| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Saint Eyes
セイントアイズ | PC | | Shokai Genteiban | | |  |
 | Samurai Shodown | MCD | | Bundled with Magazine (Demo) | | | |
 | Scholastic's The Magic School Bus Explores the Ocean | MAC | | Original | | 0496 Part No. 64964 | |
| Scholastic's The Magic School Bus Explores the Ocean | PC | 1.0 | Original | | Disc Assy. 451-052-012 0396 Part No. 90626 | |
 | Secret Service CD 55 (Strona A) | PC | | | | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Secret Service CD 55 (Strona B) | PC | | | | | |
| Secret Service CD 56 (Strona A) | PC | | | | | |
| Sega Entertainment's Arcade Sampler | PC | | | | | |
 | The Settlers III (Disc 1) | PC | | Revival | | REV036 | |
| The Settlers III (Disc 2) | PC | | Revival | | REV036 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | DigiCube PC | | DWRPS-00055 | |
| Shanghai: Dynasty
上海ダイナスティ | PC | 1.2 | PC Game Best Series Mega Hit | | | |
| Sid Meier's CivNet | PC | | Original | | MP191226DOIR | |
| Silent Thunder: A-10 Tank Killer II | PC | | Rerelease | | S691140 | |
| Silver Gene: The Mutia Chronicle 1
シルバージーン ｔｈｅ ｍｕｔｉａ ｃｈｒｏｎｉｃｌｅ 1 | PC | | Original | | CNDL-0002 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Mega-CD 32X | | T-16204F-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Mega-CD 32X | | T-16204F-50 | |
 | Soft-World Magazine No. 139: November 2000
軟體世界雜誌社 ＭｅｇａＤｉｓｃ 第１３９期 | PC | | | | | |
| Sonic R
ソニックＲ | PC | | Ultra 2000/Ultra Series | | MKW-111 | |
| Souzou Sozai: Umi Vol. 1
創造素材 海 Ｖｏｌ．１ | PHOTO-CD | | Original | | SEVI-1049 | |
| Star Trek Pinball | PC | | Bundle Version OEM | | CD-C95-675-UNU | |
| Star Trek: The Next Generation: Klingon Honor Guard (Game Disk) | MAC | | Original | | P/N 04-17512CD1 | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Starblade | MCD | | Original | | 4284-50 | |
| Starry the Universe
大宇宙 遥かなる大星雲 | PHOTO-CD | | Original | | PLP-5003 | |
| Style Game Magazine July 2000
新遊戲時代 ２０００．０７ | PC | | | | | |
| Suppin Bishoujo Vol. 3
すっぴん美少女 ｖｏｌ．３ | PHOTO-CD | | Original | | SPN-003 | |
| Supreme Warrior (Disc 1) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 1) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 2) | MCD | | Original | | T-162045-50 | |
| Supreme Warrior (Disc 2) | MCD | | Mega-CD 32X | | T-16203F-50 | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Original | | T162045 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Original | | T162045 | |
| Surgical Strike | MCD | | Original | | 4435-50, 670-6783-50 | |
| Świat Przygód z Hugo 5/2004 | PC | | | | | |
| Sanguo Mahjong Fengyun
三國麻將風雲 | PC | | Original |  | | |
| Sanguozhi IV
三國志Ⅳ | SS | 1.003 | Zhongwenban | | T-7601H-11, T-7601H-16 | |
| Sanguozhi V
三國志Ⅴ | SS | 1.000 | Zhongwenban | | T-7606H-11, T-7606H-16 | |
 | Sanguozhi VIII
三国志Ⅷ | PC | 1.0 | Original | | | |
| Sanguozhi Yingjiezhuan
三國志英傑伝 | SS | 1.000 | Zhongwenban | | T-7603H-11, T-7603H-16 | |
| Shiluo Dadi
失落大地 | PC | 1.00.000 | Original | | | |
| Shouhuzhe Zhi Jian (Disc 1)
守护者之剑 | PC | | Original | | | |
| Shouhuzhe Zhi Jian (Disc 2)
守护者之剑 | PC | | Original | | | |
 | S.C.A.R.S. | PC | 1.0 | |  | | |
| Sam & Max Hit the Road | PC | | White Label: Doubles | | | |
| Sam & Max Hit the Road | PC | 2.0 | LucasArts Classic | | 41117.101.UK | |
| Samurai Shodown | MCD | | Original | | T-60175-50 | |
| Samurai Shodown | MCD | | Original | | T-60175 | |
| The San Diego Zoo Presents... The Animals! | MCD | | Original | | T-158015-50 | |
| Sandwarriors | PC | 1.11 | Original | | CD-ICD-297-0 | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Sandwarriors: The Battle for the Sun Throne | PC | 1.0 | Original | | | |
| Saturn Bomberman | SS | 1.003 | Original | | 81070 | |
| Scarab
S.C.A.R.A.B. | PC | | Original | | EAE08801181D | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. X03-27325, Disc Assy. 452-052-002 | |
| Scholastic's The Magic School Bus Explores Inside the Earth | PC | | Original | | 0396 Part No. 66556 | |
| Scissors 'n' Stones | PC | | Original | | | |
| Scooby-Doo! Mystery of the Fun Park Phantom | PC | | Original | | | |
| Scorcher | PC | | Original | | 04-11264CD | |
