shodown Sen | XBOX360 | | Original | | SN-2005 | |
| Samurai Shodown V | XBOX | | Original | | SN-004 | |
| Samurai Shodown: Warriors Rage | PSX | | Original | | SLUS-01039 | |
| Samurai Spirits サムライ・スピリッツ | FMT | | Original | | JH-012 | |
| Samurai Spirits ~ Samurai Shodown サムライ・スピリッツ | NGCD | | Original | | NGCD-045 | |
| Samurai Spirits Sen サムライスピリッツ閃 | XBOX360 | | Original | | SN-2005 | |
| Samurai Spirits: 6beonui Seungbu 사무라이 스피리츠 6번의 승부 | WII | | Original | | RVL-RSSK-KOR | |
| Samurai Spirits: Amakusa Kourin ~ Samurai Shodown IV: Amakusa's Revenge サムライ・スピリッツ ~天草降臨~ | NGCD | | Original | | NGCD-222, NGCD-222E | |
| Samurai Spirits: Amakusa Kourin Special サムライスピリッツ 天草降臨スペシャル | PSX | | Original, PSone Books (SNK Best Collection) | | SLPS 01171 … | |
| Samurai Spirits: Kenkaku Shinan Pack サムライスピリッツ 剣客指南パック | PSX | | Original, Sample | | SCPS 45209 … | |
| Samurai Spirits: Rokuban Shoubu サムライスピリッツ 六番勝負 | WII | | Original | | RVL-RSSJ-JPN | |
| Samurai Spirits: Zankurou Musouken サムライスピリッツ 斬紅郎無双剣 | PSX | | Original, PSone Books (SNK Best Collection) | | SLPS 00350 … | |
| Samurai Spirits: Zankurou Musouken ~ Samurai Shodown III サムライ・スピリッツ 斬紅郎無双剣 | NGCD | | Original | | NGCD-087, NGCD-087E | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors | XBOX | | Original | | KO-006 | |
| Samurai Warriors 2 | PC | | Original | | 04929UK | |
| Samurai Warriors 2 | PC | | Original | | | |
| Samurai Warriors 2 | XBOX360 | | Original | | KO-2005 | |
| Samurai Warriors 2: Empires | XBOX360 | | Original | | KO-2006 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59P-EUR-E0 | |
| Samurai Warriors 3 | WII | | Original | | RVL-S59E-USA-E0 | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5E-USA | |
| Samuraj Po-Xi Super Zabawa | PC | | | | | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-87015 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| San Francisco Rush The Rock: Alcatraz Edition | PC | | Bundle Version Quantum3D OEM | | 740-0033-01 #QM049 | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLES-01208 | |
| San Francisco Rush: Extreme Racing | PSX | | Original | | SLUS-00505 | |
| Sanae-chan wa Torawarete Shimatta! (Disc 1) さなえチャンは囚われてしまった! | PC | | Original | | | |
| Sanctum: Oppositions / Cybertown | PC | | Original | | | |
| Sangaku Shashin Photo CD Series Vol. 1: Shirouma Takeshi Ushiro Tateyama Renpou 山岳写真フォトCDシリーズVol.1 白馬岳・後立山連峰 | PHOTO-CD | | Original | | AS 0001 | |
| Sangaku Shashin Photo CD Series Vol. 2: Hotaka Kamikochi 山岳写真フォトCDシリーズVol.2 穂高・上高地 | PHOTO-CD | | Original | | AS 0004 | |
| Sangaku Shashin Photo CD Series Vol. 4: Tateyama 山岳写真フォトCDシリーズVol.4[立山] | PHOTO-CD | | Original | | AS 0006 | |
| Sangoku Rensenki: Otome no Heihou! (Disc 1) 三国恋戦記 ~オトメの兵法!~ | PC | | Original | | DD-0002-1 | |
| Sangoku Rensenki: Otome no Heihou! (Disc 2) 三国恋戦記 ~オトメの兵法!~ | PC | | Original | | DD-0002-2 | |
| Sangokushi Eiketsuden 三國志英傑伝 | PSX | | Original, Koei Teiban Series | | SLPM 86744 … | |
| Sangokushi II 三國志Ⅱ | FMT | | with Soundware | | HMB-159 | |
| Sangokushi II 三國志Ⅱ | PSX | | Koei the Best | | SLPM 86607 | |
| Sangokushi III 三國志Ⅲ | FMT | | with Soundware | | HMD-131 | |
| Sangokushi III 三國志Ⅲ | PSX | | Koei the Best | | SLPM 87129 | |
| Sangokushi IV 三國志Ⅳ | FMT | | with Soundware | | HMF-139 | |
| Sangokushi Koumeiden 三國志孔明伝 | PSX | | Original, Koei the Best | | SLPM 86205 … | |
| Sangokushi Koumeiden 三國志孔明伝 | PC | | Original | | KN11-15101 | |
| Sangokushi Koumeiden 三國志孔明傳 | PC | | Original | | | |
| Sangokushi Returns 三國志リターンズ | PSX | | Koei Teiban Series | | SLPM 86171 | |
