Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sherlock Holmes: Consulting Detective: Vol. II (Disc 2) | MCD | | Original | | 4653 | |
| Sid Meier's Civilization IV: Ultimate (Disc 1) | PC | | Original, Collectors Edition | | 5052955/DVD | |
| Sid Meier's Civilization V | PC | | Original | | 5055802/DVD | |
| Sid Meier's Civilization V: Brave New World Sid Meier's Civilization V: Дивный новый мир | PC | | Original | | 5061834/DVD | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.003 | Original | | 51019 | |
| Samba de Amigo | DC | 1.001 | Original | | 51092 | |
| Sid Meier's Civilization III Complete (Disc 2) | PC | | Sid Meier's Civilization Chronicles, Green Pepper | | 51989/CD4 | |
| Sid Meier's Civilization III Complete (Disc 3) | PC | | Sid Meier's Civilization Chronicles, Green Pepper | | 51989/CD5 | |
| SimEarth | PC | | Scholastic | | 5675434C, DP19 | |
| Spider-Man: The Sinister Six | PC | | Original | | 60020-9 | |
| Silhouette Mirage シルエット・ミラージュ | SS | 1.001 | Taikan CD-ROM | | 610-6679 | |
| Saturn Bomberman Fight!! サターン・ボンバーマン・ファイト!! | SS | 0.300 | Taikenban | | 610-6801 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.001 | Tokubetsu-ban (Standalone, Bundled with Mogitate SegaSaturn Vol. 2) | | 610-6864 | |
| Shining Force III Premium Disc シャイニング・フォースⅢ プレミアム・ディスク | SS | 1.000 | Hibaihin | | 610-6979 | |
| Sentimental Graffiti 2: Third Window センチメンタルグラフティ2 サードウィンドウ | DC | 3.000 | Hibaihin | | 610-7749 | |
| Silent Hunter II Silent Hunter II: WWII U-Boat Combat Simulator | PC | 1.00.06 | Original | | 610465-CD | |
| The Sims: House Party (Expansion Pack) | PC | 1.3 | Original | | 62092, MXX08803522D | |
| The Sims: Deluxe Edition (Disc 2) | PC | 1.6 | Original, Double Deluxe | | 62092, MXX08803907D2 | |
| Star Wars: Screen Entertainment | PC | | Original, The LucasArts Archives Vol. I | | 633630 | |
| Sam & Max Hit the Road | PC | | Rerelease, The LucasArts Archives Vol. I | | 634430 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | | Original | | 635930 | |
| Star Wars: Jedi Knight: Mysteries of the Sith Star Wars: Jedi Knight: Dark Forces II: Ambush at Altyr 5 | PC | 1.0 | Demo: Bundle Version OEM | | 647030, CD-C95-990-E | |
| Star Wars: Rogue Squadron 3D: Elite Missions | PC | 1.0 | Bundle Version OEM | | 6528030, CD-C951912-LOE | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 4) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02560 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 5) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02561 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | | Original | | 7101830 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | Original | | 7101830 | |
| Star Wars: Galactic Battlegrounds: Clone Campaigns | PC | 1.0 | Original | | 7111830 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 1) | PC | 1.00.55911 | Original | | 7131830 | |
| Star Wars: Empire at War: Forces of Corruption (Disc 2) | PC | 1.00.55911 | Original | | 7131831 | |
| The Sims 3: Monte Vista | PC | | Original, The Sims 3: Worlds Bundle | | 7299103401 | |
| The Sims 3: Island Paradise (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7301203301 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims 4 (Disc 2) | PC | 1.0 | Limited Edition | | 7303703302, 7303703401 | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: Dragon Valley | PC | | Original | | 7312803402 | |
| The Sims 4: Get to Work (Expansion Pack) | PC | | Original | | 7331403301, 101385603301 | |
| Star Wars: X-Wing vs. TIE Fighter: The Academy | PC | 2.0 | Bundle Version Diamond OEM | | 75000203-100 | |
| Star Wars: Shadows of the Empire: Battle of Hoth | PC | 1.0 | Bundle Version Diamond OEM | | 75000204-100 | |
| Sid Meier's Civilization IV (Disc 1) | PC | 1.61 | Game of the Year Edition | | 77875-1.1REA | |
| Sid Meier's Civilization IV (Disc 2) | PC | 1.61 | Game of the Year Edition | | 77875-1.2REA | |
| Sega Rally Championship | SS | 1.006 | Original, Sega Saturn NetLink Bundle | | 80012, 81207 | |
| Split/Second Split/Second: Velocity | PC | | Original | | 8004905, SYX26187GM | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031832 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031834 | |
| Star Wars: Making Magic | PC | QA1.03 | Star Wars Masterpieces | | 8031835 | |
| Star Wars: Making Magic | PC | QA1.03 | Original, LucasArts Archives Vol. II, The: Star Wars Collection | | 8031835 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | PC | | The LucasArts Archives Vol. II: Star Wars Collection | | 8031836 | |
| Star Wars: X-Wing: Collector's CD-ROM | PC | 1.0 | Collector Series | | 8051831 | |
| Star Wars: X-Wing: Collector's CD-ROM / Star Wars: X-Wing vs. TIE Fighter: Flight School | PC | | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061830 | |
| Star Wars: TIE Fighter: Collector's CD-ROM | PC | 1.0.0.1 | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061831 | |
| Star Wars: Jedi Knight: Mysteries of the Sith | PC | 1.0 | Demo (LucasArts Archives Vol. IV, The: Star Wars Collection II) | | 8061833 | |
