Region | Title | System | Version | Edition | Languages | Serial | Status |
| Star Wars: Republic Commando | PC | | Original | | 3258130, 3258130R | |
| Stormrise | PC | 1.0 | Original | | SEGA-PC089 | |
| Sudden Strike 3: Arms for Victory | PC | 1.0 | Original | | EI-2238 ML02 | |
| Sam & Max: The Devil's Playhouse Sam & Max: Season Three | PC | 2.0.0.0 | Original | | | |
| The Settlers 7: Paths to a Kingdom | PC | | Original, Ubisoft Exclusive Think | | 300028951 | |
| Sid Meier's Civilization V: Gold Edition | PC | | Original | | 41252-1 | |
| Silent Hill: Homecoming | PC | | Original | | SHH/DVD/D-2523 | |
| The Sims 3 | PC | | Original | | MXX09205932D, MXX09205932D/GER | |
| The Sims 3 | PC | 1.0.631.00002 | Original | | MXX09205932D, MXX09205932D/AUS | |
| The Sims 3 | PC | 1.0.631.00001, 0.0.0.11195 | Original, The Sims 3: Deluxe | | 1539007 | |
| The Sims 3 | PC | 1.42.130.019037 | The Sims 3 Starter Pack | | 1539003301 | |
| The Sims 3 ザ・シムズ3 | PC | 1.42.130.019001 | The Sims 3 Plus Seasons, EA Best Hits | | 1539027, 15390BEPWNJP | |
| The Sims 3: Ambitions (Expansion Pack) | PC | | Original, Commemorative Edition, The Sims 3: Deluxe | | 1693207, 1945307, MXX09207406D | |
| The Sims 3: Generations (Expansion Pack) | PC | 1.0.0.1 | Original, The Sims 3 Expansion Bundle | | 1957307 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | The Sims 10th Anniversary | | 1941507 | |
| The Sims 3: High-End Loft Stuff | PC | 0.2.0.84 | Original, The Sims 3 Starter Pack | | 1941517, MXX09207146D | |
| The Sims 3: Into the Future (Expansion Pack) | PC | 1.0.0.1 | Original, Limited Edition | | 7308903401 | |
| The Sims 3: Late Night (Expansion Pack) | PC | 0.2.0.125 | Original, The Sims 3 Starter Pack | | 1915003301 | |
| The Sims 3: Pets (Expansion Pack) | PC | | Original, Limited Edition | | 1962207 | |
| The Sims 3: Showtime (Expansion Pack) ザ・シムズ3 ショータイムデータセット | PC | 1.0.0.1 | Original, Collector's Edition | | 1969007, 19690EPWNJP, 1979907 | |
| The Sims 3: Supernatural (Expansion Pack) ザ・シムズ3 スーパーナチュラルデータセット | PC | | Original, Limited Edition | | 1978103301, 19781EPWNJP | |
| The Sims 3: World Adventures The Sims 3: Мир Приключений | PC | | Original | | MXX09207028D | |
| The Sims 3: World Adventures (Expansion Pack) | PC | 0.2.0.56 | Original, The Sims 3 Expansion Bundle | | 1539307 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Original, Limited Edition | | 100255103301, 100255103311 | |
| The Sims 4 (Disc 1) | PC | 1.0 | Limited Edition | | 7303703301, 7303703303 | |
| The Sims Medieval | PC | 1.0.286.00001 | Original, Limited Edition, Collector's Edition | | MXX09207555D, MXX09208224D, MXX09208231D | |
| The Sims Medieval | PC | 1.0.286.00001 | Limited Edition | | 1945407 | |
| Spider-Man: Web of Shadows | PC | 1.0 | Original | | 33211.101.EF, 33211.101.US | |
| Split/Second Split/Second: Velocity | PC | | Original | | 8004905, SYX26187GM | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | PC | | Original | | 3578210100 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | | Original | | 3578210200 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | PC | 0.0.0.0 | Original | | 12241-1DDA | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | PC | 0.0.0.0 | Original | | 12241-1DDA2 | |