| Sangokushi VI 三國志Ⅵ | PSX | | Original, PlayStation the Best | | SCPS 45327 … | |
| Sangokushi VI with Power-Up Kit 三國志Ⅵ with パワーアップキット | PSX | | Original | | SLPM 86312 | |
| Sangokushi VII 三國志Ⅶ | PSX | | Original | | SLPM 86728 | |
| Sangokushi: Eiketsu Tenka ni Nozomu 三国志 ~英傑天下に臨む~ | PCE | | Original | | NXCD0002 | |
| Sanitarium (Disc 1) | PC | | Original | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitarium | PC | | Demo | | | |
| Sanitarium (Disc 2) | PC | | Original | | | |
| Sanitarium (Disc 3) | PC | | Original | | | |
| Sanitary Podzemelij Санитары Подземелий | PC | | Original, 1C: Kollekciya igrushek | | | |
| Sankyo Fever: Jikki Simulation SANKYO FEVER 実機シミュレーション | PSX | | Original | | SLPS 00264 | |
| Sankyo Fever: Jikki Simulation Vol. 2 SANKYO FEVER 実機シミュレーション Vol.2 | PSX | | Original | | SLPS 01176 | |
| Sankyo Fever: Jikki Simulation Vol. 3 SANKYO FEVER 実機シミュレーション Vol.3 | PSX | | Original | | SLPS 01393 | |
| Sanmi Ittai 三位一体 | PSX | | Taikenban | | SLPM 80065 | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 011143 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 001631 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 011143 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Dice | | DMM 001631 | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Original | | | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 2) | PC | | Original | | | |
| Sanyo Pachinko Paradise 2: Umi Monogatari Special 三洋パチンコパラダイス2 ~海物語・スペシャル~ | PSX | | Original | | SLPS 02389 | |
| Sanzennen Shokudou: Shoku Culture Simulation Game 三千年食堂 食カルチャーシミュレーションゲーム | MAC | | Original | | G012JAP-M | |
| Saraba Uchuu Senkan Yamato: Ai no Senshi-tachi (Disc 1) さらば宇宙戦艦ヤマト 愛の戦士たち | PSX | | Original, Sample | | SLPS 02761 | |
| Saraba Uchuu Senkan Yamato: Ai no Senshi-tachi (Disc 2) さらば宇宙戦艦ヤマト 愛の戦士たち | PSX | | Original, Sample | | SLPS 02762 | |
| Saraba Uchuu Senkan Yamato: Ai no Senshi-tachi (Disc 3) さらば宇宙戦艦ヤマト 愛の戦士たち | PSX | | Original, Sample | | SLPS 02763 | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | eXtra Klasyka XK HIT | | | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | Original | | | |
| Sąsiedzi z Piekła Rodem 1 + 2 | PC | | eXtra Klasyka Next | | | |
| Satomi no Nazo 里見の謎 | PSX | | Original | | SLPS 00613 | |
| Satomi: Yami no Kyouzou SATOMI 闇の鏡像 | PC | | Original | | | |
| Satsui no Shoumei: In the 1st Degree (Disc 1) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078A | |
| Satsui no Shoumei: In the 1st Degree (Disc 2) 殺意の証明 イン ザ ファースト ディグリー | MAC | | Original | | IP-078B | |
| Satsui no Shoumei: In the 1st Degree: Making CD-ROM 殺意の証明 イン ザ ファースト ディグリー メイキングCD-ROM | PC | | Hibaihin | | IP-081M | |
| Sayaka + Miho 沙也香/美穂 | FMT | | Original | | HMF-179 | |
| SBFR the Best 4: PKMN First History | PC | | Original | | SSEB-0055 | |
| SBK 08: Superbike World Championship | XBOX360 | | Original | | LS-2001 | |
| SBK 08: Superbike World Championship | PC | | Covermount | | | |
| SBK 09: Superbike World Championship | XBOX360 | | Original | | LS-2004 | |
| SBK 2011: FIM Superbike World Championship | XBOX360 | | Original | | LS-2021 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK X: Superbike World Championship | XBOX360 | | Original | | LS-2007 | |
| SBK: Superbike World Championship | XBOX360 | | Original | | CN-2005 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 300202 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| Scary Poems for Rotten Kids | MAC | | Original | | CDRM 397200 | |
| SCEA Gamers Day 2002: Press Info | PC | | Press Kit | | | |
| SCEE Media Assets: Games Convention / Leipzig: August 20th 2008 (Disc 1) | PC | | Press Kit | | | |
