Region | Title | System | Version | Edition | Languages | Serial | Status |
| Spider-Man 3 | XBOX360 | | Original | | AV-2018 | |
| Spider-Man: Edge of Time | XBOX360 | | Original | | AV-2226 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Splatterhouse | XBOX360 | | Original | | NM-2032 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | XBOX360 | | Original | | LA-2002 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | XBOX360 | | Original | | LA-2002 | |
| Steel Battalion: Heavy Armor 重鉄騎 STEEL BATTALION | XBOX360 | | Original | | CC-2070 | |
| Stormrise | XBOX360 | | Original | | SE-2054 | |
| Stuntman: Ignition | XBOX360 | | Original | | TQ-2036 | |
| Summer Athletics | XBOX360 | | Original | | DT-2002 | |
| Supremacy MMA | XBOX360 | | Original | | FO-2020 | |
| Supreme Commander 2 | XBOX360 | | Original | | SQ-2019 | |
| Sabre Team | CD32 | | Original | | | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| The Seven Gates of Jambala | CD32 | | Original | | | |
| Simon the Sorcerer | CD32 | | Original | | | |
| Summer Olympix | CD32 | | Original | | | |
| Super Skidmarks | CD32 | 2.2 | Original | | | |
| SimCity | CDTV | | Original | | 91133 | |
| Samurai Spirits ~ Samurai Shodown サムライ・スピリッツ | NGCD | | Original | | NGCD-045 | |
| Samurai Spirits: Amakusa Kourin ~ Samurai Shodown IV: Amakusa's Revenge サムライ・スピリッツ ~天草降臨~ | NGCD | | Original | | NGCD-222, NGCD-222E | |
| Samurai Spirits: Zankurou Musouken ~ Samurai Shodown III サムライ・スピリッツ 斬紅郎無双剣 | NGCD | | Original | | NGCD-087, NGCD-087E | |
| Shin Samurai Spirits: Haoumaru Jigokuhen ~ Samurai Shodown II 真サムライ・スピリッツ ~覇王丸地獄変~ | NGCD | | Original | | NGCD-063, NGCD-063E | |
| Shinsetsu Samurai Spirits: Bushidou Retsuden 真説サムライ・スピリッツ ~武士道烈伝~ | NGCD | | Original | | NGCD-0850 | |
| Shougi no Tatsujin: Master of Syougi 将棋の達人 | NGCD | | Original | | ADCD-010 | |
| Stakes Winner: GI Kanzen Seiha e no Michi ステークス・ウィナー ~GI完全制覇への道~ | NGCD | | Original | | NGCD-088 | |
| Samurai Shodown サムライ・ショーダウン | 3DO | | Original | | FZ-SJ3155 | |
| Samurai Shodown | 3DO | | Original | | | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Sento Monogatari: Sono I 「占都物語」 そのⅠ | 3DO | | Original | | FZ-SJ4054 | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Shock Wave: Operation JumpGate ショック・ウェーブ ~オペレーション・ジャンプゲート~ | 3DO | | Original | | FZ-SJ1665 | |
| Shock Wave: Operation JumpGate | 3DO | | Original | | | |
| Short Warp: Warp's Short Game Collection ショート・ワープ | 3DO | | Original | | FZ-SJ2357 | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Slam 'n Jam '95 スラム・ジャム ~3Dバスケットボール~ | 3DO | | Original | | FZ-SJ3156, GDT-GA271 | |
| Slam 'n Jam '95 | 3DO | | Original | | 60140-C | |
| Slam 'N Jam '95 | 3DO | | Original | | | |
| Star Control II: The Ur-Quan Masters スター・コントロールⅡ ~ア・クアン・マスターを打倒せよ!~ | 3DO | | Original | | FZ-SJ3153 | |
| Starblade 스타블레이드 | 3DO | | Original | | FZ-SM5351, GDT-GA221 | |
| Strahl | 3DO | | Original | | FZ-SM4651 | |
| Super Real Mahjong PIV + Aishou Shindan スーパーリ・アル麻雀PⅣ+相性診断 | 3DO | | Original | | FZ-SJ6451 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Original, Power-Up Campaign | | FZ-SJ3851 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Demonstration-ban, Bundled with Magazine (4 Character Demo Disc) | | FZ-JJ9DSX-4I | |