| Supreme Commander: Forged Alliance | PC | 1.5.0.1 | Original, Gold Edition | | 111603 | |
| Sangokushi: Eiketsu Tenka ni Nozomu 三国志 ~英傑天下に臨む~ | PCE | | Original | | NXCD0002 | |
| Seiryuu Densetsu: Monbit 聖竜伝説モンビット | PCE | Rev 1 | Original | | HCD1018 | |
| Seiya Monogatari: Anearth Fantasy Stories 聖夜物語 | PCE | | Bundled with Book (Dengeki PC Engine Special Edition - Taikenban) | | HMD-0004 | |
| Sexy Idol Mahjong セクシー・アイドル麻雀 | PCE | | Original | | NBCD3004 | |
| Sexy Idol Mahjong: Fashion Monogatari セクシー・アイドルま~じゃん ~ファッション物語~ | PCE | | Original | | NBCD4006 | |
| Sexy Idol Mahjong: Yakyuuken no Uta セクシー・アイドル麻雀 ~野球拳の詩~ | PCE | | Original | | NBCD4007 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | PCE | | Original | | JCCD2008 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | PCE | | Original | | JCCD1004 | |
| Sherlock Holmes: Consulting Detective | PCE | | Original | | TGXCD1011 | |
| Sherlock Holmes: Consulting Detective: Vol. II シャーロック・ホームズの探偵講座Ⅱ | PCE | | Original | | JCCD3012 | |
| Shin Nihon Pro Wrestling: '94 Battlefield in Tokyo Dome 新日本プロレスリング ’94バトルフィールド in 闘強導夢 | PCE | | Original | | FCCD4001 | |
| SimEarth: The Living Planet シムアース | PCE | | Original | | HCD2040 | |
| Snatcher CD-ROMantic スナッチャー・シーディロマンティック | PCE | | Original | | KMCD2002 | |
| Snatcher CD-ROMantic: Pilot Disk スナッチャー・シーディロマンティック パイロット・デイスク | PCE | | Original | | KMCD2001 | |
| Sol Moonarge ソル:モナージュ | PCE | | Original, Meisaku Genteiban | | ICCD3004 | |
| Sotsugyou Shashin: Miki 卒業写真 ~美姫~ | PCE | | Original | | CJCD 4005 | |
| Space Invaders: The Original Game スペース・インベーダー | PCE | | Original | | NAPR-1050 | |
| Spriggan Mark 2: Re Terraform Project スプリガン・マーク2 | PCE | | Original, Meisaku Genteiban | | NXCD2008 | |
| Star Mobile スター・モビール | PCE | | Original | | NXCD2013 | |
| Startling Odyssey II: Maryuu Sensou スタートリング・オデッセイⅡ ~魔竜戦争~ | PCE | | Original | | RFCD4003 | |
| Summer Carnival '92: Alzadick サマー・カーニバル’92 「アルザディック」 | PCE | | Original | | NXCD2012 | |
| Super CD-ROM² Taiken Soft Shuu SUPER CD‐ROM² 体験ソフト集 | PCE | | Original | | HCD1027 | |
| Super Daisenryaku SUPER 大戦略 | PCE | | Original | | MCCD 0001 | |
| Super Mahjong Taikai SUPER 麻雀大会 | PCE | | Original | | KOCD2002 | |
| Super Real Mahjong PII·III Custom スーパー・リアル麻雀PⅡ・Ⅲカスタム | PCE | | Original | | NXCD4030 | |
| Super Real Mahjong PIV Custom スーパー・リアル麻雀PⅣカスタム | PCE | | Original | | NXCD3027 | |
| Super Real Mahjong Special: Miki Kasumi Shouko no Omoide yori スーパー・リアル麻雀スペシャル ~ミキ・カスミ・ショウコの思い出より~ | PCE | | Original | | NXCD2016 | |
| Shinpi no Sekai El-Hazard: El-Hazard: The Magnificent World 神秘の世界エルハザード | PC-98 | | Original | | 21D-2077 | |
| Sorcer Kingdom ソーサル・キングダム | PC-98 | | Original | | AYPIO-001 | |
| Second Sight | XBOX | | Original | | CM-071 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Sega GT 2002 + JSRF: Jet Set Radio Future | XBOX | | Bundled with Xbox | | MS-061 | |