| Screamer | PC | | Award Winners No. 1 | | EI-1041 | |
| Screamer | PC | | Screamer Injection | | | |
| Screamer | PC | | Sold Out Extreme | | | |
| Screamer 2 | PC | | Megapak 8 | | | |
| Screamer 2 | PC | | Original | | | |
| Screamer Rally | PC | | Original, Screamer Injection | | | |
 | Screaming Skies | PC | | Tewi | | Bestell-Nr. 27669 | |
| SD Qlympics
Olympic Challenge | PC | | Grabit | | GDL031 | |
| The Secret of Monkey Island & Monkey Island 2: LeChuck's Revenge | PC | | White Label: Doubles | | | |
| Secrets of Tatjana | CDI | | Original | | 810 0046 | |
| Seek and Destroy
Seek & Destroy | CD32 | | Original | | | |
| Sega Ages Volume 1 | SS | 1.001 | Original | | T-12707H | |
| Sega Family Fun Pak | PC | | Original | | | |
| Sega Puzzle Pack | PC | | Original | | 673-01815 | |
| Sega Puzzle Pack | PC | | Original | | 85091 | |
| Sega Rally 2 (Disc 2)
Sega Rally 2: Sega Rally Championship | PC | | Original | | 40924-0819 | |
| Sega Rally Championship
Sega Racing: Sega Rally Championship | PC | | Demo | | 85051 | |
| Sega Rally Championship | PC | 1.0 | Original | | 85048 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Sega Rally Championship PC
セガラリー・チャンピオンシップ | PC | | Ultra 2000/Ultra Series | | | |
| Sega Rally Championship Plus Netlink Edition | SS | 1.001 | Net Link Game Pack | | 81215, 81608 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | 85067 | |
| Sega Touring Car Championship | SS | 1.001 | Original, Sample | | 81216 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sega Worldwide Soccer PC | PC | | 3D Power Pack | | 500-0009-50 | |
| Sensible Soccer | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 5, Demo) | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
| Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| Sewer Shark | MCD | | Original | | T-93015-50 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Shadow Fighter | CD32 | | Original | | | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original, East Meets West | | 04-12539CD | |
 | ShadowCaster | PC | | Original | | | |
| Shamrock Spring '97
Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.03 | Original | | CD-ICD-201-2 | |
| Shellshock | PC | | Kixx | | | |
| Shellshock | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Shining the Holy Ark | SS | 1.003 | Original | | 81306 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shrak
Shrak for Quake | PC | 1.0 | Original | | | |
| Shrak
Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Collector's Edition | | | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Colonization
Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.01 | Rerelease | | | |
| Silverload | PC | | | | | |
| Skeleton Krew | CD32 | | Original | | | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Sky Target: Daredevil Air Force
スカイ・ターゲット | PC | 1.0.06.19 us | PCHome | | 506-9890 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
 | Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | 063636, T162035 | |
| Slam Tilt | PC | | Original | | | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-158025-50 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| Soldier of Fortune | PC | 1.03 | Special Tactical Edition | | 1001348.101.US | |
| Soldier of Fortune | PC | 1.03 | Original | | 1000910.101.US | |
| Sonic & Garfield Pack | PC | | Original | | 85090 | |
| Sonic 3D Blast | PC | 1.00 | Original | | 85064 | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic CD | PC | | Original, Family Pack | | MK 85015-50, MK 85086-50 | |
| Sonic CD | PC | | Original | | MK 85015-50 | |
| Sonic CD | PC | | Expert Software | | 6805 01 | |
| Sonic CD | PC | | Expert Software | | 6805 02 | |
| Sonic CD | PC | 1.1 | Expert Software | | 6805 02 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Sonic R | PC | | Expert Software | | 682501.101.US | |
| Sonic R | SS | 1.000 | Original, Not for Resale | | 81800, 191306 | |
| Soul Ride | PC | | Linux (LGP) | | | |
| SoulStar | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 3, Demo) | | T 115035-50 | |
| SoulStar / Battlecorps | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 8) | | T 115035-50 / T 115045-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Arcade Collection | PC | 1.0 | Original | | 11-4150-10 | |