| Super Wing Commander スーパー・ウイング・コマンダー | 3DO | | Original | | FZ-SJ1653 | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| SD Gundam: Daizukan SDガンダム ~大図鑑~ | QIS | | Original | | BAPD-03 | |
| Sangokushi III 三國志Ⅲ | FMT | | with Soundware | | HMD-131 | |
| Sangokushi IV 三國志Ⅳ | FMT | | with Soundware | | HMF-139 | |
| Scavenger 4 スカベンジャー4 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217 | |
| Scavenger 4 スカベンジャー4 | FMT | Rev B | FM Towns Soft Collection Kaigai-hen Vol. 39 | | HME-217B | |
| Secre Volume 2: Mai Oikawa SECRE VOLUME ② 「及川 麻衣」 | FMT | | Original | | HME-180 | |
| Sekigahara 関ヶ原 | FMT | | Original | | HMD-128 | |
| Shadow of the Beast II: Juushin no Jubaku シャドー・オブ・ザ・ビーストⅡ ~獣神の呪縛~ | FMT | | Original | | HMD-184 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | | Original | | HMC-157 | |
| Shamhat: The Holy Circlet シャムハト -The Holy Circlet- | FMT | | FM-Towns Sen'you, FM-Towns Marty Sen'you | | DWFS3010, DWFT 3012 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 13 | | HMC-127 | |
| Sherlock Holmes: Consulting Detective | FMT | | Demonstration-ban | | HMC-901 | |
| Shinjuku Labyrinth 新宿ラビリンス | FMT | | Original | | FMSC0030 | |
| The Silent Service: Chinmoku no Kantai 沈黙の艦隊 | FMT | | Original | | DWFT2802 | |
| SimAnt | FMT | | Original | | HME-104 | |
| SimCity シム・シティ | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121 | |
| SimEarth: The Living Planet シムアース | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 15 | | HMC-141 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | | Original | | HMC-139 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev B | Original | | HMC-139B | |
| Software Contest Nyuusen Sakuhinshuu 2 ソフトウェア・コンテスト 入選作品集 2 | FMT | | Original | | HMD-189 | |
| Space Rogue スペース・ローグ | FMT | | Original | | HMB-180 | |
| Stronghold: Emperor no Yousai ストロングホールド ~皇帝の要塞~ | FMT | | Ving Marty Taiou Vol. 8 | | HMF-133 | |
| Super Odyssey & Dennou Planetarium スーパー・オデッセイ&電脳プラネタリウム | FMT | | Original | | HMA-237 | |
| Super Real Mahjong PII & PIII スーパー・リアル麻雀PⅡ&PⅢ | FMT | | Ving Vol. 11 | | HMD-126 | |
| Super Shooting Towns スーパー・シューティングTOWNS | FMT | | Original | | HMC-191 | |
| Super Street Fighter II: The New Challengers スーパー・ストリート・ファイターⅡ | FMT | 941011 | CD-ROM-ban (Shokai Gentei: 6-button Pad-tsuki) | | HMF-162 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Sesame Street: Numbers | MAC | | Original | | 691-0759-A, 743807A | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| Sotsugyou: Graduation 卒業 グラデュエーション | MAC | | Original | | BCRM-0012 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Shaolin's Road | CDI | | Original | | SHAOLM24011 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2, 699 011-2, 812 0031 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Solar System | CDI | 1.10 | Original | | 811 0039 | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2, 699 025-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| The Story of Samson | CDI | | Original, Demonstration Disc | | 310-690-190-2, 310690190-2 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |