Region | Title | System | Version | Edition | Languages | Serial | Status |
| Syndicate | 3DO | | Original | | | |
| Syndicate シンジケート | 3DO | | Original | | E3D-7025 | |
| Syndicate | 3DO | | Bundled with Magazine (Demo) | | | |
| Syndicate | 3DO | | Original | | | |
| Sword & Sorcery ソード・アンド・ソーサリー | 3DO | | Original | | FZ-SJ0251 | |
| Supreme Warrior (Disc 2) (Wind & Fang Tu) | 3DO | | Original | | | |
| Supreme Warrior (Disc 1) (Fire & Earth) | 3DO | | Original | | | |
| SuperModels Go Wild | 3DO | | Original | | | |
| Super Wing Commander | 3DO | | Original, Demo Disc (3DO Demo Disc Program) | | | |
| Super Wing Commander 슈퍼 윙 커맨더 | 3DO | | Original | | GDT-GA151 | |
| Super Wing Commander スーパー・ウイング・コマンダー | 3DO | | Original | | FZ-SJ1653 | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Demonstration-ban, Bundled with Magazine (4 Character Demo Disc) | | FZ-JJ9DSX-4I | |
| Super Street Fighter II X: Grand Master Challenge スーパー・ストリート・ファイターⅡX | 3DO | | Original, Power-Up Campaign | | FZ-SJ3851 | |
| Super Street Fighter II Turbo | 3DO | RE1 | Original | | FZ-SC3851, FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | RE2 | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SM3851 | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SE3851G | |
| Super Street Fighter II Turbo | 3DO | | Original | | FZ-SE3851 | |
| Super Real Mahjong PIV + Aishou Shindan スーパーリ・アル麻雀PⅣ+相性診断 | 3DO | | Original | | FZ-SJ6451 | |
| Striker: World Cup Special | 3DO | | Original | | FZ-SK0001 | |
| Strahl | 3DO | | Original | | FZ-SM4651 | |
| Stellar 7: Draxon's Revenge | 3DO | | Original | | | |
| Stellar 7: Draxon's Revenge ステラ7 ~ドラクソンの逆襲~ | 3DO | | Original | | FZ-SJ0151 | |
| Starblade 스타블레이드 | 3DO | | Original | | FZ-SM5351, GDT-GA221 | |
| Starblade スターブレード | 3DO | | Original, Power-Up Campaign | | FZ-SJ5351, FZ-SJ5351R | |
| Starblade スターブレード | 3DO | | Demonstration-ban | | FZ-JJ9DSB-4L | |
| Starblade | 3DO | | Original, Not for Resale | | FZ-SE5351, FZ-SG5351 | |
| Starblade | 3DO | | Original | | FZ-SC5351 | |
| Star Wars: Rebel Assault | 3DO | | Original | | | |
| Star Wars: Rebel Assault スター・ウォーズ レベル・アサルト | 3DO | | Original | | FZ-SJ1663 | |
| Star Fighter | 3DO | | Original | | | |
| Star Fighter | 3DO | | Bundled with Magazine | | | |
| Star Control II: The Ur-Quan Masters スター・コントロールⅡ ~ア・クアン・マスターを打倒せよ!~ | 3DO | | Original | | FZ-SJ3153 | |
| Star Control II | 3DO | | Original, Not for Resale | | | |
| Space Shuttle The Software Toolworks Presents... Space Shuttle | 3DO | | Original | | | |
| Space Pirates | 3DO | | Original | | ALG595001 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | 7373 | |
| Space Hulk: Vengeance of the Blood Angels | 3DO | | Original | | | |
| Space Ace | 3DO | RE-1 | Original | | | |
| Space Ace | 3DO | | Original | | | |
| Sotsugyou II Special: Neo Generation 卒業ⅡSPECIAL | 3DO | | Original | | FZ-SJ7451 | |
| Soccer Kid | 3DO | | Original, 3DO Action Pak, Demo Disc (3DO Demo Disc Program) | | | |
| SnowJob Starring Tracy Scoggins (Disc 2) | 3DO | | Original | | | |
| SnowJob Starring Tracy Scoggins (Disc 1) | 3DO | | Original | | | |
| Slopestyle: An Interactive Learning Cube | 3DO | | Original | | | |
| Slayer | 3DO | | Original | | | |
| Slayer | 3DO | | 3DO Action Pak | | | |
| Slam 'n Jam '95 | 3DO | | Original | | | |
| Slam 'n Jam '95 | 3DO | | Original | | 60140-C | |
| Slam 'n Jam '95 スラム・ジャム ~3Dバスケットボール~ | 3DO | | Original | | FZ-SJ3156, GDT-GA271 | |
| Sid Meier's C.P.U. Bach | 3DO | | Original | | | |
| Short Warp: Warp's Short Game Collection ショート・ワープ | 3DO | | Original | | FZ-SJ2357 | |
| Shockwave 2: Beyond the Gate (Disc 2) | 3DO | | Original | | | |
| Shockwave 2: Beyond the Gate (Disc 1) | 3DO | | Original | | | |
| Shock Wave: Operation JumpGate | 3DO | | Original | | | |
| Shock Wave: Operation JumpGate ショック・ウェーブ ~オペレーション・ジャンプゲート~ | 3DO | | Original | | FZ-SJ1665 | |
| Shock Wave | 3DO | RE2 | Original, Not for Resale | | | |
| Shock Wave | 3DO | RE1 | Original, Demo Disc (3DO Demo Disc Program) | | 7222 | |
| Shock Wave ショック・ウェーブ | 3DO | | Samples | | FZ-SD1657 | |
| Shock Wave ショックウェーブ | 3DO | | Original | | FZ-SJ1657 | |
| Shock Wave | 3DO | | Original | | | |
| Shelley Duvall's It's a Bird's Life | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | Original | | | |
| Shanghai: Triple-Threat | 3DO | | 3DO Action Pak | | | |
| SHADOW: War of Succession | 3DO | | Original | | | |
| SHADOW Warriors シャドー・ウォリアー | 3DO | | Original | | FZ-SJ0155 | |
| Sex | 3DO | | Original | | | |
| Sewer Shark | 3DO | | Original | | | |
| Sesame Street: Numbers | 3DO | | Original | | | |
| Sento Monogatari: Sono I 「占都物語」 そのⅠ | 3DO | | Original | | FZ-SJ4054 | |
| Seal of the Pharaoh | 3DO | | Original | | FZ-SM1751 | |
| Scramble Cobra | 3DO | | Original | | FZ-SM0404 | |
| The San Diego Zoo Presents... The Animals! | 3DO | | Original | | | |
| Samurai Shodown | 3DO | | Original | | | |
| Samurai Shodown サムライ・ショーダウン | 3DO | | Original | | FZ-SJ3155 | |