| Space Jam
スペース・ジャム | SS | 1.000 | Original | | T-8119G | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Speedster | PC | | Original, Argentum Collection | | | |
| Spider-Man (Disc 2) | PC | | Original | | 32249.102.US | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| SSN-21 Seawolf | PC | | EA CD-ROM Classics | | E3205CXD | |
| Star Command Revolution | PC | 1.0 | Original | | 04-12257CD | |
| Star Fighter | MAC | | | | 03239-001 | |
| Star General | PC | 1.0 | Original | | CS090339 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM
Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: Away Team | PC | 1.00 | Original | | 30025.101.US | |
| Star Trek: Klingon (Disc 3)
Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Star Wars: Jedi Knight (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight (Disc 2) | PC | | Original | | | |
 | Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | LucasArts Classic | | 41177.101.UK | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | LucasArts Classic | | 41177.102.UK | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | 9521830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | 9521830 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | 9521831 | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | 9521831 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | LucasArts Classic | | 41177.103.UK | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | | |
| Star Wars: Jedi Knight: Mysteries of the Sith
Star Wars: Jedi Knight: Mysteries of the Sith: Companion Missions | PC | 1.0 | Star Wars: Jedi Knight: Dark Forces II | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | Original | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | | | 7101830 | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Demo) | | | |
| Star Wars: Rebel Assault | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 7) | | | |
| Star Wars: Rebel Assault | MCD | | Original | | T-60075-50 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | 3121830 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Rerelease | | 646130 | |
| Star Wars: Shadows of the Empire | PC | 1.0 | Original | | 3121830 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | | Bundle Version Diamond OEM | | 75000204-100 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | 1.0 | Bundle Version Diamond OEM | | 75000204-100 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.0 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.0 | Star Wars: X-Wing vs. TIE Fighter + Balance of Power | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | 2081831 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | 1.00 | Original | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | 1.00 | Original | | 2081831 | |
 | Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc)
エックスウィング ＶＳ タイファイター | PC | 1.00 | Original, Eigoban | | 2081830 | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc)
エックスウィング ＶＳ タイファイター | PC | 1.00 | Original, Eigoban | | 2081831 | |
| Star Wars: X-Wing vs. TIE Fighter: Balance of Power | PC | 2.0.0 | Original | | | |
| Stargunner | PC | 1.0 | Original | | P/N 7235 | |
| Stars! | PC | 2.70i | Grabit | | GDL051 | |
| Starsiege | PC | 1.02 | Original | | | |
| Steel Panthers II: Modern Battles | PC | 1.00 | Original | | CS090345 | |
| Steel Panthers II: Modern Battles | PC | 1.0 | Original | | 2209310-590002 | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | 2218010-590001 | |
| Steep Slope Sliders | SS | 1.000 | Original | | 81128 | |
| Stella Gets a New Brain! | PC | | Original | | AR-4601 | |
| Stella Gets a New Brain! | PC | 2.0 | Original | | AR-4602 | |
| Stellar 7 | PC | | | | 836034910 | |
| Stellar 7 | PC | | Original | | | |
| Stellar 7 | PC | 7.3 | 5 ft. 10 Pak Vol. I | | | |
| Stonekeep | PC | 1.2 | Covermount | | CD-ICD-045-EME | |
| Street Fighter Collection (Disc 1) | SS | 1.000 | Original | | T-1222H | |
| Street Fighter Collection (Disc 2) | SS | 1.000 | Original | | T-1222H | |
| Street Racer | PC | | Original, Ubisoft Classique | | | |
| Sub Culture | PC | | Original | | | |
| Sudden Strike | PC | 1.1 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike Forever | PC | 1.21 | Sudden Strike Anthology | | PF5003/UK2 | |
| Sudden Strike II | PC | 2.0 | Sudden Strike Anthology | | PF5003/UK2 | |
| Summer Olympix | CD32 | | Original | | | |
| Super Bubsy | PC | | Original | | ALE08801309D | |
| Super Bubsy | PC | 1.0 | Original | | 5000-00414 | |
| Super Methane Bros. | CD32 | | Original | | | |
| Super Stardust 96 | PC | | CD-ROM 5 Mark-Reihe | | Art.-Nr. 2857 | |
| Super Street Fighter II Turbo | PC | 1.0 | Original | | 51100000 | |
 | Superbike Challenge | PC | | Covermount | | | |
| SuperKarts | PC | 1.01 | White Lines: Don't Do It - 3 Game Driving Pack | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | MCD | | Sega CD 32X | | T-16203F | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | MCD | | Sega CD 32X | | T-16203F | |
| Surface Tension | PC | | Original | | 722DISKE | |
| Survival: The Ultimate Challenge | PC | 1.0 | Original | | 31209.101.US | |
| SWIV 3D | PC | | Original | | SCI1901UK | |
| SWIV 3D (Playable Demo) | PC | v5.25 | | | | |
| System-Disc (KD02) Columbia | SS | 1.000 | Original | | 610-5732-06 | |
| Soldier of Fortune | PC | 1.06 | Gold Edition |  | 30173.101.US | |
| Shattered Steel | PC | 1.08 | |  | CD-ICD-201-M9 | |
| Sid Meier's Civilization II | PC | 1.02 | Original, Collector's Edition | | MPX91260DO1R | |
| Sid Meier's Civilization II | PC | | Original | | MP391260DO1R | |
| Sid Meier's Civilization II | PC | 2.42 | Rerelease | | 0-492-47-101 | |
| SoulStar | MCD | | Original | | T-115035-50 | |
| Sensible Soccer | MCD | | Original |  | T-93185-50 | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Sensible World of Soccer '96/'97 (Upgrade PC CD-ROM Disc) | PC | | Original | | | |
| Sensible World of Soccer '96/'97 | PC | 2.0 | Original | | | |
| Sensible World of Soccer: European Championship Edition | PC | 1.2 | White Label | | | |
| Savage Warriors | PC | 1.0 | Original |  | 2205110-S90001/1055SA | |
| The Smurfs | MCD | | Original | | T-151015-50 | |
| Soccer Kid | CD32 | | Original | | | |
| Soccer Kid | PC | | Original, Soft Price | | | |
| Speedboat Attack | PC | 0.9.9.0 | Covermount | | | |
 | Speedboat Attack | PC | 0.9.9.0 | Best Buys | | BB 004 | |
| StarFighter 3000 | PC | | Original | | | |
| StarFighter 3000 | PC | 1.08 | Best Buys | | BB 001 | |
| Striker 96
ストライカー’９６ | SS | 1.002 | Original | | T-8114G | |
| Syndicate Wars | PC | | Original |  | BFX05100371D | |
| Syndicate Wars | PC | | | | EA 768207 | |
| Silver (Game Disk)
銀色 | PC | 1.0 | Limited Edition |  | | |
| Sonic the Hedgehog CD
ソニック・ザ・ヘッジホッグＣＤ | PC | 1.001 | Ultra 2000/Ultra Series | | MKW-160 | |
| Samurai Spirits: Amakusa Kourin
サムライ・スピリッツ ～天草降臨～ | SS | 1.001 | Hibaihin |  | 610-6730 | |
| Samurai Spirits: Amakusa Kourin
サムライ・スピリッツ ～天草降臨～ | SS | 1.001 | Original, Samurai Spirits Best Collection, Kakuchou Ram Doukon Okaidoku Set!! | | T-3116G, T-3118G, T-3123G | |
 | Sinbad in the Lost Land
신밧드의 모험 | PC | 1.0.0.1 | Original |  | | |
 | Sega Internet-Selain | SS | 1.012 | Bundled with Net Link Internet Modem |  | 80124 | |
| Sub Culture | PC | | Original | | | |
| Skull Caps | PC | | Original | | | |
| S.T.O.R.M. (Disc 1) | PC | | Original | | A541W3GD[1] | |
| S.T.O.R.M. (Disc 2) | PC | | Original, Dice | | A541W3GD[2], DMM 031730 | |
| S.T.O.R.M. (Disc 3) | PC | | Original, Dice | | A541W3GD[3], DMM 031730 | |
| Sam & Max Hit the Road | PC | 1.0 | LucasArts Classic | | 41117.101.GM | |
| Schleichfahrt | PC | | Original, Classics | | | |
| Schleichfahrt | PC | | Original | | | |
| Schleichfahrt | PC | | | | | |
| Das Schwarze Auge: Schatten über Riva | PC | 1.00 | Original | | SPI 032 | |
| Shellshock | PC | | Original | | | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP391 307 DO1R | |
| Sid Meier's Civilization II: Fantastic Worlds | PC | | Original | | MP391 435 DO1R | |
| Die Siedler II: Gold Edition | PC | 1.51 | Original | | | |
| Siedler II, Die: Veni, Vidi, Vici | PC | 1.0 | Original | | | |
| Siedler II, Die: Veni, Vidi, Vici | PC | 1.0 | Original | | | |
