Region | Title | System | Version | Edition | Languages | Serial | Status |
| Shiroki Majo: Mou Hitotsu no Eiyuu Densetsu 白き魔女 ~もうひとつの英雄伝説~ | SS | 1.000 | Taikenban | | 610-6860 | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H-50 | |
| Shockwave Assault | SS | 1.000 | Original | | T-5005H | |
| Shougi Matsuri 将棋まつり | SS | 1.002 | Original | | T-16502G | |
| Shunsai 駿才 | SS | 1.003 | Original | | T-18703G | |
| Shutsudou! Miniskirt Police 出動!ミニスカ・ポリス | SS | 1.001 | Shokai Gentei Double Tokuten | | T-30812G | |
| Sid Meier's Civilization: Shin Sekai Shichidai Bunmei シヴィライゼーション ~新・世界七大文明~ | SS | 1.003 | Original | | T-2003G | |
| Side Pocket 3 サイド・ポケット3 | SS | 1.000 | Original | | T-1314G | |
| Silhouette Mirage シルエット・ミラージュ | SS | 1.100 | Satakore | | T-32903G | |
| Simulation RPG Tkool シミュレーションRPGツクール | SS | 1.003 | Original | | T-2106G | |
| Simulation Zoo シミュレーション・ズー | SS | 1.001 | Original | | T-18611G | |
| Skeleton Warriors | SS | 1.000 | Original | | T-7018H-50 | |
| Skeleton Warriors | SS | 1.001 | Original | | T-13204 H | |
| Slam 'n Jam '96 featuring Magic & Kareem マジック・ジョンソン・と・カリーム・アブドュール・ジャバーの スラム・ジャム’96 | SS | 1.000 | Original | | T-15905G | |
| Slam 'n Jam '96 featuring Magic & Kareem: Signature Edition | SS | 1.000 | Original | | T-15902H | |
| Slayers Royal 2 スレイヤーズろいやる2 | SS | 1.005 | Original | | T-27907G | |
| Solo Crisis ソロ・クライシス | SS | 1.000 | Original | | T-23501G | |
| Sonic R ソニックR | SS | 1.002 | Original | | GS-9170 | |
| Sotsugyou Album 卒業アルバム | SS | 1.002 | Original | | T-10504G | |
| Sotsugyou III: Wedding Bell 卒業Ⅲ -Wedding Bell- | SS | 1.003 | Shokai Genteiban | | T-10506G | |
| Sotsugyou: Graduation S 卒業S | SS | 1.001 | Original | | T-20103G | |
| Soukuu no Tsubasa: Gotha World 蒼空の翼 -GO THAWORLD- | SS | 1.000 | Sample CD | | 610-6710 | |
| Soukuu no Tsubasa: Gotha World (Disc 1) 蒼空の翼 -GOTHA WORLD- | SS | 1.000 | Original | | T-2205G | |
| Soukuu no Tsubasa: Gotha World (Disc 2) 蒼空の翼 -GOTHA WORLD- | SS | 1.000 | Original | | T-2205G | |
| Soukyuu Gurentai 蒼穹紅蓮隊 | SS | 1.003 | Original | | T-10616G | |
| Sound Novel Machi (Disc 2) (10.13-10.15 Incl.) サウンドノベル 街 | SS | 1.001 | Original | | T-34001G | |
| Sound Novel Tkool 2 サウンド・ノベル・ツクール2 | SS | 1.003 | Original | | T-2108G | |
| Sound Qube サウンド・キューブ | SS | 1.001 | Original | | T-4318G | |
| Soviet Strike | SS | 1.000 | Original | | T-5013H-50 | |
| Soviet Strike | SS | 1.000 | Original | | T-5013H-18 | |
| Soviet Strike ソビエト・ストライク | SS | 1.000 | Original | | T-10621G | |
| Space Hulk: Vengeance of the Blood Angels | SS | 1.000 | Original | | T-5007H | |
| Space Jam スペース・ジャム | SS | 1.000 | Original | | T-8119G | |
| Special Disc with SegaSaturn Internet 2 SPECIAL DISC with SEGASATURN インターネット2 | SS | 1.020 | Hibaihin | | T-31303G | |
| Spot Goes to Hollywood | SS | 1.400 | Original | | T-7001H-50 | |
| The Star Bowling (Disc 1) ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| The Star Bowling (Disc 2) ザ・スター・ボーリング | SS | 1.001 | Original | | T-21804G | |
| Star Fighter | SS | 1.001 | Original | | T-8135H | |
| Star Wars: Rebel Strike Spike | SS | 1.000 | Prototype | | | |
| StarFighter 3000 スターファイター3000 | SS | 1.000 | Original | | T-15012G | |
| Steamgear Mash スチームギア・マッシュ | SS | 1.000 | Original | | T-10301G | |
| Stellar Assault SS ステラ・アサルト・ダブル・エス | SS | 0.012 | Taikenban | | 610-6827 | |
| Stellar Assault SS ステラ・アサルト・ダブル・エス | SS | 1.001 | Original | | T-4403G | |
| Street Fighter Alpha: Warriors' Dreams | SS | 1.000 | Beta | | | |
| Street Fighter Collection (Disc 1) | SS | 1.000 | Original | | T-7033H-50 | |
| Street Fighter Collection (Disc 2) | SS | 1.000 | Original | | T-7033H-50 | |
| Street Fighter Zero ストリート・ファイターZERO | SS | 1.002 | Original | | T-1206G | |
| Street Fighter Zero ストリート・ファイターZERO | SS | 1.003 | Original | | T-1206G | |
| Street Fighter Zero 2 ストリート・ファイターZERO2 | SS | 0.950 | Taikenban | | ST-1212G | |
| Street Fighter Zero 2' ストリート・ファイターZERO2′ | SS | 1.000 | Satakore | | T-1244G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: Real Battle on Film ストリート・ファイター リアル・バトル・オン・フィルム | SS | 1.001 | Original | | T-1201G | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Street Fighter: The Movie | SS | 1.001 | Original | | T-8105H-50 | |
| Striker 96 | SS | 1.001 | Original | | T-8133H-50 | |
| Striker 96 ストライカー’96 | SS | 1.002 | Original | | T-8114G | |
| Striker 96 | SS | 1.002 | Original | | T-8133H | |
| Strikers 1945 | SS | 1.01J | Sample | | ST-14407G | |
| Suiko Enbu 水滸演武 | SS | 1.004 | Original | | T-1302G | |
| Suiko Enbu: Fuuun Saiki 水滸演舞 ~風雲再起~ | SS | 0.000 | Tameshite Miru (Sample) | | ST-1305G | |
| Suikoden: Tenmei no Chikai 水滸伝 ~天命の誓い~ | SS | 1.000 | Original | | T-7624G | |