| Star Wars: Yoda Stories / Star Wars: Behind the Magic: Vehicles Special Edition | PC | 1.0.0.1 | The LucasArts Archives Vol. IV: Star Wars Collection II | | 8061834 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Sega Saturn Bootleg II: On the Road Sega Screams Volume 1 | SS | 1.002 | Not for Resale | | 81068, 81075 | |
| Sonic Jam | SS | 1.004 | Original | | 81079 | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Sega Touring Car Championship | SS | 1.001 | Original, Sample | | 81216 | |
| Star Wars: Fall Force Gaming Preview Best Buy Preview CD | PC | 1.0 | | | 8330330 | |
| Star Wars: Empire at War | PC | 1.00.35517 | Demo | | 8330730 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Original, Collector's Edition | | 8541830 | |
| Star Wars: Empire at War (Disc 1) | PC | 1.00.36493 | Rerelease | | 8541830R | |
| Star Wars: Empire at War (Disc 2) | PC | 1.00.36493 | Original, Collector's Edition | | 8541831 | |
| Star Wars: Empire at War (Disc 2) | PC | 1.00.36493 | Rerelease | | 8541831R | |
| Slam Tilt Pinball | PC | 1.0 | Expert Software | | 8694 01 | |
| Star Trek: The Next Generation: Interactive Technical Manual | PC | 1.0 | Original | | 89078-6 | |
| SimCity | CDTV | | Original | | 91133 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0 | Original | | 9551830 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 1) | PC | 1.0.1 | Rerelease | | 9551830R1 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0 | Original | | 9551831 | |
| Star Wars: Jedi Knight: Jedi Academy (Disc 2) | PC | 1.0.1 | Rerelease | | 9551831R, 9551831R1 | |
| Sin Episodes: Emergence SiN Episodes: Emergence | PC | | Original | | 984707 | |
| Star Wars: Empire at War: Gold Pack | PC | 1.05.48824 | Original | | 9999830 | |
| Shougi no Tatsujin: Master of Syougi 将棋の達人 | NGCD | | Original | | ADCD-010 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man 2 | XBOX | | Original | | AV-043 | |
| Spider-Man 2 스파이더맨 2 | XBOX | | Original | | AV-043 | |
| Spider-Man 3 | XBOX360 | | Original | | AV-2018 | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Spider-Man: Edge of Time | XBOX360 | | Original | | AV-2226 | |
| Stubbs the Zombie in Rebel Without a Pulse | XBOX | | Original | | AY-002 | |
| Sorcer Kingdom ソーサル・キングダム | PC-98 | | Original | | AYPIO-001 | |
| SD Gundam: Daizukan SDガンダム ~大図鑑~ | QIS | | Original | | BAPD-03 | |
| Samurai Dou 3 侍道3 | PS3 | 01.01 | Original | | BCAS 20063 … | |
| Sports Champions 스포츠 챔피언 | PS3 | 01.00 | Original | | BCAS 20125 … | |
| Samurai Dou 4 侍道4 | PS3 | 01.02 | Original | | BCAS 20167 … | |
| SingStar | PS3 | 01.01 | Original | | BCES-00011 … | |
| SOCOM: Confrontation | PS3 | 01.01 | Original | | BCES-00173 | |
| SingStar: Media Information | PC | | PS3 Review Disc | | BCES-00293/REV | |
| SingStar SuomiPop | PS3 | 01.00 | Original, Promo | | BCES-00344 | |
| SingStar Mallorca Party | PS3 | 02.00 | Original | | BCES-00519 … | |
| SingStar Made in Germany | PS3 | 01.01 | Original, Promo | | BCES-00614 | |
| Sports Champions | PS3 | 01.00 | Original, Promo | | BCES-00795 … | |
| SingStar SuomiHitit | PS3 | 01.00 | Original | | BCES-00847 | |
| SOCOM: Special Forces | PS3 | 01.00 | Original | | BCES-00938 … | |
| SOCOM: Special Forces | PS3 | 01.00 | Original | | BCES-00939 | |
| Sports Champions | PS3 | 01.00 | Original | | BCES-01012 | |
| SingStar SuomiSuosikit | PS3 | 01.00 | Original | | BCES-01255 | |
| Sly Cooper: Thieves in Time | PS3 | 01.02 | Original | | BCES-01284 … | |
| Sports Champions 2 | PS3 | 01.00 | Original, Essentials, Promo | | BCES-01598 … | |
| SingStar SuomiHuiput | PS3 | 01.01 | Original | | BCES-01735 | |
| SingStar SuomiHelmet | PS3 | 01.00 | Bundled with SingStar Microphones and USB Converter | | BCES-01915 | |
| Sports Champions スポーツチャンピオン | PS3 | 01.00 | Original, Bundled with PlayStation Move: Value Pack | | BCJB 95011 … | |
| SOCOM: Confrontation ソーコム:コンフロンテーション | PS3 | 01.00 | Wireless Headset Bundle | | BCJS 30024 | |
| Shirokishi Monogatari: Inishie no Kodou 白騎士物語 -古の鼓動- | PS3 | 01.03 | Original | | BCJS 30030 | |
| Shirokishi Monogatari: Inishie no Kodou: EX Edition 白騎士物語 -古の鼓動- EX Edition | PS3 | 01.01 | Original | | BCJS 30039 | |
| Shirokishi Monogatari: Hikari to Yami no Kakusei 白騎士物語 -光と闇の覚醒- | PS3 | 01.01 | Original, PlayStation 3 the Best | | BCJS 30042 … | |
| Star Ocean: The Last Hope International スターオーシャン4 -THE LAST HOPE- INTERNATIONAL | PS3 | 01.00 | Original, Ultimate Hits | | BCKS 10106 … | |
| Sotsugyou: Graduation 卒業 グラデュエーション | MAC | | Original | | BCRM-0012 | |
| Sports Champions / Medieval Moves: Deadmund's Quest Combo Disc | PS3 | 01.00 | Not for Resale | | BCUS-90490 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Bundled with Bluetooth Headset | | BCUS-98152 | |
| Sports Champions | PS3 | 01.01 | Bundled with PlayStation Move | | BCUS-98177 | |
| Sports Champions | PS3 | 01.01 | Original, Bundled with PlayStation Move | | BCUS-98177 | |
| SOCOM: U.S. Navy SEALs: Confrontation | PS3 | 01.00 | Original | | BCUS-98183 | |
| Sly Cooper: Thieves in Time | PS3 | 01.02 | Original | | BCUS-98247 | |
| Sports Champions 2 | PS3 | 01.00 | Original | | BCUS-98278 | |