| Serious Sam II | XBOX | | Original | | TT-013 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shenmue II | XBOX | | Original | | MS-050 | |
| Shikigami no Shiro 式神の城 | XBOX | | Original, Shokai Genteiban | | MP-002 | |
| Shikigami no Shiro Evolution 式神の城 EVOLUTION | XBOX | | Blue Version, Red Version | | KI-001 | |
| Shin Sangoku Musou 2 真・三國無双2 | XBOX | | Original | | KO-003 | |
| Shin Sangoku Musou 3 真・三國無双3 | XBOX | | Original | | KO-004 | |
| Sid Meier's Pirates! | XBOX | | Original | | TT-143 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Hill 4: The Room | XBOX | | Original | | KN-031 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| Silent Scope Complete | XBOX | | Original | | KN-026 | |
| The Simpsons: Hit & Run | XBOX | | Original, Classics | | VU-021 | |
| The Simpsons: Hit & Run | XBOX | | Original, Platinum Hits, World Collection | | VU-021 | |
| The Simpsons: Road Rage | XBOX | | Platinum Hits | | EA-019 | |
| The Sims: Bustin' Out | XBOX | | Original | | EA-067 | |
| Sneak King | XBOX | | Original | | MS-211 | |
| Sonic Mega Collection Plus ソニック メガコレクション プラス | XBOX | | Original, Classics | | SE-060 | |
| Soulcalibur II | XBOX | | Original | | NM-003 | |
| Soulcalibur II | XBOX | | Original, Platinum Hits | | NM-003 | |
| Sphinx and the Cursed Mummy | XBOX | | Original | | TQ-035 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man | XBOX | | Original | | AV-006 | |
| Spider-Man 2 | XBOX | | Original | | AV-043 | |
| Spider-Man 2 스파이더맨 2 | XBOX | | Original | | AV-043 | |
| Splat Magazine Renegade Paintball | XBOX | | Original | | TT-147 | |
| Stake: Fortune Fighters | XBOX | | Original | | MD-004 | |
| Star Trek: Shattered Universe | XBOX | | Original | | TM-016 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original, World Collection | | LA-011 | |
| Star Wars: Jedi Knight: Jedi Academy | XBOX | | Original | | LA-011 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original | | LA-019 | |
| Star Wars: Republic Commando | XBOX | | Original, Platinum Hits | | LA-019 | |
| Stubbs the Zombie in Rebel Without a Pulse | XBOX | | Original | | AY-002 | |
| Sudeki 魔幻戰士 | XBOX | | Original | | MS-010 | |
| The Suffering | XBOX | | Original | | MW-021 | |
| The Suffering: Ties That Bind | XBOX | | Original | | MW-044 | |
| Superman: The Man of Steel | XBOX | | Original | | IG-022 | |
| Syberia | XBOX | | Original | | MI-006 | |
| Saints Row | XBOX360 | | Demo | | IM-2022 | |
| Saints Row IV | XBOX360 | | Original, Commander in Chief Edition | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 1) (Installation Disc) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row IV: National Treasure Edition (Disc 2) Saints Row IV: Game of the Century Edition | XBOX360 | | Original | | KM-2038 | |
| Saints Row: Gat out of Hell | XBOX360 | | Original | | KM-2048 | |
| Samurai Spirits Sen サムライスピリッツ閃 | XBOX360 | | Original | | SN-2005 | |
| Samurai Warriors 2 | XBOX360 | | Original | | KO-2005 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Scene It? Box Office Smash! | XBOX360 | | Original | | MS-2144 | |