| SCEE Media Assets: Games Convention / Leipzig: August 20th 2008 (Disc 2) | PC | | Press Kit | | | |
| SCEE Press Information: Corporate & Hardware: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 1: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Press Information: Software Disc 2: Autumn 2002 | PC | | Press Kit | | | |
| SCEE Software Brochure + Press Information: E3 2003 | PC | | Press Kit | | | |
| Scenariomania Scenariomania Vol. 1 | PC | | Original | | | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! Scene It? Campione d'Incassi: Nuovissimi filmati e quiz sul cinema | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Ciak! Si Gira! Scene It? Ciak! Si Gira! Nuovissime domande e curiosità sul mondo del cinema | XBOX360 | | Original | | WR-2044 | |
| Scene It? Grandes Éxitos de Taquilla | XBOX360 | | Original | | MS-2144 | |
| Scene It? Kinohits | XBOX360 | | Bundled with 4 Controllers | | MS-2144 | |
| A Scene It? Lights, Cameraction | XBOX360 | | Original | | MS-2098 | |
| A Scene It? Lights, Cameraction! A Scene It? Luci, Camerazione! Il gioco a quiz sul cinema | XBOX360 | | Original | | MS-2098 | |
| Scene It? Luces, Cámara, ¡Acción! Scene It? Bright Lights! Big Screen! | XBOX360 | | Bundled with 4 Controllers | | MS-2098 | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Scene Xplorer '97 Scene Explorer: From the Beginning into the Future | ACD | | Original | | | |
| Schiene & Strasse: Der 3D-Transport-Manager: 1820-2020 | PC | | Original | | | |
| Schiff-Simulator 2005 Virtual Sailor 6.8 | PC | | Original | | 31059 | |
| Schiff-Simulator 2008 Ship Simulator 2008 | PC | | Original | | | |
| Schiff-Simulator 2008 | PC | | Original | | Artikelnummer 31114 | |
| Schizm II: Kameleon (Disc 2) | PC | | Original | | | |
| Schizm II: Kameleon (Disc 3) | PC | | Original | | | |
| Schizm: Mysterious Journey (Seite A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Seite B) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Disc 1) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 2) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 3) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 4) | PC | | Original | | | |
| Schizm: Mysterious Journey (Disc 5) | PC | | Original | | | |
| Schizm: Mysterious Journey (Side A) | PC | | Rerelease | | | |
| Schizm: Mysterious Journey (Side B) | PC | | Rerelease | | | |
| Schizm: Mysterious Journey (Side A) | PC | | DVD-ROM Edition | | | |
| Schizm: Mysterious Journey (Side B) | PC | | DVD-ROM Edition | | | |
| Schizm: Prawdziwe Wyzwanie (Strona B) | PC | | Original | | AMDVD001 | |
| Die Schlaue Bande: 5. Klasse Lernsystem | PC | | Original | | | |
| Die Schlaue Bande: 6. Klasse Lernsystem | PC | | Original | | | |
| Die Schlümpfe: Farben und Formen | PC | | Original | | | |
| Schmidt Interaktivspaß: Brettspiele | PC | | Original | | S0022616 | |
| Schmidt Interaktivspaß: Mahjong | PC | | Original | | S0023095 | |
| Schmidt Interaktivspaß: Skat | PC | | Original | | S0022595 | |
| Schmidt Interaktivspaß: Spiele für Kids | PC | | Original | | S0022620 | |
| Schnappi: Das kleine Krokodil: 3 Fun-Games | PSX | | Original | | SLES-04177 … | |
| Scholar Movie Magazine Soukan-gou スコラ MOVIE MAGAZINE 創刊号 | FMT | | Original | | DWDC 4815 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the World of Animals | PC | | Original, The Magic School Bus: Bonus Pack | | 0299 Part No. X03-94114, 1001 Part No. X08-51052 | |
| Scholastic's The Magic School Bus Lands on Mars: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0400 Part No. X05-64212 | |