| Super Adventure Rockman (Disc 1) (Episode 1: Tsuki no Shinden) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 2) (Episode 2: Shitou! Wily Numbers) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Adventure Rockman (Disc 3) (Episode 3: Saigo no Tatakai!!) スーパー・アドベンチャー・ロックマン | SS | 1.000 | Rerelease | | T-1241G | |
| Super Casino Special スーパー・カジノ・スペシャル | SS | 1.003 | Original | | T-7306G | |
| Super Puzzle Fighter II Turbo | SS | 1.000 | Original | | T-7030H-50 | |
| Super Puzzle Fighter II Turbo | SS | 1.001 | Original | | T-1215H | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | P's Club Special Edition | | T-16506G | |
| Super Real Mahjong Graffiti スーパーリアル麻雀 グラフィティ | SS | 1.001 | Original | | T-16504G | |
| Super Real Mahjong P7 スーパーリアル麻雀P7 | SS | 1.003 | P's Club Special Edition | | T-16510G | |
| Super Real Mahjong P7 スーパーリアル麻雀P7 | SS | 1.003 | Original | | T-16509G | |
| Super Real Mahjong PVI スーパーリアル麻雀PⅥ | SS | 1.000 | Original | | T-16507G | |
| Super Robot Taisen F スーパー・ロボット大戦F | SS | 0.400 | Taikenban | | 610-6745 | |
| Super Tempo スーパー・テンポ | SS | 1.103 | Original | | T-26413G | |
| Sword & Sorcery ソード&ソーサリー | SS | 1.221 | Satakore | | T-5207G | |
| System-Disc (KD02) Columbia | SS | 1.000 | Original | | 610-5732-06 | |
| System-Disc (KD02) JVC | SS | 1.000 | Original | | 610-5732-03 | |
| Saka Tsuku Tokudai-gou: J.League Pro Soccer Club o Tsukurou! サカつく特大号 J.LEAGUE プロサッカークラブをつくろう! | DC | 1.003 | Original | | HDR-0126 | |
| Sakura Taisen (Omake Disc) サクラ大戦 | DC | 1.001 | Genteiban | | HDR-0089 | |
| Sakura Taisen (Disc 1) サクラ大戦 | DC | 1.009 | Genteiban | | HDR-0089 | |
| Sakura Taisen (Disc 2) サクラ大戦 | DC | 1.009 | Genteiban | | HDR-0089 | |
| Sakura Taisen (Disc 2) サクラ大戦 | DC | 1.010 | Sakura Wars Complete Box | | HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka サクラ大戦3 ~巴里は燃えているか~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8022 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Sakura Taisen 3 Movie Disc サクラ大戦3 ~巴里は燃えているか~ サクラ大戦3 ムービーディスク | DC | 1.002 | Original | | HDR-0136 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.000 | Tentou-you Demo Movie | | 610-8333 | |
| Sakura Taisen Dream Passport 3 サクラ大戦 ドリームパスポート 3 | DC | 1.007 | Original | | 610-7996 | |
| Sakura Taisen Kinematron Hanagumi Mail サクラ大戦 キネマトロン 花組メール | DC | 1.008 | Original | | HDR-0136 | |
| Sakura Taisen Online: Paris no Yuuga na Hibi サクラ大戦オンライン ~巴里の優雅な日々~ | DC | 1.007 | Original | | HDR-0185 | |
| Sakura Taisen Online: Teito no Nagai Hibi サクラ大戦オンライン ~帝都の長い日々~ | DC | 1.007 | Original | | HDR-0184 | |
| Sakura Taisen: Hanagumi Taisen Columns 2 サクラ大戦 ~花組対戦コラムス2~ | DC | 1.000 | Original | | HDR-0046 | |
| Samba de Amigo | DC | 1.002 | Bundled with Maracas Controller | | MK-51092-50 | |
| Samba de Amigo Ver. 2000 | DC | 1.001 | Original | | HDR-0131 | |
| San Francisco Rush 2049 | DC | 1.002 | Original | | T-9709D-50 | |
| San Francisco Rush 2049 | DC | 1.000 | Demo | | T-9707ND | |
| San Francisco Rush 2049 | DC | 1.001 | Original | | T-9707N | |
| Sangokushi VI 三國志Ⅵ | DC | 1.000 | Original | | T-7603M | |
| Sangokushi VI with Power-Up Kit 三國志Ⅵ with パワーアップキット | DC | 1.000 | Original | | T-7607M | |
| Seaman Esa Disc: Kimos Shu no Youchuu Hojuu Kit シーマン えさ ディスク <キモス種の幼虫補充キット> | DC | 1.001 | Bundled with Seaman Ikusei Shien Kit | | 610-7804 | |
| Sega Bass Fishing | DC | 1.020 | Original | | MK-51006-50 | |
| Sega Bass Fishing 2 | DC | 1.080 | Original | | 51166 | |
| Sega Extreme Sports セガ エクストリーム スポーツ | DC | 1.003 | Original | | HDR-0146 | |
| Sega GT | DC | 1.003 | Original | | MK-51053 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 0.800 | Taikenban | | 610-7727 | |
| Sega Marine Fishing セガマリンフィッシング | DC | 1.003 | Original | | HDR-0104 | |
| Sega Marine Fishing | DC | 1.001 | Original | | 51096 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.000 | Original | | MK-51019-50 | |
| Sega Rally 2 セガ・ラリー2 | DC | 1.04 | Original | | HDR-0010 | |
| Sega Tetris セガテトリス | DC | 2.000 | Original | | HDR-0073 | |
| Sega Worldwide Soccer 2000 | DC | 1.200 | Sample | | 952-0007-50 | |
| Sega Worldwide Soccer 2000 | DC | 1.300 | Original | | MK-51031-50 | |
| Sega Worldwide Soccer 2000: Euro Edition SWWS 2000: Euro Edition | DC | 1.030 | Original | | MK-51083-50 | |
| SegaKara for Dreamcast セガカラ for ドリームキャスト | DC | 1.002 | Bundled with Dreamcast Karaoke | | 610-7762 | |
| Seireiki Rayblade 聖霊機ライブレード | DC | 1.002 | Demo | | 610-7747 | |
| Seitai Heiki Expendable 生体兵器 エクスペンダブル | DC | 1.001 | Original | | T-15003M | |
| Sekai Fushigi Hakken! Troia 世界ふしぎ発見! トロイア | DC | 1.002 | Original | | T-39701M | |
| Sengoku Turb 戦国TURB | DC | 1.000 | Taikenban | | 610-7103 | |
| Sengoku Turb 戦国TURB | DC | 1.001 | Original | | T-38801M | |