| Score International Baja 1000: World Championship Off Road Racing Score International Baja 1000: The Official Game | XBOX360 | | Original | | AV-2083 | |
| ScreamRide | XBOX360 | | Original | | MS-2726 | |
| Sega Mega Drive Ultimate Collection | XBOX360 | | Original, Classics | | SE-2085 | |
| Shin Sangoku Musou 4 Special 真‧三國無雙4 Special | XBOX360 | | Original | | KO-2001 | |
| Shin Sangoku Musou 4 Special 真・三國無双4 Special | XBOX360 | | Original | | KO-2001 | |
| Shin Sangoku Musou 5 真‧三國無雙5 | XBOX360 | | Original | | KO-2020 | |
| Shin Sangoku Musou 5 真・三國無双5 | XBOX360 | | Original | | KO-2010 | |
| Shin Sangoku Musou 7 真‧三國無雙7 | XBOX360 | | Original | | KV-2022 | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | XBOX360 | | Original | | KO-2033 | |
| Shin Sangoku Musou: Multi Raid Special 真・三國無双 MULTI RAID Special | XBOX360 | | Original | | KO-2028 | |
| Sid Meier's Civilization Revolution | XBOX360 | | Original | | TT-2021 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| Silent Hill: Homecoming | XBOX360 | | Original | | KN-2021 | |
| The Sims 3 | XBOX360 | | Original, Classics | | EA-2274 | |
| The Sims 3: Pets ザ・シムズ3 ペット | XBOX360 | | Original, Limited Edition | | EA-2402 | |
| Smash Court Tennis 3 | XBOX360 | | Original | | NM-2029 | |
| Sniper Elite III: Ultimate Edition | XBOX360 | | Original | | FO-2051 | |
| Sniper Elite V2: Silver Star Edition Sniper Elite V2: Game of the Year Edition | XBOX360 | | Original | | FO-2024 | |
| Sonic & All-Stars Racing Transformed | XBOX360 | | Original | | SE-2141 | |
| Soulcalibur IV ソウルキャリバーⅣ | XBOX360 | | Original, Classics, Promo, SoulCalibur IV / Tekken 6 | | NM-2016 | |
| Soulcalibur V ソウルキャリバーV | XBOX360 | | Original, Fighting Edition | | NM-2109 | |
| Spider-Man 3 | XBOX360 | | Original | | AV-2018 | |
| Spider-Man: Edge of Time | XBOX360 | | Original | | AV-2226 | |
| Spider-Man: Shattered Dimensions | XBOX360 | | Original | | AV-2177 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 1) | XBOX360 | | Original | | LA-2002 | |
| Star Wars: The Force Unleashed: Ultimate Sith Edition (Disc 2) | XBOX360 | | Original | | LA-2002 | |
| Steel Battalion: Heavy Armor 重鉄騎 STEEL BATTALION | XBOX360 | | Original | | CC-2070 | |
| Stormrise | XBOX360 | | Original | | SE-2054 | |
| Stuntman: Ignition | XBOX360 | | Original | | TQ-2036 | |
| Summer Athletics | XBOX360 | | Original | | DT-2002 | |
| Sensible Soccer: European Champions | CD32 | | Original | | SSI 1 | |
| Simon the Sorcerer | CD32 | | Original | | | |
| Summer Olympix | CD32 | | Original | | | |
| Super Skidmarks | CD32 | 2.2 | Original | | | |
| SimCity | CDTV | | Original | | 91133 | |
| Samurai Spirits ~ Samurai Shodown サムライ・スピリッツ | NGCD | | Original | | NGCD-045 | |
| Samurai Spirits: Amakusa Kourin ~ Samurai Shodown IV: Amakusa's Revenge サムライ・スピリッツ ~天草降臨~ | NGCD | | Original | | NGCD-222, NGCD-222E | |
| Samurai Spirits: Zankurou Musouken ~ Samurai Shodown III サムライ・スピリッツ 斬紅郎無双剣 | NGCD | | Original | | NGCD-087, NGCD-087E | |
| Shin Samurai Spirits: Haoumaru Jigokuhen ~ Samurai Shodown II 真サムライ・スピリッツ ~覇王丸地獄変~ | NGCD | | Original | | NGCD-063, NGCD-063E | |