| Scholastic's The Magic School Bus: Jungle no Fushigi マジック スクール バス ジャングルのふしぎ | PC | | Original | | PRIR-01005 | |
| Scholastic's The Magic School Bus: Volcano Adventure: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3 | | 0401 Part No. X08-06054 | |
| Scholastic's The Magic School Bus: Whales & Dolphins: Activity Center | PC | | The Magic School Bus: Bonus Pack Volume 3, The Magic School Bus: Bonus Pack | | 0201 Part No. X06-15571 | |
| School Mates Collection | PHOTO-CD | | Original | | SJ-0001 | |
| School Rumble: Neru Musume wa Sodatsu.: DTA Daisuki Tenma Accessory スクールランブル ねる娘は育つ。 DTA<大好き 天満アクセサリー> | PC | | DX Pack | | MII-012 | |
| School Zone Flash Action Software: Multiplication/Division | PC | | Original | | 08021 | |
| School Zone Math: First & Second Grade | PC | | Original | | 08020 | |
| Schoolhouse Rock! America Rock | PC | | Original | | 21080CD | |
| Schoolhouse Rock! Thinking Games | PC | | Original | | BBT844AE-CD | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744BE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 1) (Thinking Games) | PC | | Original | | SRT744AE-CD1 | |
| Schoolhouse Rock! Thinking Games Deluxe (Disc 2) (Learning Adventures) | PC | | Original | | SRT744AE-CD2 | |
| Schoolmates: The Mystery of the Magical Bracelet | PC | | Original | | | |
| Schrottplatz-Simulator 2011 | PC | | Original | | | |
| Der Schuh des Manitu Der Schuh des Manitu: Das Computerspiel zum Film | PC | | Original | | | |
| Das Schwarze Auge: Drakensang: Am Fluss der Zeit | PC | | Original | | | |
| Das Schwarze Auge: Drakensang: Phileassons Geheimnis | PC | | Original | | | |
| Das Schwarze Auge: Drakensang: Platinum Edition | PC | | Original | | | |
| Das Schwarze Auge: Satinavs Ketten | PC | | Limitierte Erstauflage | | ECD008798M ECD008799M ECD008907K ECD900830D 23032012-00 | |
| Schwarzschild シュヴァルツシルト | FMT | | Original | | HMC-171 | |
| Schwarzschild EX: Tessa no Seigun シュヴァルツシルトEX ~鉄鎖の星群~ | PC-98 | | MS-DOS-ban | | 9214-55HM10 | |
| Schwarzschild IV: The Cradle End シュヴァルツシルトⅣ -THE CRADLE END- | FMT | | Original | | HME-223 | |
| SCI Games E3 2005 Press Kit | PC | | Press Kit | | | |
| SCI Media Kit: Version: 2 | PC | | Press Kit | | | |
| SCI Media Kit: Version: 4 SCI Media Kit: Version: 4.0 | PC | | Press Kit | | | |
| Science Arcade | PC | | Original | | Part No.: MAR476 | |
| Science Fiction: The Ultimate Collection (Disc 1) | PC | | | | 11014 | |
| Science Is Elementary 1 | PSX | | Original | | LSP-990161 … | |
| Science Is Elementary 2 | PSX | | Original | | LSP-990162 … | |
| Science Is Elementary 3 | PSX | | Original | | LSP-990163 … | |
| Scooby-Doo! Case File #1: The Glowing Bug Man | PC | | GSP | | 1063A | |
| Scooby-Doo! First Frights + Scooby-Doo! The Mystery Begins (Asset Disc) | PC | | Press Kit | | | |
| Scooby-Doo! Phantom of the Knight | PC | | SoftKey | | SPK854BB-CD | |
| Scooby-Doo! Phantom of the Knight | PC | | GSP | | 1064A | |
| Scooter's Magic Castle / Eagle Eye Mysteries in London | PC | | Original | | 1213330151 | |
| Scooter's Magic Castle & Kid Pix | PC | | Bundle Version Creative Labs OEM | | | |
| Score International Baja 1000: The Official Game | PC | | Original | | 35619./101.US | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| ScottForesman Wide World of Mathematics | PC | | Original | | 45678910 ET 030201009998 | |
| Scrabble: Champion Edition | PC | | Rerelease | | 04562 | |
| Scrabble: Champion Edition | PC | | Original | | 11191A-CD v1.0 S | |
| Scramble Cobra: Premium Version スクランブル・コブラ プレミアム・バージョン | 3DO | | Not for Sale | | FZ-JJ9PSC-5H | |