| Sengoku Turb: Fanfan I Love Me Dunce-doublentendre 戦国TURB Fanfan I ♥ me Dunce-doublentendre | DC | 1.001 | Original | | T-38805M | |
| Sentimental Graffiti: Yakusoku センチメンタルグラフティ ~約束~ | DC | 1.003 | Original | | T-20128M | |
| Seventh Cross Evolution | DC | 1.000 | Original | | T-41301N | |
| SGGG: Segagaga セガガガ | DC | 2.000 | Tentou-ban | | HDR-0171 | |
| Shadow Man | DC | 1.002 | Original | | T-8104D-50 | |
| Shadow Man | DC | 1.001 | Original | | T-8106N | |
| Shadow Man | DC | 1.010 | Original | | T-8106N | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.010 | Genteiban | | HDR-0031 | |
| Shin Honkaku Hanafuda 真 本格花札 | DC | 1.005 | Original | | T-16601M | |
| Shin Nihon Pro Wrestling: Toukon Retsuden 4 新日本プロレスリング 闘魂烈伝4 | DC | 1.006 | Shokai Genteiban | | T-28202M | |
| Shin Seiki Evangelion: Ayanami Ikusei Keikaku 新世紀エヴァンゲリオン 綾波育成計画 | DC | 1.002 | Original | | T-46303M | |
| Shin Seiki Evangelion: Typing Hokan Keikaku 新世紀エヴァンゲリオン タイピング補完計画 | DC | 1.002 | Original | | T-35102M | |
| Shinki Sekai Evolution 2: Tooi Yakusoku 神機世界 エヴォリューション 2 遠い約束 | DC | 1.002 | Original | | T-38703M | |
| The Shinri Game ザ・心理ゲーム | DC | 1.004 | Original | | T-43403M | |
| Shutokou Battle 首都高バトル | DC | 1.002 | Taikenban | | 610-7134 | |
| Silent Scope | DC | 1.000 | Original | | T-9507N | |
| Silver | DC | 1.001 | Original | | T-15109D-91 | |
| Silver | DC | 1.000 | Original | | T-15109D-92 | |
| Silver | DC | 1.000 | Original | | T-15109D-18 | |
| Silver | DC | 1.000 | Original | | T-15109D-06 | |
| Silver | DC | 1.001 | Original | | T-15108N | |
| Simple 2000 Series DC Vol. 01: Bittersweet Fools: The Ren'ai Adventure SIMPLE2000シリーズDC Vol.01 BITTERSWEET FOOLS THE 恋愛アドベンチャー | DC | 1.002 | Original | | T-47401M | |
| Simple 2000 Series DC Vol. 03: Fureai: The Ren'ai Simulation SIMPLE2000シリーズDC Vol.03 ふれあい THE恋愛シミュレーション | DC | 1.003 | Original | | T-47402M | |
| Skies of Arcadia (Disc 1) | DC | 1.000 | Original | | MK-51052-50 | |
| Skies of Arcadia (Disc 2) | DC | 1.000 | Original | | MK-51052-50 | |
| Skies of Arcadia (Disc 1) | DC | 1.002 | Original | | 51052 | |
| Skies of Arcadia (Disc 2) | DC | 1.002 | Original | | 51052 | |
| Slave Zero | DC | 1.000 | Original | | T-15104D-50 | |
| Slave Zero | DC | 1.001 | Original | | T-15106N | |
| Slave Zero | DC | 1.002 | Original | | T-15106N | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | 830-0223-50, T-17722D-50 | |
| SnoCross Championship Racing Sno-Cross Championship Racing | DC | 1.000 | Original | | T-40207N | |
| Snow Surfers | DC | 1.001 | Original | | MK-51010-50 | |
| Soldier of Fortune | DC | 1.000 | Original | | T-17726D-50 | |
| Soldier of Fortune | DC | 1.001 | Original | | T-40212N | |
| Sonic Adventure | DC | 1.000 | Trial Version for E3 | | HDR-0001 | |
| Sonic Adventure | DC | 1.004 | Original | | 51000 | |
| Sonic Adventure 2 | DC | 1.002 | Beta | | MK-5111750 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | MK-51117-50 | |
| Sonic Adventure 2 ソニックアドベンチャー2 | DC | 1.002 | Taikenban | | 610-8057 | |
| Sonic Adventure 2 | DC | 1.008 | Original | | 51117 | |
| Sonic Adventure 2: The Trial | DC | 1.001 | Demo | | 610-7994-50 | |
| Sonic Adventure International ソニックアドベンチャー・インターナショナル | DC | 1.003 | Original | | HDR-0043 | |
| Sonic Shuffle | DC | 1.000 | Original | | MK-51060-50 | |
| Sonic Shuffle ソニックシャッフル | DC | 1.001 | Original | | HDR-0125 | |
| Sonic Shuffle | DC | 1.000 | Original | | 51060 | |
| Soukou no Kihei: Space Griffon 蒼鋼の騎兵 -SPACE GRIFFON- | DC | 1.001 | Original | | T-39601M | |
| Soul Fighter | DC | 1.000 | Original | | T-41401N | |
| Soulcalibur ソウルキャリバー | DC | 0.600 | Book Bundle | | 610-7175 | |
| South Park Rally | DC | 1.001 | Original | | T-8116N | |
| South Park: Chef's Luv Shack | DC | 1.000 | Original | | T-8105D-50 | |
| Space Channel 5 スペース・チャンネル5 | DC | 0.203 | Taikenban | | 610-7368 | |
| Space Channel 5 Part 2 スペース・チャンネル5 パート2 | DC | 2.000 | Original | | HDR-0190 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-36816D-50 | |
| Spawn: In the Demon's Hand | DC | 1.000 | Original | | T-1216N | |
| Spec Ops II: Omega Squad | DC | 1.002 | Original | | T-45004D-50 | |
| Spec Ops II: Omega Squad | DC | 1.008 | Original | | T-41704N | |
| Speed Devils | DC | 1.004 | Original | | T-17702D-50 | |
| Speed Devils | DC | 1.004 | Original | | T-17702N | |
| Speed Devils: Online Racing | DC | 1.003 | Original | | T-17713D-50 | |
| Speed Devils: Online Racing | DC | 1.002 | Original | | T-17718N | |
| Spider-Man | DC | 1.000 | Original | | T-13011D-50 | |
| Spider-Man | DC | 1.000 | Original | | T-13008N | |
| Spirit of Speed 1937 | DC | 1.002 | Original | | T-8117D-50 | |
| Spirit of Speed 1937 スピリット オブ スピード 1937 | DC | 1.000 | Original | | T-8102M | |