| Die Siedler III (Disc 1) | PC | | Purple Hills | | | |
| Die Siedler III (Disc 2) | PC | | Purple Hills | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 1) | PC | | Platin Edition | | | |
| Die Siedler: Platin Editon I • II • III • IV (Disc 3) | PC | | Platin Edition | | | |
| Space in Motion: Future Trade | PC | 1.01 | Original | | | |
| Star General | PC | 1.0 | Original | | CS090341 | |
| Star Wars: X-Wing Alliance (Disc 1) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 1.0 | Star Wars: Battle Pack | | | |
| Star Wars: X-Wing Alliance (Disc 2) | PC | 1.00 | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Master Game Disc) | PC | | Original | | | |
| Star Wars: X-Wing vs. TIE Fighter (Multiplayer Disc) | PC | | Original | | | |
| Stars! | PC | 2.7a | Original | | EI-1036 | |
| Steel Panthers II: Moderne Schlachten | PC | 1.0 | Original, Cash & Carry Collection | | CS090347 | |
| Stonekeep | PC | 1.1 | Original | | CD-ICD-045-GR | |
| Stratosphere: Conquest of the Skies | PC | 1.00G | Original | | | |
| Sudden Strike | PC | 1.2 | Rerelease | | CDR8028-SP | |
| Sudden Strike | PC | 1.2 | Gold Edition! (Software Pyramide) | | | |
| Swing Plus: Total Mindcontrol | PC | | Original | | | |
| SWIV 3D | PC | | Original | | SCI1901GE/IT | |
| Sam & Max Hit the Road | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sam & Max Hit the Road | PC | | LucasArts Classic | | 41117.101.IT | |
| Screamer 2 | PC | | Original | | | |
| The Secret of Monkey Island | PC | | Collezione CD-Rom by C.T.O. | | | |
| Sid Meier's Civilization II
Civilization II di Sid Meier | PC | | CD-ROM Classic Collection 5 | | MP591260DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization
Sid Meier Presenta Civilization II: Conflitti in Civilization: Scenari | PC | | CD-ROM Classic Collection 5 | | MP 591 307 DO1R | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 2) | PC | 1.00 | LucasArts Classic | | 41177.102.IT | |
| Star Wars: Jedi Knight: Dark Forces II (Disco 1) | PC | 1.00 | LucasArts Classic | | 41177.101.IT | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.00 | LucasArts Classic | | 41177.103.IT | |
| Sudoku Master | PC | 1.0 | Microforum | | | |
| Sacrifice: Uzuki no Kubiwa
サクリファイス ～疼きの首輪～ | PC | | Original | | CNDL-0001 | |
| Sakamoto Ryouma: Ishin Kaikoku
坂本竜馬 ～維新開国～ | SS | 1.002 | Original | | T-19709G | |
| Sakura Taisen (Disc 1)
サクラ大戦 | SS | 1.005 | Original, Satakore | | GS-9037, GS-9191 | |
| Sakura Taisen (Disc 1)
サクラ大戦 | SS | 1.005 | Original | | GS-9037 | |
| Sakura Taisen (Disc 1)
サクラ大戦 | SS | 1.005 | Original, Tokubetsu Genteiban A type, Tokubetsu Genteiban B type, Fukkokuban | | GS-9037, GS-9115, GS-9117, GS-9151 | |
| Sakura Taisen (Disc 2)
サクラ大戦 | SS | 1.005 | Original | | GS-9037 | |
| Sakura Taisen (Disc 2)
サクラ大戦 | SS | 1.005 | Original, Tokubetsu Genteiban A type | | GS-9037, GS-9115 | |
| Sakura Taisen (Disc 2)
サクラ大戦 | SS | 1.005 | Original, Satakore, Tokubetsu Genteiban B type, Fukkokuban | | GS-9037, GS-9117, GS-9151, GS-9191 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.001 | Tokubetsu-ban (Standalone, Bundled with Mogitate SegaSaturn Vol. 2) | | 610-6864 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3)
サクラ大戦２ ～君、死にたもうことなかれ～ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen Teikokukagekidan Taiin Meibo
サクラ大戦 帝国華撃団隊員名簿 | SS | 1.000 | Hibaihin | | SKR-00468 | |
| Sakura Taisen: Hanagumi Taisen Columns
サクラ大戦 ～花組対戦コラムス～ | SS | 1.000 | Original | | GS-9138 | |
| Sakura Taisen: Hanagumi Taisen Columns
サクラ大戦 ～花組対戦コラムス～ | SS | 1.000 | Original | | GS-9138 | |
| Sakura Taisen: Hanagumi Tsuushin
サクラ大戦 ～花組通信～ | SS | 1.009 | Original | | GS-9134 | |
| Sakura Taisen: Hanagumi Tsuushin
サクラ大戦 ～花組通信～ | SS | 1.009 | Original | | GS-9134 | |
| Sakura Taisen: Jouki Radio Show (Disc 1) (Yuugi-ban)
サクラ大戦 ～蒸気ラジヲショウ～ | SS | 1.004 | Original | | GS-9160 | |
| Sakura Taisen: Jouki Radio Show (Disc 2) (Kayou-ban)
サクラ大戦 ～蒸気ラジヲショウ～ | SS | 1.002 | Original | | GS-9160 | |
| Salamander Deluxe Pack Plus
沙羅曼蛇 ＤＥＬＵＸＥ ＰＡＣＫ ＰＬＵＳ | SS | 1.010 | Original | | T-9520G | |
| Same Game FX | PC-FX | | Bundled with PC-FXGA | | | |
| Samurai Spirits
サムライ・スピリッツ | FMT | | Original | | JH-012 | |