| Sid Meier's Civilization III | PC | 1.07f | Small Box Release | | BIPCIV3CDRV1 | |
| The Simpsons Game | PS3 | 01.00 | Original | | BLAS 50033 … | |
| Sonic's Ultimate Genesis Collection | PS3 | 01.00 | Original, Greatest Hits | | BLAS 50098 … | |
| Shin Sangoku Musou 5: Empires 真・三國無雙5 Empires | PS3 | 01.00 | Original | | BLAS 50115 | |
| Shin Sangoku Musou 6 真・三國無雙6 | PS3 | 01.01 | Original | | BLAS 50308 | |
| Sengoku Musou 3: Empires 戦国無双3 Empires | PS3 | 01.01 | Original | | BLAS 50364 … | |
| Street Fighter X Tekken ストリートファイター Ⅹ 鉄拳 | PS3 | 01.01 | Original | | BLAS 50455 … | |
| Shin Rorona no Atelier: Hajimari no Monogatari: Arland no Renkinjutsushi 新・ロロナのアトリエ はじまりの物語 ~アーランドの錬金術士~ | PS3 | 01.02 | Original | | BLAS 50664 … | |
| Shin Sangoku Musou 7: Empires 真・三國無双7 Empires | PS3 | 01.02 | Original | | BLAS 50743 … | |
| Spider-Man 3 | PS3 | 01.02 | Original | | BLES-00055 | |
| Stuntman: Ignition | PS3 | 01.02 | Original | | BLES-00135 | |
| Sid Meier's Civilization Revolution | PS3 | 01.01 | Original | | BLES-00238 | |
| Silent Hill: Homecoming | PS3 | 01.01 | Original | | BLES-00307 | |
| SBK 08: Superbike World Championship | PS3 | 01.01 | Original | | BLES-00368 | |
| Sega Mega Drive Ultimate Collection | PS3 | 01.00 | Original | | BLES-00475 … | |
| Stormrise | PS3 | 01.00 | Original | | BLES-00513 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition | PS3 | 01.01 | Essentials | | BLES-00678 … | |
| Sengoku Basara: Samurai Heroes | PS3 | 01.00 | Original | | BLES-00832 … | |
| Spider-Man: Shattered Dimensions | PS3 | 01.00 | Original, Promo | | BLES-00946 | |
| Summer Challenge: Athletics Tournament | PS3 | 01.01 | Original | | BLES-01011 … | |
| The Sims 3 | PS3 | 01.00 | Original | | BLES-01016 … | |
| SBK 2011: FIM Superbike World Championship | PS3 | 01.00 | Original | | BLES-01226 | |
| The Sims 3: Pets | PS3 | 01.00 | Original, Limited Edition | | BLES-01368 | |
| Sonic & All-Stars Racing Transformed | PS3 | 01.02 | Original, Essentials, Limited Edition | | BLES-01646 … | |
| Short Peace: Ranko Tsukigime's Longest Day | PS3 | 01.00 | Original | | BLES-02007 | |
| Sniper Elite III: Ultimate Edition | PS3 | 01.01 | Original | | BLES-02145 | |
| Skylanders: Imaginators | PS3 | 01.00 | Starter Pack | | BLES-02240 | |
| Senjou no Valkyria 戦場のヴァルキュリア | PS3 | 01.00 | PlayStation 3 the Best | | BLJM 55008 | |
| Shin Sangoku Musou 5 真・三國無双5 | PS3 | 01.00 | Original, PlayStation 3 the Best | | BLJM 55009 … | |
| Super Street Fighter IV: Arcade Edition スーパーストリートファイターⅣ アーケードエディション | PS3 | 02.01 | Original, PlayStation 3 the Best | | BLJM 55036 … | |
| Senjou no Valkyria 戦場のヴァルキュリア | PS3 | 01.01 | Original | | BLJM 60063 | |
| Shin Sangoku Musou 5: Empires 真・三國無双5 Empires | PS3 | 01.01 | Original | | BLJM 60126 | |
| Street Fighter IV ストリートファイターIV | PS3 | 01.02 | Original | | BLJM 60130 | |
| Shaun White Snowboarding ショーン・ホワイト スノーボード | PS3 | 01.01 | Original, Ubi the Best | | BLJM 60131 … | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | PS3 | 01.04 | Original | | BLJM 60172 | |
| Super Street Fighter IV スーパーストリートファイターIV | PS3 | 01.02 | Original | | BLJM 60203 | |
| Shaun White Skateboarding ショーン・ホワイト スケートボード | PS3 | 01.01 | Original | | BLJM 60289 | |
| Shin Sangoku Musou 6 真・三國無双6 | PS3 | 01.01 | Original | | BLJM 60291 … | |
| Saints Row: The Third セインツロウ ザ・サード | PS3 | 01.01 | Original, Reprint | | BLJM 60396 … | |
| Silent Hill: HD Edition サイレントヒル HD エディション | PS3 | 01.01 | Original | | BLJM 60425 | |
| Steins;Gate: Hiyoku Renri no Darling シュタインズ・ゲート 比翼愛理のだーりん | PS3 | 01.02 | Original, Steins;Gate Double Pack | | BLJM 60464 | |
| Sengoku Basara HD Collection 戦国BASARA HDコレクション | PS3 | 01.00 | Original | | BLJM 60488 | |
| Shin Hokuto Musou 真・北斗無双 | PS3 | 01.03 | Original | | BLJM 60553 | |
| Sengoku-hime 3: Tenka o Kirisaku Hikari to Kage 戦極姫3 ~天下を切り裂く光と影~ | PS3 | 01.01 | Original, Gouka Genteiban, SystemSoft Selection | | BLJM 60555 … | |
| Shin Sangoku Musou 7 真・三國無双7 | PS3 | 01.03 | Original | | BLJM 60586 | |
| Shin Sangoku Musou 6: Moushouden 真・三國無双6 猛将伝 | PS3 | 01.02 | Original | | BLJM 61000 … | |
| Shin Koi-hime Musou: Otome Taisen Sangokushi Engi 真・恋姫†夢想 ~乙女対戦☆三国志演義~ | PS3 | 01.06 | Original | | BLJM 61101 | |
| Sengoku-hime 4: Souhahyakkei, Hana Mamoru Chikai 戦極姫4 ~争覇百計、花守る誓い~ | PS3 | 01.01 | Original, Gouka Genteiban | | BLJM 61103 … | |
| Shin Sangoku Musou 7: Moushouden 真・三國無双7 猛将伝 | PS3 | 01.01 | Original | | BLJM 61128 | |
| Strider Hiryuu ストライダー飛竜 | PS3 | 01.01 | Original | | BLJM 61153 | |
| Shining Resonance シャイニング・レゾナンス | PS3 | 01.00 | Original | | BLJM 61156 … | |
| Shallie no Atelier: Tasogare no Umi no Renkinjutsushi シャリーのアトリエ ~黄昏の海の錬金術士~ | PS3 | 01.01 | Original | | BLJM 61192 | |
| Sengoku Basara 4: Sumeragi 戦国BASARA4 皇 | PS3 | 01.00 | Original | | BLJM 61248 | |
| Sophie no Atelier: Fushigi na Hon no Renkinjutsushi ソフィーのアトリエ ~不思議な本の錬金術士~ | PS3 | 01.01 | Original | | BLJM 61309 | |
| Shin Sangoku Musou: Multi Raid 2: HD Version 真・三國無双 MULTI RAID 2 HD Version | PS3 | 01.01 | Original | | BLJM 85003 … | |
| Spider-Man 3 スパイダーマン3 | PS3 | 01.01 | Original | | BLJS 10008 | |
| Suzumiya Haruhi no Tsuisou 涼宮ハルヒの追想 | PS3 | 01.02 | Original | | BLJS 10109 | |