| Spirit of Speed 1937 | DC | 1.001 | Original | | T-8118N | |
| Sports Jam スポーツ・ジャム | DC | 1.005 | Original | | HDR-0153 | |
| Sports Jam | DC | 1.001 | Original | | T-44304N | |
| Star Gladiator 2: Nightmare of Bilstein スターグラディエイター2 ~ナイトメアオブビルシュタイン~ | DC | 1.000 | Tentou Taikenban | | 610-7181 | |
| Star Wars: Demolition | DC | 1.000 | Original | | 830-0215-50, T-13010D-50 | |
| Star Wars: Demolition | DC | 1.001 | Original | | T-23003N | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.003 | Original | | T-23002D-50 | |
| Star Wars: Episode I: Jedi Power Battles | DC | 1.004 | Original | | T-23002N | |
| StarLancer | DC | 1.003 | Original | | T-17723D-05 | |
| StarLancer | DC | 1.002 | Original | | T-40209N | |
| Street Fighter Alpha 3 | DC | 1.001 | Original | | T-1203N | |
| Street Fighter III: 3rd Strike | DC | 1.000 | Original | | T-7013D-50 | |
| Street Fighter III: 3rd Strike | DC | 1.001 | Original | | T-1213N | |
| Street Fighter III: 3rd Strike: Fight for the Future ストリート・ファイターⅢ サードストライク ~ファイト・フォー・ザ・フューチャー~ | DC | 1.003 | Original | | T-1209M | |
| Street Fighter III: Double Impact | DC | 1.001 | Original | | T-7006D-50 | |
| Street Fighter Zero 3: Saikyo-ryu Dojo ストリート・ファイターZERO3 ~サイキョー流道場~ | DC | 1.001 | Tentou Taikenban | | 610-7161 | |
| Striker Pro 2000 | DC | 1.002 | Original | | T-15111N | |
| Stunt GP | DC | 1.001 | Original | | T-22904D-50 | |
| Stupid Invaders (Disc 1) | DC | 1.000 | Original | | T-17711D-71 | |
| Stupid Invaders (Disc 2) | DC | 1.000 | Original | | T-17711D-71 | |
| Stupid Invaders (Disc 1) | DC | 1.000 | Original | | T-17711D-09 | |
| Stupid Invaders (Disc 2) | DC | 1.000 | Original | | T-17711D-09 | |
| Stupid Invaders (Disc 1) | DC | 1.001 | Original | | T-17708N | |
| Stupid Invaders (Disc 2) | DC | 1.001 | Original | | T-17708N | |
| Suigetsu: Mayoigokoro (Disc 1) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Suigetsu: Mayoigokoro (Disc 2) 水月 ~迷心~ | DC | 1.002 | Original | | T-19725M | |
| Super Euro Soccer 2000 スーパーユーロサッカー2000 | DC | 1.002 | Original | | T-15006M | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206D-50 | |
| Super Magnetic Neo | DC | 1.001 | Demo | | T-40206ND | |
| Super Magnetic Neo | DC | 1.001 | Original | | T-40206N | |
| Super Magnetic Niuniu スーパーマグネチックニュウニュウ | DC | 1.002 | Original | | T-30802M | |
| Super Magnetic Niuniu: Promotion Disc スーパーマグネチック ニュウニュウ Promotion Disc | DC | 1.000 | Demo | | 610-7386 | |
| Super Producers: Mezase Show Biz Kai スーパープロデューサーズ 目指せショウビズ界 | DC | 1.001 | Original | | T-14303M | |
| Super Puzzle Fighter II X for Matching Service スーパーパズルファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1250M | |
| Super Runabout スーパーランナバウト | DC | 1.002 | Taikenban | | 610-7803 | |
| Super Runabout スーパーランナバウト | DC | 1.003 | Original | | T-22101M | |
| Super Runabout スーパーランナバウト | DC | 2.001 | Original | | T-22101M | |
| Super Runabout: San Francisco Edition スーパーランナバウト サンフランシスコエディション | DC | 1.000 | Original | | T-22102M | |
| Super Runabout: San Francisco Edition | DC | 1.005 | Original | | T-12511N | |
| Super Speed Racing スーパースピードレーシング | DC | 1.004 | Original | | HDR-0013 | |
| Super Street Fighter II X for Matching Service スーパーストリートファイターⅡX フォー マッチング サービス | DC | 1.001 | Original | | T-1236M | |
| Surf Rocket Racers | DC | 1.000 | Original | | T-40216N | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703D-50, T-17703D-74 | |
| Suzuki Alstare: Extreme Racing | DC | 1.000 | Original | | T-17703N | |
| Sydney 2000 | DC | 1.001 | Original | | T-36808D-03 | |
| Sydney 2000 | DC | 1.000 | Original | | T-36808D-09 | |
| Sydney 2000 | DC | 1.000 | Original | | T-36808N | |
| Space Channel 5 Theme Music: Mexican Flyer スペース・チャンネル5 | DC | 1.080 | Not for Sale | | | |
| Sturmwind | DC | 1.0 | Unlicensed (Rerelease) | | | |
| Super Game Converter | DC | 1.000 | Unlicensed | | | |
| Super Prologue 21 Games Vol. 1 スーパー・プロローグ21 ゲームス Vol.1 | SP21 | 1.002 | Original | | SKT-3500 | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCP-EUR | |
| Samurai Jack: The Shadow of Aku | GC | | Original | | DL-DOL-GJCE-USA | |
| Scaler | GC | | Original | | DL-DOL-GKUE-USA | |
| Scooby-Doo! Fluch der Folianten | GC | | Original | | DL-DOL-GC3D-NOE | |
| Scooby-Doo! La Nuit des 100 Frissons | GC | | Original | | DL-DOL-GIHF-FRA | |
| Scooby-Doo! Le Livre des Ténèbres | GC | | Original | | DL-DOL-GC3F-FRA | |
| Scooby-Doo! Nacht der 100 Schrecken | GC | | Original | | DL-DOL-GIHD-NOE | |
| Scooby-Doo! Night of 100 Frights | GC | Rev 1 | Original | | DL-DOL-GIHE-USA | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DP-EUR | |
| Scooby-Doo! Unmasked | GC | | Original | | DL-DOL-G5DE-USA | |
| The Scorpion King: Rise of the Akkadian | GC | | Original | | DL-DOL-GSKE-USA | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ | GC | | Taikenban | | DL-DOL-PGPJ-JPN | |