| Sangoku Engi x Sangoku Seishi
三國演義×三國正史 | PC | 1.0 | Original | | RON003 | |
| Sangokushi II
三國志Ⅱ | PC | 1.0 | Original | | KN11-98101 | |
| Sangokushi Koumeiden
三國志孔明伝 | PC | | Original | | KN11-15101 | |
| Sangokushi Koumeiden
三國志孔明伝 | SS | 1.000 | Original | | T-7629G | |
| Sangokushi Returns
三國志リターンズ | SS | 1.000 | Original, Sangokushi Value Set | | T-7617G, T-7636G | |
| Sangokushi V
三國志Ⅴ | PC | 1.0 | Original | | KN11-00106 | |
| Sangokushi: Returns
三國志 リターンズ | PC | 1.0 | Kikan Gentei Hatsubai | | | |
| Sankyo Fever: Jikki Simulation S
ＳＡＮＫＹＯ ＦＥＶＥＲ 実機シミュレーションＳ | SS | 1.004 | Original, Satakore, Genteiban | | T-32101G, T-32102G, T-32104G | |
| Saturn Bomberman
サターン・ボンバーマン | SS | 1.001 | SegaNet Sen'you | | T-14305G | |
| Saturn Super Henshuubu Hen: Taikenban Saturn Soft Taizen
サターン・スーパー 編集部 編 体験版サターンソフト大全 | SS | 1.000 | | | 610-6020-04 | |
| Saturn Super Henshuubu Hen: Taikenban Saturn Soft Taizen
サターン・スーパー 編集部 編 体験版サターンソフト大全 | SS | 1.000 | | | 610-6020-04 | |
| Saturn Super Vol. 10 Furoku CD-ROM
サターン・スーパー Ｖｏｌ．１０ 付録ＣＤ‐ＲＯＭ | SS | 1.000 | | | 610-6020-11 | |
| Saturn Super Vol. 11 Furoku CD-ROM
サターン・スーパー Ｖｏｌ．１１ 付録ＣＤ‐ＲＯＭ | SS | 1.000 | | | 610-6020-12 | |
| Saturn Super Vol. 2
サターン・スーパー Ｖｏｌ．２ | SS | 1.000 | | | 610-6020-02 | |
| Saturn Super Vol. 2
サターン・スーパー Ｖｏｌ．２ | SS | 1.000 | | | 610-6020-02 | |
| Saturn Super Vol. 2
サターン・スーパー Ｖｏｌ．２ | SS | 1.000 | | | 610-6020-02 | |
| Saturn Super Vol. 3
サターン・スーパー Ｖｏｌ．３ | SS | 1.001 | | | 610-6020-03 | |
| Saturn Super Vol. 3
サターン・スーパー Ｖｏｌ．３ | SS | 1.001 | | | 610-6020-03 | |
| Saturn Super Vol. 4
サターン・スーパー Ｖｏｌ．４ | SS | 1.000 | | | 610-6020-05 | |
| Saturn Super Vol. 5
サターン・スーパー Ｖｏｌ．５ | SS | 1.000 | | | 610-6020-006 | |
| Saturn Super Vol. 6
サターン・スーパー Ｖｏｌ．６ | SS | 1.000 | | | 610-6020-07 | |
| Saturn Super Vol. 6
サターン・スーパー Ｖｏｌ．６ | SS | 1.000 | | | 610-6020-07 | |
| Saturn Super Vol. 7
サターン・スーパー Ｖｏｌ．７ | SS | 1.000 | | | 610-6020-08 | |
| Saturn Super Vol. 8
サターン・スーパー Ｖｏｌ．８ | SS | 1.000 | | | 610-6020-09 | |
| Saturn Super Vol. 9 Furoku CD-ROM
サターン・スーパー Ｖｏｌ．９ 付録ＣＤ‐ＲＯＭ | SS | 1.000 | | | 610-6020-10 | |
| Savaki
サバキ | SS | 1.002 | Original | | T-5208G | |
| Schwarzschild GX: Sabita Sousei
シュヴァルツシルトＧＸ ～錆びた蒼星～ | PC-98 | | Original | | 9531-77-01 | |
| Schwarzschild GXR: Toki no Tsukaibito
シュヴァルツシルトＧＸＲ 時現の遣人 | PC | | Original | | ID NO.9674-68-01 | |
| Secre Volume 7: Reiko Chiba
ＳＥＣＲＥ ＶＯＬＵＭＥ ⑦ 「千葉 麗子」 | FMT | | Original | | HME-209 | |
| Sega Ages: I Love Mickey Mouse: Fushigi no Oshiro Daibouken & I Love Donald Duck: Georgia Ou no Hihou
セガエイジス アイ・ラブ・ミッキー・マウス ～ふしぎのお城 大冒険～ ／ アイ・ラブ・ドナルド・ダック ～グルジア王の秘宝～ | SS | 1.000 | Original | | GS-9179 | |
| Sega Ages: Phantasy Star Collection
セガ・エイジス ファンタシー・スター・コレクション | SS | 1.003 | Original | | GS-9186 | |
| Sega Ages: Space Harrier
セガエイジス スペース・ハリアー | SS | 1.002 | Original, Gentei Special Set | | GS-9108, GS-9111 | |
| Sega Ages: Space Harrier
セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 | |
| Sega Ages: Space Harrier
セガエイジス スペース・ハリアー | SS | 1.102 | Original | | GS-9108 | |
| Sega International Victory Goal
セガ インターナショナル ビクトリー・ゴール | SS | 1.000 | Original | | GS-9044 | |
| Sega Worldwide Soccer '98
セガ・ワールドワイド・サッカー’９８ | SS | 1.002 | Original | | GS-9187 | |
| Sega Worldwide Soccer PC
セガワールドワイドサッカーＰＣ | PC | 1.09J | PCHome | | 506-9781 | |
| SegaColle Sega Bible Mogitate SegaSaturn Soukan-gou
セガコレセガバイブルモギタテセガサターン。 創刊号 １９９７．１１ | SS | 1.000 | Hibaihin | | 610-6805-01 | |
| Seikai Risshiden: Kimi wa Nihon no Leader ni Nareru ka!
政界立志伝～君は日本のリーダーになれるか！～ | PC | | | | MSDJ-99094 | |
| Seikimatsu Taimaden Tsumugi-chan SOS
世紀末退魔伝つむぎちゃんＳＯＳ | PC | | Original | | EXC-0011 | |
| Sengoku Blade: Sengoku Ace Episode II
戦国ブレード | SS | 1.002 | Mihonhin | | ST-14410G | |
| Sengoku Blade: Sengoku Ace Episode II (Disc 1)
戦国ブレード | SS | 1.002 | Original | | T-14410G | |
| Sengoku Blade: Sengoku Ace Episode II (Disc 2) (Sengoku Kawaraban: Digital Edition)
戦国ブレード | SS | 1.002 | Original | | T-14410G | |
| Senkutsu Katsuryu Taisen: Chaos Seed (Disc 1) (Game Disc)
仙窟活龍大戦 カオス・シード | SS | 1.005 | Original | | T-30902G | |
| Senkutsu Katsuryu Taisen: Chaos Seed (Disc 1) (Game Disc)
仙窟活龍大戦 カオス・シード | SS | 2.000 | Satakore | | T-30904G | |