| Super Robot Taisen OG Saga: Masoukishin III: Pride of Justice スーパーロボット大戦OGサーガ ~魔装機神Ⅲ PRIDE OF JUSTICE~ | PS3 | 01.00 | Original | | BLJS 10223 | |
| Super Robot Taisen OG: The Moon Dwellers スーパーロボット大戦OG ムーン・デュエラーズ | PS3 | 01.00 | Original | | BLJS 10335 | |
| Samurai Dou 3 Plus 侍道3 Plus+ | PS3 | 01.01 | PlayStation 3 the Best | | BLJS 50009 | |
| Samurai Dou 4 Plus 侍道4 Plus+ | PS3 | 02.01 | PlayStation 3 the Best | | BLJS 50021 | |
| Short Peace: Tsukigime Ranko no Ichiban Nagai Hi SHORT PEACE 月極蘭子のいちばん長い日 | PS3 | 01.01 | Original | | BLJS 92001 | |
| Spider-Man: Web of Shadows 스파이더 맨: 웹 오브 쉐도우 | PS3 | 01.00 | Original | | BLKS 20086 … | |
| Stuntman: Ignition | PS3 | 01.02 | Original | | BLUS-30073 | |
| Sid Meier's Civilization Revolution | PS3 | 01.01 | Original | | BLUS-30130 | |
| Silent Hill: Homecoming | PS3 | 01.00 | Original | | BLUS-30169 | |
| Score International Baja 1000: The Official Game | PS3 | 01.00 | Original | | BLUS-30230 | |
| SBK: Superbike World Championship | PS3 | 01.01 | Original | | BLUS-30236 | |
| Ski-Doo Snowmobile Challenge | PS3 | 01.04 | Original | | BLUS-30272 | |
| Stormrise | PS3 | 01.00 | Original | | BLUS-30328 | |
| Spider-Man: Shattered Dimensions | PS3 | 01.01 | Original | | BLUS-30499 | |
| SBK 09: Superbike World Championship SBK: Superbike World Championship | PS3 | 01.01 | Original | | BLUS-30519 | |
| The Sims 3 | PS3 | 01.00 | Original, Greatest Hits | | BLUS-30609 … | |
| SBK X: Superbike World Championship | PS3 | 01.00 | Original | | BLUS-30683 | |
| Spider-Man: Edge of Time | PS3 | 01.00 | Original | | BLUS-30760 | |
| Sonic & All-Stars Racing Transformed | PS3 | 01.01 | Bonus Edition | | BLUS-30839 | |
| Sherlock Holmes: Crimes & Punishments | PS3 | 01.01 | Original | | BLUS-31412 | |
| Sing!! Sega Game Music Presented by B. B. Queens | MCD | | Original | | BVRR-1 | |
| Steel Battalion: Heavy Armor 重鉄騎 STEEL BATTALION | XBOX360 | | Original | | CC-2070 | |
| Shogo: Mobile Armor Division | PC | 1.0 | Original | | CD 651/02 | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | 5 ft. 10 PAK Vol. 2 | | CD 7011 SPI | |
| Star Trek: Starfleet Academy: Strategic Command (Disc 1) | PC | 1.0 | Original | | CD-C95-1044-0 | |
| Star Trek: Starfleet Academy: Strategic Command (Disc 2) | PC | 1.0 | Original | | CD-C95-1044-1 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Interplay Rerelease | | CD-C95-1141-0 | |
| Star Trek: Starfleet Command II: Empires at War (Disc 1) | PC | 1.0.0.2 | Original | | CD-C95-1185-0 | |
| Star Trek: Starfleet Command II: Empires at War (Disc 2) | PC | 1.0.0.2 | Original | | CD-C95-1185-1 | |
| Star Trek: Starfleet Command: Orion Pirates | PC | 2.5.0.0 | Original | | CD-C95-1290-0 | |
| Shogo: Mobile Armor Division | PC | 2.2 | Dual Jewel | | CD-C95-1298-0 | |
| Star Trek Pinball | PC | 1.00 | Covermount | | CD-C95-675-EME | |
| Star Trek: Klingon Academy | PC | 1.0 | Interactive Demo | | CD-C95-856-D1 | |
| Star Trek: Starfleet Academy: Cadet Briefing | PC | 0.99 | Star Trek: Federation Compilation | | CD-C95-893-0 | |
| Star Trek: Judgment Rites | PC | | Star Trek: Federation Compilation | | CD-C95-893-1 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | Star Trek: Federation Compilation | | CD-C95-893-2 | |
| Sacrifice | PC | | Bundle Version MSI OEM | | CD-C951041-MSY4E | |
| Stonekeep | PC | 1.2 | Covermount | | CD-ICD-045-EME | |
| Star Trek: Judgment Rites | PC | | Original, Limited CD-ROM Collector's Edition | | CD-ICD-200-0, CD-ICD-728-2 | |
| Star Trek: Judgment Rites (Collector's Disc) | PC | | Limited CD-ROM Collector's Edition | | CD-ICD-200-1 | |
| Star Trek: 25th Anniversary Enhanced CD-ROM Star Trek: 25th Anniversary | PC | | White Label, White Label: Doubles, Star Trek: Federation Compilation | | CD-ICD-301-0 | |
| Star Trek: Starfleet Command: Gold Edition | PC | 1.02.01 | Covermount | | CD-W581177-DSE | |
| Sanitarium (Disc 1) | PC | 1.0 | Original | | CD090736 | |
| Star Trek: Starfleet Academy: Chekov's Lost Missions | PC | 1.0 | Original | | CD2-W95-846-EUR | |
| Shanghai: Große Momente | PC | | Original | | CDD-3109-04-2 | |
| Sid Meier's Civilization III: Conquests | PC | 1.0 | Original, Scholastic | | CDR9704405 | |
| Space Quest IV: Roger Wilco and the Time Rippers | PC | 1.0 | SoftKey, SierraOriginals | | CDRM SQU344AE-CD, S4840220012ZZ | |
| Software JukeBox: Home & Entertainment Edition: Vol. 1 No. 1 | PC | | Original | | CDRM1006830 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Star Trek: Deep Space Nine: Harbinger: Holosuite Missions | PC | 1.0 | Original, Star Trek Emissary Gift | | CIENPCD043 | |
| Sid Meier's Civilization III | PC | 1.07f | Original, Gold Edition, Limited Edition | | CIVIL3PCUS/A, Part # 04-22252CD, Part No. 04-23072CD1 | |
| Sotsugyou Shashin: Miki 卒業写真 ~美姫~ | PCE | | Original | | CJCD 4005 | |
| Showcase 2000/01 Codemasters PC Demo: New Titles: November 2000 | PC | | Demo | | CLED 0003, MBETCD2200 | |
| Second Sight | XBOX | | Original | | CM-071 | |
| Steel Panthers II: Modern Battles | PC | 1.00 | Original | | CS090345 | |