| SD Media Launcher for GameCube / Wii SDメディアランチャー Wii用/GC用 | GC | | Unlicensed | | | |
| SeaWorld Adventure Parks: Shamu's Deep Sea Adventures | GC | | Original | | DL-DOL-GJZP-EUR | |
| Second Sight | GC | | Original | | DL-DOL-GISE-USA | |
| Sega Soccer Slam セガ サッカースラム | GC | | Original | | DL-DOL-GSSJ-JPN | |
| Serious Sam: Next Encounter | GC | | Original | | DL-DOL-G3BP-EUR | |
| Serious Sam: Next Encounter | GC | Rev 1 | Original | | DL-DOL-G3BE-USA | |
| Shadow the Hedgehog シャドウ・ザ・ヘッジホッグ | GC | | Original | | DL-DOL-GUPJ-JPN | |
| Shaman King: Soul Fight シャーマンキング ソウルファイト | GC | Rev 1 | Original | | DL-DOL-GSEJ-JPN | |
| Shinki Sekai Evolutia 神機世界エヴォルシア | GC | | Original | | DL-DOL-GEVJ-JPN | |
| Shonen Jump's One Piece: Grand Adventure | GC | | Original | | DL-DOL-GOQE-USA | |
| Shonen Jump's One Piece: Pirates' Carnival | GC | | Original | | DL-DOL-GIPE-USA | |
| Shrek 2 | GC | Rev 1 | Player's Choice | | DL-DOL-G3RP-UKV | |
| Shrek 2 | GC | | Original | | DL-DOL-G3RM-SWE | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9P-EUR | |
| Shrek Extra Large | GC | | Original | | DL-DOL-GS9E-USA | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYP-EUR | |
| Shrek Super Party | GC | | Original | | DL-DOL-GSYE-USA | |
| Il Signore degli Anelli: Il ritorno del Re | GC | | Original | | DL-DOL-GKLI-ITA | |
| Il Signore degli Anelli: Le Due Torri | GC | | Original | | DL-DOL-GLOI-ITA | |
| The Sims ザ・シムズ | GC | | Original | | DL-DOL-G4PJ-JPN | |
| SmaBro DX Event-you Disc スマブラDX イベント用ディスク | GC | | Promo | | DL-DOL-D24J-DIS | |
| Smashing Drive | GC | | Original | | DL-DOL-GSDE-USA | |
| Smuggler's Run: Warzones | GC | | Original | | DL-DOL-GSRE-USA | |
| Sonic Adventure DX ソニック アドベンチャー DX デラックス | GC | | Original | | DL-DOL-GASJ-JPN | |
| Sonic Riders | GC | | Original | | DL-DOL-GXEP-EUR | |
| Sonic Riders ソニックライダーズ | GC | | Original | | DL-DOL-GXEJ-JPN | |
| Space Raiders スペース レイダース | GC | | Original | | DL-DOL-GIJJ-JPN | |
| Space Raiders 스페이스 레이더스 | GC | | Original | | DL-DOL-GIJK-KOR | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAF-FRA | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAD-NOE | |
| Spartan: Total Warrior | GC | | Original | | DL-DOL-GWAE-USA | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWP-EUR | |
| Spawn: Armageddon | GC | | Original | | DL-DOL-GPWE-USA | |
| Special Jinsei Game Special 人生ゲーム | GC | | Original | | DL-DOL-GLIJ-JPN | |
| Speed Kings | GC | | Original | | DL-DOL-GDCE-USA | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSMP-UKV | |
| Spider-Man | GC | | Original | | DL-DOL-GSMF-FRA | |
| Spider-Man | GC | | Original | | DL-DOL-GSMD-NOE | |
| Spider-Man スパイダーマン | GC | | Original | | DL-DOL-GSMJ-JPN | |
| Spider-Man | GC | Rev 1 | Player's Choice | | DL-DOL-GSME-USA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2F-FRA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2D-NOE | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2I-ITA | |
| Spirits & Spells | GC | | Original | | DL-DOL-G2PE-USA | |
| SpyHunter | GC | | Original | | DL-DOL-GSHE-USA | |
| SRS: Street Racing Syndicate | GC | | Original | | DL-DOL-GCSP-EUR | |
| SRS: Street Racing Syndicate | GC | Rev 1 | Original | | DL-DOL-GCSP-EUR | |
| SRS: Street Racing Syndicate | GC | | Original | | DL-DOL-GCSE-USA | |
| SSX 3 | GC | | Original | | DL-DOL-GXBJ-JPN | |
| SSX 3 | GC | | Original | | DL-DOL-GXBE-USA | |
| SSX on Tour | GC | | Original | | DL-DOL-GXOP-EUR | |
| SSX on Tour | GC | | Original | | DL-DOL-GXOX-FRA | |
| SSX Tricky | GC | | Jitsuen-you Sample | | DL-DOL-DSTJ-DIS | |
| Star Fox Adventures スターフォックスアドベンチャー | GC | Rev 1 | Original | | DL-DOL-GSAJ-JPN | |
| Star Fox: Assault スターフォックス アサルト | GC | | Original | | DL-DOL-GF7J-JPN | |
| Star Wars: Bounty Hunter | GC | | Original | | DL-DOL-GBWF-FRA | |
| Star Wars: Bounty Hunter | GC | | Original | | DL-DOL-GBWI-ITA | |
| Star Wars: Bounty Hunter | GC | | Original | | DL-DOL-GBWS-ESP | |
| Star Wars: Jedi Knight II: Jedi Outcast | GC | | Original | | DL-DOL-GJKF-FRA | |
| Star Wars: Jedi Knight II: Jedi Outcast | GC | | Original | | DL-DOL-GJKD-NOE | |
| Star Wars: La Guerra dei Cloni | GC | | Original | | DL-DOL-GSXI-ITA | |
| Star Wars: Las Guerras Clon | GC | | Original | | DL-DOL-GSXS-ESP | |
| Star Wars: Rogue Squadron II スター・ウォーズ ローグ スコードロン Ⅱ | GC | | Original | | DL-DOL-GSWJ-JPN | |
| Star Wars: Rogue Squadron II スター・ウォーズ ローグ スコードロン Ⅱ | GC | | Jitsuen-you Sample | | DL-DOL-DSWJ-DIS | |
| Star Wars: Rogue Squadron II: Rogue Leader | GC | | Original | | DL-DOL-GSWD-NOE | |
| Star Wars: Rogue Squadron II: Rogue Leader | GC | | Original | | DL-DOL-GSWI-ITA | |