| Senkutsu Katsuryu Taisen: Chaos Seed (Disc 2) (Omake Disc)
仙窟活龍大戦 カオス・シード | SS | 1.003 | Original | | T-30902G | |
| Sentimental Graffiti (Disc 1) (Game Disc)
センチメンタル・グラフティ | SS | 1.003 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 1) (Game Disc)
センチメンタル・グラフティ | SS | 1.003 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 1) (Game Disc)
センチメンタル・グラフティ | SS | 1.003 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 1) (Game Disc)
センチメンタル・グラフィティ | SS | 1.003 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 2) (Second Window)
センチメンタル・グラフティ | SS | 1.000 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 2) (Second Window)
センチメンタル・グラフティ | SS | 1.000 | Original | | T-20106G | |
| Sentimental Graffiti (Disc 2) (Second Window)
センチメンタル・グラフティ | SS | 1.000 | Original | | T-20106G | |
| Sentimental Graffiti: First Window
センチメンタル・グラフティ ～ファースト・ウィンドウ～ | SS | 1.002 | Original | | T-20111G | |
| Sento Monogatari Sono I
「占都物語」そのⅠ | SS | 1.000 | Original | | T-6801G | |
| Sexy Parodius
セクシー・パロディウス | SS | 1.040 | Original | | T-9514G | |
| Shadows of the Tusk
シャドウズ・オブ・ザ・タスク | SS | 1.001 | Original | | T-14319G | |
| Shanghai Gensoutan: Teito Kitan Gaiden (Disc Otsu)
上海幻想譚 ～帝都奇譚外伝～ | PC | | Original | | | |
| Shanghai: Banri no Choujou: The Great Wall
上海 ～万里の長城～ | SS | 1.005 | Satakore | | T-1527G | |
| Shanghai: Great Moments
上海 ～グレート・モーメンツ～ | SS | 1.200 | Original | | T-1512G | |
| Shanghai: Great Moments
上海 ～グレート・モーメンツ～ | SS | 1.200 | Original | | T-1512G | |
| Shichuu Suimei Pitagraph
四柱推命ピタグラフ | SS | 1.060 | Original | | T-19501G | |
| Shienryuu
紫炎龍 | SS | 1.000 | Original | | T-29102G | |
| Shin Nihon Pro Wrestling: '94 Battlefield in Tokyo Dome
新日本プロレスリング ’９４バトルフィールド ｉｎ 闘強導夢 | PCE | | Original | | FCCD4001 | |
| Shin Onryou Senki (Disc 1)
真怨霊戦記 | PC | | Original | | | |
| Shin Onryou Senki (Disc 2)
真怨霊戦記 | PC | | Original | | | |
| Shining the Holy Ark
シャイニング・ザ・ホーリィアーク | SS | 1.005 | Original | | T-33101G | |
| Shining the Holy Ark
シャイニング・ザ・ホーリィアーク | SS | 1.005 | Original | | T-33101G | |
| Shinpi no Sekai El-Hazard: El-Hazard: The Magnificent World for Sega Saturn
神秘の世界エルハザード ＦＯＲ ＳＥＧＡ ＳＡＴＵＲＮ | SS | 1.002 | Shokai Tokuten | | T-22202G | |
| Shinrei Jusatsushi Taroumaru
心霊呪殺師 太郎丸 | SS | 1.004 | Original | | T-4804G | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga...
真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| Shippuu Dotou!!
疾風怒濤！！ | PC | | Original | | ZP-0002 | |
| Shiroki Majo: Mou Hitotsu no Eiyuu Densetsu
白き魔女 ～もうひとつの英雄伝説～ | SS | 1.000 | Taikenban | | 610-6860 | |
| Shiroki Majo: Mou Hitotsu no Eiyuu Densetsu (Disc 1)
白き魔女 ～もうひとつの英雄伝説～ | SS | 1.001 | Original | | T-14322G | |
| Shiroki Majo: Mou Hitotsu no Eiyuu Densetsu (Disc 2)
白き魔女 ～もうひとつの英雄伝説～ | SS | 1.001 | Original | | T-14322G | |
| Shutsudou! Miniskirt Police
出動！ミニスカ・ポリス | SS | 1.001 | Shokai Gentei Double Tokuten | | T-30812G | |
| Sid Meier's Civilization II
シヴィライゼーションⅡ | PC | 2.11J | Original, Value Pack | | | |
| Sid Meier's Civilization II: Fantastic Worlds
シヴィライゼーションⅡ ファンタスティックワールド | PC | 2.7.81 | Original | | | |
| Simulation Pro Yakyuu '99
シミュレーションプロ野球'９９ | PC | 1.0 | PCHome | | 506-9801 | |
| Simulation Zoo
シミュレーション・ズー | SS | 1.001 | Original | | T-18611G | |
| Slayers Royal 2
スレイヤーズろいやる２ | SS | 1.005 | Original | | T-27907G | |
| Slayers Royal 2
スレイヤーズろいやる２ | SS | 1.005 | Original | | T-27907G | |
| Snatcher
スナッチャー | SS | 1.000 | Original | | T-9508G | |
| Sol Divide
ソル・ディバイド | SS | 1.000 | Original | | T-14423G | |
| Solo Crisis
ソロ・クライシス | SS | 1.000 | Original | | T-23501G | |
| Solo Crisis
ソロ・クライシス | SS | 1.000 | Original | | T-23501G | |
| Solo Crisis
ソロ・クライシス | SS | 1.001 | Taiken Sample-ban | | 610-6802 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sorcerian Forever
ソーサリアン・フォーエバー | PC | | Premium-ban | | NF03006 | |
| Sotsugyou II: Neo Generation
卒業Ⅱ －Ｎｅｏ ｇｅｎｅｒａｔｉｏｎ－ | SS | 1.000 | Original | | T-5301G | |
| Sotsugyou II: Neo Generation
卒業Ⅱ －Ｎｅｏ ｇｅｎｅｒａｔｉｏｎ－ | SS | 1.000 | Original | | T-5301G | |
| Sotsugyou R: Graduation Real
卒業Ｒ －Ｇｒａｄｕａｔｉｏｎ Ｒｅａｌ－ | PC-FX | | Original | | FXNAV602 | |
| Sound Novel Machi (Disc 1) (10.11-10.13 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.)
サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Spiritual Soul 2: The Blue-Eyed Elementaler
スピリチュアル ソウル ２ ～蒼き瞳の精霊使い～ | PC | | Original | | | |
| Spot Goes to Hollywood
スポット・ゴーズ・トゥー・ハリウッド | SS | 1.000 | Original | | T-7014G | |
| Stakes Winner 2: Saikyouba Densetsu
ステークス・ウィナー２ ～最強馬伝説～ | SS | 1.006 | Original | | T-3115G | |
| Standard 1500: The Mahjong Joou
スタンダード１５００ Ｔｈｅ 麻雀女王 | PC | 1.0 | Original | | SD-100287 | |
| The Star Bowling (Disc 1)
ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| The Star Bowling (Disc 2)
ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| Steamgear Mash
スチームギア・マッシュ | SS | 1.000 | Original | | T-10301G | |
| Steamgear Mash
スチームギア・マッシュ | SS | 1.000 | Original | | T-10301G | |
| Strahl: Himerareshi Nanatsu no Hikari
シュトラール ～秘められし七つの光～ | SS | 1.004 | Original | | T-20501G | |
| Street Fighter Zero
ストリート・ファイターＺＥＲＯ | SS | 1.002 | Original | | T-1206G | |
| Street Fighter Zero
ストリート・ファイターＺＥＲＯ | SS | 1.002 | Original | | T-1206G | |
| Street Fighter Zero
ストリート・ファイターＺＥＲＯ | SS | 1.003 | Original | | T-1206G | |
| Street Fighter: Real Battle on Film
ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film
ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film
ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Sugoventure: Dragon Master Silk Gaiden
すごべんちゃー ～ドラゴン・マスター・シルク外伝～ | SS | 1.000 | Original | | T-19505G | |
| Suikoden: Tenmei no Chikai
水滸伝・天命の誓い | PC | 1.0 | Original | | KN10-14103 | |
| Suikoden: Tenmei no Chikai
水滸伝 ～天命の誓い～ | SS | 1.000 | Original | | T-7624G | |
| Super Adventure Rockman (Disc 1) (Episode 1: Tsuki no Shinden)
スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 2) (Episode 2: Shitou! Wily Numbers)
スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 3) (Episode 3: Saigo no Tatakai!!)
スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Casino Special
スーパーカジノ スペシャル | PC | | PCHome | | 506-9780 | |
| Super Power League FX
スーパー・パワー・リーグＦＸ | PC-FX | | Original | | FXHUD504 | |
| Super Prologue 21 Games Vol. 1
スーパー・プロローグ２１ ゲームス Ｖｏｌ．１ | SP21 | 1.002 | Original | | SKT-3500 | |
| Super Real Mahjong Graffiti
スーパーリアル麻雀 グラフィティ | SS | 1.001 | P's Club Special Edition | | T-16506G | |
| Super Real Mahjong Graffiti
スーパーリアル麻雀 グラフィティ | SS | 1.001 | Original | | T-16504G | |
| Super Real Mahjong P7
スーパーリアル麻雀Ｐ７ | SS | 1.003 | P's Club Special Edition | | T-16510G | |
| Super Real Mahjong P7
スーパーリアル麻雀Ｐ７ | SS | 1.003 | Original | | T-16509G | |
| Super Real Mahjong PVI
スーパーリアル麻雀ＰⅥ | SS | 1.000 | Original | | T-16507G | |
| Super Real Mahjong PVI
スーパーリアル麻雀ＰⅥ | SS | 1.000 | P's Club Special Edition | | T-16508G | |
| Super Robot Taisen F
スーパー・ロボット大戦Ｆ | SS | 0.400 | Taikenban | | 610-6745 | |
| Super Robot Taisen F
スーパー・ロボット大戦Ｆ | SS | 1.003 | Original | | T-20610G | |
| Super Robot Taisen F
スーパー・ロボット大戦Ｆ | SS | 2.002 | Original | | T-20610G | |
| Super Robot Taisen F: Kanketsu-hen
スーパー・ロボット大戦Ｆ 完結編 | SS | 1.003 | Original | | T-20612G | |
| Super Robot Taisen F: Kanketsu-hen
スーパー・ロボット大戦Ｆ 完結編 | SS | 1.003 | Original | | T-20612G | |
| Super Robot Taisen F: Kanketsu-hen
スーパーロボット大戦Ｆ 完結編 | SS | 2.000 | Original | | T-20612G | |
| Super Robot Taisen F: Kanketsu-hen
スーパーロボット大戦Ｆ 完結編 | SS | 2.000 | Original | | T-20612G | |
| Super Street Fighter II: The New Challengers
スーパー・ストリート・ファイターⅡ | FMT | 941011 | CD-ROM-ban (Shokai Gentei: 6-button Pad-tsuki) | | HMF-162 | |
| Sword & Sorcery
ソード＆ソーサリー | SS | 1.220 | Original | | T-5202G | |
| Sword & Sorcery
ソード＆ソーサリー | SS | 1.221 | Satakore | | T-5207G | |
| The Soul
소울 | PC | | Original | | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic) | PC | | eXtra Klasyka Next |  | | |
| Saga Heroes of Might and Magic I-III (Heroes of Might and Magic II) | PC | | eXtra Klasyka Next | | | |
| Saga The Settlers I-IV (The Settlers I + II) | PC | | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 1) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Saga The Settlers I-IV (The Settlers III: Złota Edycja - Disc 2) | PC | 1.60 | eXtra Klasyka XK Gold | | | |
| Saga: Gniew Wikingów | PC | 1.0.0.1 | eXtra Klasyka | | | |
| The Settlers II: Złota Edycja | PC | 1.51 | eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 1) | PC | | Nowa eXtra Klasyka | | | |
| The Settlers III: Złota Edycja (Disc 2) | PC | | Nowa eXtra Klasyka | | | |