| Steel Panthers II: Moderne Schlachten | PC | 1.0 | Original, Cash & Carry Collection | | CS090347 | |
| Silent Hunter: Commander's Edition | PC | | Original, SoftKey, Qualitäts-Super Preis Software | | CS090456, PSH844AG-CD | |
| Steel Panthers III: Brigade Command: 1939-1999 | PC | 1.0 | Original | | CS090545 | |
| Sanitarium (Disc 2) | PC | 1.0 | Original | | CS090737 | |
| Sanitarium (Disc 3) | PC | 1.0 | Original | | CS090738 | |
| Screamer 2 Screamer 2: Sheer Speed Road Racing | PC | | Original | | D83011 | |
| SimCity 2000 Special Edition | PC | | Dice | | DCG 006681 | |
| SimIsle: Missions in the Rainforest | PC | | Dice | | DCG 007084 | |
| SimCopter | PC | | Dice | | DCG 007268 | |
| SimEarth SimEarth: The Living Planet | PC | | Dice | | DCG 007305 | |
| SimTower: The Vertical Empire | PC | 1.0 | Dice | | DCG 007343 | |
| SimTown | PC | | Dice | | DCG 008661 | |
| SimSafari | PC | | Dice | | DCG 008685 | |
| Streets of SimCity | PC | | Dice | | DCG 012187, DMM 012194 | |
| SimCity 3000 | PC | | Dice | | DCG 013290 | |
| Syberia | PC | SSV1.0 | Demo | | DEM379CD | |
| STCC 2: Swedish Touring Car Championship | PC | 3.1 | Original | | DGE08903453D | |
| Shikigami no Shiro II 式神の城Ⅱ | GC | | Original | | DL-DOL-G2SJ-JPN | |
| Sonic Gems Collection | GC | | Original, Player's Choice | | DL-DOL-G2XE-USA | |
| Sonic Gems Collection ソニック ジェムズ コレクション | GC | | Original | | DL-DOL-G2XJ-JPN | |
| Sonic Gems Collection | GC | | Original | | DL-DOL-G2XP-EUR | |
| The Sims: Bustin' Out | GC | | Original | | DL-DOL-G4ME-USA | |
| The Sims: Bustin' Out | GC | | Original, Player's Choice | | DL-DOL-G4MP-EUR-01, DL-DOL-G4MP-NOE, DL-DOL-G4MP-UKV | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OE-USA | |
| The Sims 2: Pets | GC | | Original | | DL-DOL-G4OP-EUR | |
| Super Mario Strikers | GC | | Original, Best Seller | | DL-DOL-G4QE-USA | |
| Super Mario Strikers スーパーマリオ ストライカーズ | GC | | Original | | DL-DOL-G4QJ-JPN | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZE-USA | |
| The Sims 2 | GC | | Original | | DL-DOL-G4ZP-EUR | |
| The Sims | GC | | Original, Player's Choice | | DL-DOL-GCIE-USA-01 | |
| The Sims | GC | | Original | | DL-DOL-GCIP-EUR, DL-DOL-GCIP-NOE | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQE-USA | |
| The Simpsons: Hit & Run | GC | | Original, Player's Choice | | DL-DOL-GHQP-EUR | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2E-USA | |
| Spider-Man 2 | GC | | Original | | DL-DOL-GK2P-UKV | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSE-USA | |
| Super Mario Sunshine スーパーマリオサンシャイン | GC | | Original | | DL-DOL-GMSJ-JPN | |
| Super Mario Sunshine | GC | | Original, Player's Choice | | DL-DOL-GMSP-EUR, DL-DOL-GMSP-EUR-01 | |
| Shonen Jump's One Piece: Grand Battle | GC | | Original | | DL-DOL-GOPE-USA | |
| Spider-Man | GC | | Original | | DL-DOL-GSME-USA | |
| Spider-Man | GC | | Original | | DL-DOL-GSMP-EUR, DL-DOL-GSMP-UKV | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOE-USA | |
| Sonic Mega Collection ソニック メガコレクション | GC | | Original | | DL-DOL-GSOJ-JPN | |
| Sonic Mega Collection | GC | | Original, Player's Choice | | DL-DOL-GSOP-EUR, DL-DOL-GSOP-EUR-01 | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPE-USA | |
| The Simpsons: Road Rage | GC | | Original | | DL-DOL-GSPP-EUR | |
| Superman: Shadow of Apokolips | GC | | Original | | DL-DOL-GSUE-USA | |
| SSX on Tour with Mario SSX オン ツアー with マリオ | GC | | Original | | DL-DOL-GXOJ-JPN | |
| Sphinx and the Cursed Mummy | GC | | Original | | DL-DOL-GXPE-USA | |
| Sphinx and the Cursed Mummy | GC | | Original | | DL-DOL-GXPP-EUR, DL-DOL-GXPP-NOE | |
| Super Mario Stadium: Miracle Baseball スーパーマリオスタジアム ミラクルベースボール | GC | | Original | | DL-DOL-GYQJ-JPN | |
| Santa Fe Mysteries: The Elk Moon Murder (Disc 1) | PC | | Dice | | DMM 011143 | |
| Summer Athletics | XBOX360 | | Original | | DT-2002 | |
| The Secret of the Silver Earring Sherlock Holmes: The Secret of the Silver Earring | PC | | Rerelease (DVD-ROM) | | DVD590CD | |
| Sherlock Holmes Chronicles | PC | 1.0 | Original | | DVD732CD | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |
| Shamhat: The Holy Circlet シャムハト -The Holy Circlet- | FMT | | FM-Towns Sen'you, FM-Towns Marty Sen'you | | DWFS3010, DWFT 3012 | |
| The Silent Service: Chinmoku no Kantai 沈黙の艦隊 | FMT | | Original | | DWFT2802 | |
| SimCity 3000 シムシティ3000 | PC | 1.0.557.0 | Original, DigiCube PC, Shokaiban | | DWOKD-00046, EMW-4047 | |
| SimPeople Deluxe シムピープル デラックス | PC | | DigiCube PC | | DWOKD-00085 | |
| Sequence Palladium シークエンス パラディウム | PC | | DigiCube, Media Kite Great Series | | DWRPM-00089, MKW-182 | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| The Sims 3 | XBOX360 | | Original, Classics | | EA-2274 | |
| The Sims 3: Pets ザ・シムズ3 ペット | XBOX360 | | Original, Limited Edition | | EA-2402 | |
| Shogun: Total War: The Mongol Invasion | PC | | Original | | EAE08803486D | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| Söldner-X: Himmelsstürmer | PC | | Limited Edition | | EAS-0002 | |
| Superbike World Championship | PC | | Original | | EAX08801929D | |
| Sid Meier's SimGolf | PC | 1.03 | Original, EA Classics | | EAX08803576D | |