| Scratches: Graffi Mortali | PC | | Original | | | |
| Screamball: The Ultimate Pinball Experience | PC | | Original | | | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| ScreamRide | XBOX360 | | Original | | MS-2726 | |
| Screendisc Interactive Preview Systems: The Preview System | CDI | | Original | | | |
| Scribblenauts Unlimited (Asset Disc) | PC | | Press Kit | | | |
| Scribblenauts Unlimited | PC | | Original | | 5000145356 | |
| Scudetto 5 Scudetto Championship Manager 5 | XBOX | | Original | | ES-026 | |
| SD Gundam Eiyuuden: Daikessen!! Kishi vs. Musha SDガンダム英雄伝 大決戦!! 騎士 VS 武者 | PSX | | Original | | SLPS 03145 | |
| SD Gundam: Daizukan SDガンダム ~大図鑑~ | QIS | | Original | | BAPD-03 | |
| SD Gundam: GGeneration SDガンダム ジージェネレーション | PSX | | Original | | SLPS 01560 | |
| SD Gundam: GGeneration (Premium Disc) SDガンダム ジージェネレーション プレミアムディスク | PSX | | Original | | SLPS 01561 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: GGeneration-0 (Disc 1) SDガンダム ジージェネレーション・ゼロ | PSX | | Original | | SLPS 02200 | |
| SD Gundam: GGeneration-0 (Disc 2) SDガンダム ジージェネレーション・ゼロ | PSX | | Original | | SLPS 02201 | |
| SD Gundam: GGeneration-F (Disc 1) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84004 | |
| SD Gundam: GGeneration-F (Disc 1) SDガンダム ジージェネレーション・エフ | PSX | | Original, Limited Edition | | SLPS 02900 … | |
| SD Gundam: GGeneration-F (Disc 2) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84005 | |
| SD Gundam: GGeneration-F (Disc 2) SDガンダム ジージェネレーション・エフ | PSX | | Original, Limited Edition | | SLPS 02901 … | |
| SD Gundam: GGeneration-F (Disc 3) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84006 | |
| SD Gundam: GGeneration-F (Disc 3) SDガンダム ジージェネレーション・エフ | PSX | | Original, Limited Edition | | SLPS 02902 … | |
| SD Gundam: GGeneration-F (Disc 4) (Premium Disc) SDガンダム ジージェネレーション・エフ | PSX | | Limited Edition | | SLPS 02903 | |
| SD Gundam: GGeneration-F (Disc 4) (Premium Disc) SDガンダム ジージェネレーション・エフ | PSX | | Koudansha 8-shi Rengou Kikaku Tokubetsu-ban | | SLPM 84007 | |
| SD Gundam: GGeneration-F (Disc 4) (Premium Disc) SDガンダム ジージェネレーション・エフ | PSX | | Original | | SLPS 02915 | |
| SD Gundam: GGeneration-F.I.F SDガンダム ジージェネレーション・エフイフ | PSX | | Original | | SLPS 03195 | |
| SD Gundam: Over Galaxian SDガンダム オーバーギャラクシアン | PSX | | Original | | SLPS 00385 | |
| SD Media Launcher for GameCube / Wii SDメディアランチャー Wii用/GC用 | GC | | Unlicensed | | | |
| SD Qlympics Olympic Challenge | PC | | Grabit | | GDL031 | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Sea War Sea War: Entscheidungsschlacht im Pazifik | PC | | Original | | SPI 023 | |
| Seal: Travelers of Destiny SEAL~運命の旅人~ | PC | | Original | | MKD-1390 | |
| Search and Rescue Search and Rescue Helicopter Flight Sim | PC | | Original | | | |
| Seasons Greetings from Philips Media | CDI | | Original | | | |
| Second Sight | XBOX | | Original | | CM-071 | |
| Secre Demo Disk | FMT | | Hibaihin | | HME-921 | |
| Secre Fuumin no Omochabako セクレ・フーミンのおもちゃ箱 | 3DO | | Original | | FZ-SJ2651 | |
| Secre Volume 2: Mai Oikawa SECRE VOLUME ② 「及川 麻衣」 | FMT | | Original | | HME-180 | |
| Secre Volume 3: Fumie Hosokawa SECRE VOLUME ③ 「細川 ふみえ」 | FMT | | Original | | HME-191 | |
| Secre Volume 4: Hitomi Fujisaki SECRE VOLUME ④ 「藤崎 仁美」 | FMT | | Original | | HME-196 | |
| Secre Volume 5: Tina Gushiken SECRE VOLUME ⑤ 「具志堅 ティナ」 | FMT | | Sample | | HME-204 | |
| Secre Volume 6: Reiko Kato SECRE VOLUME ⑥ 「かとう れいこ」 | FMT | | Original | | HME-205 | |
| Secre Volume 7: Reiko Chiba SECRE VOLUME ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 | |
| Secre Volume I: Naoko Iijima SECRE VOLUME ① 「飯島 直子」 | FMT | | Original | | HME-168 | |
