| Region | Title | System | Version | Edition | Languages | Serial | Status |
|---|
 | Sega Worldwide Soccer PC | PC | | 3D Power Pack |  | 500-0009-50 |  |
| Sensible Soccer | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 5, Demo) | | | ![2 and more dumps from original media [!]](/images/status/green.png "2 and more dumps from original media [!]") |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.02 | Original | | | |
| Settlers II, The: Veni, Vidi, Vici | PC | 1.51 | Rerelease | | | |
 | Settlers II, The: Veni, Vidi, Vici | MAC | 1.0.0 | Original | | | |
| Seven Kingdoms | PC | 1.0 | Original | | 04033 CD | |
| Sewer Shark | MCD | | Original | | T-93015-50 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Sewer Shark | MCD | | Bundled with Sega CD | | 4101 | |
| Shadow Fighter | CD32 | | Original | | | |
| The Shadow of the Third Moon | ACD | 1.1 | Original | | | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Premier Collection | | MSHADPEN70 | |
 | Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original | | CDR5002 | |
| Shadow Warrior
Lo Wang is Shadow Warrior | PC | 1.2 | Original, East Meets West | | 04-12539CD | |
 | ShadowCaster | PC | | Original | | | |
| Shamrock Spring '97
Shamrock Spring '97 Demo Disk | PC | | | | | |
| Shanghai: Dynasty | PC | 1.0 | Original | | 1000053.101.UK | |
| Shattered Steel | PC | 1.01 | Original | | CD-ICD-201-M9 | |
| Shattered Steel | PC | 1.03 | Original | | CD-ICD-201-2 | |
| Shellshock | PC | | Kixx | | | |
| Shellshock | PC | | Original | | | |
| Sherlock Holmes: Consulting Detective | MCD | | Bundled with Sega CD (Sherlock Holmes: Consulting Detective / Sega Classics Arcade Collection Bundle) | | T-4501 | |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 1) | MCD | | Original | | 4653 | |
| Shining Force CD | MCD | | Original | | 4656-50 | |
| Shining the Holy Ark | SS | 1.003 | Original | | 81306 | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shivers Two: Harvest of Souls (Disc 2) | PC | 1.0.0.2 | Original | | | |
| Shrak
Shrak for Quake | PC | 1.0 | Original | | | |
| Shrak
Shrak for Quake | PC | 2.0 | Rerelease | | | |
| Sid Meier's Civilization Chronicles (Disc 1) | PC | | Original | | 31074-1.1 | |
| Sid Meier's Civilization Chronicles (Disc 2) | PC | | Original | | 31074-1.2 | |
| Sid Meier's Civilization II | MAC | 1.0 | Original | | P/N 7327A | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Collector's Edition | | | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 D01R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | MP 191 307 DO1R | |
| Sid Meier's Civilization II Scenarios: Conflicts in Civilization | PC | 2.62 | Original | | 0-520-47-101 | |
| Sid Meier's Colonization
Sid Meier's Colonization: Create a New Nation | PC | 3.141592 | Rerelease | | P/N 70119 | |
| Silent Thunder: A-10 Tank Killer II | PC | 1.01 | Rerelease | | | |
| Silverload | PC | | | | | |
| Skeleton Krew | CD32 | | Original | | | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Ski Racing: Extreme Edition
Sierra Sports Ski Racing '99: Extreme Edition | PC | 1.0.0.14 | Sierra Originals: Sports | | S0014001 | |
 | Sky Target: Daredevil Air Force
スカイ・ターゲット | PC | 1.0.06.19 us | PCHome | | 506-9890 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T-162035-50 | |
| Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Sega CD 32X | | T16204F | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Original | | T162035 | |
| Slam City with Scottie Pippen (Disc 4) (Smash) | MCD | | Sega CD 32X | | T16204F | |
 | Slam City with Scottie Pippen (Disc 1) (Fingers) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 2) (Juice) | MCD | | Original | | 063636, T162035 | |
| Slam City with Scottie Pippen (Disc 3) (Mad Dog) | MCD | | Original | | 063636, T162035 | |
| Slam Tilt | PC | | Original | | | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-158025-50 | |
| The Software Toolworks' Star Wars Chess | MCD | | Original | | T-87035 | |
| Soldier of Fortune | PC | 1.03 | Special Tactical Edition | | 1001348.101.US | |
| Soldier of Fortune | PC | 1.03 | Original | | 1000910.101.US | |
| Sonic & Garfield Pack | PC | | Original | | 85090 | |
| Sonic 3D Blast | PC | 1.00 | Original | | 85064 | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sonic CD | PC | | Original, Family Pack | | 500-0014-50, MK 85015-50, MK 85086-50 | |
| Sonic CD | PC | | Original | | MK 85015-50 | |
| Sonic CD | PC | | Expert Software | | 6805 01 | |
| Sonic CD | PC | | Expert Software | | 6805 02 | |
| Sonic CD | PC | 1.1 | Expert Software | | 6805 02 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sonic R
ソニックＲ | SS | 1.002 | Original | | GS-9170 | |
| Sonic R | PC | | Expert Software | | 682501.101.US, 682501.101.US 01 | |
| Sonic R | SS | 1.000 | Original, Not for Resale | | 81800, 191306 | |
 | Soul Ride | PC | | Linux (LGP) | | | |
| SoulStar | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 3, Demo) | | T 115035-50 | |
| SoulStar / Battlecorps | MCD | | Bundled with Magazine (Playable Demo - Mega Power Disc 8) | | T 115035-50 / T 115045-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015-50 | |
| The Space Adventure: Cobra: The Legendary Bandit | MCD | | Original | | T-143015 | |
| Space Arcade Collection | PC | 1.0 | Original | | 11-4150-10 | |
| Space Jam
スペース・ジャム | SS | 1.000 | Original | | T-8119G | |
| Spear of Destiny: Super CD Pack | PC | | Super CD Pack | | | |
| Speedster | PC | | Original, Argentum Collection | | | |
| Spider-Man (Disc 2) | PC | | Original | | 32249.102.US | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | CD-C951932-LOE | |
| Sports Car GT | PC | 1.52m | Bundle Version OEM | | | |
| SSN-21 Seawolf | PC | | EA CD-ROM Classics | | E3205CXD | |
| Star Command Revolution | PC | 1.0 | Original | | 04-12257CD | |
| Star Fighter | MAC | | | | 03239-001 | |
| Star Fighter | PC | | Original | | 03240-001 | |
| Star General | PC | 1.0 | Original | | CS090339 | |
| Star General | PC | 1.0 | Original | | 2211210-590001 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM
Star Trek: 25th Anniversary | PC | | Original | | | |
| Star Trek: Away Team | PC | 1.00 | Original | | 30025.101.US | |
| Star Trek: Klingon (Disc 3)
Star Trek: Klingon: The Ultimate Interactive Adventure | PC | 1.0 | Original | | | |
| Star Wars: Jedi Knight (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight (Disc 2) | PC | | Original | | | |
 | Star Wars: Jedi Knight: Dark Forces II (Disc 1) | PC | | Original | | | |
| Star Wars: Jedi Knight: Dark Forces II (Disc 2) | PC | | Original | | | |