| Secret Files: Tunguska | PC | 1.03 | Original, Xplosiv | | ECD008099M 00060722-01, XP-2221 3026412 | |
| Sega Rally 2 (Disc 1) (Install Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-1 | |
| Sega Rally 2 (Disc 2) (Play Disc) Sega Rally 2: Sega Rally Championship | PC | | Original, Xplosiv | | EI-1183-2 | |
| Sudden Strike 3: Arms for Victory | PC | 1.0 | Original | | EI-2238 ML02 | |
| SimPeople Kanzenban (Disc 1) シムピープル 完全版 | PC | 1.44 | SimPeople Kanzenban 3, SimPeople Kanzenban | | EMW-4110, EMW-4160 | |
| SimPeople Kanzenban (Disc 2) シムピープル 完全版 | PC | 1.44 | SimPeople Kanzenban 3, SimPeople Kanzenban | | EMW-4110, EMW-4160 | |
| SimCity 4 Deluxe (Disc 1) シムシティ4 デラックス | PC | 1.1.613.0 | Original | | EMW-4134 | |
| SimCity 4 Deluxe (Disc 1) シムシティ4 デラックス | PC | 1.1.613.0 | Original, EA Best Hits | | EMW-4134 | |
| SimCity 4 Deluxe (Disc 2) シムシティ4 デラックス | PC | 1.1.613.0 | Original, EA Best Hits | | EMW-4134 | |
| Sesame Street: Elmo's Reading: Preschool and Kindergarten (Disc 1) (Reading Basics) | PC | | Original | | EPK-744AE-CD1 | |
| Speed Busters BGamer 045 (Disc 1) | PC | 1.01 | Focus Essential, Covermount | | ESS262 | |
| Saban's Power Rangers: Time Force | PC | | PC Fun Club, THQ Double Pack (Focus Essential) | | ESS589, PFC024/D | |
| Shin Nihon Pro Wrestling: '94 Battlefield in Tokyo Dome 新日本プロレスリング ’94バトルフィールド in 闘強導夢 | PCE | | Original | | FCCD4001 | |
| Sega Rally Championship PC | PC | 2.11 | Fair Game, Grabit | | FG-1282, GDL016 | |
| Shinjuku Labyrinth 新宿ラビリンス | FMT | | Original | | FMSC0030 | |
| Sniper Elite V2: Silver Star Edition Sniper Elite V2: Game of the Year Edition | XBOX360 | | Original | | FO-2024 | |
| Sniper Elite III: Ultimate Edition | XBOX360 | | Original | | FO-2051 | |
| The Simpsons: Virtual Springfield | PC | 1.0 | Original | | FXE08701727D | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Demonstration-ban, Bundled with Magazine (4 Character Demo Disc) | | FZ-JJ9DSX-4I | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Wing Commander スーパー・ウイング・コマンダー | 3DO | | Original | | FZ-SJ1653 | |
| Shock Wave: Operation JumpGate ショック・ウェーブ ~オペレーション・ジャンプゲート~ | 3DO | | Original | | FZ-SJ1665 | |
| Short Warp: Warp's Short Game Collection ショート・ワープ | 3DO | | Original | | FZ-SJ2357 | |
| Star Control II: The Ur-Quan Masters スター・コントロールⅡ ~ア・クアン・マスターを打倒せよ!~ | 3DO | | Original | | FZ-SJ3153 | |
| Samurai Shodown サムライ・ショーダウン | 3DO | | Original | | FZ-SJ3155 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Original, Power-Up Campaign | | FZ-SJ3851 | |
| Sento Monogatari: Sono I 「占都物語」 そのⅠ | 3DO | | Original | | FZ-SJ4054 | |
| Super Real Mahjong PIV + Aishou Shindan スーパーリ・アル麻雀PⅣ+相性診断 | 3DO | | Original | | FZ-SJ6451 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Seima Densetsu 3x3 Eyes 聖魔伝説 3×3EYES | MCD | | Original | | G-6007, GD0004JG | |
| SimEarth シムアース | MCD | | Original | | G-6008 | |
| Sega Classic Arcade Collection: Limited Edition セガクラシック | MCD | | Original | | G-6012 | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Original | | GAG744AE-CD | |
| Super Solvers: Gizmos & Gadgets! | PC | 1.1 | Original | | GAG744AE-CD | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Space Sniper Maya (Disc 1) スペーススナイパー マヤ | PC | | Original | | GOR-0004 1/2 | |
| Space Sniper Maya (Disc 2) スペーススナイパー マヤ | PC | | Original | | GOR-0004 2/2 | |
| Shinsetsu Yumemi Yakata: Tobira no Oku ni Dareka ga... 真説・夢見館 扉の奥に誰かが… | SS | 1.000 | Original | | GS-9005 | |
| SimCity 2000 シムシティ2000 | SS | 1.041 | Original | | GS-9027 | |
| Sega Rally Championship セガラリー・チャンピオンシップ | SS | 1.000 | Original | | GS-9047 | |
| Shining Wisdom シャイニング・ウィズダム | SS | 1.000 | Original | | GS-9057 | |
| Shining Wisdom シャイニング・ウィズダム | SS | 1.000 | Original | | GS-9057 | |
| Sega Rally Championship Plus セガラリー・チャンピオンシップ・プラス | SS | 1.000 | Original, Satakore | | GS-9116, GS-9149 | |
| Shin Seiki Evangelion: 2nd Impression 新世紀エヴァンゲリオン ~セカンド・インプレッション~ | SS | 1.012 | Original | | GS-9129 | |
| Shin Seiki Evangelion: 2nd Impression 新世紀エヴァンゲリオン ~セカンド・インプレッション~ | SS | 1.012 | Original | | GS-9129 | |
| Sakura Taisen: Hanagumi Tsuushin サクラ大戦 ~花組通信~ | SS | 1.009 | Original | | GS-9134 | |
| Sakura Taisen: Hanagumi Tsuushin サクラ大戦 ~花組通信~ | SS | 1.009 | Original | | GS-9134 | |
| Sakura Taisen: Hanagumi Taisen Columns サクラ大戦 ~花組対戦コラムス~ | SS | 1.000 | Original | | GS-9138 | |
| Sonic Jam ソニック・ジャム | SS | 1.005 | Original | | GS-9147 | |
| Sega Ages: Columns Arcade Collection セガエイジス コラムス・アーケード・コレクション | SS | 1.008 | Original | | GS-9161 | |
| Sega Ages: Memorial Selection Vol. 2 セガエイジス メモリアル・セレクションVOL.2 | SS | 1.000 | Original | | GS-9163 | |
| Sega Touring Car Championship セガ・ツーリングカー・チャンピオンシップ | SS | 1.003 | Original | | GS-9164 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.002 | Shokai Tokutenban | | GS-9169 | |
| Sega Ages: I Love Mickey Mouse: Fushigi no Oshiro Daibouken & I Love Donald Duck: Georgia Ou no Hihou セガエイジス アイ・ラブ・ミッキー・マウス ~ふしぎのお城 大冒険~ / アイ・ラブ・ドナルド・ダック ~グルジア王の秘宝~ | SS | 1.000 | Original | | GS-9179 | |
| Shoujo Kakumei Utena: Itsuka Kakumei Sareru Monogatari (Disc 1) 少女革命ウテナ ~いつか革命される物語~ | SS | 1.001 | Original | | GS-9182 | |