| Secret Game: Code:Revise: Trial Version シークレットゲーム CODE:Revise 体験版 | PC | | Demo | | | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Secret Mission | CDI | | Original | | 814 0133 | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| The Secret of Monkey Island モンキー・アイランド | FMT | | Original | | HMD-155 | |
| The Secret of Monkey Island モンキー・アイランド ~ユーレイ海賊大騒動!~ | MCD | | Original | | T-60044 | |
| The Secret of Monkey Island | MCD | | Limited Run Games | | | |
| The Secret of Monkey Island | MCD | | Original | | T-60035 | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| The Secret of Monkey Island: Special Edition (International Trailer) | PC | | Press Kit | | | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| The Secret of the Silver Earring (Disc 1) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD1 | |
| The Secret of the Silver Earring (Disc 2) Sherlock Holmes: The Secret of the Silver Earring | PC | | Original | | 652106-CD2 | |
| Secret Weapons of the Luftwaffe | PC | | Original | | 2156010-590001/I042, CDRM1003790 | |
| The Secrets of Da Vinci: The Forbidden Manuscript (Disc 1) Sekrety Leonarda Da Vinci: Zakazany Manuskrypt | PC | | | | | |
| Seek & Find Mysteries 2 | PC | | Original | | | |
| Sega Classic Arcade Collection: Limited Edition セガクラシック | MCD | | Original | | G-6012 | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega Classics Arcade Collection: Limited Edition | MCD | | Original | | 4127 | |
| Sega Dreamcast Wired by AT&T WorldNet Service | PC | | Promo | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Game Honpo: Wonder Boy V, Monster World III セガゲーム本舗 ワンダーボーイⅤ モンスターワールドⅢ | PC | | Original | | SGH-013 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future 세가 GT 2002 + 젯 셋 라디오 퓨처 · 噴射小子 未來版 | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega Marine Fishing | PC | | Sega Bass Fishing & Sega Marine Fishing: Xplosiv | | EI-1606 | |
| Sega Mega Drive Classic Collection Volume 1 | PC | | Original | | SEGA-PC118 | |
| Sega Mega Drive Classic Collection Volume 2 | PC | | Original | | SEGA-PC119 | |
| Sega Mega Drive Classic Collection Volume 3 | PC | | Original | | SEGA-PC120 | |
| Sega Mega Drive Classic Collection Volume 4 | PC | | Original | | SEGA-PC121 | |
| Sega Mega Drive Ultimate Collection | XBOX360 | | Original, Classics | | SE-2085 | |
| Sega Memorial Selection: Dear 80's Videogame Best 3 | PC | | Ultra 2000/Ultra Series | | MKW-183 | |
| Sega Network Taisen Mahjong MJ5 セガネットワーク対戦麻雀MJ5 | SRE | | Original | | DVR-0027 | |
| Sega Network Taisen Mahjong MJ5 Evolution セガネットワーク対戦麻雀MJ5 EVOLUTION | SRE | | Original | | DVR-0071 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083 | |
| Sega Network Taisen Mahjong MJ5 R Evolution セガネットワーク対戦麻雀MJ5 R EVOLUTION | SRE | | Original | | DVR-0083D | |
| Sega Press Materials | PC | | Press Kit | | | |
| Sega Rally 2 (Disc 1) (Install Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-1 | |
| Sega Rally 2 (Disc 2) (Play Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-2 | |
| Sega Rally 2 (Disc 1) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0919 | |
| Sega Rally 2 (Disc 2) Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally 2: Sega Rally Championship (Install Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally 2: Sega Rally Championship (Play Disc) セガラリー2 | PC | | DigiCube PC | | DWRPD-00081 | |
| Sega Rally Championship Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship PC | PC | | Green Pepper | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Original | | 670-9827 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | MKW-031 | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship PC セガラリー・チャンピオンシップ | PC | | Mihon-hin | | 670-10314 | |