| Star Wars: Rogue Squadron III スター・ウォーズ ローグ スコードロンⅢ | GC | | Original | | DL-DOL-GWXJ-JPN | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRP-EUR | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRF-FRA | |
| Star Wars: Rogue Squadron III: Rebel Strike | GC | | Original | | DL-DOL-GLRD-NOE | |
| Star Wars: The Clone Wars | GC | | Original | | DL-DOL-GSXF-FRA | |
| Star Wars: The Clone Wars | GC | | Original | | DL-DOL-GSXD-NOE | |
| Star Wars: The Clone Wars スター・ウォーズ クローン戦争 | GC | | Original | | DL-DOL-GSXJ-JPN | |
| Starsky & Hutch | GC | | Original | | DL-DOL-GT5E-USA | |
| Street Hoops | GC | | Original | | DL-DOL-GHPE-USA | |
| Strike Force Bowling | GC | | Original | | DL-DOL-G5BE-USA | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3MP-EUR | |
| The Sum of All Fears | GC | | Original | | DL-DOL-G3ME-USA | |
| Summoner: A Goddess Reborn | GC | | Original | | DL-DOL-GS2P-EUR | |
| Summoner: La Déesse Réincarnée | GC | | Original | | DL-DOL-GS2F-FRA | |
| Super Bubble Pop | GC | | Original | | DL-DOL-GBYE-USA | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | Rev 1 | Original | | DL-DOL-GMSJ-JPN | |
| Super Mario Sunshine 슈퍼 마리오 선샤인 | GC | | Original | | DL-DOL-GMSE-KOR | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Original | | DL-DOL-GM2J-JPN | |
| Super Monkey Ball 2 スーパーモンキーボール2 | GC | | Taikenban | | DL-DOL-DM2J-DIS | |
| Super Puzzle Bobble All Stars スーパーパズルボブル オールスターズ | GC | | Original | | DL-DOL-G3SJ-JPN | |
| Super Puzzle Bobble All Stars 슈퍼퍼즐버블 올스타 | GC | | Original | | DL-DOL-G3SW-KOR | |
| Super Robot Taisen GC スーパーロボット大戦GC | GC | | Original | | DL-DOL-GRWJ-JPN | |
| Super Smash Bros. Melee 대난투 스매쉬 브라더스 DX | GC | | Original | | DL-DOL-GALE-KOR | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUP-EUR | |
| Surf's Up | GC | | Original | | DL-DOL-GXUE-USA | |
| Swingerz Golf 와!와! 골프 | GC | | Original | | DL-DOL-GWGE-KOR | |
| Swingerz Golf | GC | | Original | | DL-DOL-GWGE-USA | |
| SX Superstar | GC | | Original | | DL-DOL-GS3P-EUR | |
| SX Superstar | GC | | Original | | DL-DOL-GS3E-USA | |
| The Saddle Club | WII | | Original | | RVL-SSLP-EUR-B0 | |
| Safar'Wii | WII | | Original | | RVL-RD6P-EUR-B0 | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWP-EUR | |
| Safari Adventures: Africa | WII | | Original | | RVL-RFWE-USA-B0 | |
| Safecracker | WII | | Original | | RVL-RQFP-EUR | |
| Safecracker | WII | | Original | | RVL-RQFE-USA | |
| Saint | WII | | Original | | RVL-RZCE-USA-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YP-EUR-B0 | |
| Sam & Max: Beyond Time and Space | WII | | Original | | RVL-R3YE-USA-B0 | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | Rev 1 | Original | | RVL-R3XP-EUR | |
| Sam & Max: Season One | WII | | Beta | | | |
| Sam & Max: Season One | WII | | Original | | RVL-R3XE-USA | |
| Samba de Amigo サンバDEアミーゴ | WII | | Original | | RVL-R3BJ-JPN | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSP-EUR | |
| Samurai Shodown Anthology | WII | | Original | | RVL-RSSE-USA | |
| Samurai Spirits: 6beonui Seungbu 사무라이 스피리츠 6번의 승부 | WII | | Original | | RVL-RSSK-KOR | |
| Samurai Spirits: Rokuban Shoubu サムライスピリッツ 六番勝負 | WII | | Original | | RVL-RSSJ-JPN | |
| Samurai Warriors: Katana | WII | | Original | | RVL-RS5P-EUR | |
| Samurai Warriors: Katana | WII | | Beta | | | |
| Sangokushi 11 with Power-Up Kit 三國志11 with パワーアップキット | WII | | Original | | RVL-R35J-JPN | |
| Sangokushi 11 with Power-Up Kit 三國志11 with パワーアップキット | WII | Rev 1 | Koei the Best | | RVL-R35J-JPN-1 | |
| Santa Claus Is Comin' to Town! | WII | | Original | | RVL-SX5E-USA-B0 | |
| Satisfashion: Rock the Runway | WII | | Original | | RVL-SS5E-USA-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCU-AUS-B0 | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCP-EUR | |
| Scarface: The World Is Yours | WII | | Original | | RVL-RSCE-USA | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCX-CAN-B0 | |
| Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCE-USA-B0 | |
| Scene It? Ciak! Si Gira! Scene It? Bright Lights! Big Screen! | WII | | Original | | RVL-SSCI-ITA-B0 | |
| Scene It? Estrellas en la Pantalla Gigante | WII | | Original | | RVL-SSCS-ESP-B0 | |
| Scene It? Ganz großes Kino! | WII | | Original | | RVL-SSCD-NOE-B0 | |
| Scene It? Lumières ! Action ! | WII | | Original | | RVL-SSCF-FRA-B0 | |
| Science Papa | WII | | Original | | RVL-RZEP-EUR-B0 | |
| Science Papa | WII | | Original | | RVL-RZEE-USA-B0 | |
| Scooby-Doo! and the Spooky Swamp | WII | | Original | | RVL-SJ2E-USA-B0 | |
| Score International Baja 1000: The Official Game | WII | | Original | | RVL-RJCE-USA | |
| Score International Baja 1000: World Championship Off Road Racing | WII | | Original | | RVL-RJCP-EUR-B0 | |