| Shoujo Kakumei Utena: Itsuka Kakumei Sareru Monogatari (Disc 2) 少女革命ウテナ ~いつか革命される物語~ | SS | 1.001 | Original | | GS-9182 | |
| Shining Force III: Scenario 2: Nerawareta Miko シャイニング・フォースⅢ シナリオ2 ~狙われた神子~ | SS | 1.003 | Original | | GS-9188 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | SS | 1.004 | Original | | GS-9198 | |
| Sonic Jam ソニック・ジャム | SS | 1.008 | Satakore | | GS-9200 | |
| Sega Rally Championship 세가 랠리 | SS | 1.000 | Original | | GS-9506J | |
| Spy Kids: Mega Mission Zone | PC | 3.6.27 | Original | | H3343 | |
| Seiryuu Densetsu: Monbit 聖竜伝説モンビット | PCE | Rev 1 | Original | | HCD1018 | |
| Super CD-ROM² Taiken Soft Shuu SUPER CD‐ROM² 体験ソフト集 | PCE | | Original | | HCD1027 | |
| SimEarth: The Living Planet シムアース | PCE | | Original | | HCD2040 | |
| Shenmue: Ichishou Yokosuka (Shenmue Passport) シェンムー 一章 横須賀(シェンムーパスポート) | DC | 1.014 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Disc 1) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Disc 2) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Shenmue: Ichishou Yokosuka (Disc 3) シェンムー 一章 横須賀 | DC | 1.007 | Original, Genteiban | | HDR-0016, HDR-0031 | |
| Sega GT: Homologation Special セガGT ホモロゲーションスペシャル | DC | 1.006 | Original | | HDR-0054 | |
| Samba de Amigo サンバDEアミーゴ | DC | 1.000 | Original | | HDR-0063 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.002 | Original, Shokai Genteiban Puru Puru Pack Fuzoku Set | | HDR-0082, HDR-0108 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Preview Disc サクラ大戦3 ~巴里は燃えているか~ プレビュウディスク | DC | 1.001 | DC Game Bundle | | HDR-0082, HDR-0108 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 1) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 2) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Sakura Taisen 3: Paris wa Moeteiru ka (Disc 3) サクラ大戦3 ~巴里は燃えているか~ | DC | 1.003 | Original, Shokai Genteiban A, Shokai Genteiban B, Memorial Pack, Sakura Wars Complete Box | | HDR-0147, HDR-0148, HDR-0152, HDR-0194, HDR-0201 | |
| Shenmue II (Disc 1) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 2) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 3) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Shenmue II (Disc 4) シェンムーⅡ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0164, HDR-0179 | |
| Sakura Taisen 4: Koi seyo Otome: Preview Disc サクラ大戦4 ~恋せよ乙女~ プレビュウDisc | DC | 1.001 | DC Game Bundle | | HDR-0184, HDR-0189 | |
| Sakura Taisen 3: Paris wa Moeteiru ka: Drama Download Disc サクラ大戦3 ~巴里は燃えているか~ ドラマダウンロードディスク | DC | 1.000 | Original, Shokai Genteiban, Sakura Wars Complete Box | | HDR-0191, HDR-0201, HDR-0202 | |
| Sakura Taisen 4: Koi seyo Otome サクラ大戦4 ~恋せよ乙女~ | DC | 1.003 | Original, Shokai Genteiban | | HDR-0191, HDR-0202 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 1) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 2) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Disc 3) サクラ大戦2 ~君、死にたもうことなかれ~ | DC | 1.005 | Memorial Pack, Sakura Wars Complete Box | | HDR-0193, HDR-0201 | |
| Super Odyssey & Dennou Planetarium スーパー・オデッセイ&電脳プラネタリウム | FMT | | Original | | HMA-237 | |
| SimCity シム・シティ | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 13 | | HMC-127 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | | Original | | HMC-139 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev B | Original | | HMC-139B | |
| SimEarth: The Living Planet シムアース | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 15 | | HMC-141 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | | Original | | HMC-157 | |
| Super Shooting Towns スーパー・シューティングTOWNS | FMT | | Original | | HMC-191 | |
| Sherlock Holmes: Consulting Detective | FMT | | Demonstration-ban | | HMC-901 | |
| Seiya Monogatari: Anearth Fantasy Stories 聖夜物語 | PCE | | Bundled with Book (Dengeki PC Engine Special Edition - Taikenban) | | HMD-0004 | |
| Super Real Mahjong PII & PIII スーパー・リアル麻雀PⅡ&PⅢ | FMT | | Ving Vol. 11 | | HMD-126 | |
| Sekigahara 関ヶ原 | FMT | | Original | | HMD-128 | |
| Sangokushi III 三國志Ⅲ | FMT | | with Soundware | | HMD-131 | |
| Shadow of the Beast II: Juushin no Jubaku シャドー・オブ・ザ・ビーストⅡ ~獣神の呪縛~ | FMT | | Original | | HMD-184 | |
| Software Contest Nyuusen Sakuhinshuu 2 ソフトウェア・コンテスト 入選作品集 2 | FMT | | Original | | HMD-189 | |
| SimAnt | FMT | | Original | | HME-104 | |
| Secre Volume 2: Mai Oikawa SECRE VOLUME ② 「及川 麻衣」 | FMT | | Original | | HME-180 | |
| Stronghold: Emperor no Yousai ストロングホールド ~皇帝の要塞~ | FMT | | Ving Marty Taiou Vol. 8 | | HMF-133 | |
| Sangokushi IV 三國志Ⅳ | FMT | | with Soundware | | HMF-139 | |
| Super Street Fighter II: The New Challengers スーパー・ストリート・ファイターⅡ | FMT | 941011 | CD-ROM-ban (Shokai Gentei: 6-button Pad-tsuki) | | HMF-162 | |
| Starry Sky: In Summer Portable Starry☆Sky ~in Summer~ Portable | PSP | 1.02 | Original, Shokai Genteiban | | HONEY-002, … | |
| Starry Sky: In Winter Portable Starry☆Sky ~In Winter~ Portable | PSP | 1.01 | Original, Shokai Genteiban | | HONEY-004, … | |
| Spy Kids 3-D: Game Over | PC | | Original | | I6100 | |