| Sega Saturn Development Tool Kit | PC | | Original | | 610-5750 | |
| Sega Smash Pack II | PC | | Bundle Version Tiny OEM | | KDGT44 | |
| Sega Smash Pack Twin Pack | PC | | Original | | 30884.101.US | |
| Sega Soccer Slam | XBOX | | Original | | IG-041 | |
| Sega Touring Car Championship 世嘉巡回车大赛 | PC | | Original | | | |
| Sega Touring Car Championship | PC | | Fair Game: Quality Value | | FG-1306 EUROPEAN | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Segare Ijiri せがれいじり | PSX | | Otameshi Disc | | SLPM 80426 | |
| Segare Ijiri せがれいじり | PSX | | Original | | SLPM 86230 | |
| SegaSaturn: Graphic & Sound Tools for Macintosh | SS | | Original | | N16-1000 | |
| SegaSaturn: Movie Tools: Cinepak for Sega Saturn | SS | | Hybrid Version | | L17-1000 | |
| Sei Shirasagi Jogakuen Vol. 3: Sunada Misaki-hen 聖シラサギ女学園 Vol.3 砂田 ミサキ編 | PC | | Original | | SCR-1997-03 | |
| Seijo Vampire 聖女ヴァンパイア | PC | | Original | | MMM-7881 | |
| Seikai no Monshou 星界の紋章 | PSX | | Original | | SLPS 02323 | |
| Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka! 政界立志伝~君は日本のリーダーになれるか!~ | PC | | | | MSDJ-99094 | |
| Seikaku Shindan Game: Ukiyo-e Sumo-hen 性格診断ゲーム 浮世絵相撲編 | PHOTO-CD | | Original | | NPCD-1005 | |
| Seiken Densetsu: Legend of Mana 聖剣伝説 レジェンド オブ マナ | PSX | | Original, Square Millennium Collection, PSone Books, Ultimate Hits, Sample (Asia) | | SCPS 45416 … | |
| Seikimatsu Taimaden Tsumugi-chan SOS 世紀末退魔伝つむぎちゃんSOS | PC | | Original | | EXC-0011 | |
| Seikon no Joka: Hikari to Yami no Seioujo 聖痕のジョカ ~光と闇の聖王女~ | PSX | | Original | | SLPS 00483 | |
| Seima Densetsu 3x3 Eyes 聖魔伝説 3×3EYES | MCD | | Original | | G-6007, GD0004JG | |
| Seimei Handan 姓名判断 | 3DO | | Original | | FZ-SJ4053 | |
| Seirei Shoukan: Princess of Darkness 精霊召喚 ~プリンセス オブ ダークネス~ | PSX | | Taikenban Special Disc | | SLPM 80271 | |
| Seishoujo Kantai Virgin Fleet 聖少女艦隊・バージン・フリート | PSX | | Original | | SLPM 86191 | |
| Seiya Monogatari: Anearth Fantasy Stories 聖夜物語 | PCE | | Bundled with Book (Dengeki PC Engine Special Edition - Taikenban) | | HMD-0004 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 1) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Seiyuu Kantoku Simulation: Standby Say You! (Disc 2) 声優監督シミュレーション スタンバイSay You! | PC | | | | HMW-1 | |
| Sekigahara 関ヶ原 | FMT | | Original | | HMD-128 | |
| Sell It to Me! Part One: Preparing The Way | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Handling Telephone Sales Enquiries and Making Appraisals Pay | CDI | | Original | | | |
| Selling for Real: Interactive Video Sales Training: Paperwork, Bloody Paperwork and Selling to Women | CDI | | Original | | | |
| Semper Fi | PC | | Original | | | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3P-EUR-B0 | |
| Sengoku Basara: Samurai Heroes | WII | | Original | | RVL-SB3E-USA-B0 | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! 戦国美少女絵巻 空を斬る!! | PC | | Original | | TGL-98 0220 | |
| Sengoku Bishoujo Emaki: Kuu o Kiru!! Harukaze no Shou 戦国美少女絵巻 空を斬る!! ~春風の章~ | PC | | Original | | | |
| Sengoku Cyber: Fujimaru Jigokuhen 戦国サイバー 藤丸地獄変 | PSX | | Original | | SCPS 10011 | |
| Sengoku Musou 2 with Moushouden 戦国無双2 with 猛将伝 | XBOX360 | | Original | | KO-2005 | |
| Sengoku-hime 2: Senran no Yo, Gunyuu Arashi no Gotoku 戦極姫2 ~戦乱の世、群雄嵐の如く~ | XBOX360 | | Original | | SY-2002 | |
| Senkai Taisen: TV Animation Senkaiden Houshin Engi yori 仙界大戦 ~TVアニメーション仙界伝封神演義より~ | PSX | | Original | | SLPS 02736 | |