| Scrabble Interactive | WII | | Original | | RVL-RVHP-EUR-B0 | |
| SD Gundam: Gashapon Wars SDガンダム ガシャポンウォーズ | WII | | Original | | RVL-SD9J-JPN-B0 | |
| SD Gundam: GGeneration Wars SDガンダム ジージェネレーション ウォーズ | WII | | Original | | RVL-R77J-JPN | |
| SD Gundam: GGeneration World SDガンダム ジージェネレーション ワールド | WII | | Original | | RVL-SDJJ-JPN-B0 | |
| SD Gundam: Scad Hammers SDガンダム スカッドハンマーズ | WII | | Original | | RVL-RSDJ-JPN | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7P-EUR | |
| Sea Monsters: A Prehistoric Adventure | WII | | Original | | RVL-RC7E-USA | |
| Secret Files 2: Puritas Cordis | WII | | | | RVL-RZFP-EUR | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUP-EUR | |
| Secret Files: Tunguska | WII | | Original | | RVL-RTUE-USA-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85P-EUR-B0 | |
| The Secret Saturdays: Beasts of the 5th Sun | WII | | Original | | RVL-R85E-USA-B0 | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2) 戦国BASARA2 | WII | | Original | | RVL-RBSJ-1-JPN | |
| Sengoku Basara 2: Heroes: Double Pack (Sengoku Basara 2: Heroes) 戦国BASARA2 英雄外伝 | WII | | Original | | RVL-RBSJ-0-JPN | |
| Sengoku Basara 3 戦国BASARA3 | WII | | Original | | RVL-SB3J-JPN-B0 | |
| Sengoku Basara 3: Utage 戦国BASARA3 宴 | WII | | Original | | RVL-S3HJ-JPN-B0 | |
| Sengoku Musou: Katana 戦国無双 KATANA | WII | | Original | | RVL-RS5J-JPN | |
| Sesame Street: Cookie's Counting Carnival: The Videogame | WII | | Original | | RVL-SS4U-AUS-B0 | |
| Sesame Street: Elmo's A-to-Zoo Adventure: The Videogame | WII | | Original | | RVL-SS3U-AUS-B0 | |
| Sesame Street: Elmo's Musical Monsterpiece: The Videogame | WII | | Original | | RVL-SSSE-USA-B0 | |
| Sesame Street: Ready, Set, Grover! The Videogame | WII | | Original | | RVL-SESU-AUS-B0 | |
| Sesame Street: Ready, Set, Grover! with Elmo: The Videogame | WII | | Original | | RVL-SESE-USA-B0 | |
| Shakedown: Hawaii | WII | | Original | | RVL-SEVP-EUR-B0 | |
| Shanghai 上海 | WII | | Original | | RVL-RS8J-JPN | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | | Original | | RVL-SHIJ-JPN-B0 | |
| Shape Boxing 2: Wii de Enjoy Diet! シェイプボクシング2 Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-SHIJ-JPN-B0 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | | Original | | RVL-REKJ-JPN-1 | |
| Shape Boxing: Wii de Enjoy Diet! シェイプボクシング Wiiでエンジョイダイエット! | WII | Rev 1 | Original | | RVL-REKJ-JPN-1 | |
| Sharuui Takoron しゃるうぃ~☆たころん | WII | | Original | | RVL-RTKJ-JPN | |
| Shaun White Skateboarding | WII | | Original | | RVL-SHNE-USA-B0 | |
| Shaun White Snowboarding: Road Trip | WII | | Beta | | | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NE-USA-B0 | |
| Shaun White Snowboarding: World Stage | WII | | Original | | RVL-R6NP-UKV-B0 | |
| Shawn Johnson Gymnastics | WII | | Original | | RVL-SJVE-USA-B0 | |
| Shikakui Atama o Maruku Suru. Wii シカクいアタマをマルくする。 Wii | WII | | Original | | RVL-R4MJ-JPN | |
| Shikigami no Shiro III 式神の城Ⅲ | WII | | Original | | RVL-RS4J-JPN | |
| Shimano Extreme Fishing | WII | | Original | | RVL-R39P-EUR-B0 | |
| Shimano Xtreme Fishing | WII | | Original | | RVL-R39E-USA-B0 | |
| Shin Chan: Las Nuevas Aventuras para Wii! | WII | | Original | | RVL-RC4S-ESP | |
| Shin Chuuka Taisen: Michael to Meimei no Bouken 新・中華大仙 ~マイケルとメイメイの冒険~ | WII | | Original | | RVL-RTDJ-JPN | |
| Shiren the Wanderer | WII | | Beta | | | |
| Shiren the Wanderer | WII | | Original | | RVL-RFSE-USA-B0 | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Beta | | | |
| Shonen Jump One Piece: Unlimited Adventure | WII | | Original | | RVL-RIPE-USA | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDP-EUR-B0 | |
| Sid Meier's Pirates! | WII | | Original | | RVL-SIDE-USA-B0 | |
| Silent Hill: Shattered Memories | WII | | Original | | RVL-R5WE-USA-B0 | |
| SimAnimals シムアニマル | WII | | Original | | RVL-R4AJ-JPN | |
| SimAnimals: Africa シムアニマル アフリカ | WII | | Original | | RVL-R7AJ-JPN-B0 | |
| SimAnimals: Africa | WII | | Original | | RVL-R7AE-USA-B0 | |
| SimCity Creator | WII | Rev 1 | Original | | RVL-R4CP-AUS | |
| SimCity Creator | WII | | Beta | | | |
| SimCity Creator | WII | | Original | | RVL-R4CP-EUR | |
| SimCity Creator シムシティ クリエイター | WII | | Original | | RVL-R4CJ-JPN | |
| SimCity Creator | WII | | Original | | RVL-R4CE-USA | |
| SimCity Namanui Dosi 심시티 나만의 도시 | WII | | Original | | RVL-R4CK-KOR | |
| I Simple 2000 Series Wii Vol. 1: The Table Game: Mahjonggo, Shougi, Card, Hanafuda, Reversi, Gomoku Narabe SIMPLE2000シリーズWii Vol.1 THE テーブルゲーム ~麻雀・囲碁・将棋・カード・花札・リバーシ・五目ならべ~ | WII | | Original | | RVL-RZ8J-JPN | |
| Simple 2000 Series Wii Vol. 2: The Party Game SIMPLE2000シリーズWii Vol.2 THE パーティーゲーム | WII | | Original | | RVL-RZ9J-JPN | |