| Sol Moonarge ソル:モナージュ | PCE | | Original, Meisaku Genteiban | | ICCD3004 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 1) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| Sacred: La Leggenda dell'Arma Sacra (Disco 2) | PC | 1.6.66 | FX Interactive | | IT v.1.6.66 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | PCE | | Original | | JCCD1004 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | PCE | | Original | | JCCD2008 | |
| Sherlock Holmes: Consulting Detective: Vol. II シャーロック・ホームズの探偵講座Ⅱ | PCE | | Original | | JCCD3012 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Suzuki Alstare: Extreme Racing | PC | | Bundle Version Tiny OEM | | KDGT6 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 1) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04060 | |
| Sequence Palladium 3: Utakata no Ametsuchi (Disc 2) シークエンス・パラディウム3 ~泡沫の天地~ | PC | | Original | | KGD-04061 | |
| Sequence Palladium 2: Yami no Shousei シークエンス・パラディウム2 ~闇の笑声~ | PC | 1.0 Build 1049 | Original | | KGD-9990 | |
| Shikigami no Shiro Evolution 式神の城 EVOLUTION | XBOX | | Blue Version, Red Version | | KI-001 | |
| Saints Row IV | XBOX360 | | Original, Commander in Chief Edition | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 1) (Installation Disc) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 2) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Snatcher CD-ROMantic: Pilot Disk スナッチャー・シーディロマンティック パイロット・デイスク | PCE | | Original | | KMCD2001 | |
| Snatcher CD-ROMantic スナッチャー・シーディロマンティック | PCE | | Original | | KMCD2002 | |
| Space Invaders スペースインベーダー | PC | | Yuuyuu 1,480-yen (Publishing Distribution) | | KMK-1210, MKY-055 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Shin Sangoku Musou 2 真・三國無双2 | XBOX | | Original | | KO-003 | |
| Shin Sangoku Musou 3 真・三國無双3 | XBOX | | Original | | KO-004 | |
| Shin Sangoku Musou 4 Special 真‧三國無雙4 Special | XBOX360 | | Original | | KO-2001 | |
| Shin Sangoku Musou 4 Special 真・三國無双4 Special | XBOX360 | | Original | | KO-2001 | |
| Samurai Warriors 2 | XBOX360 | | Original | | KO-2005 | |
| Shin Sangoku Musou 5 真・三國無双5 | XBOX360 | | Original | | KO-2010 | |
| Shin Sangoku Musou 5 真‧三國無雙5 | XBOX360 | | Original | | KO-2020 | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | XBOX360 | | Original | | KO-2028 | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | XBOX360 | | Original | | KO-2033 | |
| Super Mahjong Taikai SUPER 麻雀大会 | PCE | | Original | | KOCD2002 | |
| Shin Sangoku Musou 7 真‧三國無雙7 | XBOX360 | | Original | | KV-2022 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original, World Collection | | LA-011 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | XBOX360 | | Original | | LA-2002 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | XBOX360 | | Original | | LA-2002 | |
| Star Wars: Galactic Battlegrounds: Die Klonkrieg-Kampagnen | PC | | Original, Galactic Battlegrounds Saga | | LAD08903869D | |
| Star Wars: Episode I: Racer スター・ウォーズ エピソード1 レーサー | PC | | Original, EA Best Selections, EA Best Selections (Rerelease) | | LAMW-4001, LAMWB-7001, LAMWB-7004, LAMWD-701 | |
| The Secret of Googol 1a: Reshaping Googol: The Submarine | PSX | | Original | | LSP-020160 … | |
| The Secret of Googol 3: The Googol Counting Fair: Midways | PSX | | Original | | LSP-020260 … | |
| The Secret of Googol 6: Googolfest: Arcade Isle / Moon Feast Isle | PSX | | Original | | LSP-020570 … | |
| Str.at.e.s. 2: Matchamania! | PSX | | Original | | LSP-030102 … | |
| Str.at.e.s. 4: Titlerama! | PSX | | Original | | LSP-030104 … | |
| Star Wars: Behind the Magic: Vehicles Special Edition (Demo) | PC | 1.0 | Collezione CD-Rom by C.T.O. | | LUC633 | |
| Super Daisenryaku SUPER 大戦略 | PCE | | Original | | MCCD 0001 | |
| Saikyou Densetsu: Mahjong Haou 2: Kanzenban 最強伝説 麻雀覇王2 完全版 | PC | 1.04 | Best Selections | | MCM-0004 | |
| Stake: Fortune Fighters | XBOX | | Original | | MD-004 | |
| Super Solvers Mission: T.H.I.N.K. | PC | 1.01 | Original | | MEM744BE-CD | |
| Syberia | XBOX | | Original | | MI-006 | |
| Sonic CD | PC | | Original, Family Pack | | MK 85015-50, MK 85086-50 | |
| Sonic & Knuckles Collection | PC | | Original | | MK 85037-50 | |
| Sega Rally Championship PC | PC | 1.0 | Original | | MK 85048-50 | |
| Sega Worldwide Soccer PC | PC | | Original | | MK 85056-50 | |
| Sonic 3D: Flickies' Island | PC | | Original | | MK 85064-50 | |
| Sega Touring Car Championship | PC | 1.0 | Original | | MK 85067-50 | |
| Sonic R | PC | | Original | | MK 85076-50 | |
| Sonic Adventure | DC | 1.003 | Original | | MK-51000-50 | |
| Sega Rally 2 Sega Rally 2: Sega Rally Championship | DC | 1.001 | Original | | MK-51019-50 | |
| Shenmue II (Disc 1) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 2) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 3) | DC | 1.001 | Original | | MK-51184-50 | |
| Shenmue II (Disc 4) | DC | 1.001 | Original | | MK-51184-50 | |
| Sega Rally 2 (Install Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sega Rally 2 (Play Disc) Sega Rally 2: Sega Rally Championship | PC | 2.0.0.2 | Original | | MK-85078-40 | |
| Sonic 3D: Flickies' Island | SS | 1.000 | Original | | MK81062-50 | |
| Sonic Jam | SS | 1.000 | Original | | MK81079-50 | |
| Shinobi-X: Shin Shinobi Den | SS | 1.000 | Original | | MK81082-50 | |