| Senkai Tsuuroku Seishi: TV Animation Senkaiden Houshin Engi yori 仙界通録正史 ~TVアニメーション仙界伝封神演義より~ | PSX | | Original | | SLPS 03176 | |
| Senkaku Mondai o Yatchimasu 2 尖閣問題を殺っちます2 | PC | | Original | | | |
| Sensible Soccer 2006 | XBOX | | Original | | CM-091 | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Sentimental Graffiti センチメンタルグラフティ | PSX | | Original | | SLPS 03184 | |
| Sentimental Graffiti (Disc 1) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01A | |
| Sentimental Graffiti (Disc 2) センチメンタルグラフティ | PC | | Original | | ID NO.9718-X8-01B | |
| Sentimental Graffiti: Yakusoku センチメンタルグラフティ~約束~ | PSX | | Original | | SLPS 03183 | |
| Sentimental Journey センチメンタル・ジャーニー | PSX | | Original | | SLPS 01473 | |
| Sentinel: Descendants in Time (Disc 1) | PC | | Original | | | |
| Sentinel: Descendants in Time (Disc 2) | PC | | Original | | | |
| Sento Monogatari: Sono I 占都物語 そのI | PSX | | Original | | SLPS 00124 | |
| Sento Monogatari: Sono I 「占都物語」 そのI | PC | | Original | | | |
| Sento Monogatari: Sono I 「占都物語」 そのⅠ | 3DO | | Original | | FZ-SJ4054 | |
| Sentou Kokka Kai: Improved 戦闘国家-改- IMPROVED | PSX | | Original, PlayStation the Best | | SCPS 10034 … | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora 戦闘妖精雪風 ~妖精の舞う空~ | XBOX | | Original | | AQ-003 | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 1) (Installation CD-ROM) 戦闘妖精雪風~妖精の舞う空~ | PC | | Original | | SYYi-V1.00 | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (Disc 2) (Game CD-ROM) 戦闘妖精雪風~妖精の舞う空~ | PC | | Original | | SYYg-V1.00 | |
| Septentrion: Out of the Blue セプテントリオン ~Out of the Blue~ | PSX | | Major Wave | | SLPM 86612 | |
| Sequence Palladium シークエンス パラディウム | PC | | Original | | KGDP004 | |
| Sequence Palladium シークエンス パラディウム | PC | | DigiCube, Media Kite Great Series | | DWRPM-00089, MKW-182 | |
| Sequence Palladium 2 Mania Kit | PC | | Original | | KGD-0060 | |
| Sequence Palladium 2: Yami no Shousei シークエンス・パラディウム2 ~闇の笑声~ | PC | | Rerelease | | KGD-04080 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 1) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04060 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 2) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04061 | |
| Sequence Palladium Aizouban シークエンス パラディウム 愛蔵版 | PC | | Original | | KGDP075 | |
| Sequence Palladium Mania Kit: Desktop Accessory シークエンス・パラディウム マニアキット デスクトップアクセサリ | PC | | Original | | WIC-6346 | |
| Sequence Palladium Premium Digital Novel | PC | | PC Game Bundle | | KGD-06021 | |
| Seraphim: Saigo no Tenshi セラフィム 最後の天使 | PC | | Original | | SCR-003 | |
| Serial Experiments Lain (Disc 1) シリアル・エクスペリメンツ・レイン | PSX | | Original | | SLPS 01603 | |
| Serial Experiments Lain (Disc 2) シリアル・エクスペリメンツ・レイン | PSX | | Original | | SLPS 01604 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| Serious Sam | XBOX | | Original | | TT-004 | |
| Serious Sam 3: BFE | PC | | Original | | MTC000692-D | |
| The Serious Sam Collection | XBOX360 | | Original | | MK-2010 | |
| The Serious Sam Collection | XBOX360 | | Original | | VQ-2010 | |
| Serious Sam HD | XBOX360 | | Promo | | MK-2004 | |
| Serious Sam HD: The First Encounter | PC | | Original | | | |
| Serious Sam HD: The Second Encounter Serious Sam HD: Второе Пришествие | PC | | Original | | | |
| Serious Sam II | PC | | Original | | | |
| Serious Sam II | PC | | Sold Out Software | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 1) | PC | | Original | | | |
| Serious Sam II (Disc 2) | PC | | Original | | | |
| Serious Sam II (Disc 3) | PC | | Original | | | |
| Serious Sam II (Disc 4) (Play) | PC | | Original | | | |