| Shinsetsu Samurai Spirits: Bushidou Retsuden 真説サムライ・スピリッツ ~武士道烈伝~ | NGCD | | Original | | NGCD-0850 | |
| Shougi no Tatsujin: Master of Syougi 将棋の達人 | NGCD | | Original | | ADCD-010 | |
| Stakes Winner: GI Kanzen Seiha e no Michi ステークス・ウィナー ~GI完全制覇への道~ | NGCD | | Original | | NGCD-088 | |
| Samurai Shodown サムライ・ショーダウン | 3DO | | Original | | FZ-SJ3155 | |
| Samurai Shodown | 3DO | | Original | | | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Sento Monogatari: Sono I 「占都物語」 そのⅠ | 3DO | | Original | | FZ-SJ4054 | |
| Shock Wave: Operation JumpGate ショック・ウェーブ ~オペレーション・ジャンプゲート~ | 3DO | | Original | | FZ-SJ1665 | |
| Shock Wave: Operation JumpGate | 3DO | | Original | | | |
| Short Warp: Warp's Short Game Collection ショート・ワープ | 3DO | | Original | | FZ-SJ2357 | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Star Control II: The Ur-Quan Masters スター・コントロールⅡ ~ア・クアン・マスターを打倒せよ!~ | 3DO | | Original | | FZ-SJ3153 | |
| Super Real Mahjong PIV + Aishou Shindan スーパーリ・アル麻雀PⅣ+相性診断 | 3DO | | Original | | FZ-SJ6451 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Original, Power-Up Campaign | | FZ-SJ3851 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Demonstration-ban, Bundled with Magazine (4 Character Demo Disc) | | FZ-JJ9DSX-4I | |
| Super Wing Commander スーパー・ウイング・コマンダー | 3DO | | Original | | FZ-SJ1653 | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| SD Gundam: Daizukan SDガンダム ~大図鑑~ | QIS | | Original | | BAPD-03 | |
| Sangokushi III 三國志Ⅲ | FMT | | with Soundware | | HMD-131 | |
| Sangokushi IV 三國志Ⅳ | FMT | | with Soundware | | HMF-139 | |
| Secre Volume 2: Mai Oikawa SECRE VOLUME ② 「及川 麻衣」 | FMT | | Original | | HME-180 | |
| Sekigahara 関ヶ原 | FMT | | Original | | HMD-128 | |
| Shadow of the Beast II: Juushin no Jubaku シャドー・オブ・ザ・ビーストⅡ ~獣神の呪縛~ | FMT | | Original | | HMD-184 | |
| Shadow of the Beast: Mashou no Okite シャドー・オブ・ザ・ビースト ~魔性の掟~ | FMT | | Original | | HMC-157 | |
| Shamhat: The Holy Circlet シャムハト -The Holy Circlet- | FMT | | FM-Towns Sen'you, FM-Towns Marty Sen'you | | DWFS3010, DWFT 3012 | |
| Sherlock Holmes: Consulting Detective シャーロック・ホームズの探偵講座 | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 13 | | HMC-127 | |
| Sherlock Holmes: Consulting Detective | FMT | | Demonstration-ban | | HMC-901 | |
| Shinjuku Labyrinth 新宿ラビリンス | FMT | | Original | | FMSC0030 | |
| The Silent Service: Chinmoku no Kantai 沈黙の艦隊 | FMT | | Original | | DWFT2802 | |
| SimAnt | FMT | | Original | | HME-104 | |
| SimCity シム・シティ | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 6 | | HMB-121 | |
| SimEarth: The Living Planet シムアース | FMT | | FM Towns Soft Collection Kaigai-hen Vol. 15 | | HMC-141 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | | Original | | HMC-139 | |
| Software Contest Nyuusen Sakuhinshuu 1 ソフトウェア・コンテスト 入選作品集 1 | FMT | Rev B | Original | | HMC-139B | |
| Software Contest Nyuusen Sakuhinshuu 2 ソフトウェア・コンテスト 入選作品集 2 | FMT | | Original | | HMD-189 | |
| Stronghold: Emperor no Yousai ストロングホールド ~皇帝の要塞~ | FMT | | Ving Marty Taiou Vol. 8 | | HMF-133 | |
| Super Odyssey & Dennou Planetarium スーパー・オデッセイ&電脳プラネタリウム | FMT | | Original | | HMA-237 | |