| Simple Wii Series Vol. 1: The Minna de Kart Race SIMPLE Wii シリーズ Vol.1 THE みんなでカート・レース | WII | | Original | | RVL-RZ2J-JPN | |
| Simple Wii Series Vol. 2: The Minna de Bass Tsuri Taikai SIMPLE Wii シリーズ Vol.2 THE みんなでバス釣り大会 | WII | | Original | | RVL-RZ3J-JPN | |
| Simple Wii Series Vol. 3: Asonde Oboeru: The Party Casino SIMPLE Wii シリーズ Vol.3 遊んで覚える THE パーティー・カジノ | WII | | Original | | RVL-RZ4J-JPN | |
| Simple Wii Series Vol. 4: The Shooting Action SIMPLE Wii シリーズ Vol.4 THE シューティング・アクション | WII | | Original | | RVL-RZ5J-JPN | |
| Simple Wii Series Vol. 5: The Block Kuzushi SIMPLE Wii シリーズ Vol.5 THE ブロックくずし | WII | | Original | | RVL-RZ6J-JPN | |
| Simple Wii Series Vol. 6: The Wai Wai Combat SIMPLE Wii シリーズ Vol.6 THE ワイワイ・コンバット | WII | | Original | | RVL-RZ7J-JPN | |
| Les Simpson: Le Jeu | WII | | Original | | RVL-RSNF-FRA | |
| The Simpsons Game Los Simpson: El Videojuego / I Simpson: Il Videogioco | WII | | Original | | RVL-RSNX-EUS | |
| Die Simpsons: Das Spiel | WII | | Original | | RVL-RSND-NOE | |
| The Sims 2: Castaway | WII | | Beta | | | |
| The Sims 2: Castaway | WII | Rev 1 | Original | | RVL-R42P-EUR | |
| The Sims 2: Pets | WII | | Original | | RVL-R4PP-EUR | |
| The Sims 3 | WII | | Beta | | | |
| Sin Junghwa-daeseon: Michaelgwa Meimeiui Moheom 신중화대선 ~마이클과 메이메이의 모험~ | WII | | Original | | RVL-RTDK-KOR | |
| Sing 4: The Hits Edition | WII | | Original | | RVL-SIHE-USA-B0 | |
| Six Flags Fun Park | WII | | Original | | RVL-R6FE-USA | |
| Skate City Heroes | WII | | Original | | RVL-RHUP-EUR-B0 | |
| Skate It スケート イット | WII | | Original | | RVL-RVSJ-JPN | |
| Skate It | WII | | Beta | | | |
| Ski and Shoot | WII | | Original | | RVL-RUME-USA | |
| Ski-Doo Snowmobile Challenge | WII | | Beta | | | |
| Ski-Doo Snowmobile Challenge | WII | | Original | | RVL-R87E-USA-B0 | |
| The Sky Crawlers: Innocent Aces | WII | | Original | | RVL-RQRP-EUR-B0 | |
| Sky Crawlers: Innocent Aces スカイ・クロラ イノセン・テイセス | WII | | Original | | RVL-RQRJ-JPN | |
| Skylanders: Giants | WII | | Starter Pack | | RVL-SKYY-USA-B0 | |
| Skylanders: Giants | WII | | Booster Pack | | RVL-SKYZ-EUZ-B0 | |
| Skylanders: Spyro no Daibouken スカイランダーズ スパイロの大冒険 | WII | | Starter Pack | | RVL-SSPJ-JPN-B0 | |
| Skylanders: Spyro's Adventure | WII | | Starter Pack | | RVL-SSPY-BRA-B0 | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPP-EUR-B2 | |
| Skylanders: Spyro's Adventure | WII | Rev 1 | Starter Pack | | RVL-SSPX-SCN-B0 | |
| Skylanders: Spyro's Adventure | WII | Rev 2 | Starter Pack | | RVL-SSPX-SCN-B1 | |
| Skylanders: Spyro's Adventure | WII | Rev 3 | Starter Pack | | RVL-SSPX-SCN-B2 | |
| Skylanders: SuperChargers Racing | WII | | Starter Pack | | RVL-SKNE-USA-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: Swap Force | WII | | Starter Pack | | RVL-SVXI-EUZ-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXF-FAH-B0 | |
| Skylanders: Swap Force | WII | Rev 1 | Starter Pack | | RVL-SVXI-EUZ-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8D-FAH-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Skylanders: Trap Team | WII | Rev 1 | Starter Pack | | RVL-SK8I-EUZ-B0 | |
| Skylanders: Trap Team | WII | | Starter Pack | | RVL-SK8P-EUR-B0 | |
| Skyscraper | WII | | Original | | RVL-R3KP-UKV-B1 | |
| Sled Shred featuring the Jamaican Bobsled Team | WII | | Original | | RVL-R9YE-USA-B0 | |
| Smart Series Presents: Jaja's Adventure | WII | | Original | | RVL-R67E-USA-B0 | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDP-EUR | |
| Smiley World: Island Challenge | WII | | Original | | RVL-RIDE-USA-B0 | |
| The Smurfs 2 | WII | | Original | | RVL-S2XE-USA-B0 | |
| The Smurfs Party Pack | WII | | Original | | RVL-S7SP-EUR-B0 | |
| The Smurfs: Dance Party | WII | | Toys R Us | | RVL-SDUX-USA-B0 | |
| Sniper Elite | WII | | Original | | RVL-SSNP-EUR-B0 | |
| So Blonde: Back to the Island | WII | | Original | | RVL-RVJP-EUR-B0 | |
| Sonic and the Black Knight | WII | | Original | | RVL-RENP-EUR | |
| Sonic Colors ソニック カラーズ | WII | | Original | | RVL-SNCJ-JPN-B0 | |
| Sonic Riders: Shooting Star Story ソニックライダーズ シューティングスターストーリー | WII | | Original | | RVL-RS9J-JPN | |
| Sonic to Ankoku no Kishi ソニックと暗黒の騎士 | WII | | Original | | RVL-RENJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Original | | RVL-RSRJ-JPN | |
| Sonic to Himitsu no Ring ソニックと秘密のリング | WII | | Taikenban | | RVL-DSRJ-JPN | |
| Sonic World Adventure ソニック ワールドアドベンチャー | WII | | Original | | RVL-RSVJ-JPN | |
| Soulcalibur Legends ソウルキャリバーレジェンズ | WII | | Original | | RVL-RSLJ-JPN | |
| Soulcalibur Legends 소울 칼리버 레전즈 | WII | | Original | | RVL-RSLK-KOR | |
| Space Camp | WII | | Original | | RVL-RIYP-EUR | |
| Space Camp | WII | | Original | | RVL-RIYE-USA | |
| Space Chimps | WII | | Original | | RVL-RP9E-USA | |