| Super Real Mahjong PII & PIII スーパー・リアル麻雀PⅡ&PⅢ | FMT | | Ving Vol. 11 | | HMD-126 | |
| Super Shooting Towns スーパー・シューティングTOWNS | FMT | | Original | | HMC-191 | |
| Super Street Fighter II: The New Challengers スーパー・ストリート・ファイターⅡ | FMT | 941011 | CD-ROM-ban (Shokai Gentei: 6-button Pad-tsuki) | | HMF-162 | |
| Spider-Man | HS | 1.0 (USE1) | Original | | K6593-9609 | |
| Seven Kingdoms: Artwork | MAC | | Art Assets | | | |
| SimCity 2000 Special Edition | MAC | 1.0 | Original | | 0126-000-0601-A | |
| SimCity 2000: CD Collection | MAC | 1.0 | Original | | 0026-000-0601-A | |
| SimPeople シムピープル | MAC | | Original, EA Best Selections | | EAM-7020, EAMD-702 | |
| The Sims | MAC | | .mac | | 51005-1CDA | |
| SimTown: The Town You Build Yourself! | MAC | | Original | | 0037-000-0601-A, 0037-029-0601-A | |
| Sotsugyou: Graduation 卒業 グラデュエーション | MAC | | Original | | BCRM-0012 | |
| Space Adventure: With Buzz Aldrin & Tom McDonough | MAC | | Original, Bundle Version Apple OEM | | CDRM1239480 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 1) | MAC | 1.0 | Original | | 3092130 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) | MAC | 1.0 | Original | | 3092131 | |
| Sid Meier's Civilization IV | MAC | 1.61 | Original | | 11250-1DDA | |
| Sid Meier's Civilization V | MAC | | Original | | 12350-1DDA | |
| SimCity 4 Deluxe Edition | MAC | | Original | | 10830-1DDA | |
| The Sims 2 | MAC | 1.0 Rev E (v7535) | Original | | 10880-1DDA | |
| The Sims 2: Seasons (Expansion Pack) | MAC | 1.7 | Original | | 11610-1DDA | |
| Stubbs the Zombie in Rebel Without a Pulse | MAC | 1.0 (v418) | Original | | 11010-1DDA | |
| Santa Claus' Mice Les Souris du Pere Noel | CDI | | Original | | 811 0012, 812 0023 | |
| Secret Mission | CDI | | Original | | 810 0272 | |
| Shadoan Kingdom II: Shadoan | CDI | 1.03 | Original | | 810 0280 | |
| Shaolin's Road | CDI | | Original | | SHAOLM24011 | |
| The Smithsonian Presents the Riches of Coins | CDI | | Original, Demonstration Disc | | 310-690-088-2, 310690088-2 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2, 699 011-2, 812 0031 | |
| The Smithsonian Presents: Stamps: Windows on the World | CDI | | Original | | 310690011-2 | |
| Steel Machine | CDI | 1.14 | Original | | 810 0160 | |
| Stickybear Math | CDI | | Original, Demonstration Disc | | 310-690-082-2, 310690082-2 | |
| Stickybear Maths | CDI | 1.08 | Original, For Demonstration Only | | 810 0064, 818 0043 | |
| Sting: Ten Summoner's Tales | CDI | 1.03 | Original | | 089 5664 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2, 699 025-2 | |
| Story Machine: Magic Tales | CDI | | Original | | 310690025-2 | |
| Story Machine: Star Dreams | CDI | | Original | | 310690024-2 | |
| Strip Poker Live | CDI | | Original | | IM99002 | |
| Sakura Taisen: Teigeki Secret File サクラ大戦 ~帝劇シークレット・ファイル~ | PHOTO-CD | | Magazine Bundle | | SSMP-00001 | |
| SimCity 2000 for Pocket PC | PPC | 1.0 | Original | | | |
| Spider-Man Course-Poursuite à Manhattan | VFLASH | | Original | | 093065(FR) | |
| Sega Network Taisen Mahjong MJ4 Evolution セガネットワーク対戦麻雀MJ4 Evolution | LINDBERGH | 1.001 | Lindbergh Red EX | | DVP-0081 | |